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STOCKHOLDERS’ EQUITY (Details Narrative) - USD ($)	3 Months Ended		12 Months Ended
	Mar. 31, 2025	Mar. 31, 2024	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022	Feb. 21, 2025
Accumulated Other Comprehensive Income (Loss) [Line Items]
Number of options outstanding	136,183
Number of options outstanding	136,183		139,577
Stock option, exercise price	$ 3.63					$ 3.72
Share based compensation intrinsic value	$ 0
Share based compensation expense	0	$ 0
Employees [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Share based compensation expense	81,052	637
Unamortized stock option expense	465,616
Non-Employees [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Share based compensation expense	154,962	$ 161,224
Unamortized stock option expense	$ 338,915
Share-Based Payment Arrangement, Option [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Number of options issued	0	53,025
Number of options outstanding	136,183		139,577
Stock option, exercise price	$ 3.72		$ 5.29
Share based compensation expense	$ 236,014	$ 161,861
Unamortized stock option expense	$ 804,531
Weighted average period for unamortized stock compensation (in years)	2 years 9 months 25 days
Share-Based Payment Arrangement, Option [Member] | General and Administrative Expense [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Share based compensation expense	$ 134,769	52,360
Share-Based Payment Arrangement, Option [Member] | Research and Development Expense [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Share based compensation expense	$ 101,245	$ 109,501
2006 Equity Incentive Plan [Member] | Minimum [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Stock option, exercise price						56.00
2006 Equity Incentive Plan [Member] | Maximum [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Stock option, exercise price						70.00
2016 Equity Incentive Plan [Member] | Minimum [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Stock option, exercise price						24.36
2016 Equity Incentive Plan [Member] | Maximum [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Stock option, exercise price						$ 278.88
2016 Plan [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Number of additional shares granted			14,062	13,329	13,162
Number of shares available for grant	62,412		91,371
Common Stock [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Number of shares issued for cash	20,303	0
Warrant [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Shares issuable under warrants	354,904
Warrant exercise price	$ 58.97
Warrants outstanding, intrinsic value	$ 0

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