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Common stock reserved for future issuance (Details) - shares
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Deferred Compensation Arrangements [Abstract]      
Stock option grants outstanding (see Note 7) 2,022,353 1,891,058 1,659,170
Reserved for future stock option grants (see Note 7) 121,750 147,217  
Reserved for note conversion (see Note 2) 977,398 977,398  
Reserved for exercise of outstanding warrants (see Note 8) 169,335 313,375  
Total common stock reserved for future issuance 3,290,836 3,329,048