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Cover - USD ($)
 12 Months Ended
Dec. 31, 2021
Mar. 31, 2022
Mar. 29, 2021
Document Type 10-K    
Amendment Flag false    
Document Annual Report true    
Document Transition Report false    
Document Period End Date Dec. 31, 2021    
Document Fiscal Period Focus FY    
Document Fiscal Year Focus 2021    
Current Fiscal Year End Date --12-31    
Entity File Number 000-51353    
Entity Registrant Name Protagenic Therapeutics, Inc.\new    
Entity Central Index Key 0001022899    
Entity Tax Identification Number 06-1390025    
Entity Incorporation, State or Country Code DE    
Entity Address, Address Line One 149 Fifth Avenue    
Entity Address, City or Town New York    
Entity Address, State or Province NY    
Entity Address, Postal Zip Code 10010    
City Area Code (212)    
Local Phone Number 994-8200    
Entity Well-known Seasoned Issuer No    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Non-accelerated Filer    
Entity Small Business true    
Entity Emerging Growth Company false    
Entity Shell Company false    
Entity Public Float     $ 66,316,269
Entity Common Stock, Shares Outstanding   17,253,278  
Documents Incorporated by Reference None    
ICFR Auditor Attestation Flag false    
Auditor Firm ID 206    
Auditor Name MaloneBailey, LLP    
Auditor Location Houston, Texas    
Common Stock [Member]      
Title of 12(b) Security Common Stock, par value $0.0001    
Trading Symbol PTIX    
Security Exchange Name NASDAQ    
Warrant [Member]      
Title of 12(b) Security Common Stock Purchase Warrant    
Trading Symbol PTIXW    
Security Exchange Name NASDAQ