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Unamortized stock compensation term.

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Unamortized stock option expense.

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Exercise price per share or per unit of warrants or rights outstanding.

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Number of equity instruments other than options outstanding, including both vested and non-vested instruments.

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Number of additional shares authorized for issuance under share-based payment arrangement.

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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Gross number of share options (or share units) granted during the period.

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Fair value of options vested. Excludes equity instruments other than options, for example, but not limited to, share units, stock appreciation rights, restricted stock.

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STOCKHOLDERS’ DEFICIT (Details Narrative) - USD ($)				12 Months Ended
STOCKHOLDERS’ DEFICIT (Details Narrative) - USD ($)	Jan. 06, 2022	Jan. 01, 2022	Jan. 01, 2021	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Accumulated Other Comprehensive Income (Loss) [Line Items]
Number of shares issued, conversion of convertible securities				18,911
Stock options outstanding				1,357,466	1,380,216
Stock options outstanding weighted average exercise price				$ 7.39
Stock options. intrinsic value				$ 0
Options to purchase shares				12,500	145,750
Weighted average period for unamortized stock compensation				3 years 4 months 13 days
Warrant shares, outstanding				1,537,158	1,533,158	1,001,765
Warrant [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Share based compensation expense				$ 20,433	$ 0
Warrant shares, outstanding				1,537,158
Warrant exercise price				$ 13.49
Class of warrant or right, outstanding, intrinsic value				$ 0
Option forfeited	4,000
Warrants to purchase common stock	4,000
Warrant term	5 years
Warrant exercise price	$ 5.00
Employees [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Share based compensation expense				182,748	769,479
Unamortized stock option expense				8,566
Non-Employees [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Share based compensation expense				661,500	$ 749,277
Unamortized stock option expense				$ 1,334,107
Share-Based Payment Arrangement, Option [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Stock options outstanding				1,357,466	1,380,216	1,399,466
Stock options outstanding weighted average exercise price				$ 7.39	$ 7.36	$ 5.88
Options to purchase shares	12,500			12,500	145,750
Stock options exercise price	$ 4.84			$ 4.84	$ 19.08
Share based compensation expense				$ 844,248	$ 1,518,756
Stock options, fair value	$ 68,614
Stock options, weighted average remaining contractual term	10 years			5 years 4 months 28 days	6 years 3 months 25 days	6 years 5 months 23 days
Share-Based Payment Arrangement, Option [Member] \| General and Administrative Expense [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Share based compensation expense				$ 747,830	$ 1,513,835
Share-Based Payment Arrangement, Option [Member] \| Research and Development Expense [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Share based compensation expense				$ 96,418	$ 4,921
Share-Based Payment Arrangement, Option [Member] \| Minimum [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Stock options exercise price				$ 4.84
Share-Based Payment Arrangement, Option [Member] \| Maximum [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Stock options exercise price				$ 22.40
Equity Option [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Unamortized stock option expense				$ 1,342,673
2016 Plan [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Number of additional shares granted		184,260	142,457
Number of shares available for grant				1,543,872	1,359,612