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Common stock reserved for future issuance (Details)
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Notes to Financial Statements      
Stock option grants outstanding (see Note 7) 1,659,170 1,624,188 1,410,090
Reserved for future stock option grants (see Note 7) 215,898 62,438  
Reserved for note conversion (see Note 2) 1,050,325 620,844  
Reserved for exercise of outstanding warrants (see Note 11) 1,033,776 607,776  
Total common stock reserved for future issuance 3,959,169 2,915,246