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Note 7 - Stockholders' Equity (Deficit) (Details Textual) |  |  |  |  |  | 3 Months Ended | 9 Months Ended | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Jul. 27, 2016 $ / shares shares | Jun. 27, 2016 $ / shares shares | Apr. 15, 2016 $ / shares shares | Feb. 12, 2016 USD ($) $ / shares shares | Apr. 01, 2012 shares | Sep. 30, 2016 $ / shares shares | Mar. 31, 2016 USD ($) | Sep. 30, 2016 USD ($) $ / shares shares | Dec. 31, 2015 USD ($) $ / shares shares | Dec. 31, 2014 USD ($) $ / shares shares | Jun. 26, 2016 $ / shares shares | Oct. 02, 2015 $ / shares shares | Oct. 01, 2015 shares | Dec. 31, 2013 shares | Mar. 15, 2006 shares
Common Stock, Shares Authorized | 100,000,000 | 100,000,000 |  |  |  | 100,000,000 |  | 100,000,000 | 20,000,000 | 20,000,000 | 100,000,000,000 | 20,000,000 | 10,000,000 |  |
Common Stock, Par or Stated Value Per Share | $ / shares | $ 0.0001 | $ 0.0001 |  | $ 0.0001 |  | $ 0.0001 |  | $ 0.0001 | $ 0.0001 | $ 0.001 | $ 0.000001 | $ 0.001 |  |  |
Preferred Stock, Shares Authorized | 20,000,000 | 20,000,000 |  |  |  | 20,000,000 |  | 20,000,000 | 20,000,000 |  | 5,000,000,000 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number |  |  |  |  |  | 2,592,229 |  | 2,592,229 | 1,707,744 | 1,217,744 |  |  |  | 977,744 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  |  |  |  |  | 1,974,445 | 490,000 | 240,000 |  |  |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares |  |  |  |  |  |  |  | $ 1.25 | $ 1.25 | $ 1 |  |  |  |  |
Allocated Share-based Compensation Expense | $ |  |  |  |  |  |  |  | $ 450,566 |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Number of Shares |  |  |  |  |  |  |  | 133,229 |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares |  |  |  |  |  |  |  |  | $ 1 |  |  |  |  |  |
Series B Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Shares Authorized |  |  |  |  |  | 18,000,000 |  | 18,000,000 | 18,000,000 |  |  |  |  |  |
Predecessor Warrants [Member] | Series B Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  | 295,945 |  |  |  |  |  |  |  |  |  |  |
Private Placement [Member] | Series B Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  | 423,291 |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Expiration Period |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares |  |  |  | $ 1.25 |  |  |  |  |  |  |  |  |  |  |
Private Placement [Member] | Placement Agent Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares |  |  | $ 1.25 |  |  |  |  |  |  |  |  |  |  |  |
Private Placement [Member] | Placement Agent Warrants [Member] | Series B Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  | 127,346 |  |  |  |  |  |  |  |  |  |  |  |
Protagenic Therapeutics Inc [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Business Combination, Stock Warrant Conversion Ratio |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |
Debt Instrument, Face Amount | $ |  |  |  | $ 665,000 |  |  |  |  |  |  |  |  |  |  |
Debt Instrument, Increase, Accrued Interest | $ |  |  |  | $ 35,000 |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Expiration Period |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |  |
Protagenic Therapeutics Inc [Member] | Predecessor Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  | 295,945 |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares |  |  |  | $ 1.25 |  |  |  |  |  |  |  |  |  |  |
Protagenic Therapeutics Inc [Member] | Placement Agent Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  | 127,346 |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares |  |  |  | $ 1.25 |  |  |  |  |  |  |  |  |  |  |
Protagenic Therapeutics Inc [Member] | Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  | 3,403,367 |  |  |  |  |  |  |  |  |  |  |
Each Member of Board of Directors [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  | 40,000 |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares |  |  | $ 1.25 |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Additional |  |  | 5,000 |  |  |  |  |  |  |  |  |  |  |  |
Director [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  | 175,000 |  |  |  |  |  |  |  |  |  |  |  |
Employees and Consultants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  | 1,008,299 |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares |  |  | $ 1.25 |  |  |  |  |  |  |  |  |  |  |  |
Former Executives [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  |  |  | 17,785 |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares |  |  |  |  |  |  |  | $ 1.25 |  |  |  |  |  |  |
Employee Stock Option [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Allocated Share-based Compensation Expense | $ |  |  |  |  |  |  |  |  | $ 190,751 | $ 85,168 |  |  |  |  |
Employee Stock Option [Member] | Each Member of Board of Directors [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |  |  | 2 years |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period |  |  | 10 years |  |  |  |  |  |  |  |  |  |  |  |
Employee Stock Option [Member] | Employees and Consultants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |  |  | 4 years |  |  |  |  |  |  |  |  |  |  |  |
Employee Stock Option [Member] | Former Executives [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period |  |  |  |  |  |  |  | 3 years |  |  |  |  |  |  |
Employee Stock Option [Member] | Minimum [Member] | Employees and Consultants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period |  |  | 10 years |  |  |  |  |  |  |  |  |  |  |  |
Employee Stock Option [Member] | Maximum [Member] | Employees and Consultants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |  |  | 1 year |  |  |  |  |  |  |  |  |  |  |  |
The 2006 Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number |  |  |  |  |  | 2,592,229 |  | 2,592,229 | 292,256 | 782,256 |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  |  |  |  |  |  | 490,000 | 240,000 |  |  |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares |  |  |  |  |  |  |  |  | $ 1.25 | $ 1 |  |  |  |  |
The 2006 Plan [Member] | Chief Financial Officer [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  | 100,000 |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares |  |  |  | $ 1.25 |  |  |  |  |  |  |  |  |  |  |
The 2006 Plan [Member] | Employee Stock Option [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized |  |  |  |  | 2,000,000 | 2,000,000 |  | 2,000,000 |  |  |  |  |  |  | 140,000
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |  |  |  |  |  |  |  | 5 years |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period |  |  |  |  |  |  |  | 10 years | 10 years |  |  |  |  |  |
The 2006 Plan [Member] | Employee Stock Option [Member] | Chief Financial Officer [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |  |  |  | 3 years |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period |  |  |  | 10 years |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting, Number of Monthly Installments |  |  |  | 35 |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting, Monthly Installment, Shares |  |  |  | 0.18 |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting, Final Monthly Installment, Shares |  |  |  | 2,778 |  |  |  |  |  |  |  |  |  |  |
Allocated Share-based Compensation Expense | $ |  |  |  |  |  |  | $ 5,192 | $ 10,383 |  |  |  |  |  |  |
The 2006 Plan [Member] | Employee Stock Option [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |  |  |  |  | 1 year |  |  | 1 year | 180 days |  |  |  |  |  |
The 2006 Plan [Member] | Employee Stock Option [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |  |  |  |  | 5 years |  |  |  | 5 years |  |  |  |  |  |
Stock Conversion from Series B Preferred Stock to Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible Preferred Stock, Shares Issued upon Conversion | 1 | 1 |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity Note, Stock Split, Conversion Ratio |  | 15,463.7183 |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse Stock Split [Member] | Series B Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity Note, Stock Split, Conversion Ratio | 15,463.7183 |  |  | 15,463.7183 |  |  |  |  |  |  |  |  |  |  |

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- Definition Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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