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Common stock reserved for future issuance (Details)
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
Notes to Financial Statements        
Stock option grants outstanding (see Note 10) 1,624,188 1,410,090    
Reserved for future stock option grants (see Note 10) 62,438 90,571 170,243 73,750
Reserved for note conversion (see Note 2) 620,844       
Reserved for exercise of outstanding warrants (see Note 11) 607,776 624,442    
Total common stock reserved for future issuance 2,915,249 2,125,103