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STOCKHOLDERS’ DEFICIT (Details Narrative) - USD ($) |  |  |  | 12 Months Ended
--- | --- | --- | --- | ---
Jan. 06, 2022 | Jan. 01, 2022 | Jan. 01, 2021 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Accumulated Other Comprehensive Income (Loss) [Line Items] |  |  |  |  |  |
Number of shares issued, conversion of convertible securities |  |  |  | 18,911 |  |
Stock options outstanding |  |  |  | 1,357,466 | 1,380,216 |
Stock options outstanding weighted average exercise price |  |  |  | $ 7.39 |  |
Stock options. intrinsic value |  |  |  | $ 0 |  |
Options to purchase shares |  |  |  | 12,500 | 145,750 |
Weighted average period for unamortized stock compensation |  |  |  | 3 years 4 months 13 days |  |
Warrant shares, outstanding |  |  |  | 1,537,158 | 1,533,158 | 1,001,765
Warrant [Member] |  |  |  |  |  |
Accumulated Other Comprehensive Income (Loss) [Line Items] |  |  |  |  |  |
Share based compensation expense |  |  |  | $ 20,433 | $ 0 |
Warrant shares, outstanding |  |  |  | 1,537,158 |  |
Warrant exercise price |  |  |  | $ 13.49 |  |
Class of warrant or right, outstanding, intrinsic value |  |  |  | $ 0 |  |
Option forfeited | 4,000 |  |  |  |  |
Warrants to purchase common stock | 4,000 |  |  |  |  |
Warrant term | 5 years |  |  |  |  |
Warrant exercise price | $ 5.00 |  |  |  |  |
Employees [Member] |  |  |  |  |  |
Accumulated Other Comprehensive Income (Loss) [Line Items] |  |  |  |  |  |
Share based compensation expense |  |  |  | 182,748 | 769,479 |
Unamortized stock option expense |  |  |  | 8,566 |  |
Non-Employees [Member] |  |  |  |  |  |
Accumulated Other Comprehensive Income (Loss) [Line Items] |  |  |  |  |  |
Share based compensation expense |  |  |  | 661,500 | $ 749,277 |
Unamortized stock option expense |  |  |  | $ 1,334,107 |  |
Share-Based Payment Arrangement, Option [Member] |  |  |  |  |  |
Accumulated Other Comprehensive Income (Loss) [Line Items] |  |  |  |  |  |
Stock options outstanding |  |  |  | 1,357,466 | 1,380,216 | 1,399,466
Stock options outstanding weighted average exercise price |  |  |  | $ 7.39 | $ 7.36 | $ 5.88
Options to purchase shares | 12,500 |  |  | 12,500 | 145,750 |
Stock options exercise price | $ 4.84 |  |  | $ 4.84 | $ 19.08 |
Share based compensation expense |  |  |  | $ 844,248 | $ 1,518,756 |
Stock options, fair value | $ 68,614 |  |  |  |  |
Stock options, weighted average remaining contractual term | 10 years |  |  | 5 years 4 months 28 days | 6 years 3 months 25 days | 6 years 5 months 23 days
Share-Based Payment Arrangement, Option [Member] | General and Administrative Expense [Member] |  |  |  |  |  |
Accumulated Other Comprehensive Income (Loss) [Line Items] |  |  |  |  |  |
Share based compensation expense |  |  |  | $ 747,830 | $ 1,513,835 |
Share-Based Payment Arrangement, Option [Member] | Research and Development Expense [Member] |  |  |  |  |  |
Accumulated Other Comprehensive Income (Loss) [Line Items] |  |  |  |  |  |
Share based compensation expense |  |  |  | $ 96,418 | $ 4,921 |
Share-Based Payment Arrangement, Option [Member] | Minimum [Member] |  |  |  |  |  |
Accumulated Other Comprehensive Income (Loss) [Line Items] |  |  |  |  |  |
Stock options exercise price |  |  |  | $ 4.84 |  |
Share-Based Payment Arrangement, Option [Member] | Maximum [Member] |  |  |  |  |  |
Accumulated Other Comprehensive Income (Loss) [Line Items] |  |  |  |  |  |
Stock options exercise price |  |  |  | $ 22.40 |  |
Equity Option [Member] |  |  |  |  |  |
Accumulated Other Comprehensive Income (Loss) [Line Items] |  |  |  |  |  |
Unamortized stock option expense |  |  |  | $ 1,342,673 |  |
2016 Plan [Member] |  |  |  |  |  |
Accumulated Other Comprehensive Income (Loss) [Line Items] |  |  |  |  |  |
Number of additional shares granted |  | 184,260 | 142,457 |  |  |
Number of shares available for grant |  |  |  | 1,543,872 | 1,359,612 |

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