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Note 8 - Collaborative Agreements (Details Textual) - USD ($) | 12 Months Ended | 133 Months Ended | 142 Months Ended
--- | --- | --- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2015 | Sep. 30, 2016
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Number of Shares | 1,707,744 |  | 1,707,744 |
Research and Development Expense, Sponsored Research | $ 170,575 | $ 67,270 |  |
University of Toronto [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures |  |  | 25,000 |
University of Toronto [Member] | Employee Stock Option [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period |  |  | 10 years |
University of Toronto [Member] | Minimum [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price | $ 0.26 |  | $ 0.26 |
University of Toronto [Member] | Maximum [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price | 1 |  | $ 1 |
Professor [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures |  |  | 483,299 | 275,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price | $ 1 |  | $ 1 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Number of Shares | 62,500 |  | 62,500 | 125,000
Professor [Member] | Minimum [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price | $ 0.26 |  | $ 0.26 |
Professor [Member] | Minimum [Member] | Employee Stock Option [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period |  |  | 10 years | 10 years
Professor [Member] | Maximum [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price | $ 1 |  | $ 1 | $ 1
Professor [Member] | Maximum [Member] | Employee Stock Option [Member] |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period |  |  | 13 years | 13 years

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- Definition Represents the amount of research and development expense attributable to sponsored research during the period. + References No definition available. + Details
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- Definition The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iii) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Net number of share options (or share units) granted during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(iv)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Number of non-vested options outstanding. + References No definition available. + Details
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