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Note 3 - Summary of Significant Accounting Policies (Details Textual) - USD ($) |  | 3 Months Ended | 6 Months Ended | 9 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | ---
Feb. 12, 2016 | Sep. 30, 2016 | Sep. 30, 2015 | Jun. 30, 2015 | Sep. 30, 2016 | Sep. 30, 2015 | Dec. 31, 2015 | Dec. 31, 2014 | Feb. 16, 2016
Private Placement [Member] | Series B Preferred Stock [Member] | Placement Agent Warrants [Member] |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Issued | 127,346 |  |  |  |  |  |  |  |
Private Placement [Member] | Series B Preferred Stock [Member] | Strategic Bio Partners [Member] | Debt Settlement [Member] |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Issued | 295,945 |  |  |  |  |  |  |  |
Options and Warrants [Member] |  |  |  |  |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount |  |  |  |  | 6,418,887 | 4,801,112 | 5,111,111 | 4,371,111 |
Convertible Preferred Shares [Member] |  |  |  |  |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount |  |  |  |  | 2,796,929 | 0 |  |  |
Goodwill, Fair Value Disclosure |  |  |  |  |  |  |  |  | $ 0
Fair Value Assumptions, Expected Dividend Rate |  |  |  |  | 0.00% |  |  |  |
Derivative, Gain (Loss) on Derivative, Net |  | $ (938) |  |  | $ (29,332) |  |  |  |
Goodwill, Impairment Loss |  |  |  |  | $ 404,169 |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount |  |  |  |  | 9,215,816 | 4,801,112 |  |  |

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