<SEC-DOCUMENT>0001171843-17-006846.txt : 20171109
<SEC-HEADER>0001171843-17-006846.hdr.sgml : 20171109
<ACCEPTANCE-DATETIME>20171109165142
ACCESSION NUMBER:		0001171843-17-006846
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20171109
DATE AS OF CHANGE:		20171109

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			RedHill Biopharma Ltd.
		CENTRAL INDEX KEY:			0001553846
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-209702
		FILM NUMBER:		171191597

	BUSINESS ADDRESS:	
		STREET 1:		21 HA'ARBA'A STREET
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			64739
		BUSINESS PHONE:		972-3-541-3131

	MAIL ADDRESS:	
		STREET 1:		21 HA'ARBA'A STREET
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			64739
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>f424b5_110917.htm
<DESCRIPTION>FORM 424B5
<TEXT>
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<P STYLE="margin: 0"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: right; margin: 0pt 0"><B>Filed Pursuant to Rule 424(b) (5)</B></P>

<P STYLE="font-size: 10pt; text-align: right; margin: 0pt 0"><B>Registration No.&nbsp;333-209702</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>PROSPECTUS SUPPLEMENT</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>(To Prospectus dated March 11, 2016)</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><FONT STYLE="font-size: 14pt"><B>4,090,909 American Depositary Shares Representing 40,909,090&nbsp;Ordinary Shares</B></FONT></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B>&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;<IMG SRC="logo.jpg" ALT=""></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 18pt; text-align: center; margin: 0pt 0"><B>RedHill Biopharma Ltd.</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We are offering&nbsp;4,090,909&nbsp;American Depositary Shares (&ldquo;ADSs&rdquo;)
representing&nbsp;40,909,090&nbsp;of our ordinary shares, par value NIS 0.01 per share (&ldquo;Ordinary Shares&rdquo;). Each ADS
represents 10 Ordinary Shares.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Our ADSs are listed on The NASDAQ Capital Market (&ldquo;The NASDAQ&rdquo;)
under the symbol &ldquo;RDHL.&rdquo;&nbsp;On&nbsp;November 7, 2017, the last reported sale price of our ADSs on The NASDAQ was
$7.50 per ADS.&nbsp;Our Ordinary Shares are also listed on the Tel Aviv Stock Exchange (the &ldquo;TASE&rdquo;) under the symbol
&ldquo;RDHL.&rdquo;&nbsp;On November 7, 2017, the last reported sale price of our Ordinary Shares on the TASE was NIS 2.72, or
$0.77 per Ordinary Share (based on the exchange rate reported by the Bank of Israel on such date).</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We are an &ldquo;emerging growth company&rdquo; as that term is
used in the Jumpstart Our Business Startups Act of 2012 and, as such, we have elected to comply with certain reduced public company
reporting requirements for this prospectus and may elect to comply with certain reduced public company reporting requirements for
future filings.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>Investing in our securities involves a high degree of risk. Please
read &ldquo;Risk Factors&rdquo; beginning on page S-14 of this prospectus supplement, on page 3 of the accompanying
prospectus and in the documents incorporated by reference into this prospectus supplement.</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>None of the United States Securities and Exchange Commission,
the Israeli Securities Authority, any state securities commission or any other regulatory body, has approved or disapproved of
these securities or passed upon the adequacy or accuracy of this prospectus supplement or the accompanying prospectus. Any representation
to the contrary is a criminal offense. </B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">PER ADS </FONT></TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1pt solid; text-align: center"><FONT STYLE="font-size: 10pt">TOTAL</FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 72%"><FONT STYLE="font-size: 10pt">Public Offering Price&#9;</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 11%; text-align: right"><P STYLE="margin: 0pt 0">5.50</P>


</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 11%; text-align: right"><P STYLE="margin: 0pt 0">22,500,000</P>


</TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: white">
    <TD><FONT STYLE="font-size: 10pt">Underwriting Discounts and Commissions (1)&#9;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><P STYLE="margin: 0pt 0">0.33</P>


</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><P STYLE="margin: 0pt 0">1,350,000</P>


</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD><FONT STYLE="font-size: 10pt">Proceeds to Us, before Expenses &#9;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><P STYLE="margin: 0pt 0">5.17</P>


</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><P STYLE="margin: 0pt 0">21,150,000</P>


</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%"><FONT STYLE="font-size: 10pt">(1)&nbsp;&nbsp;</FONT></TD>
    <TD STYLE="width: 95%"><FONT STYLE="font-size: 10pt">We may
elect to pay certain of the underwriters an additional fee based on their efforts and results of the offering of up to 1% of the
aggregate gross proceeds we receive from this offering. See &ldquo;Underwriting.&rdquo;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Three of our directors have agreed to purchase 209,090 ADSs in the aggregate in this offering. The underwriters will receive the same
underwriting discount on any ADSs purchased by these persons as they will on the other ADSs sold to the public in this
offering.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Delivery of the ADSs is expected to be made on or about November
13, 2017. We have granted the underwriters an option for a period of 30 days to purchase up to an additional 613,636&nbsp;ADSs
representing&nbsp;6,136,360&nbsp;Ordinary Shares at a price of $5.50 per ADS less underwriting discounts and commissions. If the
underwriters exercise the option in full, the total underwriting discounts and commissions payable by us will be approximately
$1.6 million, before payment of any discretionary fee, and the total proceeds to us, before expenses,
will be approximately $24.3&nbsp;million.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<P STYLE="text-align: center; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt"><I>Joint
Book-Running Managers</I></FONT></P>

<P STYLE="text-align: center; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt"><I>&nbsp;</I></FONT></P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 70%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 50%; text-align: center"><FONT STYLE="font-size: 18pt"><B>Cantor</B></FONT></TD>
    <TD STYLE="width: 50%; text-align: center"><FONT STYLE="font-size: 18pt"><B>Nomura</B></FONT></TD></TR>
</TABLE>

<P STYLE="text-align: center; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt"><I>&nbsp;</I></FONT></P>

<P STYLE="text-align: center; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><I>Lead Manager</I>&nbsp;</P>

<P STYLE="text-align: center; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="text-align: center; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><B>SMBC Nikko</B></P>


<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><I>Co-Managers</I></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 70%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="text-align: center; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; width: 50%"><FONT STYLE="font-size: 9pt"><B>H.C.
    Wainwright &amp; Co.</B></FONT></TD>
    <TD STYLE="text-align: center; font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; width: 50%"><FONT STYLE="font-size: 9pt"><B>Roth
    Capital Partners</B></FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">Prospectus Supplement dated November&nbsp;8, 2017.&nbsp;</P>



<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>



<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><FONT STYLE="font-variant: small-caps"><B>Table Of Contents</B></FONT></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR>
    <TD STYLE="vertical-align: bottom; width: 90%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 10%; text-align: right"><FONT STYLE="font-size: 10pt"><B>&nbsp;Page</B></FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt"><B>Prospectus Supplement</B></FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_001"><FONT STYLE="font-size: 10pt">About this Prospectus Supplement</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_001"><FONT STYLE="font-size: 10pt">S-2</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_002"><FONT STYLE="font-size: 10pt">Cautionary Note Regarding Forward-Looking Statements</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_002"><FONT STYLE="font-size: 10pt">S-3</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_003"><FONT STYLE="font-size: 10pt">Prospectus Supplement Summary</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_003"><FONT STYLE="font-size: 10pt">S-4</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_005"><FONT STYLE="font-size: 10pt">Summary Financial Data</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_005"><FONT STYLE="font-size: 10pt">S-12</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_006"><FONT STYLE="font-size: 10pt">Risk Factors</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_006"><FONT STYLE="font-size: 10pt">S-14</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_007"><FONT STYLE="font-size: 10pt">Use of Proceeds</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_007"><FONT STYLE="font-size: 10pt">S-43</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_008"><FONT STYLE="font-size: 10pt">Dilution</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_008"><FONT STYLE="font-size: 10pt">S-44</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_009"><FONT STYLE="font-size: 10pt">Capitalization and Indebtedness</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_009"><FONT STYLE="font-size: 10pt">S-45</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_010"><FONT STYLE="font-size: 10pt">Price Range of Our Ordinary Shares</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_010"><FONT STYLE="font-size: 10pt">S-46</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_011"><FONT STYLE="font-size: 10pt">Price Range of Our ADSs</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_011"><FONT STYLE="font-size: 10pt">S-47</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_012"><FONT STYLE="font-size: 10pt">Dividend Policy</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_012"><FONT STYLE="font-size: 10pt">S-47</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_013"><FONT STYLE="font-size: 10pt">Material Tax Considerations</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_013"><FONT STYLE="font-size: 10pt">S-48</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_014"><FONT STYLE="font-size: 10pt">Underwriting</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_014"><FONT STYLE="font-size: 10pt">S-55</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_015"><FONT STYLE="font-size: 10pt">Notice to Investors</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_015"><FONT STYLE="font-size: 10pt">S-59</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_016"><FONT STYLE="font-size: 10pt">Legal Matters</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_016"><FONT STYLE="font-size: 10pt">S-63</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_017"><FONT STYLE="font-size: 10pt">Experts</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_017"><FONT STYLE="font-size: 10pt">S-64</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_035"><FONT STYLE="font-size: 10pt">Where You Can Find More Information</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_035"><FONT STYLE="font-size: 10pt">S-64</FONT></A></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><A HREF="#a_070"><FONT STYLE="font-size: 10pt">Incorporation of Information by Reference</FONT></A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_070"><FONT STYLE="font-size: 10pt">S-64</FONT></A></TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: middle">
    <TD STYLE="width: 90%">&nbsp;</TD>
    <TD STYLE="font-weight: bold; text-align: right; width: 10%">Page</TD></TR>
<TR STYLE="vertical-align: middle">
    <TD COLSPAN="2" STYLE="font-weight: bold; text-align: left">Prospectus</TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_019">About This Prospectus</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_019">2</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_020">RedHill Biopharma Ltd.</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_020">2</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_021">Risk Factors</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_021">3</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_022">Forward-Looking Statements</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_022">3</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_023">Capitalization</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_023">4</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_024">Price Range of Our Ordinary Shares</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_024">4</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_025">Price Range of Our ADSs</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_025">5</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_026">Use of Proceeds</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_026">6</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_027">Description of Ordinary Shares</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_027">6</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_028">Description of American Depositary Shares</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_028">6</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_029">Description of Warrants</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_029">7</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_030">Description of Subscription Rights</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_030">7</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_031">Description of Units</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_031">8</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_032">Plan of Distribution</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_032">8</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_033">Legal Matters</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_033">11</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_034">Experts</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_034">11</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_035">Where You Can Find More Information</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_035">11</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_036">Incorporation of Information by Reference</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_036">12</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_037">Enforceability of Civil Liabilities</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_037">12</A></TD></TR>
<TR STYLE="vertical-align: middle">
    <TD><A HREF="#a_038">Offering Expenses</A></TD>
    <TD STYLE="text-align: right"><A HREF="#a_038">13</A></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><A NAME="a_001"></A><B>ABOUT THIS PROSPECTUS SUPPLEMENT</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">You should rely only on the information provided in this prospectus
supplement and the accompanying prospectus, all information incorporated by reference herein and therein, as well as the additional
information described under &ldquo;Incorporation of Information by Reference&rdquo; on page S-64 of this prospectus supplement.
We have not, and the underwriters have not, authorized anyone to provide you with different information. If anyone provides you
with different or inconsistent information, you should not rely on it. This prospectus supplement and the accompanying prospectus
do not constitute an offer to sell, or a solicitation of an offer to purchase, the securities offered by this prospectus supplement
and the accompanying prospectus in any jurisdiction where it is unlawful to make such offer or solicitation. You should not assume
that the information contained in this prospectus supplement or the accompanying prospectus, or any document incorporated by reference
in this prospectus supplement or the accompanying prospectus, is accurate as of any date other than the date on the front cover
of the applicable document. Neither the delivery of this prospectus supplement nor any distribution of securities pursuant to this
prospectus supplement shall, under any circumstances, create any implication that there has been no change in the information set
forth or incorporated by reference into this prospectus supplement or in our affairs since the date of this prospectus supplement.
Our business, financial condition, results of operations and prospects may have changed since that date.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">This prospectus supplement and the accompanying prospectus are part
of a registration statement (No. 333-209702) that we filed with the Securities and Exchange Commission, or the SEC, using a &ldquo;shelf&rdquo;
registration process. This document comprises two parts. The first part is this prospectus supplement, which describes the specific
terms of this offering and also adds to and updates information contained in the accompanying prospectus and the documents incorporated
by reference herein, in addition to information concerning the option to purchase additional ADSs granted by us to the underwriters.
The second part, the accompanying prospectus, gives more general information, some of which may not apply to this offering. Generally,
when we refer to this prospectus, we are referring to both parts of this document combined. If the description of the offering
varies between this prospectus supplement and the accompanying prospectus or the documents incorporated herein by reference filed
prior to the date of this prospectus supplement, you should rely on the information contained in this prospectus supplement. However,
if any statement in one of these documents is inconsistent with a statement in another document having a later date &mdash; for
example, a document incorporated by reference in the accompanying prospectus &mdash; the statement in the document having the later
date modifies or supersedes the earlier statement.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Before purchasing any securities, you should carefully read both
this prospectus supplement and the accompanying prospectus, together with the additional information described under the headings,
&ldquo;Where You Can Find More Information&rdquo; and &ldquo;Incorporation of Information by Reference,&rdquo; on <FONT STYLE="background-color: white">page
S-</FONT> 64 <FONT STYLE="background-color: white">of</FONT> this prospectus supplement.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Unless the context otherwise requires, all references to &ldquo;RedHill,&rdquo;
&ldquo;we,&rdquo; &ldquo;us,&rdquo; &ldquo;our,&rdquo; the &ldquo;Company&rdquo; and similar designations refer to RedHill Biopharma
Ltd. The term &ldquo;NIS&rdquo; refers to New Israeli Shekels, the lawful currency of the State of Israel, the terms &ldquo;dollar,&rdquo;
&ldquo;US$&rdquo; or &ldquo;$&rdquo; refer to U.S. dollars, the lawful currency of the United States (&ldquo;U.S.&rdquo;). Our
functional and presentation currency is the U.S. dollar. Foreign currency transactions in currencies other than the U.S. dollar
are translated in this prospectus supplement into U.S. dollars using exchange rates in effect at the date of the transactions.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We further note that the representations, warranties and covenants
made by us in any agreement that is filed as an exhibit to any document that is incorporated by reference herein were made solely
for the benefit of the parties to such agreement, including, in some cases, for the purpose of allocating risk among the parties
to such agreements, and should not be deemed to be a representation, warranty or covenant to you. Moreover, such representations,
warranties or covenants were accurate only as of the date when made. Accordingly, such representations, warranties and covenants
should not be relied on as accurately representing the current state of our affairs.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We are offering to sell, and seeking offers to buy, ADSs representing
our Ordinary Shares only in jurisdictions where offers and sales are permitted. The distribution of this prospectus supplement
and the accompanying prospectus and the offering of the ADSs in certain jurisdictions may be restricted by law. Persons outside
the U.S. who come into possession of this prospectus supplement and the accompanying prospectus must inform themselves about, and
observe any restrictions relating to, the offering of the ADSs and the distribution of this prospectus supplement and the accompanying
prospectus outside the U.S. This prospectus supplement and the accompanying prospectus do not constitute, and may not be used in
connection with, an offer to sell, or a solicitation of an offer to buy, any securities offered by this prospectus supplement and
the accompanying prospectus by any person in any jurisdiction in which it is unlawful for such person to make such an offer or
solicitation.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; text-indent: 0.5in; margin: 0pt 0"><A NAME="a_002"></A><B>CAUTIONARY NOTE REGARDING FORWARD-LOOKING
STATEMENTS</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">This prospectus supplement, the accompanying prospectus, and the
information incorporated by reference herein and therein may include forward looking statements. These statements involve known
and unknown risks, uncertainties and other factors that may cause our actual results, performance or achievements to be materially
different from any future results, performance or achievements expressed or implied by the forward-looking statements. In some
cases, you can identify forward-looking statements by terms including &ldquo;anticipates,&rdquo; &ldquo;believes,&rdquo; &ldquo;could,&rdquo;
&ldquo;estimates,&rdquo; &ldquo;expects,&rdquo; &ldquo;intends,&rdquo; &ldquo;may,&rdquo; &ldquo;plans,&rdquo; &ldquo;potential,&rdquo;
&ldquo;predicts,&rdquo; &ldquo;projects,&rdquo; &ldquo;should,&rdquo; &ldquo;will,&rdquo; &ldquo;would,&rdquo; and similar expressions
intended to identify forward-looking statements. Forward-looking statements reflect our current views with respect to future events
and are based on assumptions and subject to risks and uncertainties. In addition, certain sections of this prospectus supplement,
the accompanying prospectus, and the information incorporated by reference herein contain information obtained from independent
industry and other sources that we have not independently verified. You should not put undue reliance on any forward-looking statements.
Unless we are required to do so under U.S. federal securities laws or other applicable laws, we do not intend to update or revise
any forward-looking statements.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Our ability to predict our operating results or the effects
of various events on our operating results is inherently uncertain. Therefore, we caution you to consider carefully the
matters described under the caption &ldquo;Risk Factors&rdquo; on <FONT STYLE="background-color: white">page&nbsp;S-14
of</FONT> this prospectus supplement, and certain other matters discussed in this prospectus supplement, the accompanying
prospectus, and the information incorporated by reference herein and therein, and other publicly available sources. Such
factors and many other factors beyond our control could cause our actual results, performance or achievements to be
materially different from any future results, performance or achievements that may be expressed or implied by the
forward-looking statements.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Factors that could cause our actual results to differ materially
from those expressed or implied in such forward-looking statements include, but are not limited to:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="text-align: center; width: 4%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify; width: 96%">estimates of our expenses, future revenues, capital requirements and our needs for additional financing;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">our receipt of regulatory clarity and approvals for our therapeutic candidates, and the timing of other regulatory filings and approvals;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the initiation, timing, progress and results of our research, manufacturing, preclinical studies, clinical trials, and other therapeutic candidate development efforts, as well as the extent and number of additional studies that we may be required to conduct;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">our ability to advance our therapeutic candidates into clinical trials or to successfully complete our preclinical studies or clinical trials;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">our ability to establish and maintain corporate collaborations;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">that products we promote or commercialize may be withdrawn from the market by regulatory authorities and our need to comply with continuing laws, regulations and guidelines to maintain clearances and approvals for our products;&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">our ability to acquire products approved for marketing in the U.S. that achieve commercial success and maintain our own marketing and commercialization capabilities;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the research, manufacturing, clinical development, commercialization, and market acceptance of our therapeutic candidates and commercial products;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the interpretation of the properties and characteristics of our therapeutic candidates and of the results obtained with our therapeutic candidates in research, preclinical studies or clinical trials;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the implementation of our business model, strategic plans for our business, therapeutic candidates and commercial products;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the impact of other companies and technologies that compete with us within our industry;&nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the scope of protection we are able to establish and maintain for intellectual property rights covering our therapeutic candidates and our ability to operate our business without infringing or violating the intellectual property rights of others;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">parties from whom we license our intellectual property defaulting in their obligations towards us; and</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the impact of the political and security situation in Israel and in the U.S. on our business.</TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><A NAME="a_003"></A><B>PROSPECTUS SUPPLEMENT SUMMARY</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I></I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I>This summary highlights selected information about us, this offering
and information contained in greater detail elsewhere in this prospectus supplement, the accompanying prospectus, any free writing
prospectus that we have authorized for use, and in the documents incorporated by reference. This summary is not complete and does
not contain all of the information that you should consider before investing in our ADSs. You should carefully read and consider
this entire prospectus supplement, the accompanying prospectus and the documents, including financial statements and related notes,
and information incorporated by reference into this prospectus supplement, including the financial statements and &ldquo;Risk Factors&rdquo;
starting <FONT STYLE="background-color: white">on page S-14 of</FONT> this prospectus supplement, before making an investment decision.
If you invest in our securities, you are assuming a high degree of risk.</I></P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I></I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>Our Business</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We are a specialty biopharmaceutical company primarily focused on
late clinical-stage development and commercialization of proprietary drugs for the treatment of gastrointestinal (&ldquo;GI&rdquo;),
and inflammatory diseases and cancer.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Depending on the specific development program, our therapeutic candidates
are designed to exhibit greater efficacy and provide improvements over existing drugs by improving their safety profile, reducing
side effects, reducing the number of administrations, using a more convenient administration form or providing a cost advantage.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">In addition to our primary focus on the development of clinical-stage
GI products, we have established commercial presence and capabilities in the U.S., intended primarily to support potential future
launch of our GI-related therapeutic candidates currently under development in the U.S. We currently promote three GI products
in the U.S., Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release
Capsules 49.3mg under agreements with third parties.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>Product Pipeline</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The table below summarizes our current pipeline of products and
product candidates, as well as the target indication.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><img src="pipeline.jpg"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I>* Estimated timeline or indication in the pipeline chart is subject
to changes in development plans and regulatory requirements/clarifications, including complementary /additional studies </I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I>** BEKINDA<SUP>&reg;</SUP>, YELIVA<SUP>&reg;</SUP>, RIZAPORT<SUP>&reg;</SUP>
and TALICIA<SUP>&trade;</SUP> are proposed tradenames which are subject to FDA review and approval </I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I></I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I>***EnteraGam<SUP>&reg;</SUP> (a serum-derived bovine immunoglobulin/protein
isolate, or SBI) is a </I>&ldquo;medical food&rdquo; <I>which must be administered under medical supervision </I></P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><B>Recent Developments</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><B><I>TALICIA&trade;&nbsp;(RHB-105)</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">In June 2017, we initiated a confirmatory Phase III study with TALICIA<SUP>&trade;</SUP>&nbsp;(RHB-105)
for the treatment of&nbsp;<I>Helicobacter pylori</I>&nbsp;(&ldquo;<I>H. pylori</I>&rdquo;) infection (the &ldquo;ERADICATE Hp2
study&rdquo;), which is currently ongoing. The ERADICATE Hp2 study is a two-arm, randomized, double-blind, active comparator study
and is planned to enroll 444 non-investigated dyspepsia patients with confirmed&nbsp;<I>H. pylori</I>&nbsp;infection in up to 65
clinical sites in the U.S., with a primary endpoint of eradication of&nbsp;<I>H. pylori</I>&nbsp;infection at 42 through 70 days
after initiation of treatment. We expect to receive top-line results from the ERADICATE Hp2 study in the fourth quarter of 2018.
Subject to a successful outcome and any additional regulatory feedback, the ERADICATE Hp2 study is expected to complete the package
required for a potential submission of U.S. New Drug Application (&ldquo;NDA&rdquo;) for TALICIA (RHB-105).</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>RHB-104</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I>Crohn&rsquo;s Disease</I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We are currently conducting a randomized, double-blind,
placebo-controlled first Phase III study with RHB-104 for Crohn&rsquo;s disease (the &ldquo;MAP US study&rdquo;) in
approximately 150 clinical sites in the U.S., Canada, Europe, Israel, Australia and New Zealand. We have recently accelerated
the timelines for the ongoing MAP US study by curtailing the number of subjects enrolled in the study from 410 to 331
subjects, while maintaining statistical power of over 80% with a treatment effect of 15%. A&nbsp;review of the blended
efficacy rate of the current blinded data, as well as additional input from experts, including statisticians and key opinion
leaders, suggests that the total number of treatment successes is consistent with the predefined expected treatment outcomes
and that the study has sufficient enrollment to potentially demonstrate efficacy. We estimate that as a result of the
curtailment, the development program will be shortened by approximately one year. The curtailed enrollment has been completed
in November 2017 with a total of 331 subjects, and top-line results are expected in mid-2018.&nbsp; The estimated cost saving
from the curtailment is approximately $14 million. We remain blinded to the data from the ongoing MAP US study and cannot
ascertain the potential impact of the curtailed number of subjects on the study&rsquo;s final outcome. Additional clinical
studies are likely to be required to support an NDA for RHB-104. If the MAP US study results are positive, we intend to meet
with the U.S. Food and Drug Administration (&ldquo;FDA&rdquo;) and key opinion leaders to present the data package
and discuss the preferred development path.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Two pre-planned independent Data and Safety Monitoring Board (&ldquo;DSMB&quot;)
meetings have been held to review data from the MAP US study, in which unanimous recommendations to continue the study without
any changes to the protocol, investigator&rsquo;s brochure, study conduct or informed consent form were given. At the first DSMB
meeting, held in December 2016, safety data from the study was reviewed. At the second DSMB meeting, held in July 2017, safety
and efficacy data from the first 222 subjects who had completed week 26 assessments of the study was reviewed.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">In addition, in an ongoing open-label extension Phase III study
(the &ldquo;MAP US2 study&rdquo;), we continue to evaluate the safety and efficacy of&nbsp;RHB-104 in subjects who remain with
active Crohn&rsquo;s disease (CDAI &ge; 150) after 26 weeks of blinded study therapy in the ongoing Phase III MAP US study. These
subjects have the opportunity to receive treatment with RHB-104 for a 52-week period in the open-label MAP US2 study. We expect
that the data collected in the MAP US2 study will be supplemental to the MAP US study data. The MAP US2 study&rsquo;s primary endpoint
is disease remission at week 16, defined as CDAI of less than 150. The MAP US2 study is planned to enroll approximately 50-70 subjects
 in the U.S., Canada, Europe, Israel and New Zealand. We are planning additional open-label studies
with RHB-104 for Crohn&rsquo;s disease to generate further supportive clinical data for potential future marketing applications.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We have conducted several supportive studies with the current formulation
of RHB-104, and a long-term population pharmacokinetic study is ongoing as part of the Phase III MAP US study. We also continue
to advance the development program for a commercial companion diagnostic for the detection of <I>Mycobacterium avium paratuberculosis</I>&nbsp;(&ldquo;MAP&rdquo;)
bacteria in Crohn&rsquo;s disease patients in collaboration with several U.S. universities and with Q<SUP>2</SUP>&nbsp;Solutions.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><I>Nontuberculous Mycobacteria (NTM) Infections </I></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">In light of recent discussions with the FDA on our design of a
single pivotal Phase III study in support of an NDA filing for a first-line treatment of NTM infections, we plan, subject to
further input from the FDA, to initiate a pivotal Phase III study with RHB-104 for the treatment of NTM infections in the
first half of 2018.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The study is intended to assess the efficacy and safety of RHB-104
as a first-line treatment for NTM infections caused by <I>mycobacterium avium complex</I> (MAC). According to Prevots DR <I>et
al.</I> (Am J Respir Crit Care Med, 2010), approximately 80% of pulmonary NTM infections in the U.S. are associated with MAC. RHB-104
is targeting an annual potential U.S. market for pulmonary NTM caused by MAC infection estimated to exceed $500 million, based
on an analysis by Foster Rosenblatt, a provider of analytic consulting and management development services for the life sciences
industry.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In January 2017, we announced that RHB-104 had been granted
Qualified Infectious Disease Product (&ldquo;QIDP&rdquo;) designation by the FDA for the treatment of NTM infections. The QIDP
designation was granted under the Generating Antibiotic Incentives Now (GAIN) Act, which was passed as part of the Food and Drug
Administration Safety and Innovation Act, and which is intended to encourage development of new antibiotic drugs for the treatment
of serious or life-threatening infections that have the potential to pose a serious threat to public health.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>BEKINDA</I></B><SUP>&reg; </SUP><B><I>(RHB-102)</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I>Acute Gastroenteritis and Gastritis</I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">In June 2017, we announced positive top-line results from the randomized,
double-blind, placebo-controlled Phase III study (the &ldquo;GUARD study&rdquo;) with BEKINDA<SUP>&reg;</SUP>&nbsp;(RHB-102) 24mg
for acute gastroenteritis and gastritis. The study successfully met its primary endpoint of efficacy in acute gastroenteritis and
gastritis. BEKINDA<SUP>&reg;</SUP>&nbsp;24mg was also found to be safe and well tolerated in this indication. The GUARD study evaluated
the efficacy and safety of BEKINDA<SUP>&reg;</SUP>&nbsp;24mg in treating acute gastroenteritis and gastritis in 321 adults and
children over the age of 12. The primary endpoint of the study was the proportion of patients without further vomiting, without
rescue medication, and who were not given intravenous hydration from 30 minutes post first dose of the study drug until 24 hours
post dose, compared to placebo. In September 2017, we met with the FDA to discuss the study results and the clinical and regulatory
path towards potential marketing approval of BEKINDA<SUP>&reg;</SUP> 24mg in the U.S. Following the guidance provided at the meeting,
we are currently working with the FDA to design the confirmatory Phase III study to support a potential NDA with BEKINDA<SUP>&reg;
</SUP>24mg for acute gastroenteritis and gastritis, which we plan to initiate in the first half of 2018.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I>Diarrhea-predominant Irritable Bowel Syndrome (&ldquo;IBS-D&rdquo;)
</I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We recently announced positive top-line results from the Phase II
clinical study of BEKINDA<SUP>&reg;</SUP>&nbsp;(RHB-102) 12mg for the treatment of diarrhea-predominant irritable bowel syndrome
(IBS-D). The randomized, double-blind, placebo-controlled Phase II study evaluated the efficacy and safety of BEKINDA<SUP>&reg;</SUP>&nbsp;12mg
in 126 subjects over 18 years old at 16 clinical sites in the U.S. BEKINDA<SUP>&reg;</SUP> 12mg Phase II study successfully met
its primary endpoint, improving the primary efficacy outcome of stool consistency response (in accordance with the FDA guidance
definition) by an absolute difference of 19.4%, with 54.7% responders of subjects treated with BEKINDA<SUP>&reg;</SUP> (n=75) vs.
35.3% responders of the placebo subjects (n=51) (p=0.05). While not powered for statistical significance of the secondary efficacy
endpoints, we believe the study suggested clinically meaningful improvement in both secondary efficacy endpoints of abdominal pain
response and overall response (combined stool consistency and abdominal pain response). Top-line results from the Phase II study
demonstrated that BEKINDA<SUP>&reg;</SUP>&nbsp;12mg improved the overall worst abdominal pain response rate by 11.5% vs. placebo
(50.7% with BEKINDA<SUP>&reg;</SUP> 12mg (n=75) vs. 39.2% with placebo (n=51); (p=0.28)) and the overall response by an absolute
difference of 15.8% in favor of the BEKINDA<SUP>&reg;</SUP>&nbsp;12mg arm (41.3% with BEKINDA<SUP>&reg;</SUP>&nbsp;12mg (n=75)
vs. 25.5% with placebo (n=51); (p=0.10)).</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">BEKINDA<SUP>&reg;</SUP>&nbsp;12mg was also shown to be safe and
well tolerated. No serious adverse events or new or unexpected safety issues were noted in the study, suggesting the potential
of BEKINDA<SUP>&reg;</SUP> 12mg, if approved, to become a first-line standard of care treatment for IBS-D. We continue to analyze
the data from the Phase II study with BEKINDA<SUP>&reg;</SUP>&nbsp;12 mg, including all secondary endpoints. We are also analyzing
drug allocation and pharmacokinetics in the study, including some aberrant findings which we believe are not expected to have a
material impact on the final results. We plan to initiate one or more pivotal Phase III studies with BEKINDA&reg; 12mg for the
treatment of IBS-D in the first half of 2018.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><B><I>YELIVA</I></B><I><SUP>&reg;</SUP> <B>(ABC294640)</B></I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">A Phase IIa clinical study with YELIVA<SUP>&reg;</SUP>&nbsp;in patients
with advanced, unresectable, intrahepatic and extrahepatic cholangiocarcinoma is planned to be initiated in the fourth quarter
of 2017 at the Mayo Clinic. In April 2017, the FDA granted YELIVA<SUP>&reg;</SUP>&nbsp;(ABC294640) orphan drug designation for
the treatment of cholangiocarcinoma. The orphan drug designation allows us to benefit from various development incentives to develop
YELIVA<SUP>&reg;</SUP> for this indication, including tax credits for qualified clinical testing, the waiver of a prescription
drug user fee (PDUFA fee) upon submission of a potential marketing application and, if approved, a seven-year marketing exclusivity
period (subject to certain exceptions) for the treatment of cholangiocarcinoma.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">A Phase Ib study to evaluate YELIVA<SUP>&reg;</SUP>&nbsp;as a radioprotectant for the
prevention of mucositis in head and neck cancer patients undergoing therapeutic radiotherapy is planned to be initiated in the
coming months.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">A Phase II study with YELIVA<SUP>&reg;</SUP> for ulcerative colitis is expected to be
initiated in the coming months.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">A Phase II study with YELIVA<SUP>&reg;</SUP>&nbsp;for the treatment
of advanced hepatocellular carcinoma (HCC) is ongoing at the Medical University of South Carolina (MUSC) Hollings Cancer Center.
The study is supported by a grant from the National Cancer Institute (&ldquo;NCI&rdquo;), awarded to MUSC, which is intended to
fund a broad range of studies on the feasibility of targeting sphingolipid metabolism for the treatment of a variety of solid tumor
cancers, with additional support from us.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">A Phase Ib/II study with YELIVA<SUP>&reg;</SUP>&nbsp;for the treatment
of refractory or relapsed multiple myeloma is ongoing at Duke University Medical Center. The study is supported by a $2 million
grant from the NCI Small Business Innovation Research Program (SBIR) awarded to Apogee Biotechnology Corporation, in conjunction
with Duke University, with additional support from us.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">A Phase I/II clinical study evaluating YELIVA<SUP>&reg;</SUP>&nbsp;in
patients with refractory/relapsed diffuse large B-cell lymphoma and kaposi sarcoma patients was until recently open at the Louisiana
State University Health Sciences Center and was supported by a grant from the NCI awarded to Apogee Biotechnology Corporation.
This investigator sponsored study was opened to enrollment prior to our licensing of YELIVA<SUP>&reg; </SUP>from Apogee Biotechnology
Corporation. The NCI grant for the study is not being renewed due to the absence of patients being enrolled in this investigator
sponsored study. As such, the study is being discontinued by Louisiana State University Health Sciences Center.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><B><I>MESUPRON</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We are working on several oncology projects evaluating multiple
clinical candidates including MESUPRON as a component spanning oncology indications where strong unmet medical need exists. We
have recently received a Notice of Allowance from the U.S. Patent and Trademark Office for a patent that will recite claims directed
to a combination of YELIVA<SUP>&reg;</SUP>, MESUPRON, and a known antibiotic. The claims in the patent will also be directed to
methods of treating cancer, or preventing cancer, by administering YELIVA<SUP>&reg;</SUP> and a known antibiotic. Upon issuance,
in addition to the existing intellectual property protection covering the individual compounds, we believe the new patent will
provide us with intellectual property protection covering our combination for the potential treatment of cancer, prevention of
cancer recurrence or progression and inhibition of growth and proliferation of cancer cells.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We have also identified a new mechanism of action for MESUPRON inhibition
of trypsin. We are currently evaluating potential utilization of MESUPRON in several GI indications.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">In October 2017, the FDA granted MESUPRON orphan drug designation
for the adjuvant treatment of pancreatic cancer. The orphan drug designation allows us to benefit from various development incentives
to develop MESUPRON for this indication, including tax credits for qualified clinical testing, waiver of a prescription drug user
fee (PDUFA fee) upon submission of a potential marketing application and, if approved, a seven-year marketing exclusivity period
(subject to certain exceptions) for the adjuvant treatment of pancreatic cancer.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>RIZAPORT</I></B><SUP>&reg;</SUP> <B><I>(RHB-103)</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We, together with IntelGenx Corp., resubmitted the NDA for RIZAPORT<SUP>&reg;
</SUP>to the FDA in October 2017. If the RIZAPORT<SUP>&reg;</SUP> NDA resubmission is deemed completed and permits a full review
by the FDA, a Prescription Drug User Fee Act (PDUFA) date is expected to be set by the FDA for the first half of 2018. The re-submission
of the NDA follows the receipt of a complete response letter from the FDA as announced on February 4, 2014.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The Ministry of Health of Luxembourg granted national marketing
authorization for RIZAPORT<SUP>&reg;</SUP>&nbsp;(5mg and 10mg) in April 2017. The national marketing authorization was granted
in Luxembourg on the basis of the European Decentralized Procedure (DCP), in which Luxembourg served as the Concerned Member State.
The approval in Luxembourg marked the completion of the current marketing approval process for RIZAPORT<SUP>&reg;</SUP>&nbsp;under
the European DCP. RIZAPORT<SUP>&reg;</SUP>&nbsp;was also approved in October 2015 for marketing in Germany, which served as the
Reference Member State, and a national Marketing Authorization Application (MAA) has been submitted in Spain. Under EU law, product
sales must be made within three years of marketing approval in order to maintain such approval. We have not yet made sales in Germany
or Luxemburg.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">A first commercialization agreement for RIZAPORT<SUP>&reg;</SUP>&nbsp;was
signed with Grupo JUSTE S.A.Q.F (now Exeltis Healthcare, S.L.) for Spain in July 2016. A second commercialization agreement for
RIZAPORT<SUP>&reg;</SUP>&nbsp;was signed with Pharmatronic Co. for South Korea in December 2016.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We are continuing discussions with additional potential commercialization
partners for RIZAPORT<SUP>&reg;</SUP>&nbsp;in the U.S., Europe and other territories.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>Ebola Virus Disease Therapy</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Following guidance received from the U.S. National Institute of
Allergy and Infectious Diseases (NIAID) Safety Committee, we plan to initiate a pre-clinical study to evaluate our proprietary
experimental combination therapy for the treatment of Ebola virus disease in the fourth quarter of 2017 or first quarter of 2018.
Our research collaboration with the NIAID, part of the National Institutes of Health, is intended to evaluate survival outcome
and assess disease severity through comparison of viral loads and cytokine levels in active treatment arms and placebo. The study
follows encouraging results from preliminary non-clinical studies we have conducted in conjunction with NIAID using our proprietary
experimental therapy. Top-line results from the pre-clinical research are expected in 2018.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>Commercial Activities in the U.S.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We have established the headquarters of our U.S. commercial operations
in Raleigh, North Carolina. Our U.S. operations are intended to set the stage for the potential launch of our proprietary, late-clinical
stage GI products, if approved by the FDA.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">In December 2016, we entered into a Co-Promotion Agreement with
a subsidiary of Concordia International Corp for the promotion of Donnatal<B><I><SUP>&reg;</SUP></I></B>&nbsp;(Phenobarbital, Hyoscyamine
Sulfate, Atropine Sulfate, Scopolamine Hydrobromide) in the U.S. Donnatal<B><I><SUP>&reg;</SUP></I></B>&nbsp;&nbsp;is an anticholinergic
and barbiturate combination drug product used as an adjunctive therapy for irritable bowel syndrome (IBS), a condition characterized
by abdominal pain, bloating, and diarrhea or constipation.&nbsp;&nbsp;It may also be used as an adjunctive therapy for acute enterocolitis
and duodenal ulcers. We commenced promotional activities for Donnatal<B><I><SUP>&reg;</SUP></I></B>&nbsp;in June 2017.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">In April 2017, we entered into a license agreement with Entera Health
Inc. (&ldquo;Entera Health&rdquo;) pursuant to which we were granted exclusive commercialization U.S. rights to EnteraGam<B><I><SUP>&reg;</SUP></I></B>.
EnteraGam<B><I><SUP>&reg;</SUP></I></B>&nbsp;(serum-derived bovine immunoglobulin/protein isolate, SBI)&nbsp;is a FDA-regulated
&ldquo;medical food&rdquo; product intended for the dietary management of chronic diarrhea and loose stools.&nbsp;EnteraGam<B><I><SUP>&reg;</SUP></I></B>&nbsp;must
be administered under medical supervision. We initiated commercialization activities for EnteraGam<B><I><SUP>&reg;</SUP></I></B>
in June 2017.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">In August 2017, we entered into a commercialization agreement with
ParaPRO LLC (&ldquo;ParaPRO&rdquo;), an Indiana-based specialty pharmaceutical company, granting us the exclusive rights to promote
Esomeprazole Strontium Delayed-Release Capsules 49.3mg to gastroenterologists in certain U.S. territories. Esomeprazole Strontium
Delayed-Release Capsules 49.3mg is a FDA-approved prescription proton pump inhibitor (PPI) drug product indicated for adults for
the treatment of gastroesophageal reflux disease (GERD), risk reduction of NSAID-associated gastric ulcer,&nbsp;<I>H. pylori</I>&nbsp;eradication
to reduce the risk of duodenal ulcer recurrence and for pathological hypersecretory conditions, including Zollinger-Ellison syndrome.
In September 2017, we initiated the promotion of Esomeprazole Strontium Delayed-Release Capsules 49.3mg in selected U.S. territories.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Our GI-focused sales force consists of approximately 40 sales representatives.
Initial net revenues for the second quarter of 2017 from the GI-products were approximately $0.5 million. We continue to pursue
the acquisition of additional commercial GI products in the U.S.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>Expanded Access Program (EAP) </I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We have adopted an Expanded Access Program (EAP), allowing patients
with life-threatening diseases potential access to our investigational new drugs that have not yet received regulatory marketing
approval. Expanded access (sometimes referred to as &ldquo;compassionate use&rdquo;) is possible outside our clinical trials, under
certain eligibility criteria, when a certain investigational new drug is needed to treat a life-threatening condition and when
there is some clinical evidence suggesting that the drug might be effective for that condition. Following the adoption of the program,
we continue to receive patient requests to obtain access to our investigational drugs. Subject to the evaluation of eligibility
and all other necessary regulatory, reporting and other conditions and approvals required in all relevant jurisdictions, we provide
certain patients with an investigational new drug under the EAP.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>Financial Update</B></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 373.35pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We are currently finalizing our financial results for the three
months ended September 30, 2017. While complete financial information and operating data as of and for such period are not yet
available, based on the information and data currently available, as of September 30, 2017, we had approximately $39.4 million
of cash and short-term investments.  Our current cash resources are not sufficient to
complete the research and development of all of our therapeutic candidates. We believe our existing capital resources should be
sufficient to fund our operations for at least the next 12 months. Additional information and disclosures would be required for
a more complete understanding of our financial position and results of operations as of September 30, 2017.&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The estimated cash and short-term investments have neither been
audited nor reviewed by our independent registered public accounting firm, nor has our independent registered public accounting
firm expressed an opinion or any other form of assurance with respect thereto. Our financial statements and operating data as of
and for the nine months ended September 30, 2017, will not be available until after this offering is completed.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>Corporate Information</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We were incorporated as a limited liability company under the laws
of the State of Israel on August 3, 2009. Our principal executive offices are located at 21 Ha&rsquo;arba&rsquo;a Street, Tel Aviv,
Israel and our telephone number is +972 (3) 541-3131. Our web site address is http://www.redhillbio.com. The information on our
web site does not constitute part of this prospectus. Our registered agent in the U.S. is Puglisi &amp; Associates. The address
of Puglisi &amp; Associates is 850 Library Avenue, Suite 204, Newark, Delaware 19715.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>THE OFFERING</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="vertical-align: top; width: 28%"><FONT STYLE="font-size: 10pt">ADSs offered by us in the offering&nbsp;</FONT></TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 71%"><FONT STYLE="font-size: 10pt">4,090,909 ADSs representing 40,909,090&nbsp;
    Ordinary Shares (4,704,545 ADSs representing 47,045,450 Ordinary Shares if the underwriters exercise
    their option to purchase additional ADSs in full).</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Total Ordinary Shares outstanding immediately after this offering</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">212,729,434&nbsp;Ordinary Shares. If the underwriters exercise their option in full, the total Ordinary
Shares outstanding immediately after this offering will be&nbsp;218,865,794 Ordinary Shares.</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">The ADSs</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">
        <P STYLE="font-size: 10pt; margin: 0pt 0">Each ADS represents 10 Ordinary Shares.&nbsp;The ADSs initially will be evidenced by
        American Depositary Receipts (&ldquo;ADRs&rdquo;), executed and delivered by The Bank of New York Mellon, as depositary (the &ldquo;Depositary&rdquo;).</P>
        <P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font-size: 10pt; margin: 0pt 0">The Depositary, as depositary, will be the holder of the Ordinary Shares underlying your
        ADSs and you will have rights as provided in the Deposit Agreement dated as of December 26, 2012, among us, The Bank of New York
        Mellon, as Depositary, and all owners and holders from time to time of ADSs issued thereunder (the &ldquo;Deposit Agreement&rdquo;),
        a form of which has been filed as Exhibit 1 to the Registration Statement on Form F-6 filed by the Depositary with the SEC on December
        6, 2012.</P>
        <P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font-size: 10pt; margin: 0pt 0">Subject to compliance with the relevant requirements set out in the prospectus, you may
        turn in your ADSs to the Depositary in exchange for Ordinary Shares underlying your ADSs.</P>
        <P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font-size: 10pt; margin: 0pt 0">The Depositary will charge you fees for such exchanges pursuant to the Deposit Agreement.</P>
        <P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font-size: 10pt; margin: 0pt 0">You should carefully read the &ldquo;Description of American Depositary Shares&rdquo;
        section of the accompanying prospectus and the Deposit Agreement to better understand the terms of the ADSs.</P></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Offering Price</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">The public offering price is $5.50&nbsp;per one ADS.</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Option to purchase additional ADSs </FONT></TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">We have granted the underwriters an option to purchase up to an additional&nbsp;613,636&nbsp;ADSs representing&nbsp;6,136,360&nbsp;Ordinary
Shares.</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="vertical-align: top; width: 28%">
        <P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font-size: 10pt; margin: 0pt 0">Use of Proceeds</P></TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 71%">
        <P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font-size: 10pt; margin: 0pt 0">We currently intend to use the net proceeds from the sale of our ADSs in this offering
        to fund clinical development programs, for potential acquisitions, to support commercial operations and for general corporate purposes.</P>
        <P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font-size: 10pt; margin: 0pt 0">See &ldquo;Use of Proceeds&rdquo; for additional information.</P></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Listing </FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Our ADSs are listed on The NASDAQ under the symbol &ldquo;RDHL&rdquo; and our Ordinary Shares currently trade on the TASE in Israel under the symbol &ldquo;RDHL&rdquo;. </FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Risk factors</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Before deciding to invest in our ADSs, you should carefully consider the risks related to our business, the offering and our securities, and our location in Israel. See &ldquo;Risk Factors&rdquo; on page&nbsp;S-14 of this prospectus supplement.</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Dividend Policy</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">We have never declared or paid any cash dividends to our shareholders, and we currently do not expect to declare or pay any cash dividends in the foreseeable future. See &ldquo;Dividend Policy.&rdquo;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Depositary </FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">The Bank of New York Mellon</FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The number of Ordinary Shares to be outstanding immediately after
the offering as shown above is based on 171,820,344 Ordinary Shares outstanding as of October 31, 2017, and excludes, as of such
date (i) 26,171,798 Ordinary Shares issuable upon the exercise of outstanding options to purchase 26,171,798 Ordinary Shares at
a weighted average exercise price of $1.05 per share (equivalent to 2,602,179 ADSs at a weighted average exercise price of $10.5
per ADS), and (ii) 20,254,580 Ordinary Shares issuable upon the exercise of outstanding non-tradable warrants to purchase 20,254,580
Ordinary Shares at an exercise price of $1.333 per share (equivalent to 2,025,458 ADSs at an exercise price of $13.33 per ADS).</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Unless otherwise stated, outstanding share information throughout
this prospectus supplement excludes such outstanding securities. Except as otherwise indicated, all information in this prospectus
supplement assumes no exercise by the underwriters of their option to purchase an additional&nbsp;613,636 ADSs.&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Three of our directors have agreed to purchase 209,090 ADSs in
the aggregate in this offering. The underwriters will receive the same underwriting discount on any ADSs purchased by these
persons as they will on the other ADSs sold to the public in this offering.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin-top: 0pt; margin-bottom: 0pt"><A NAME="a_005"></A><B>SUMMARY FINANCIAL DATA </B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We derived the summary financial statement data for the years ended
December&nbsp;31, 2014, 2015 and 2016 set forth below from our audited financial statements and related notes incorporated by reference
in this prospectus supplement. We derived the summary financial statement data as of June 30, 2017 and for the six months ended
June 30, 2016 and 2017 from our unaudited condensed interim financial statements and related notes incorporated by reference in
this prospectus supplement. Our results for interim periods are not necessarily indicative of the results that may be expected
for the entire year. You should read the information presented below together with our financial statements, the notes to those
statements and the other financial information incorporated by reference in this prospectus supplement and the accompanying prospectus.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="11" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1.1pt solid">Year Ended December 31,</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1.1pt solid">2014</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1.1pt solid">2015</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1.1pt solid">2016</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="11" STYLE="font-size: 10pt; text-align: center">(U.S. Dollars, in thousands, except per share and weighted average shares data)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">Statement of Comprehensive Loss</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="width: 61%; font-size: 10pt; text-align: left">Net Revenues</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">7,014</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">3</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">101</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">Cost of Revenues</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,050</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">-</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">-</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Research and development expenses, net</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">12,700</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">17,771</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">25,241</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">General, administrative and business development expenses</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4,011</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4,134</TD><TD STYLE="font-size: 10pt; text-align: left">(2)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5,403</TD><TD STYLE="font-size: 10pt; text-align: left">(3)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Other (expenses) income</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">100</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">(100</TD><TD STYLE="font-size: 10pt; text-align: left">)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">-</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Operating loss</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">10,647</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">22,002</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">30,543</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Financial income</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">319</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,124</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,548</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Financial expenses</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">383</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">212</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">375</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Financial expenses (income), net</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">64</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">(912</TD><TD STYLE="font-size: 10pt; text-align: left">)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">(1,173</TD><TD STYLE="font-size: 10pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Loss and comprehensive loss</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">10,711</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">21,090</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">29,370</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Loss per ordinary share (in U.S. dollars) (4):</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">Basic</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.12</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.19</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.23</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt">Diluted</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.13</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.19</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.24</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Number of Ordinary Shares used in computing Loss per ordinary share (in thousands):</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">Basic</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">86,610</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">110,814</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">128,514</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt">Diluted</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">87,222</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">111,715</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">128,809</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>



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<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="7" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1.1pt solid">Six Months ended <BR> June 30,</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1.1pt solid">2016</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1.1pt solid">2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-style: normal">&nbsp;</TD>
    <TD NOWRAP COLSPAN="7" STYLE="font-size: 10pt; font-style: normal; text-align: center">(<FONT STYLE="font-size: 10pt; font-style: normal"><B>unaudited</B><FONT STYLE="font-weight: normal">)</FONT></FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="font-size: 10pt; text-align: center">(U.S. Dollars, in thousands, except per share and weighted average shares data)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">Statement of Comprehensive Loss</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="width: 68%; font-size: 10pt; text-align: left">Net Revenues</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 12%; font-size: 10pt; text-align: right">1</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 12%; font-size: 10pt; text-align: right">483</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">Cost of Revenues</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">-</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">272</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Research and development expenses, net</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">10,707</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">16,571</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Selling, Marketing and Business Development Expenses</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">736</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3,981</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">General and administrative expenses</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,655</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3,255</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Other (expenses) income</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">-</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">(45</TD><TD STYLE="font-size: 10pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Operating loss</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">13,097</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">23,641</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Financial income</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,025</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4,078</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Financial expenses</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">56</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Financial income, net</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,021</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4,022</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Loss and comprehensive loss</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">12,076</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">19,619</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Loss per ordinary share (in U.S. dollars) (4):</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt">Basic</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.09</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.11</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">Diluted</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.10</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.11</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Number of Ordinary Shares used in computing Loss per ordinary share (in thousands):</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt">Basic</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">127,237</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">170,640</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">Diluted</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">127,250</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">170,640</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>



<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="7" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1.1pt solid">As of June 30, 2017</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1.1pt solid">Actual</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1.1pt solid">As Adjusted</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="7" STYLE="font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(<B>unaudited</B>)</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="7" STYLE="font-size: 10pt; text-align: center">(U.S. Dollars, in thousands)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">Balance Sheet Data</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="width: 68%; font-size: 10pt; text-align: left">Cash and short term investments&#9;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 12%; font-size: 10pt; text-align: right">51,066</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 12%; font-size: 10pt; text-align: right"><P STYLE="margin: 0pt 0">71,696</P>


</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Working capital&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">44,990</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right"><P STYLE="margin: 0pt 0">65,620</P>


</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Total assets&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">61,985</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right"><P STYLE="margin: 0pt 0">82,615</P>


</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Total liabilities&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">13,182</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right"><P STYLE="margin: 0pt 0">13,182</P>


</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Accumulated deficit&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">(108,242</TD><TD STYLE="font-size: 10pt; text-align: left">)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right"><P STYLE="margin: 0pt 0">(108,242</P>


</TD><TD STYLE="font-size: 10pt; text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt">Equity&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">48,803</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right"><P STYLE="margin: 0pt 0">69,433</P>


</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;______________________</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">(1) Consists of $900 for selling, marketing and business development expenses and $3,111 for general and administrative expenses.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">(2) Consists of $1,386 for selling, marketing and business development expenses and $2,748 for general and administrative expenses.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">(3) Consists of $1,555 for selling, marketing and business development expenses and $3,848
for general and administrative expenses.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">(4) See Note 2(P) of the notes to the financial statements
incorporated by reference in this prospectus supplement and the accompanying prospectus for an explanation of the determination
of the number of shares used to compute basic and dilutive per share amounts for the years ended December&nbsp;31, 2014, 2015 and
2016 and the six months ended June 30, 2016 and 2017.&nbsp;</P>



<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The as adjusted balance sheet data above reflects the application
of the net proceeds from the sale of 4,090,909&nbsp;ADSs representing&nbsp;40,909,090 Ordinary Shares from this offering, after
deducting the underwriting discounts and commissions and estimated offering expenses payable by us in connection with this offering.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><A NAME="a_006"></A><B>RISK FACTORS </B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I>You should carefully consider the risks described below and in
our annual report on Form&nbsp;20-F for the year ended December&nbsp;31, 2016, as well as the other information included or incorporated
by reference in this prospectus supplement and the accompanying prospectus, including our financial statements and the related
notes, before you decide to buy our securities. The risks and uncertainties described below and incorporated by reference in this
prospectus supplement are not the only risks facing us. We may face additional risks and uncertainties not currently known to us
or that we currently deem to be immaterial. Any of the risks described below or incorporated by reference in this prospectus supplement,
and any such additional risks, could materially adversely affect our business, financial condition or results of operations. In
such case, you may lose all or part of your original investment.</I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B>Risks Related to Our Financial Condition and Capital
Requirements</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I></I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Since our incorporation in 2009, we have focused
primarily on the development and acquisition of late clinical-stage therapeutic candidates and more recently on the acquisition
of therapeutic products for promotion and/or commercialization in the U.S. and we have a history of operating losses. We expect
to incur additional losses in the future and may never be profitable.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Since our incorporation in 2009, we have focused primarily
on the development and acquisition of late clinical-stage therapeutic candidates. All of our therapeutic candidates are in the
clinical development stage and none of our therapeutic candidates has been approved for marketing or is being marketed or commercialized
in the U.S., although RIZAPORT<B><I><SUP>&reg;</SUP></I></B> has been approved for marketing in Germany and Luxemburg but has yet
to be marketed.&nbsp;&nbsp;Although we were granted certain rights to promote, but not sell or distribute, Donnatal<B><I><SUP>&reg;</SUP></I></B>
in certain U.S. territories pursuant to an exclusive commercialization agreement with a subsidiary of Concordia International Corp.
(&ldquo;Concordia&rdquo;), and in 2017, we obtained certain rights to commercialize EnteraGam<B><I><SUP>&reg;</SUP></I></B> in
the U.S. and certain rights to promote Esomeprazole Strontium Delayed-Release Capsules 49.3mg in certain U.S. territories, we have
not yet generated a significant revenue from these products.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Most of our therapeutic candidates will require additional
clinical trials before we can obtain the regulatory approvals in order to initiate commercial sales, if at all. We have incurred
losses since inception, principally as a result of research and development, selling, marketing and business development expenses
and general and administrative expenses in support of our operations. We experienced net losses of approximately $19.6 million
in the first six months of 2017, $29.4 million in 2016, $21.1 million in 2015 and $10.7 million in 2014.&nbsp;&nbsp;As of June
30, 2017, we had an accumulated deficit of approximately $108.2 million.&nbsp;&nbsp;We may incur significant additional losses
as we continue to focus our resources on prioritizing, selecting and advancing our therapeutic candidates, promoting Donnatal<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, commercializing EnteraGam<B><I><SUP>&reg;</SUP></I>,</B> and products
that we may promote or commercialize in the future.&nbsp;&nbsp;Our ability to generate meaningful revenue and achieve profitability
depends mainly upon our ability, alone or with others, to successfully develop our therapeutic candidates, obtain the required
regulatory approvals in various territories and commercialize our therapeutic candidates, promote Donnatal<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, and commercialize EnteraGam<B><I><SUP>&reg;</SUP></I></B> and products
that we may acquire or for which we may acquire commercialization rights in the future.&nbsp;&nbsp;We may be unable to achieve
any or all of these goals with regard to our therapeutic candidates or our products we may market.&nbsp;&nbsp;As a result, we may
never be profitable or achieve significant or sustained revenues.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Our limited operating history makes it difficult
to evaluate our business and prospects.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We have a limited operating history and our operations
to date have been limited primarily to acquiring and in-licensing therapeutic candidates and rights to promote products in certain
U.S. territories, research and development, raising capital and recruiting scientific and management personnel and third-party
partners. Except with respect to RHB-106 and related rights, which is out-licensed to Valeant Pharmaceuticals International, Inc.
(&ldquo;Valeant&rdquo;), which agreement is currently subject to discussion with Valeant, including renegotiation of its
terms, and with respect to RIZAPORT<B><I><SUP>&reg;</SUP></I></B>, for which we have received marketing approval in Germany and
Luxemburg and have entered into exclusive license agreements to commercialize in Spain and South Korea, we have not yet demonstrated
an ability to commercialize or obtain regulatory approval for any of our therapeutic candidates. Consequently, any predictions
about our future performance may not be accurate, and you may not be able to fully assess our ability to complete development or
commercialization of our therapeutic candidates, the success of EnteraGam<B><I><SUP>&reg;</SUP></I></B> that we commercialize and
products that we may promote or commercialize in the future, the success of promoting Donnatal<B><I><SUP>&reg;</SUP></I></B> and
Esomeprazole Strontium Delayed-Release Capsules 49.3mg, obtain regulatory approvals, reimbursement, achieve market acceptance or
competitive pricing for our therapeutic candidates, Donnatal<B><I><SUP>&reg;</SUP></I></B> EnteraGam<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg and products that we may promote or commercialize in the future.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Our current working capital may not be sufficient
to complete our research and development with respect to any or all of our therapeutic candidates or to commercialize our products
or products to which we have rights, including to promote Donnatal<SUP>&reg;</SUP></I></B>, <B><I>EnteraGam&reg; and Esomeprazole
Strontium Delayed-Release Capsules 49.3mg. We will need to raise additional capital to achieve our strategic objectives of acquiring,
in-licensing, developing and commercializing therapeutic candidates, promoting Donnatal<SUP>&reg;</SUP> and Esomeprazole Strontium
Delayed-Release Capsules 49.3mg, commercializing EnteraGam&reg;, and products that we may promote or commercialize in the future,
and our failure to raise sufficient capital would significantly impair our ability to fund our operations, develop our therapeutic
candidates, or commercialize EnteraGam&reg; or the products we may commercialize in the future, or promote products such as Donnatal<SUP>&reg;</SUP>,
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, attract development or commercial partners and retain key personnel.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We have funded our operations primarily through public and private
offerings of our securities. We plan to fund our future operations through commercialization and out-licensing of our therapeutic
candidates, commercialization of in-licensed or acquired products and raising additional capital through the sale of equity or
debt. These amounts are not sufficient to complete the research and development of all of our therapeutic candidates, and we are
also not yet certain of the financial impact of our commercialization activities.&nbsp;&nbsp;Accordingly, we may need to raise
additional capital in the future.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">To date, our business has generated limited revenues. As we plan
to continue expending funds in research and development, including clinical trials, as well as to continue to commercialize EnteraGam<B><I><SUP>&reg;</SUP></I></B>,
promote Donnatal<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, and to acquire additional
products, we will need to raise additional capital in the future through either debt or equity financing or pursuant to development
or commercialization agreements with third parties with respect to particular therapeutic candidates. However, we cannot be certain
that we will be able to raise capital on commercially reasonable terms or at all, or that our actual cash requirements will not
be greater than anticipated. We may have difficulty raising needed capital or securing a development or commercialization partner
in the future as a result of, among other factors, our lack of revenues from commercialization of the therapeutic candidates and
promoting of Donnatal<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg and commercializing
EnteraGam<B><I><SUP>&reg;</SUP></I></B> and products that we may promote or commercialize in the future, as well as the inherent
business risks associated with our company, our therapeutic candidates, Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, and products that we may promote or commercialize in the future, and
present and future market conditions. To the extent we are able to generate meaningful revenues from Donnatal<B><I><SUP>&reg;</SUP></I></B>,
EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, we may still need to raise
capital because the revenues from Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole
Strontium Delayed-Release Capsules 49.3mg, may not be sufficient to cover all of our operating expenses and may not be sufficient
to cover our commercial operations expenses. In addition, global and local economic conditions may make it more difficult for us
to raise needed capital or secure a development or commercialization partner in the future and may impact our liquidity. If we
are unable to obtain future financing or obtain sufficient future financing, we may be forced to delay, reduce the scope of, or
eliminate one or more of our research, development or commercialization programs for our therapeutic candidates, promotion of Donnatal<B><I><SUP>&reg;</SUP></I></B>,
EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, and products that we may promote
or commercialize in the future, any of which may have material adverse effect on our business, financial condition and results
of operations. Moreover, to the extent we are able to raise capital through the issuance of debt or equity securities, it could
result in substantial dilution to existing shareholders.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Our long-term capital requirements are subject to
numerous risks.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Our long-term capital requirements are expected to depend
on many potential factors, including:&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="text-align: center; width: 3%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify; width: 97%">the number of therapeutic candidates in development;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the regulatory clarity and path of each of our therapeutic candidates;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the progress, success and cost of our clinical trials and research and development programs including manufacturing;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the identification and acquisition of additional therapeutic candidates;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the costs, timing and outcome of regulatory review and obtaining regulatory clarity and approval of our therapeutic candidates and addressing regulatory and other issues that may arise post-approval;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the costs of enforcing our issued patents and defending intellectual property-related claims;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the costs of manufacturing, developing and maintaining sales, marketing and distribution channels;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">our ability to successfully commercialize our therapeutic candidates, promote Donnatal<FONT STYLE="font-size: 10pt"><B><I><SUP>&reg;</SUP></I></B> <FONT STYLE="font-weight: normal; font-style: normal">and Esomeprazole Strontium Delayed-Release Capsules 49.3mg,&nbsp;&nbsp;commercialize EnteraGam</FONT></FONT><FONT STYLE="font-size: 10pt"><B><I><SUP>&reg;</SUP></I></B><FONT STYLE="font-weight: normal; font-style: normal">,<SUP>-</SUP>and products that we may promote or commercialize, including through securing commercialization agreements with third parties and favorable pricing and market share or through securing and maintaining our own commercialization capabilities;</FONT></FONT></TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">our ability to successfully commercialize products that we develop or acquire or for which we acquire commercialization rights; and</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">our consumption of available resources, including a more rapidly consumption than currently anticipated, resulting in the need for additional funding sooner than anticipated.</TD></TR>
</TABLE>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B>Risks Related to Our Business and Regulatory Matters</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>If we or our development or commercialization partners
are unable to obtain or maintain the FDA or other foreign regulatory clearance and approval for our therapeutic candidates or products
we may promote or commercialize, we or our commercialization partners will be unable to commercialize our therapeutic candidates
or products we may promote or commercialize.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">To date, other than our limited experience in
promoting Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B>&nbsp;and Esomeprazole Strontium
Delayed-Release Capsules 49.3mg, we have not marketed, distributed or sold any therapeutic candidate or product, although we
have obtained marketing approval for RIZAPORT<B><I><SUP>&reg;</SUP></I></B> in Germany and Luxembourg. In June 2017, we
commenced promoting Donnatal<B><I><SUP>&reg;</SUP></I></B>&nbsp;(phenobarbital &amp; belladonna alkyloids) in the U.S.
Donnatal<B><I><SUP>&reg;</SUP></I></B>&nbsp;is an anticholinergic and barbiturate combination drug product used as an
adjunctive therapy for IBS, a condition characterized by abdominal pain, bloating, and diarrhea or
constipation.&nbsp;&nbsp;It may also be used as an adjunctive therapy for acute enterocolitis and duodenal ulcers. See
&ldquo;&ndash;We or our commercialization partners are subject to risks related to the regulatory environment of the Drug
Efficacy Study Implementation review program with respect to Donnatal<B><I><SUP>&reg;</SUP></I></B>&rdquo;.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In June 2017, we commenced selling EnteraGam<B><I><SUP>&reg;</SUP></I></B>&nbsp;in
certain territories in the U.S., and in September 2017, we commenced promoting Esomeprazole Strontium DR Capsules 49.3mg to gastroenterologists
in certain U.S. territories. EnteraGam<B><I><SUP>&reg;</SUP></I></B>&nbsp;is a FDA-regulated &ldquo;medical food&rdquo; product
intended for the dietary management of chronic diarrhea and loose stools, which must be administered under medical supervision.
Esomeprazole Strontium DR Capsules 49.3mg is an FDA-approved PPI drug product indicated for adults for the treatment of gastroesophageal
reflux disease (GERD), risk reduction of NSAID-associated gastric ulcer,&nbsp;<I>H. pylori</I>&nbsp;eradication to reduce the risk
of duodenal ulcer recurrence and for pathological hypersecretory conditions, including Zollinger-Ellison syndrome.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Currently, we have seven therapeutic candidates in various
programs and clinical development stages, TALICIA&trade; for the eradication of <I>H. pylori</I> infection; RHB-104
for the treatment of Crohn&rsquo;s disease with an ongoing first Phase III study, a completed proof-of-concept Phase IIa study
for multiple sclerosis, and a planned pivotal Phase III study for NTM infections; RHB-106 (out-licensed to Valeant)
for bowel preparation; BEKINDA<B><I><SUP>&reg;</SUP></I></B> (RHB-102) for acute gastroenteritis and gastritis, irritable bowel
syndrome with diarrhea (&ldquo;IBS-D&rdquo;), and other indications; YELIVA<B><I><SUP>&reg;</SUP></I></B> (ABC294640), a sphingosine
kinase-2 (&ldquo;SK2&rdquo;) selective inhibitor targeting multiple oncology, inflammatory and gastrointestinal (&ldquo;GI&rdquo;)
indications;&nbsp; MESUPRON for targeting GI and other solid tumor cancers; and RIZAPORT<B><I><SUP>&reg;</SUP></I></B> (RHB-103)
for the treatment of acute migraine headaches. Our therapeutic candidates are subject to extensive governmental laws, regulations
and guidelines relating to development, clinical trials, manufacturing and commercialization of drugs. Other than RIZAPORT<B><I><SUP>&reg;</SUP></I></B>
which has received marketing approval to date only in Germany and Luxemburg, we may not be able to obtain marketing approval for
any of our therapeutic candidates in a timely manner or at all.&nbsp;&nbsp;Further, in order to maintain our marketing approvals
for RIZAPORT&reg; in Germany and Luxemburg, we need to make product sales within three years of our receipt of marketing approval
or seek an extension. We received marketing approval for Germany in October 2015 and Luxemburg in April 2017. We have not yet made
sales of RIZAPORT&reg; in these jurisdictions.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition, although we have certain rights to promote
Donnatal<B><I><SUP>&reg;</SUP></I></B>&nbsp;in the U.S., which is currently included in the FDA DESI review program, we cannot
guarantee that our co-promotion partner will continue to be allowed to sell or promote Donnatal<B><I><SUP>&reg;</SUP></I></B> in
the U.S. without unforeseen regulatory developments that may lead to the FDA requiring Donnatal to gain an NDA approval. In addition,
unforeseen regulatory developments may lead to a loss of the right to commercialize EnteraGam or promote Esomeprazole Strontium
Delayed-Release Capsules 49.3mg.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Any material delay in obtaining or maintaining, or
the failure to obtain or maintain, required regulatory clearances and approvals will increase our costs and materially
adversely affect our ability to generate meaningful revenues.&nbsp;&nbsp;Any regulatory clearance or approval to market a
therapeutic candidate, Donnatal<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg or
products that we may promote or commercialize may be subject to limitations on the indicated uses for marketing or may impose
restrictive conditions of use, including cautionary information, thereby altering or eliminating the size of the market for
the therapeutic candidate, Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole
Strontium Delayed-Release Capsules 49.3mg, or products that we may promote or commercialize in the future. We also are, and
will be, subject to numerous regulatory requirements from both the FDA and other foreign regulatory authorities that govern
the conduct of clinical trials, manufacturing and marketing authorization, pricing and third-party reimbursement. Moreover,
clearance or approval by one regulatory authority does not ensure clearance or approval by other regulatory authorities in
separate jurisdictions. Each jurisdiction may have different approval processes and requirements and may impose additional
testing, development and manufacturing requirements for our therapeutic candidates,
Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release
Capsules 49.3mg and products that we may promote or commercialize in the future. Additionally, the FDA or other foreign
regulatory authorities may change its clearance or approval policies or adopt new laws, regulations or guidelines in a manner
that materially delays or impairs our ability to obtain the necessary regulatory clearances or approvals or our ability to
commercialize our therapeutic candidates, promote
Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release
Capsules 49.3mg and products that we may promote or commercialize in the future. See &ldquo;&ndash;We or our
commercialization partners are subject to risks related to the regulatory environment of the Drug Efficacy Study
Implementation review program with respect to Donnatal<B><I><SUP>&reg;</SUP></I></B>&rdquo;.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We or our commercialization partners are subject
to risks related to the regulatory environment of the Drug Efficacy Study Implementation review program with respect to Donnatal<SUP>&reg;</SUP></I>.</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Currently, we promote Donnatal<B><I><SUP>&reg;</SUP></I>.</B>
Donnatal<B><I><SUP>&reg;</SUP></I></B> is a pre-1962 drug that is not FDA-approved, but it is currently cleared to be marketed
and sold in the U.S. as it is included in the Drug Efficacy Study Implementation (&ldquo;DESI&rdquo;) review program of the FDA.&nbsp;&nbsp;Donnatal<B><I><SUP>&reg;</SUP></I></B>
was first commercialized before Congress&rsquo;s 1962 amendment to the Food Drug and Cosmetic Act. The 1962 amendment required
evidence of efficacy to be granted FDA approval.&nbsp;&nbsp;At that time, the FDA introduced the DESI program to evaluate the efficacy
of drugs approved before 1962.&nbsp;&nbsp;Under DESI, Donnatal<B><I><SUP>&reg;</SUP></I></B> is not an FDA-approved drug, but it
is cleared to be marketed and sold until a final determination regarding efficacy is made. To our knowledge at this time and based
on our review of docketed correspondence with the FDA, the FDA has not made a final determination as to the efficacy of Donnatal<B><I><SUP>&reg;</SUP></I></B>.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Based on our review of docketed correspondence with the
FDA, our co-promotion partner, Concordia, is currently a party to the unresolved Notice of Opportunity Hearing for anticholinergic
and barbiturate combination drug products. We make no assurances that the FDA will not seek to begin a hearing process to remove
Donnatal<B><I><SUP>&reg;</SUP></I></B> from the market, commence proceedings to remove Donnatal<B><I><SUP>&reg;</SUP></I></B> from
the market, or otherwise remove Donnatal<B><I><SUP>&reg;</SUP></I></B> from the market at any time. If this were to happen, it
could have a material adverse effect on our reputation, business, financial condition, and results of operations. It could also
be the case that other manufacturers would try to take advantage of the regulatory uncertainty to launch illegal copies of Donnatal<B><I><SUP>&reg;</SUP></I></B>.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Our offering of EnteraGam<SUP>&reg;</SUP> as a &ldquo;medical
food&rdquo; in the U.S. may be challenged by regulatory authorities.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">EnteraGam<B><I><SUP>&reg;</SUP></I></B> is sold under
physician supervision in the U.S. as a &ldquo;medical food,&rdquo; on the basis of its meeting the criteria for &ldquo;medical
foods&rdquo; in the Federal Food, Drug, and Cosmetic Act (FDCA) and FDA regulations. The term &ldquo;medical food&rdquo; is defined
in the FDCA as a food which is formulated to be consumed or administered enterally under the supervision of a physician and which
is intended for the specific dietary management of a disease or condition for which distinctive nutritional requirements, based
on recognized scientific principles, are established by medical evaluation. &ldquo;Medical foods&rdquo;are not required to undergo
premarket review or approval by the FDA.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">To our knowledge, EnteraGam<B><I><SUP>&reg;</SUP></I></B>
meets the criteria for &ldquo;medical foods&rdquo; established by the FDCA, and the labeling and promoting of EnteraGam<B><I><SUP>&reg;</SUP></I></B>
is consistent with FDA regulatory requirements. However, our offering of EnteraGam<B><I><SUP>&reg;</SUP></I></B> as a &ldquo;medical
food&rdquo; could be challenged by the FDA. The FDA has previously issued warning letters to other companies challenging the classification
of their products as &ldquo;medical foods.&rdquo; These letters indicate that the FDA may be applying a more narrow interpretation
of what qualifies as a &ldquo;medical food.&rdquo; Given this enhanced focus on &ldquo;medical food&rdquo; companies, we cannot
provide any assurance that we will not also receive such a letter and the FDA could take the position that EnteraGam<B><I><SUP>&reg;</SUP></I></B>
may not be lawfully sold in the U.S. as a &ldquo;medical food.&rdquo; If such a challenge were to occur we could incur significant
costs responding to such a claim and defending the status of EnteraGam<B><I><SUP>&reg;</SUP></I></B> as a &ldquo;medical food&rdquo;
and ultimately litigation. If we or Entera Health are not able to demonstrate to the FDA&rsquo;s satisfaction that the EnteraGam<B><I><SUP>&reg;</SUP></I></B>
meets the regulatory requirements for &ldquo;medical foods,&rdquo; we would need to suspend further sale and distribution of EnteraGam<B><I><SUP>&reg;</SUP></I></B>
in, and could be required to withdraw EnteraGam<B><I><SUP>&reg;</SUP></I></B> from the U.S. market. The drug development process
can be lengthy and may involve the expenditure of substantial monetary and other resources. Furthermore, the process is uncertain,
as there can be no assurance that EnteraGam<B><I><SUP>&reg;</SUP></I></B> will ultimately be approved by the FDA as a drug. The
U.S. is the only territory in which we have rights to promote EnteraGam<B><I><SUP>&reg;</SUP></I></B>, and the cessation of such
sales, even for a limited period, could have a material adverse effect on our operations, financial situation, operating results
and business prospects.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Clinical trials and related non-clinical studies
may involve a lengthy and expensive process with an uncertain outcome, and results of earlier studies and trials may not be predictive
of future trial results. We or our development or commercialization partners will not be able to commercialize our therapeutic
candidates and products we may promote or commercialize without completing such trials, even products that may have already been
cleared or approved for marketing.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We have limited experience in conducting and managing
the clinical trials that are required to obtain regulatory approvals and commence commercial sales of our therapeutic candidates.
Clinical trials and related non-clinical studies are expensive, complex, can take many years and have uncertain outcomes. We cannot
predict whether we, independently or through third parties, will encounter problems with any of the completed, ongoing or planned
clinical trials that will cause delays, including suspension of a clinical trial, delay of data analysis or release of the final
report. The clinical trials of our therapeutic candidates may take significantly longer to complete than is estimated. Failure
can occur at any stage of the testing and we may experience numerous unforeseen events during, or as a result of, the clinical
trial process that could materially delay or prevent the obtainment of a regulatory approval and commercialization of our current
or future therapeutic candidates.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In connection with the clinical trials for our therapeutic
candidates and other therapeutic candidates that we may seek to develop in the future, either on our own or through licensing or
partnering agreements, we face various risks and uncertainties, including but not limited to:</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="text-align: center; width: 4%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify; width: 96%">delays or failure in securing clinical investigators or trial sites for the clinical trials;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">delays or failure in receiving import or other government approvals to ensure appropriate drug supply;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">delays or failure in obtaining institutional review board (IRB) and other regulatory approvals to commence or continue a clinical trial;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">expiration of clinical trial material before or during our trials as a result of degradation of, or other damage to, the clinical trial material;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">negative or inconclusive results or results that are not sufficiently positive from clinical trials;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the FDA or other foreign regulatory authorities may disagree with the number, design, size, conduct or implementation of our clinical studies;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the FDA or other foreign regulatory authorities may require us to conduct additional clinical trials or studies in connection with therapeutic candidates in development as well as for products that have already been cleared and approved for marketing;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">inability to monitor patients adequately during or after treatment;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">problems with investigator or patient compliance with the trial protocols;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">a therapeutic candidate may not prove safe or efficacious; there may be unexpected or even serious adverse events and side effects from the use of a therapeutic candidate;</TD></TR>
</TABLE>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="text-align: center; vertical-align: top; width: 4%">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify; width: 96%">the results with respect to any therapeutic candidate may not confirm the positive results from earlier preclinical studies or clinical trials;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the results may not meet the level of statistical significance required by the FDA or other foreign regulatory authorities;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the results may justify only limited or restrictive uses, including the inclusion of warnings and contraindications, which could significantly limit the marketability and profitability of a therapeutic candidate;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the clinical trials may be delayed or not completed due to the failure to recruit suitable candidates or if there is a lower rate of suitable candidates than anticipated or if there is a delay in recruiting suitable candidates; and</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">changes to the current regulatory requirements related to clinical trials which can delay, hinder or lead to unexpected costs in connection with our receiving the applicable regulatory clearances or approvals.</TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">A number of companies in the pharmaceutical and biotechnology
industries, including those with greater resources and experience than us, have suffered significant setbacks in advanced clinical
trials, even after seeing promising results in earlier clinical trials. As such, despite the results reported in earlier clinical
trials of our therapeutic candidates, we do not know if the clinical trials we conduct will demonstrate adequate efficacy and safety
sufficient to obtain regulatory approval to market our therapeutic candidates. If any of the clinical trials of any of our current
or future therapeutic candidates does not produce favorable results, our ability to obtain regulatory approval for the therapeutic
candidate may be adversely impacted, which could have a material adverse effect on our business, financial condition and results
of operations.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>If we are unable to establish collaborations for
our therapeutic candidates or products we may promote or commercialize, or otherwise not be able raise substantial additional capital,
we will likely need to alter our development and commercialization plans.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Our drug development programs and the potential commercialization
of our therapeutic candidates and products that we may promote or commercialize<B><I>,</I></B> will require additional cash to
fund expenses. As such, our strategy includes either selectively partnering or collaborating with multiple pharmaceutical and biotechnology
companies to assist us in furthering development or potential commercialization of our therapeutic candidates, promoting products
that we may promote or commercialize, in whole or in part, in some or all jurisdictions or through securing our own commercialization
capabilities. With respect to potential new third-party partners for the development or commercialization of our therapeutic candidates
and&nbsp;development or commercialization of products that we may promote or commercialize, we may not be successful in entering
into collaborations with third parties on acceptable terms, or at all. In addition, if we fail to negotiate and maintain suitable
development, commercialization or promotion agreements or otherwise raise substantial additional capital to secure our own commercialization
capabilities, we may have to limit the size or scope of our activities or we may have to delay one or more of our development or
commercialization programs. Any failure to enter into development or commercialization agreements with respect to the development,
marketing and commercialization of any therapeutic candidate or failure to develop, market and commercialize such therapeutic candidate
independently may have an adverse effect on our business, financial condition and results of operations.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Any collaborative arrangements that we have established
or may establish may not be successful, or we may otherwise not realize the anticipated benefits from these collaborations, including
our out-licensing of RHB-106 and RIZAPORT<SUP>&reg;</SUP></I></B>, <B><I>as well as promotion of Donnatal<SUP>&reg;</SUP>, EnteraGam<SUP>&reg;</SUP>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg. We do not control third parties with whom we have or may have collaborative
arrangements, and we rely on such third parties to achieve results which may be significant to us. In addition, any future collaborative
arrangements may place the development or commercialization of our therapeutic candidates, promotion of Donnatal<SUP>&reg;</SUP>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg or commercialization of, EnteraGam<SUP>&reg;</SUP>, products that we
may promote or commercialize in the future, outside our control, may require us to relinquish important rights or may otherwise
be on terms unfavorable to us.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Each of our collaborative arrangements requires us to
rely on external consultants, advisors, and experts for assistance in several key functions, including clinical development, manufacturing,
regulatory, market research, intellectual property and commercialization. We do not control these third parties, but we rely on
such third parties to achieve results which may be significant to us. To date, we have out-licensed one of our therapeutic candidates,
RHB-106, and related rights to Valeant and have entered into exclusive license agreements with Grupo JUSTE, S.A.Q.F. (now Exeltis
Healthcare, S.L.) and Pharmatronic Co. to commercialize RIZAPORT<B><I><SUP>&reg;</SUP></I></B> in Spain and South Korea, respectively.
We do not control Valeant, Exeltis Healthcare, S.L. or Pharmatronic Co., but we rely on Valeant to clinically develop and commercialize
RHB-106 and related rights and we rely on Exeltis Healthcare, S.L. and Pharmatronic Co. to obtain regulatory approvals and commercialize
RIZAPORT<B><I><SUP>&reg;</SUP></I></B> in Spain and South Korea, respectively. In addition, with respect to Donnatal<B><I><SUP>&reg;</SUP></I></B>,
EnteraGam&reg; and Esomeprazole Strontium Delayed-Release Capsules 49.3mg we rely on Concordia, Entera Health and ParaPRO respectively,
as the party responsible for, among others, the manufacture, supply, and other operating responsibilities.&nbsp;&nbsp; Relying
upon collaborative arrangements to develop and commercialize our therapeutic candidates, such as RHB-106 and RIZAPORT<B><I><SUP>&reg;</SUP></I></B>,
EnteraGam<B><I><SUP>&reg;</SUP></I></B> which we sell or market and other products that we may promote or commercialize in the
future, and Donnatal<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg which are products
that we promote, subjects us to a number of risks, including&nbsp;but not limited to the following:</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="text-align: center; width: 4%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify; width: 96%">our collaborators may default on their obligations to us and we may be forced to either terminate or negotiate such arrangements;</TD></TR>
</TABLE>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0">&nbsp;</P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="text-align: center; vertical-align: top; width: 4%">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify; width: 96%">we may not be able to control the amount and timing of resources that our collaborators may devote to our therapeutic candidates, Donnatal<FONT STYLE="font-size: 10pt"><B><I><SUP>&reg;</SUP></I></B> <FONT STYLE="font-weight: normal; font-style: normal">and Esomeprazole Strontium Delayed-Release Capsules 49.3 mg which are products that we promote, EnteraGam</FONT></FONT><FONT STYLE="font-size: 10pt"><B><I><SUP>&reg;</SUP></I></B> <FONT STYLE="font-weight: normal; font-style: normal">which is a product we sell or market, or products that we may promote or commercialize in the future;</FONT></FONT></TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">should a collaborator fail to comply with applicable laws, rules, or regulations when performing services for us, we could be held liable for such violations;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">our collaborators may experience financial difficulties, making it difficult for them to fulfill their obligations to us, including payment obligations, or they may experience changes in business focus;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">our collaborators&rsquo; partners may fail to secure adequate
    commercial supplies of our therapeutic candidates upon or after obtaining marketing approval, if at all, for Donnatal<FONT STYLE="font-size: 10pt"><B><I><SUP>&reg;</SUP></I></B> <FONT STYLE="font-weight: normal; font-style: normal">or
    Esomeprazole Strontium Delayed-Release Capsules 49.3mg, EnteraGam</FONT></FONT><FONT STYLE="font-size: 10pt"><B><I><SUP>&reg;</SUP></I></B> <FONT STYLE="font-weight: normal; font-style: normal">which
    is a product we sell or market, or of products that we may promote or commercialize;</FONT></FONT></TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">our collaborators' partners may have a shortage of qualified personnel;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">we may be required to relinquish important rights, such as marketing and distribution rights;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">business combinations or significant changes in a collaborator&rsquo;s business or business strategy may adversely affect a collaborator&rsquo;s willingness or ability to complete its obligations under any arrangement;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">under certain circumstances, a collaborator could move forward with a competing therapeutic candidate or product developed either independently or in collaboration with others, including our competitors; and</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">collaborative arrangements are often terminated or allowed to expire, which could delay the development and may increase the cost of developing our therapeutic candidates or may limit or terminate our rights to promote Donnatal<FONT STYLE="font-size: 10pt"><B><I><SUP>&reg;</SUP></I></B><FONT STYLE="font-weight: normal; font-style: normal">, EnteraGam</FONT></FONT><FONT STYLE="font-size: 10pt"><B><I><SUP>&reg;</SUP></I></B> <FONT STYLE="font-weight: normal; font-style: normal">and Esomeprazole Strontium Delayed-Release Capsules 49.3mg&nbsp;in the U.S.&nbsp;or products we may promote or commercialize in the future.</FONT></FONT></TD></TR>
</TABLE>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition, our reliance upon our partners in connection
with our promotional activities subjects us to a number of additional risks, including&nbsp;but not limited to, the following</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="text-align: center; width: 4%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify; width: 96%">we do not control our partners&rsquo; communications with the FDA, and the FDA may determine to withdraw the products from the market due to any action or inaction taken by our partners (see &ldquo;&ndash;Donnatal<FONT STYLE="font-size: 10pt"><B><I><SUP>&reg;</SUP></I></B><FONT STYLE="font-weight: normal; font-style: normal">, EnteraGam</FONT></FONT><FONT STYLE="font-size: 10pt"><B><I><SUP>&reg;</SUP></I></B> <FONT STYLE="font-weight: normal; font-style: normal">and Esomeprazole Strontium Delayed-Release Capsules 49.3mg or products which we may promote or commercialize may be withdrawn from the market at any time due to product withdrawal requests by the FDA or other foreign regulatory authorities.&rdquo;);</FONT></FONT></TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">we rely on our partners to take enforcement action to protect the IP and regulatory protections if any of our commercial products. Their failure to diligently protect these products could materially affect our commercial success;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">we rely on our partners to manufacture Donnatal<FONT STYLE="font-size: 10pt"><B><I><SUP>&reg;</SUP></I></B><FONT STYLE="font-weight: normal; font-style: normal">,
    EnteraGam</FONT></FONT><FONT STYLE="font-size: 10pt"><B><I><SUP>&reg;</SUP></I></B> <FONT STYLE="font-weight: normal; font-style: normal">and
    Esomeprazole Strontium Delayed-Release Capsules 49.3mg through third-party manufacturers with the requisite quality and
    manufacturing standards as required under applicable laws and regulations, and we also rely on those same partners to supply
    their respective products, which may result in us having those respective products in insufficient quantities or on timelines
    insufficient to achieve adequate or successful promotion and sale of their respective products in the
    U.S.;&nbsp;</FONT></FONT></TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">Our same partners may significantly create or change reimbursement agreements or increase or decrease the price of their respective products to a level that could adversely affect our sales or revenues; &nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">we rely on those same partners for most decisions relating to the promotion, sales and marketing of their respective products and any action or inaction taken by those same partners may adversely affect the sales of their respective products; &nbsp;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">our partners may change or create new agreements with wholesalers, PBMs, or other important stakeholders which may significantly impact our ability to achieve commercial success, or they may fail to negotiate reimbursement agreements with payors which could also negatively affect our commercial success;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">our partners may change the price of their respective products to a level that could adversely affect our sales or revenues;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">those same partners may not be successful in maintaining or expanding reimbursement from government or third-party payors, such as insurance companies, health maintenance organizations and other health plan administrators, which may adversely affect the sales of their respective products;&nbsp;and</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">those same partners may terminate their agreements with us after an agreed upon period for reasons set forth in those same partners&rsquo; respective agreements with us.&nbsp;&nbsp;</TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">If any of these or other scenarios materialize, they could
have an adverse effect on our business, financial condition or results of operations.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition, Concordia has recently announced that in
conjunction with its efforts to strengthen its capital structure, it has decided to use a 30-day grace period to defer the payment
of approximately $26 million of interest on its $735 million unsecured notes. As a result of Concordia's financial condition, we
are subject to the additional risks that Concordia may delay, reduce or cease payments to us under the Co-Promotion Agreement or
otherwise be unable or unwilling to meet its obligations to us under the Co-Promotion Agreement, including its manufacture, supply,
and other operating responsibilities. If any of these scenarios materialize, it could have an adverse effect on our business, financial
condition or results of operations.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Donnatal<SUP>&reg;</SUP>, EnteraGam<SUP>&reg;</SUP>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg or products which we may promote or commercialize in the future may
be withdrawn from the market at any time due to product withdrawal requests by the FDA or other foreign regulatory authorities.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Products we acquire or to which we acquire certain commercialization
rights may be subject to withdrawal requests by the FDA or other foreign regulatory authorities for various reasons.&nbsp;&nbsp;For
instance, certain products, such as Donnatal<B><I><SUP>&reg;</SUP></I></B>, may be subject to regulatory review due to their classification
as a DESI product which the FDA has the right to determine as ineffective and impose limitations or request withdrawal of the product
from the market. Donnatal<B><I><SUP>&reg;</SUP></I></B> is currently subject to the FDA&rsquo;s DESI proceedings, to determine
its effectiveness and the right to continue to be marketed in the U.S. and there is no assurance as to the outcome of such proceedings.
To our knowledge at this time and based on our review of docketed correspondence with the FDA, the FDA has not made a final determination
as to the efficacy of Donnatal<B><I><SUP>&reg;</SUP></I></B>. &nbsp;In addition, the process and timing of any FDA DESI proceedings
with respect to Donnatal<B><I><SUP>&reg;</SUP></I></B> are unclear.&nbsp;&nbsp;Historically, the FDA has generally permitted products
to stay on the market during these proceedings, although there is no assurance as to the time of commencement of such proceedings
or whether the FDA will in fact grant such permission to any future DESI-related proceedings, including for Donnatal<B><I><SUP>&reg;</SUP></I></B>.
EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg may also be subject to withdrawal
requests by the FDA. EnteraGam<B><I><SUP>&reg;</SUP></I></B>&rsquo;s status as a &ldquo;medical food&rdquo; in the U.S. may be
challenged by regulatory authorities which may result in its withdrawal from the market until additional regulatory requirements
are met. Regulatory authorities in other jurisdictions may have similar procedures that may subject any product we may promote
or commercialize to limitations or withdrawal requests.&nbsp;&nbsp;In addition, the FDA or other foreign regulatory authorities
may determine that the chemistry, manufacturing and controls (&ldquo;CMC&rdquo;) of marketed products that we develop, acquire
or to which we acquire commercialization rights, such as Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg is unsatisfactory due to the manufacturing standards of the products.
If either of these or any regulatory action is taken, Donnatal<B><I><SUP>&reg;</SUP></I></B>&nbsp;, EnteraGam<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg or &nbsp;any product we promote or commercialize could be withdrawn
from the market at any time. In addition, we could suffer from delays in further commercialization of any product we promote or
commercialize.&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We may not be successful in acquiring products or
companies that own the rights to, or otherwise acquire commercialization rights to, products cleared or approved for marketing
in the U.S. or elsewhere that achieve commercial success or in further establishing our own marketing and commercialization capabilities.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Part of our strategy is to identify and acquire rights
to products that have been cleared or approved for marketing in the U.S. or elsewhere, in particular, those with a therapeutic
focus on GI, inflammation or cancer.&nbsp;&nbsp;Specifically, we seek to acquire rights to products that are already commercialized,
which would enable us to commercialize such products independently and further establish our own marketing and commercialization
capabilities in the U.S.&nbsp;&nbsp;We have entered into a Co-Promotion Agreement with Concordia pursuant to which we were granted
certain rights to promote Donnatal<B><I><SUP>&reg;</SUP></I></B> in the U.S.,&nbsp;which was our first agreement to commercialize
a product being marketed in the U.S.&nbsp;&nbsp;&nbsp;We have also entered into a license agreement with Entera Health pursuant
to which we were granted the exclusive U.S. rights to EnteraGam<B><I><SUP>&reg;</SUP></I></B>, and we have entered into a commercialization
agreement with ParaPRO pursuant to which we were granted the exclusive rights to promote to gastroenterologists in certain U.S.
territories Esomeprazole Strontium Delayed-Release Capsules 49.3mg. However, there can be no assurance as to our ability to identify
and acquire rights to any additional products, in particular those with a therapeutic focus on GI, inflammation or cancer.&nbsp;&nbsp;If
we are not successful in acquiring any additional products or in promoting Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, we may not be able to further establish or maintain our own marketing
and commercialization capabilities in the U.S. This may limit our ability to commercialize products on our own and may require
us to contract with third-party development or commercialization partners which may not be on commercially favorable terms. Additionally,
these efforts to further establish and maintain our commercial capabilities in the U.S. could be found more costly than our forecast
and have an adverse effect on our business, financial condition and results of operations.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition, there can be no assurance that we will accurately
or consistently identify products approved or cleared for marketing that will achieve commercial success or that we will be able
to successfully commercialize.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>If we are unable to maintain, train and build an
effective sales and marketing infrastructure, we will not be able to commercialize and grow our products and product candidates
successfully.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">To further establish and maintain our own marketing and
commercialization capabilities in the U.S. we may need to expand, among other things, our development, regulatory, manufacturing,
marketing and sales capabilities and to increase or maintain our personnel to accommodate sales. We may not be able to secure sales
personnel or organizations that are adequate in number or expertise to successfully market and sell our products in the U.S. This
risk would be accentuated if we acquire products in areas outside of GI therapeutics since our sales forces is GI-focused. If we
are unable to expand our sales and marketing capability, train our sales force effectively or provide any other capabilities necessary
to commercialize our products and therapeutic candidates, we may need to contract with third parties to market and sell our products.
Our employees and sales personnel must comply with applicable regulatory requirements and restrictions, including, but not limited
to, &ldquo;fair balance&rdquo; promotion of our products and state and federal anti-kickback laws. If we are unable to establish
and maintain compliant and adequate sales and marketing capabilities, we may not be able to increase our product revenue, may generate
increased expenses and may be subject to regulatory and compliance investigation and enforcement.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Expanding and maintaining our commercial infrastructure
for our commercial capabilities in the U.S. is a significant undertaking that requires substantial financial and managerial resources,
and we may encounter delays or may not be successful in our efforts.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">While we are currently promoting Donnatal<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg in the U.S., we have only recently begun to promote products in the
U.S. and we have limited experience in promoting products.&nbsp;&nbsp;We are currently promoting and selling EnteraGam<B><I><SUP>&reg;</SUP></I></B>
in the U.S., and we likewise have only recently begun to promote and commercialize products in the U.S. and we have limited experience
in marketing and selling products. Establishing, maintaining and/or expanding the necessary capabilities are competitive and time-consuming
and the commercialization of any of Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole
Strontium Delayed-Release Capsules 49.3mg requires a significant expenditure of operating, financial and management resources.&nbsp;&nbsp;Even
with those investments, we may not be able to effectively promote Donnatal<B><I><SUP>&reg;</SUP></I></B> or Esomeprazole Strontium
Delayed-Release Capsules 49.3mg promote or commercialize EnteraGam<B><I><SUP>&reg;</SUP></I>,</B> or we may incur more expenditures
than anticipated in order to maximize our sales.&nbsp;&nbsp;We cannot guarantee that we will be able to establish, maintain and/or
expand our sales, marketing, distribution and market access capabilities, and enter into and maintain any agreements necessary
for commercialization with payers and third-party providers on acceptable terms, if at all.&nbsp;&nbsp;If we are unable to establish,
maintain and/or expand such capabilities, either on our own or by entering into agreements with others, or are unable to do so
in an efficient manner or on a timely basis, we will not be able to maximize our commercialization of Donnatal<B><I><SUP>&reg;</SUP></I></B>,
EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, which would adversely affect
our business, operating results and financial condition.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Even if the promotion and/or commercialization of Donnatal<B><I><SUP>&reg;</SUP></I></B>,
EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg are successful, we may fail
to further our business strategy as anticipated or to achieve anticipated benefits and success.&nbsp;&nbsp;We may incur higher
than expected costs in connection with our promotion of Donnatal<B><I><SUP>&reg;</SUP></I></B> or Esomeprazole Strontium Delayed-Release
Capsules 49.3mg or commercialization of EnteraGam<B><I><SUP>&reg;</SUP></I></B> and we may encounter general economic and business
conditions that adversely affect these products.&nbsp;&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition, if we incur higher than expected costs in
connection with our promotion of Donnatal<B><I><SUP>&reg;</SUP></I></B>, or Esomeprazole Strontium Delayed-Release Capsules 49.3mg,
or commercialization of EnteraGam<B><I><SUP>&reg;</SUP></I></B>, we may need to reduce or terminate our commercial activities,
which may have a material adverse effect on our business.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We have no history of independently commercializing
therapeutic candidates or marketed products, and may have difficulty promoting Donnatal<SUP>&reg;</SUP> or Esomeprazole Strontium
Delayed-Release Capsules 49.3mg, commercializing EnteraGam<SUP>&reg;</SUP>, or promoting or commercializing any therapeutic candidates
or products we may acquire the rights in the future.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We have no prior experience in commercializing therapeutic
candidates or marketed products on our own, which may materially increase marketing and sales expenses or cause us to be ineffective
in these efforts.&nbsp;&nbsp;In June 2017, we began promoting Donnatal<B><I><SUP>&reg;</SUP></I></B> and EnteraGam<B><I><SUP>&reg;</SUP></I></B>
in the U.S., and in September 2017 we began promoting Esomeprazole Strontium Delayed-Release Capsules 49.3mg to gastroenterologists
in certain U.S. territories. There can be no assurance we will successfully commercialize our therapeutic candidates or promote
Donnatal<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg or commercialize EnteraGam<B><I><SUP>&reg;</SUP></I></B>
or any products we may promote or commercialize in the future. &nbsp;&nbsp;In addition, many companies, both public and private,
including well-known pharmaceutical companies and smaller niche-focused companies, are currently selling, marketing and distributing
drug products that directly compete with the therapeutic candidates that we may seek to commercialize. Many of these companies
have significantly greater financial capabilities, marketing and sales experience and resources than us. As a result, our competitors
may be more successful than we are in commercializing products.&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white"><B><I>We rely on third parties
to conduct our clinical trials and related non-clinical studies and those third parties may not perform satisfactorily, including
but not limited to failing to meet established deadlines for the completion of such clinical trials.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We currently do not have the ability to independently
conduct clinical trials and related non-clinical studies for our therapeutic candidates, and we rely on third parties, such as
contract research organizations, medical institutions, contract laboratories, development and commercialization partners, clinical
investigators and independent study monitors to perform these functions. Our reliance on these third parties for research and development
activities reduces our control over these activities. Furthermore, these third parties may also have relationships with other entities,
some of which may be our competitors. Although we have, in the ordinary course of business, entered into agreements with such third
parties, other than with respect to RHB-106 and related rights, which we have out-licensed to Valeant, we continue to be responsible
for confirming that each of our clinical trials and related non-clinical studies is conducted in accordance with its general investigational
plan and protocol. Moreover, the FDA requires us to comply with regulations and standards, commonly referred to as good clinical
practices (&ldquo;GCP&rdquo;), for conducting, recording and reporting the results of clinical trials to assure that data and reported
results are credible and accurate and that the trial participants are adequately protected, and regulatory authorities in other
jurisdictions may have similar responsibilities and requirements. Our reliance on third parties does not relieve us of these responsibilities
and requirements. If these third parties do not successfully carry out their contractual duties or meet expected deadlines, we
may be required to replace them or perform such functions independently. Although we believe that there are a number of other third-party
contractors we could engage to continue these activities, it may result in a delay of the affected trial and additional costs.
Accordingly, we may be materially delayed in obtaining regulatory approvals for our therapeutic candidates and may be materially
delayed in our efforts to successfully commercialize our therapeutic candidates for targeted diseases.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition, our ability to bring our therapeutic candidates
to market depends on the quality and integrity of data that we present to regulatory authorities in order to obtain marketing authorizations.
Although we attempt to audit and control the quality of third-party data, we cannot guarantee the authenticity or accuracy of such
data, nor can we be certain that such data has not been fraudulently generated.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>If third parties do not manufacture our therapeutic
candidates or do not manufacture and sell any products we may promote or commercialize, , including Donnatal<SUP>&reg;</SUP>, EnteraGam<SUP>&reg;</SUP>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg,&nbsp;in sufficient quantities, in the required timeframe, and at an
acceptable cost and quality, clinical development and commercialization of our therapeutic candidates or promotion of products
we may promote or commercialize would be delayed and sales of any product we may promote or commercialize may be adversely affected.</I></B>
&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We do not currently own or operate manufacturing facilities.
We rely, and expect to continue to rely, on third parties to manufacture clinical and commercial quantities of our therapeutic
candidates and products that we may promote or commercialize. For RIZAPORT<B><I><SUP>&reg;</SUP></I></B>, we rely on IntelGenx
Corp. to supply and provide sufficient quantities in the required timeframe for registration and sales in Spain and South Korea,
and for Donnatal<B><I><SUP>&reg;</SUP></I></B>, we rely on Concordia, which has a manufacturing agreement with a third party to
provide sufficient quantities of Donnatal<B><I><SUP>&reg;</SUP></I></B> in the required timeframe. For EnteraGam we rely on Entera
Health and the manufacturer, The Lauridsen Group, Inc., to provide sufficient quantities of EnteraGam in the required timeframe,
and for Esomeprazole Strontium Delayed-Release Capsules 49.3mg we rely on ParaPRO, which has a manufacturing agreement with a third
party to provide sufficient quantities of Esomeprazole Strontium Delayed-Release Capsules 49.3mg in the required timeframe. Our
reliance on third parties includes our reliance on them for quality assurance related to regulatory compliance. Our current and
anticipated future reliance upon others for the manufacture of our therapeutic candidates and any products that we may promote
or commercialize may adversely affect our future operations and our ability to develop therapeutic candidates and commercialize
any therapeutic candidates and any products that we may promote or commercialize on a timely and competitive basis.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We may not be able to maintain our existing or future
third-party manufacturing arrangements on acceptable terms, if at all. If for some reason our manufacturers or our development
or commercialization partners&rsquo; manufacturers do not perform as agreed or expected, we or our partners may be required to
replace them, in which event we may incur added costs and delays in identifying, engaging, qualifying and training any such replacements,
and such additional costs and delays may adversely impact our ability to obtain regulatory clearances and approvals to commercialize
our therapeutic candidates or any product we may promote or commercialize, or make such commercialization or marketing economically
unfeasible.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"><B><I>We rely on third&nbsp;parties to manufacture and supply us with high
quality active pharmaceutical ingredients (&ldquo;APIs&rdquo;) in the quantities we require on a timely basis.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We currently do not manufacture any APIs ourselves. Instead,
we rely on third-party vendors for the development, manufacture and supply of our APIs that are used to formulate our therapeutic
candidates and products we may promote or commercialize. If these suppliers are incapable or unwilling to meet our current or future
needs on acceptable terms or at all, we could experience a delay in obtaining regulatory clearances or approvals for our therapeutic
candidates or products that we may promote or commercialize or in conducting clinical trials of our therapeutic candidates and
incur additional costs or experience an adverse effect on our sale of any product we may promote or commercialize.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">While there may be several alternative suppliers of APIs
on the market, we have yet to conclude extensive investigations into the quality or availability of their APIs. As a result, we
can provide no assurances that supply sources will not be interrupted from time to time. Changing API suppliers or finding and
qualifying new API suppliers can be costly and take a significant amount of time. Many APIs require significant lead time to manufacture.
There can also be challenges in maintaining similar quality or technical standards from one manufacturing batch to the next.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">If we are not able to find stable, affordable, high quality,
or reliable supplies of our APIs, we may not be able to produce enough supplies of our therapeutic candidates or products we may
promote or commercialize, which could have a material adverse effect on our business, financial condition or results of operations.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We anticipate continued reliance on third-party
manufacturers if we are successful in obtaining marketing approval from the FDA and other regulatory agencies for any of our therapeutic
candidates and reliance on third-party manufacturers for any products that we may promote, promote or commercialize, including
Donnatal<SUP>&reg;</SUP></I></B>, <B><I>EnteraGam&reg; and Esomeprazole Strontium Delayed-Release Capsules 49.3mg.</I></B> &nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">To date, our therapeutic candidates have been manufactured
in relatively small quantities for preclinical testing and clinical trials as well as for other regulatory purposes by third-party
manufacturers. If the FDA or other regulatory agencies approve any of our therapeutic candidates for commercial sale, we expect
that we would continue to rely, at least initially, on third-party manufacturers to produce commercial quantities of our approved
therapeutic candidates. In addition, we rely on and we expect to continue to rely on third-party manufacturers to produce commercial
quantities of Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release
Capsules 49.3mg or any product that we may gain the rights to in the future in order to promote or commercialize. These manufacturers
may not be able to successfully increase or maintain the manufacturing capacity for any of our therapeutic candidates that may
be approved in the future, Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium
Delayed-Release Capsules 49.3mg or any product we may gain the rights to in order to promote or commercialize in the future, in
a timely or economic manner, or at all. Except for current FDA regulations with respect to &ldquo;medical foods,&rdquo; significant
scale-up of manufacturing may require additional validation studies, which the FDA must review and approve. Foreign regulatory
agencies may also require approval of additional validation studies for scaling up the manufacturing process of any of our products
including &ldquo;medical foods&rdquo; If the third-party manufacturers are unable to successfully increase or maintain the manufacturing
capacity for a therapeutic candidate or for products that we may promote or commercialize, or if we are unable to secure replacement
third-party manufacturers or unable to establish our own manufacturing capabilities, the commercial launch of any approved products
may be delayed or there may be a shortage in supply which could have a material adverse effect on our business, financial condition
or results of operations.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We and our third-party manufacturers or our partners'
manufacturers are, and will be, subject to regulations of the FDA and other foreign regulatory authorities.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We and our third-party manufacturers or our partners'
manufacturers are, and will be, required to adhere to laws, regulations and guidelines of the FDA and other foreign regulatory
authorities setting forth current good manufacturing practices (&ldquo;cGMP&rdquo;). These laws, regulations and guidelines cover
all aspects of the manufacturing, testing, quality control and recordkeeping relating to our therapeutic candidates with varying
cGMP rigors depending on what phase each of our respective therapeutic candidates is in with respect to its drug development process
and any products we may promote or commercialize, including Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg. We and our third-party manufacturers and our partners' manufacturers
may not be able to comply with applicable laws, regulations and guidelines. We and our third-party manufacturers and our partners'
manufacturers are and will be subject to unannounced inspections by the FDA, state regulators and similar foreign regulatory authorities
outside the U.S. Our failure, or the failure of our third-party manufacturers or our partners' manufacturers, to comply with applicable
laws, regulations and guidelines could result in the imposition of sanctions on us, including fines, injunctions, civil penalties,
failure of regulatory authorities to grant marketing approval of our therapeutic candidates, delays, suspension or withdrawal of
approvals, license revocation, seizures or recalls of our therapeutic candidates and commercially marketed products, operating
restrictions and criminal prosecutions, any of which could significantly and adversely affect regulatory approval and supplies
of our therapeutic candidates and commercially marketed products, and materially and adversely affect our reputation, business,
financial condition and results of operations.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Our therapeutic candidates, Donnatal<SUP>&reg;</SUP>,
EnteraGam&reg; and Esomeprazole Strontium Delayed-Release Capsules 49.3mg and any product we may promote or commercialize in the
future, even if all regulatory clearances and approvals are obtained, will be subject to ongoing regulatory review. If we fail
to comply with continuing U.S. and applicable foreign laws, regulations and guidelines, we could lose those clearances and approvals,
if required at all, and our reputation, busines</I></B>s<B><I>, financial condition and results of operations may be materially
and adversely affected.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We and/or our commercialization partners, as applicable,
will be subject to ongoing reporting obligations with respect to our therapeutic candidates, even if they receive regulatory clearance
or approval, and with respect to Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole
Strontium Delayed-Release Capsules 49.3mg and any cleared or approved product that we may gain the rights to promote or commercialize
in the future, &nbsp;including pharmacovigilance, and the manufacturing operations of our therapeutic candidates, Donnatal<B><I><SUP>&reg;</SUP></I></B>,
EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg and any other product we may
promote or commercialize, whether currently or in the future, will be subject to continuing regulatory review, including inspections
by the FDA and other foreign regulatory authorities. The results of any ongoing review may result in withdrawal from the market
of a therapeutic candidate, Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium
Delayed-Release Capsules 49.3mg or another product we may promote or commercialize, interruption of manufacturing operations or
imposition of labeling or marketing limitations for such therapeutic candidate or product. Since many more patients are exposed
to drugs following their marketing clearance or approval, serious but infrequent adverse reactions that were not observed in clinical
trials may be observed during the commercial marketing of the therapeutic candidate or any product we may promote or commercialize,
including Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release
Capsules 49.3mg. &nbsp;As we develop our therapeutic candidates or commercialize our products, we may also periodically discuss
with the FDA and other regulatory authorities certain clinical, regulatory and manufacturing matters and, our views may, at times,
differ from those of the FDA and other regulatory authorities. For example, the FDA may seek to regulate our therapeutic candidates
or any product we may promote or commercialize that consist of two or more active ingredients as combination drugs under its Combination
Drug Policy. The Combination Drug Policy requires that we demonstrate that each active ingredient in a drug product contributes
to the product&rsquo;s claimed effect. If the FDA raises questions regarding whether available data and information provided to
the FDA demonstrate the contribution of each active ingredient in such combination drug products, we may be required to provide
additional information, which may require us to conduct additional preclinical studies or clinical trials. If we and/or our commercialization
partners, as applicable, are required to conduct additional clinical trials or other testing of our therapeutic candidates, Donnatal<B><I><SUP>&reg;</SUP></I></B>,
EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, or any other product we may
promote or commercialize, we may face substantial additional expenses, be delayed in obtaining marketing clearance or approval,
if required by the FDA, or may never obtain marketing clearance or approval for such therapeutic candidate or product we may promote
or commercialize, including Donnatal<B><I><SUP>&reg;</SUP></I></B>. In addition, Donnatal<B><I><SUP>&reg;</SUP></I></B> is currently
subject to the FDA&rsquo;s DESI proceedings to determine its effectiveness and the right to continue to be marketed in the U.S.,
and there is no assurance as to the outcome of such proceedings.&nbsp; To our knowledge at this time and based on our review of
docketed correspondence with the FDA, the FDA has not made a final determination as to the efficacy of Donnatal<B><I><SUP>&reg;</SUP></I></B>.&nbsp;
See &ldquo;&ndash; &nbsp;Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium
Delayed-Release Capsules 49.3mg or products which we may promote or commercialize may be withdrawn from the market at any time
due to product withdrawal requests by the FDA or other foreign regulatory authorities.&rdquo;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition, in April 2017, the FDA granted YELIVA<SUP>&reg;</SUP>&nbsp;orphan
drug designation for the treatment of cholangiocarcinoma. If we fail to maintain orphan drug exclusivity for YELIVA&reg;, our competitors
may sell products equivalent to YELIVA&reg; to treat the same conditions and our revenues could be reduced.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In November 2014, the FDA granted RHB-105 a QIDP designation.
In January 2017, we announced that RHB-104 had been granted QIDP designation by the FDA for the treatment of NTM infections. If
RHB-105 and/or RHB-104 fails to maintain its QIDP designation, it could significantly increase the development time for RHB-105
and RHB-104 for the treatment of NTM infections, as the case may be.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition, third-party manufacturers and the manufacturing
facilities that we and our development or commercialization partners use to manufacture any therapeutic candidate and any other
products that we may promote or commercialize, including Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, will be subject to periodic review and inspection by the FDA and may
be subject to similar review by other regulatory authorities. Later discovery of previously unknown problems with any therapeutic
candidate or product we may promote or commercialize, including Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, manufacturer or manufacturing process, or failure to comply with rules
and regulatory requirements, may result in actions, including but not limited to the following:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="text-align: center; width: 4%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify; width: 96%">restrictions on such therapeutic candidate, marketed product, manufacturer or manufacturing process;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">warning letters from the FDA or other foreign regulatory authorities;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">withdrawal of the therapeutic candidate or marketed product from the market;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">suspension or withdrawal of regulatory approvals;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">refusal to approve pending applications or supplements to approved applications that we or our development or commercialization partners&nbsp;submit;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">voluntary or mandatory recall;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">fines;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">refusal to permit the import or export of our therapeutic candidates or products that we may promote or commercialize;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">product seizure or detentions;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">injunctions or the imposition of civil or criminal penalties; and</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">adverse publicity.</TD></TR>
</TABLE>

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<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">If we or our commercialization partners, suppliers, third-party
contractors or clinical investigators are slow to adapt, or are unable to adapt, to changes in existing regulatory requirements
or the adoption of new regulatory requirements or policies, we and our development or commercialization partners may lose marketing
clearance or approval for any of our therapeutic candidates if any of our therapeutic candidates are approved, and we may lose
marketing clearance or approval of any products already cleared or approved for marketing in any jurisdiction, resulting in decreased
or lost revenue from such therapeutic candidates and products and could also result and other civil or criminal sanctions, including
fines and penalties.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Modifications to our therapeutic candidates, or
to any product that we may promote or commercialize, may require new regulatory clearances or approvals or may require us or our
development or commercialization partners, as applicable, to recall or cease marketing of any of our cleared or approved products,
if any, or delay further studies of our therapeutic candidates in human subjects until clearances or approvals are obtained.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Modifications to our therapeutic candidates and any products
we may promote or commercialize including Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole
Strontium Delayed-Release Capsules 49.3mg, after they have been cleared or approved for marketing, if at all, may require new regulatory
clearance or approvals, and, if necessitated by a problem with a marketed product, may result in the recall or suspension of marketing
of the previously approved and marketed product until clearances or approvals of the modified product are obtained. The FDA and
other regulatory authorities require pharmaceutical product and device manufacturers to initially make and document a determination
of whether or not a modification requires a new approval, supplement or clearance. A manufacturer may determine in conformity with
applicable laws, regulations and guidelines that a modification may be implemented without pre-clearance by the FDA or other regulatory
authorities. However, the FDA or other regulatory authorities can review a manufacturer&rsquo;s decision and may disagree. The
FDA or other regulatory authorities may also on their own initiative determine that a new clearance or approval is required. If
the FDA or other regulatory authorities require new clearances or approvals of any pharmaceutical product for which we or our partners,
including development or commercialization partners previously received marketing approval, we or our partners, including development
or commercialization partners may be required to recall and stop marketing such marketed product, which could require us or our
partners, including development or commercialization partners to redesign the marketed product and may cause a material adverse
effect on our reputation, business, financial condition and results of operations.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We may depend on our ability to identify and in-license
or acquire therapeutic candidates to achieve commercial success, including products approved for marketing in the U.S. or elsewhere.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Our seven therapeutic candidates were all acquired or
licensed by us from third parties. We evaluate internally and with external consultants each therapeutic candidate. However, there
can be no assurance as to our ability to accurately or consistently identify therapeutic candidates or products that have been
approved or cleared for marketing in the U.S. or elsewhere that are likely to achieve commercial success. In addition, even if
we identify additional therapeutic candidates or products that have been approved or cleared for marketing in the U.S. or elsewhere
that are likely to achieve commercial success, there can be no assurance as to our ability to in-license or acquire such therapeutic
candidates or products under favorable terms or at all.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We compete with other entities for some in-license
or acquisition opportunities.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">As part of our overall strategy, we pursue opportunities
to in-license or acquire therapeutic candidates and products that have been approved or cleared for marketing in the U.S. We may
compete for in-license and acquisition opportunities with other established and well-capitalized companies. As a result, we may
be unable to in-license or acquire additional therapeutic candidates or products that have been approved or cleared for marketing
in the U.S. at all or on favorable terms. Our failure to further in-license or acquire therapeutic candidates or products that
have been approved or cleared for marketing in the U.S. in the future may materially hinder our ability to grow and could materially
harm our business, financial condition and results of operations.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>If we cannot meet our obligations under our acquisition,
in-license or other development or commercialization agreements or renegotiate our obligations under such agreements, or if other
events occur that are not within our control such as bankruptcy of a licensor or a partner, we could lose the rights to our therapeutic
candidates or products we may promote or commercialize, experience delays in developing or commercializing our therapeutic candidates
or products we may promote or</I></B> commercialize <B><I>or incur additional costs, which could have a material adverse effect
on our business, financial condition and results of operations.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We acquired our rights to three of our therapeutic candidates,
TALICIA&trade;, RHB-104 and RHB-106, from a third party pursuant to an asset and purchase agreement. In addition, we in-licensed
our rights to four other therapeutic candidates, BEKINDA<B><I><SUP>&reg;</SUP></I></B>, YELIVA<B><I><SUP>&reg;</SUP></I></B>,
MESUPRON and RIZAPORT<B><I><SUP>&reg;</SUP></I></B> pursuant to license agreements in which we received exclusive perpetual licenses
to certain patent rights and know-how related to these therapeutic candidates.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We have also obtained certain rights to promote Donnatal<B><I><SUP>&reg;</SUP></I></B>
in the U.S. under a co-promotion agreement, the exclusive U.S. rights to EnteraGam<B><I><SUP>&reg;</SUP></I></B> pursuant to a
license agreement, and exclusive rights to promote Esomeprazole Strontium Delayed-Release Capsules 49.3mg to gastroenterologists
in certain U.S. territories pursuant to a commercialization agreement. These agreements require us to make payments and satisfy
various performance obligations in order to maintain our rights and licenses with respect to these therapeutic candidates and marketed
products. If we do not meet our obligations under these agreements, or if other events occur that are not within our control such
as the bankruptcy of a licensor, we could lose the rights to our therapeutic candidates, experience delays in developing or commercializing
our therapeutic candidates or incur additional costs, any of which could have a material adverse effect on our business, financial
condition and results of operations. In addition, our agreement with IntelGenx Corp. for RIZAPORT<B><I><SUP>&reg;</SUP></I></B>
requires us to renegotiate certain provisions of the agreement in the event the agreed-to budget is exceeded by a certain amount.
In the event we are required to renegotiate this agreement, there is no guarantee that we will agree upon new terms promptly, or
at all, which could delay the development or commercialization of RIZAPORT<B><I><SUP>&reg;</SUP></I></B>.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition, we are responsible for the cost of filing
and prosecuting certain patent applications and maintaining certain issued patents licensed to us. If we do not meet our obligations
under these agreements in a timely manner&nbsp;or if other events occur that are not within our control, such as the bankruptcy
of a licensor, which impact our ability to prosecute certain patent applications and maintain certain issued patents licensed to
us, we could lose the rights to our therapeutic candidates which could have a material adverse effect on our business, financial
condition and results of operations. We manage a large portfolio of patents and may decide to discontinue maintaining certain patents
in certain territories for various reasons, such as a current belief that the commercial market for the therapeutic candidate will
not be large or that there is a near-term patent expiration that may reduce the value of the therapeutic candidate. In the event
we discontinue maintaining such patents, we may not be able to enforce rights for our therapeutic candidates or protect our therapeutic
candidates from competition in those territories.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Our business could suffer if we are unable to attract
and retain key employees.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">The loss of the services of members
of senior management or other key personnel could delay or otherwise adversely impact the successful completion of our planned
clinical trials or the commercialization of our therapeutic candidates and any product we may promote or commercialize, including
Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules
49.3mg, or otherwise affect our ability to manage our company effectively and to carry out our business plan. These key personnel
are Dror Ben-Asher, our Chief Executive Officer, Reza Fathi, Ph.D., our Senior Vice President for Research and Development, Gilead
Raday, our Chief Operating Officer, Adi Frish, our Senior Vice President for Business Development and Licensing, Guy Goldberg,
our Chief Business Officer, and Micha Ben Chorin, our Chief Financial Officer. We do not maintain key-man life insurance. Although
we have entered into employment or consultancy agreements with all of the members of our senior management team, members of our
senior management team may resign at any time. High demand exists for senior management and other key personnel in the pharmaceutical
industry. There can be no assurance that we will be able to continue to retain and attract such personnel.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Our growth and success also depend on our ability to attract
and retain additional highly qualified scientific, technical, business development, marketing, sales, managerial and finance personnel.
We experience intense competition for qualified personnel, and the existence of non-competition agreements between prospective
employees and their former employers may prevent us from hiring those individuals or subject us to liability from their former
employers. In addition, as part of our plan to promote Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg and potentially products we may develop, we will need to expand and
maintain our marketing and sales capabilities. While we attempt to provide competitive compensation packages to attract and retain
key personnel, many of our competitors are likely to have greater resources and more experience than we have, making it difficult
for us to compete successfully for key personnel. If we cannot attract and retain sufficiently qualified suitable employees on
acceptable terms, we may not be able to develop and commercialize competitive therapeutic candidates and our commercialized products.
Further, any failure to effectively integrate new personnel could materially prevent us from successfully growing our company.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We face several risks associated with international
business</I>.</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We operate our business in multiple international jurisdictions.
Such operations could be materially affected by changes in foreign exchange rates, capital and exchange controls, expropriation
and other restrictive government actions, changes in intellectual property legal protections and remedies, trade regulations and
procedures and actions affecting approval, production, pricing, and marketing of, reimbursement for and access to, our therapeutic
candidates and products we may promote or commercialize, including Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, as well as by political unrest, unstable governments and legal systems
and inter-governmental disputes. Any of these changes could have a material adverse effect on our business, financial condition
and results of operations. Additionally, because our corporate headquarters are in Israel while our commercial headquarters are
in the U.S., there is additional risk in our ability as a company to control the activities occurring in the U.S., due to the geographic
separation within the company.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B>Risks Related to Our Industry</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Even if our therapeutic candidates or any product
we may promote or commercialize, receive, have received regulatory clearance or approval or do not require regulatory clearance
or approval, they may not become commercially viable products.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Except for RIZAPORT<B><I><SUP>&reg;</SUP></I></B>, which
has been approved for marketing in Germany and Luxembourg but has yet to be marketed, none of our therapeutic candidates have been
cleared or approved for marketing, and none of our therapeutic candidates is currently being marketed or commercialized in any
jurisdiction. We were granted certain rights to promote Donnatal<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release
Capsules 49.3mg in the U.S., which we recently began promoting in the U.S., and to commercialize EnteraGam<B><I><SUP>&reg;</SUP></I></B>,
all three of which we recently began promoting in the U.S. Even if any of our therapeutic candidates or any product we may promote
or commercialize receive, have received or do not require regulatory clearance or approval, it may not become a commercially viable
product. For example, even if we or our development or commercialization partners receive regulatory clearance or approval to market
a therapeutic candidate, or have received regulatory clearance or approval to promote or commercialize any product, the clearance
or approval may be subject to limitations on the indicated uses or subject to labeling or marketing restrictions which could materially
and adversely affect their marketability and profitability. In addition, a new therapeutic candidate may appear promising at an
early stage of development or after clinical trials but never reach the market, or it may reach the market but not result in sufficient
product sales, if any. A therapeutic candidate or any product that we may promote or commercialize, may not result in commercial
success for various reasons, including but not limited to:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="text-align: center; width: 5%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify; width: 95%">difficulty in large-scale manufacturing, including yield and quality;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">low market acceptance by physicians, healthcare payors, patients and the medical community as a result of lower demonstrated clinical safety or efficacy compared to products, prevalence and severity of adverse side effects, or other potential disadvantages relative to alternative treatment methods;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">insufficient or unfavorable levels of reimbursement from government or third-party payors, such as insurance companies, health maintenance organizations and other health plan administrators;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">infringement on proprietary rights of others for which we or our development or commercialization partners have not received licenses;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">incompatibility with other therapeutic candidates or marketed products;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">other potential advantages of alternative treatment methods and competitive forces that may make it more difficult for us to penetrate a particular market segment, if at all;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">ineffective marketing, sales and distribution activities and support;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">lack of significant competitive advantages over existing products on the market;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">lack of cost-effectiveness or unfavorable pricing compared to other alternatives available on the market;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">inability to generate sufficient revenues from the sale or marketing of a product in view of the economic arrangements that we have with commercialization or other partners;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">changes to labels, indications or other regulatory requirements as they relate to the commercialization of our products;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">inability to establish collaborations with third-party development or commercialization partners on acceptable terms, or at all, and our inability or unwillingness for cost or other reasons to commercialize the therapeutic candidates or any product we may promote or commercialize on our own; and</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">timing of market introduction of competitive products.</TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Physicians, various other health care providers, patients,
payors or the medical community in general may be unwilling to accept, utilize or recommend any of our approved therapeutic candidates
and any product we may promote or commercialize. If we are unable, either on our own or through third parties, to manufacture,
commercialize or market our proposed formulations, therapeutic candidates or any product we may promote or commercialize when planned,
or to develop them commercially, we may not achieve any market acceptance or generate meaningful revenue.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>Unexpected product safety or efficacy concerns may arise and
cause any product we may promote or commercialize to fail to gain or lose market acceptance.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Unexpected safety or efficacy concerns can arise with respect to
any product we may promote or commercialize, whether or not scientifically justified, potentially resulting in product recalls,
withdrawals and/or declining sales, as well as product liability, consumer fraud and/or other claims. The market perception and
reputation of any product we may promote or commercialize and their safety and efficacy are important to our business and the continued
acceptance of any product we may promote or commercialize Any negative publicity about any of our products, such as the pricing
of any product we may promote or commercialize , discovery of safety issues with any product we may promote or commercialize ,
adverse events involving any product we may promote or commercialize, or even public rumors about such events, could have a material
adverse effect on our business, financial condition and results of operation. In addition, the discovery of one or more significant
problems with a product similar to one of any product we may promote or commercialize that implicate (or are perceived to implicate)
an entire class of products or the withdrawal or recall of such similar products could have an adverse effect on the commercialization
of any product we may promote or commercialize. New data about any product we may promote or commercialize, or products similar
to any product we may promote or commercialize, could cause us reputational harm and could negatively impact demand for any product
we may promote or commercialize due to real or perceived side effects or uncertainty regarding safety or efficacy and, in some
cases, could result in product withdrawal. Any of the foregoing could have a material adverse effect on our business, financial
condition and results of operations.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>The market for our therapeutic candidates and for
any product we may promote&nbsp;or commercialize is rapidly changing and competitive, and new drug delivery mechanisms, drug delivery
technologies, new drugs, treatments and products which may be developed by others could impair our ability to maintain and grow
our business and remain competitive.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">The pharmaceutical and biotechnology industry is highly
competitive, and we face significant competition from many pharmaceutical, biopharmaceutical and biotechnology companies that are
researching, developing and marketing products designed to address the indications for which we are currently developing therapeutic
candidates or may develop therapeutic candidates in the future or for which we may promote or commercialize products. There are
various other companies that currently market, are in the process of developing or may develop in the future products that address
all of the indications or diseases treated by our therapeutic candidates or products that we may promote or commercialize.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">New drug delivery mechanisms, drug delivery technologies,
new drugs and new treatments that have been developed or that are in the process of being developed or will be developed by others
may render our therapeutic candidates and products we may promote or commercialize noncompetitive or obsolete, or we may be unable
to keep pace with technological developments or other market factors. Some of these technologies may have an entirely different
approach or means of accomplishing similar therapeutic effects compared to our therapeutic candidates and products we may promote
or commercialize. In addition, Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole
Strontium Delayed-Release Capsules 49.3mg and products we may promote or commercialize may compete with products for market share,
and generic drugs or products that treat the same indications as Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg or products we may promote or commercialize can have an adverse effect
on our revenues by reducing our market share or requiring us to reduce the price of the products we market. &nbsp;In the case of
Donnatal, we are aware of at least two products that are, to our understanding, illegal copies that currently are being sold in
the U.S. The FDA has not taken action against these products and this has had a negative effect on our commercial success.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Technological competition from, and commercial capabilities
of, pharmaceutical and biotechnology companies, universities, governmental entities and others is intense and is expected to increase.
Many of these entities have significantly greater research and development capabilities, human resources and budgets than we do,
as well as substantially more marketing, manufacturing, financial and managerial resources. These entities represent significant
competition for us. Acquisitions of, or investments in, competing pharmaceutical or biotechnology companies by large corporations
could increase such competitors&rsquo; financial, marketing, manufacturing and other resources.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">The potential widespread acceptance of therapies that
are alternatives to ours may limit market acceptance of our formulations, therapeutic candidates or products we may promote or
commercialize, even if commercialized. Many of our targeted diseases and conditions can also be treated by other medications or
drug delivery technologies. These treatments may be widely accepted in medical communities and have a longer history of use, among
other possible advantages. The established use of these competitive drugs may limit the potential for our therapeutic candidates
to receive widespread acceptance if commercialized and may limit the potential for widespread acceptance of promoting Donnatal<B><I><SUP>&reg;</SUP></I></B>,
EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg and for products we may promote
or commercialize.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We could be adversely affected if healthcare reform
measures substantially change the market for medical care or healthcare coverage in the U.S.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">On March 23, 2010, President Obama signed the Patient
Protection and Affordable Care Act (P.L. 111-148) and on March 30, 2010, the President signed the Health Care and
Education Reconciliation Act (P.L. 111-152), collectively commonly referred to as the &ldquo;Healthcare Reform Law.&rdquo;
The Healthcare Reform Law included a number of new rules regarding health insurance, the provision of healthcare, and conditions
to reimbursement for healthcare services provided to Medicare and Medicaid patients. Through the law making process, substantial
changes have been and continue to be made to the current system for paying for healthcare in the U.S., including changes made in
order to extend medical benefits to tens of millions of Americans who lacked insurance coverage and to contain healthcare costs.
Extending coverage to a large population could substantially change the structure of the health insurance system and the methodology
for reimbursing medical services and drugs. This legislation is one of the most comprehensive and significant reforms ever experienced
by the U.S. in the healthcare industry and has significantly changed the way healthcare is financed by both governmental and private
insurers. This legislation has impacted the scope of healthcare insurance and incentives for consumers and insurance companies,
among others.&nbsp;Additionally, the Healthcare Reform Law&rsquo;s provisions are designed to encourage providers to find cost
savings in their clinical operations. Pharmaceuticals represent a significant portion of the cost of providing care. Through modified
reimbursement rates and other incentives, the U.S. government is requiring that providers identify the most cost-effective services,
supplies and pharmaceuticals. This environment has caused changes in the purchasing habits of consumers and providers and resulted
in specific attention to the pricing negotiation, product selection and utilization review surrounding pharmaceuticals. This attention
may result in our therapeutic candidates and products we may promote or commercialize being chosen less frequently or the pricing
being substantially lowered.&nbsp;&nbsp;Some of the provisions of the Healthcare Reform Law have not yet been fully implemented
and regulatory guidance continues to be issued.&nbsp;&nbsp;At this stage, it is difficult to estimate the full extent of the direct
or indirect impact of the Healthcare Reform Law on us.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">These structural changes could entail further modifications
to the existing system of private payors and government programs (such as Medicare, Medicaid and the State Children&rsquo;s Health
Insurance Program), creation of government-sponsored healthcare insurance sources, or some combination of both, as well as other
changes. Restructuring the coverage of medical care in the U.S. could impact the reimbursement for prescribed drugs and pharmaceuticals,
such as those we and our development or commercialization partners are currently developing or those that we may promote or commercialize.
If reimbursement for approved therapeutic candidates or any product we may promote or commercialize, if any, is substantially
reduced or otherwise adversely affected in the future, or rebate obligations associated with them are substantially increased,
it could have a material adverse effect on our business, financial condition and results of operations.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Extending medical benefits to those who currently lack
coverage will likely result in substantial cost to the U.S. federal government, which may force significant additional changes
to the healthcare system in the U.S. Much of the funding for expanded healthcare coverage may be sought through cost savings. While
some of these savings may come from realizing greater efficiencies in delivering care, improving the effectiveness of preventive
care and enhancing the overall quality of care, much of the cost savings may come from reducing the cost of care and increased
enforcement activities. Cost of care could be reduced by decreasing the level of reimbursement for medical services or products
(including those therapeutic candidates currently being developed by us or our development or commercialization partners or any
product we may promote or commercialize, including Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg), or by restricting coverage (and, thereby, utilization) of medical
services or products. In either case, a reduction in the utilization of, or reimbursement for, any therapeutic candidate or any
product we may promote or commercialize, including Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, or for which we receive marketing approval in the future, could have
a material adverse effect on our business, financial condition and results of operations.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Several states and private entities initially mounted
legal challenges to the Healthcare Reform Law, and they continue to litigate various aspects of the legislation. On July 26, 2012,
the U.S. Supreme Court generally upheld the provisions of the Healthcare Reform Law at issue as constitutional. However, the U.S.
Supreme Court held that the legislation improperly required the states to expand their Medicaid programs to cover more individuals.
As a result, the states have a choice as to whether they will expand the number of individuals covered by their respective state
Medicaid programs. Some states have determined that they will not expand their Medicaid programs and will develop other cost-saving
and coverage measures to provide care to currently uninsured individuals. Many of these efforts to date have included the institution
of Medicaid-managed care programs. The manner in which these cost-saving and coverage measures are implemented could have a material
adverse effect on our business, financial condition and results of operations. Further, the healthcare regulatory environment has
seen significant changes in recent years and is still in flux.&nbsp;&nbsp;Legislative initiatives to modify, limit, replace, or
repeal the Healthcare Reform Law and judicial challenges continue, and may increase in light of the current administration and
legislative environment.&nbsp;&nbsp;We cannot predict the impact on our business of future legislative and legal challenges to
the Healthcare Reform Law or other changes to the current laws and regulations.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>If third-party payors do not adequately reimburse
customers for any of our therapeutic candidates that are approved or cleared for marketing or for products that we may promote
or commercialize, including Donnatal<SUP>&reg;</SUP>, EnteraGam<SUP>&reg;</SUP> and Esomeprazole Strontium Delayed-Release Capsules
49.3mg, they might not be purchased or used, and our revenues and profits will not increase and they may decrease.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Our revenues and profits will depend heavily upon the
availability of adequate reimbursement for the use of our approved or cleared therapeutic candidates, if any, and any products
that we may promote or commercialize, from governmental or other third-party payors, both in the U.S. and in foreign markets. Reimbursement
by a third-party payor may depend upon a number of factors, including but not limited to the third-party payor&rsquo;s determination
that the use of an approved or cleared therapeutic candidate and product is, among others:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="text-align: center; width: 4%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; width: 96%">a covered benefit under its health plan;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle">safe, effective and medically necessary;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle">appropriate for the specific patient;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle">cost-effective; and</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle">neither experimental nor investigational.</TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Obtaining reimbursement approval for a therapeutic candidate
or for any product that we may promote or commercialize from any government or other third-party payor is a time-consuming and
costly process that could require us or our development or commercialization partners to provide supporting scientific, clinical
and cost-effectiveness data for the use of our therapeutic candidates or any product that we may promote or commercialize to each
payor. Even when a payor determines that a therapeutic candidate or any product that we may promote or commercialize is eligible
for reimbursement, the payor may impose coverage limitations that preclude payment for some uses that are approved by the FDA or
other foreign regulatory authorities. Reimbursement rates may vary according to the use of the therapeutic candidate or the use
of any product that we may promote or commercialize and the clinical setting in which it used, may be based on payments allowed
for lower-cost products that are already reimbursed, may be incorporated into existing payments for products or services, and may
reflect budgetary constraints or imperfections in Medicare, Medicaid or other data used to calculate these rates. In particular,
reimbursement for our products may not be available from Medicare and Medicaid, and reimbursement from other third-party payors
may be limited. For example, reimbursement both from government and private payors for Donnatal<B><I><SUP>&reg;</SUP></I></B> &nbsp;
may be limited or non-existent due to its status as a DESI product. &nbsp;Also, successful commercialization of Esomeprazole Strontium
Delayed-Release Capsules 49.3mg requires a conducive reimbursement environment. If this product does not receive adequate reimbursement
coverage, or if reimbursement coverage is reduced or otherwise adversely affected, then its commercial prospects could be severely
limited. In addition, because EnteraGam is a &ldquo;medical food&rdquo; it is subject to unique FDA regulations and requirements
that could limit its market potential, and our ability to get reimbursement coverage could be limited because of this product.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In the U.S., there have been, and we expect that there
will continue to be, federal and state proposals to constrain expenditures for medical products and services, which may affect
payments for our therapeutic candidates or for any product that we may promote or commercialize in the U.S. In addition, there
is a growing emphasis on comparative effectiveness research, both by private payors and by government agencies. To the extent other
drugs or therapies are found to be more effective than our products, payors may elect to cover such therapies in lieu of our products
or reimburse our products at a lower rate.&nbsp;&nbsp;Legislation that reduces reimbursement for our therapeutic candidates could
adversely impact how much or under what circumstances healthcare providers will prescribe or administer our therapeutic candidates,
if approved, or for any product that we may promote or commercialize. This could materially and adversely impact our business,
financial condition and results of operations by reducing our ability to generate meaningful revenue, raise capital, obtain additional
collaborators and market. At this stage, we are unable to estimate the extent of the direct or indirect impact of any such federal
and state proposals.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Furthermore, the Centers for Medicare and Medicaid Services
frequently change product descriptors, coverage policies, product and service codes, payment methodologies and reimbursement values.
Third-party payors often follow Medicare coverage policy and payment limitations in setting their own reimbursement rates, and
both the Centers for Medicare and Medicaid Services and other third-party payors may have sufficient market power to demand significant
price reductions. Price reductions or other significant coverage policies or payment limitations could materially and adversely
affect our business, financial condition and results of operations.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"><B><I>We are subject to additional U.S. federal and state laws and regulations
relating to our business, and our failure to comply with those laws could have a material adverse effect on our business, financial
condition and results of operations.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0; background-color: white">We are subject to additional healthcare regulation
and enforcement by the U.S. federal government and the states in which we conduct or will conduct our business. The laws that may
affect our ability to operate include, but are not limited to, the following:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0; background-color: white"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="text-align: center; width: 4%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify; width: 96%">the federal Anti-Kickback Statute, which prohibits, among other things, persons from knowingly and willfully soliciting, receiving, offering or paying remuneration, directly or indirectly, in exchange for or to induce either the referral of an individual for, or the purchase, order or recommendation of, any good or service for which payment may be made under government healthcare programs such as the Medicare and Medicaid programs;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the federal Anti-Inducement Law (also known as the Civil Monetary Penalties Law), which prohibits a person from offering or transferring remuneration to a Medicare or State healthcare program beneficiary that the person knows or should know is likely to influence the beneficiary&rsquo;s selection of a particular provider, practitioner or supplier of any item or service for which payment may be made, in whole or in part, by Medicare or a State healthcare program;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the Ethics in Patient Referrals Act of 1989, commonly referred to as the Stark Law, which prohibits physicians from referring Medicare or Medicaid patients for certain designated health services where that physician or family member has a financial relationship with the entity providing the designated health service, unless an exception applies;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">federal false claims laws that prohibit, among other things, individuals or entities from knowingly presenting, or causing to be presented, claims for payment from Medicare, Medicaid or other government healthcare programs that are false or fraudulent;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the so-called federal &ldquo;Sunshine Act&rdquo;, which requires pharmaceutical and medical device companies to monitor and report certain financial relationships with physicians and other healthcare providers to the Centers for Medicare and Medicaid Services for disclosure to the public;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the federal Food, Drug, and Cosmetic Act, which among other things, strictly regulates drug product and medical device marketing, prohibits manufacturers from marketing such products for off-label use and regulates the distribution of samples;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">federal criminal laws that prohibit executing a scheme to defraud any healthcare benefit program or making false statements relating to healthcare matters; and</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">state law equivalents of each of the above federal laws, such as anti-kickback and false claims laws which may apply to items or services reimbursed by any third-party payor, including commercial insurers.</TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0; background-color: white"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0; background-color: white"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Further, the Healthcare Reform Law, among other things, amends the
intent requirement of the federal anti-kickback and criminal healthcare fraud statutes. A person or entity can now be found guilty
of fraud or an anti-kickback violation without actual knowledge of the statute or specific intent to violate it. In addition, the
Healthcare Reform Law provides that the government may assert that a claim including items or services resulting from a violation
of the federal Anti-Kickback Statue constitutes a false or fraudulent claim for purposes of the False Claims Act.</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">Possible sanctions for violation
of these anti-kickback laws include monetary fines, civil and criminal penalties, exclusion from Medicare, Medicaid and other government
programs and forfeiture of amounts collected in violation of such prohibitions. Any violations of these laws, or any action against
us for violation of these laws, even if we successfully defend against it, could result in a material adverse effect on our reputation,
business, financial condition and results of operations.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">The Healthcare Reform Law also
imposes reporting requirements on certain medical device and pharmaceutical manufacturers, among others, to make annual public
disclosures of certain payments and other transfers of value to physicians and teaching hospitals and ownership or investment interests
held by physicians or their immediate family members. Failure to submit required information may result in civil monetary penalties
of up to an aggregate of $150,000 per year (or up to an aggregate of $1 million per year for &ldquo;knowing failures&rdquo;), for
all payments, transfers of value or ownership or investment interests that are not reported. Manufacturers were required to begin
data collection on August 1, 2013 and report such data to the Centers for Medicare and Medicaid Services by March 31<SUP>st</SUP>
of each year.&nbsp;&nbsp;The Centers for Medicare and Medicaid Services made the data publicly available on its searchable database
beginning in September 2014.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">In addition, there has been a
recent trend of increased federal and state regulation of payments made to physicians for marketing, medical directorships, and
other purposes. Some states, such as California, Massachusetts and Vermont, mandate implementation of corporate compliance programs,
along with the tracking and reporting of gifts, compensation and other remuneration to physicians, and some states limit or prohibit
such gifts.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">Most recently, there has been
a trend in federal and state legislation aimed at requiring pharmaceutical companies to disclose information about their production
and marketing costs, and ultimately lowering costs for drug products. Several states have introduced bills that would require disclosure
of certain pricing information for prescription drugs that have no threshold amount or are above a certain annual wholesale acquisition
cost, and in June 2016 Vermont became the first state to pass legislation requiring certain drug companies to disclose information
relating to justification of certain price increases. The U.S. Congress has also introduced bills targeting prescription drug price
transparency.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">Any such implementation of legislation
requiring publication of drug costs could materially and adversely impact our business, financial condition and results of operations
by promoting a reduction in drug prices. As such, patients may choose to use other low-cost, established drugs or therapies.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">The scope and enforcement of
these laws are uncertain and subject to change in the current environment of healthcare reform, especially in light of the lack
of applicable precedent and regulations. We cannot predict the impact on our business, financial condition nor results of operations
of any changes in these laws. Federal or state regulatory authorities may challenge our current or future activities under these
laws. Any such challenge could have a material adverse effect on our reputation, business, financial condition and results of operations.
Any state or federal regulatory review of us, regardless of the outcome, would be costly and time-consuming.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B><I>Our marketing, promotional and business practices, including with respect to pricing,
as well as the manner in which sales forces interact with purchasers, prescribers and patients, are subject to extensive regulation
and any material failure to comply could result in significant sanctions against us.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><B><I>&nbsp;</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">The marketing, promotional and business practices, including with respect to pricing,
of pharmaceutical companies, as well as the manner in which companies&rsquo; in-house or third party sales forces interact with
purchasers, prescribers, and patients, are subject to extensive regulation, enforcement of which may result in the imposition of
civil and/or criminal penalties, injunctions, and/or limitations on marketing practices for some of our products and/or pricing
restrictions or mandated price reductions for some of our products. Many companies have been the subject of claims related to these
practices asserted by state or federal authorities. These claims have resulted in fines and other consequences, such as entering
into corporate integrity agreements with the U.S. government. Companies may not promote drugs for &ldquo;off-label&rdquo; uses-that
is, uses that are not described in the product&rsquo;s labeling and that differ from those approved by the FDA or other applicable
regulatory agencies. A company that is found to have improperly promoted off-label uses may be subject to significant liability,
including civil and administrative remedies, as well as criminal sanctions. In addition, management&rsquo;s attention could be
diverted from our business operations and our reputation could be damaged.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white"><B><I>We must comply with the
U.S. Foreign Corrupt Practices Act.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white">The U.S. Foreign Corrupt Practices
Act (the &ldquo;FCPA&rdquo;) applies to companies, such as us, with a class of securities registered under the Securities Exchange
Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;). The FCPA to which various of our operations may be subject generally
prohibits companies and their intermediaries from engaging in bribery or making other improper payments to officials for the purpose
of obtaining or retaining business. In various jurisdictions, our operations require that we and third parties acting on our behalf
routinely interact with government officials, including medical personnel who may be considered government officials for purposes
of these laws because they are employees of state-owned or controlled facilities. Our policies mandate compliance with these anti-bribery
laws, however, we operate in many parts of the world that have experienced governmental and/or private corruption to some degree.
As a result, the existence and implementation of a robust anti-corruption program cannot eliminate all risk that unauthorized reckless
or criminal acts have been or will be committed by our employees or agents. If our employees or other agents are found to have
engaged in such practices, we could suffer severe penalties. Violations of the FCPA, or allegations of such violations, could disrupt
our business and result in a material adverse effect on our financial condition, results of operations and cash flows.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; background-color: white"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><B><I>We could be exposed to significant drug product liability claims which could be
time consuming and costly to defend, divert management attention and adversely impact our ability to obtain and maintain insurance
coverage.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">The clinical trials that we conduct, and the testing,
manufacturing, marketing and commercial sale and use or misuse of our therapeutic candidates and any products we may promote or
commercialize, involve and will involve an inherent risk that significant liability claims may be asserted against us or our development
or commercial partners. Product liability claims or other claims related to our therapeutic candidates and any products we may
promote or commercialize, regardless of merit or their outcome, could require us to spend significant time and money in litigation
or to pay significant settlement amounts or judgments. A product liability claim could also significantly harm our reputation and
the market price of our shares and delay market acceptance of our therapeutic candidates and decrease demand for any products that
we promote or commercialize, including Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole
Strontium Delayed-Release Capsules 49.3mg. In addition, regardless of merit or eventual outcome, product liability claims may result
in:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: middle">
    <TD STYLE="width: 4%; text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="width: 96%">decreased demand for approved products;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="vertical-align: middle">
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD>impairment of our business reputation;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="vertical-align: middle">
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD>withdrawal of clinical trial participants;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="vertical-align: middle">
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD>initiation of investigations by regulators;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="vertical-align: middle">
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD>litigation costs;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="vertical-align: middle">
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD>distraction of management&rsquo;s attention from our primary business;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="vertical-align: middle">
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD>substantial monetary awards to patients or other claimants;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="vertical-align: middle">
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD>loss of revenues; and</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="vertical-align: middle">
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD>the inability to commercialize our product candidates.</TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We currently have a product liability policy that includes
coverage for our clinical trials and our commercial operations However, our insurance may prove inadequate to cover claims or litigation
costs, especially in the case of wrongful death claims. Any successful product liability or other claim may prevent us from obtaining
adequate liability insurance in the future on commercially desirable or reasonable terms. An inability to obtain sufficient insurance
coverage at an acceptable cost or otherwise to protect against potential product liability claims could prevent or inhibit the
commercialization of our therapeutic candidates or products we may promote or commercialize.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>If serious adverse events or other undesirable side
effects are identified during the use of our investigational new drugs that have not yet received regulatory marketing approval
under the Expanded Access Program (EAP), it may adversely affect our development of such therapeutic candidates.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Patients who receive access to investigational new drugs that have
not yet received regulatory marketing approval through expanded access programs may be suffering from life-threatening illnesses
and poor prognosis and may have exhausted all other available therapies. The risk for serious adverse events in this patient population
is high, which could have a negative impact on the prospects of our therapeutic candidates that are provided under EAP.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Serious adverse events or other undesirable side effects
in connection with the use of our therapeutic candidates provided under EAP could cause significant delays or an inability to successfully
develop or commercialize such therapeutic candidates, which would materially harm our business. In particular, any such serious
adverse events or other undesirable side effects could cause us or regulatory authorities to interrupt, delay or halt non-clinical
studies and clinical trials, or could make it more difficult for us to enroll patients in our clinical trials. If serious adverse
events or other undesirable side effects, or unexpected characteristics of our investigational new drugs that have not yet received
regulatory marketing approval are observed in patients who was granted expanded access to our investigational new drugs under the
EAP, further clinical development of such product candidate may be delayed or we may not be able to continue development of such
product candidates at all, and the occurrence of these events could have a material adverse effect on our business. Undesirable
side effects caused by our therapeutic candidates could also result in the delay or denial of regulatory approval by the FDA or
other regulatory authorities or in a more restrictive label than we expect.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Global economic conditions may make it more difficult
for us to commercialize our therapeutic candidates and any products that we may promote or commercialize.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">The pharmaceutical industry, like other industries and
businesses, continues to face the effects of the challenging economic environment. Patients experiencing the effects of the challenging
economic environment, including high unemployment levels and increases in co-pays, may switch to generic products, delay treatments,
skip doses or use other less effective treatments to reduce their costs. Challenging economic conditions in the U.S. include the
demands by payors for substantial rebates and formulary restrictions limiting access to brand-name drugs. In addition, in Europe
and in a number of emerging markets there are government-mandated reductions in prices for certain pharmaceutical products, as
well as government-imposed access restrictions in certain countries. All of the aforesaid may make it more difficult for us to
commercialize our therapeutic candidates and any products that we may promote or commercialize including Donnatal<B><I><SUP>&reg;</SUP></I></B>,
EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Our business involves risks related to handling
regulated substances which could severely affect our ability to conduct research and development of our therapeutic candidates.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In connection with our or our development or commercialization
partners&rsquo; research and clinical development activities, as well as the manufacture of materials and therapeutic candidates
and any products that we may promote or commercialize, we and our development or commercialization partners are subject to federal,
state and local laws, rules, regulations and policies governing the use, generation, manufacture, storage, air emission, effluent
discharge, handling and disposal of certain materials, biological specimens and waste. We and our development or commercialization
partners may be required to incur significant costs to comply with environmental and health and safety regulations in the future.
Our research and clinical development, as well as the activities of our manufacturing and commercialization partners, both now
and in the future, may involve the controlled use of hazardous materials, including but not limited to certain hazardous chemicals.
We cannot completely eliminate the risk of accidental contamination or injury from these materials. In the event of such an occurrence,
we could be held liable for any damages that result and any such liability could exceed our resources.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Security breaches and other disruptions could compromise
our information and expose us to liability, which would cause our business and reputation to suffer.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In the ordinary course of our business, we may collect
and store sensitive data, including intellectual property, our proprietary business information and that of our suppliers and business
partners, as well as personally identifiable information of patients, clinical trial participants and employees. We also have outsourced
elements of our information technology structure, and as a result, we are managing independent vendor relationships with third
parties who may or could have access to our confidential information. Similarly, our business partners and other third party providers
possess certain of our sensitive data. The secure maintenance of this information is critical to our operations and business strategy.
Despite our security measures, our information technology and infrastructure may be vulnerable to attacks by hackers or breached
due to employee, vendor, or business partner error, malfeasance or other disruptions. We, our partners, vendors and other third
party providers could be susceptible to attacks on our, and their, information security systems, which attacks are of ever-increasing
levels of sophistication and are made by groups and individuals with a wide range of motives and expertise, including criminal
groups. Any such breach could compromise our, and their, networks and the information stored there could be accessed, publicly
disclosed, lost or stolen. Any such access, disclosure or other loss of information could result in legal claims or proceedings,
liability under laws that protect the privacy of personal information, disrupt our operations, and damage our reputation, any of
which could adversely affect our business.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B>Risks Related to Intellectual Property</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We may be unable to adequately protect or enforce
our rights to intellectual property, causing us to lose valuable rights. Loss of patent rights may lead us to lose market share
and anticipated profits.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Our success depends, in part, on our ability, and the
ability of our development or commercialization partners to obtain patent protection for our therapeutic candidates and any products
that we may promote or commercialize, maintain the confidentiality of our trade secrets and know-how, operate without infringing
or violating on the proprietary rights of others and prevent others from infringing or violating on our proprietary rights.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We try to protect our proprietary position by, among other
things, filing U.S., European, and other patent applications related to our therapeutic candidates, inventions and improvements
that may be important to the continuing development of our therapeutic candidates, and we plan to try to do the same with products
we may acquire, promote or commercialize in the future, where this is possible.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Because the patent position of pharmaceutical companies
involves complex legal and factual questions, we cannot predict the scope, validity or enforceability of patents with certainty.
Our issued patents and the issued patents of our development or commercialization partners may not provide us with any competitive
advantages, may be held invalid or unenforceable as a result of legal challenges by third parties or could be circumvented. Ownership
of the patent rights we in-license from our development or commercialization partners or the patent rights to the products already
approved for marketing that we acquire or for which we acquire commercialization rights may be challenged, and as a result, the
rights we in-license and the rights to products we acquire may turn out not to be exclusive or we may not actually have rights
under the patents despite receiving representations from a development or commercialization partner. Our competitors may also independently
develop drug delivery technologies or products similar to ours or design around or otherwise circumvent patents issued to, or licensed
by, us. Thus, any patents that we own or license from others may not provide any protection against competitors. Our pending patent
applications, those we may file in the future or those we may license from third parties may not result in patents being issued.
If these patents are issued, they may not provide us with proprietary protection or competitive advantages. The degree of future
protection to be afforded by our proprietary rights is uncertain because legal means afford only limited protection and may not
adequately protect our rights or permit us to gain or keep our competitive advantage.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Patent rights are territorial; thus, the patent protection
we do have will only extend to those countries in which we have issued patents. Even so, the laws of certain countries do not protect
our intellectual property rights to the same extent as do the laws of the U.S. and the European Union. Competitors may successfully
challenge our patents, produce similar drugs or products that do not infringe our patents, or produce drugs in countries where
we have not applied for patent protection or that do not respect our patents. Furthermore, it is not possible to know the scope
of claims that will be allowed in published applications and it is also not possible to know which claims of granted patents, if
any, will be deemed enforceable in a court of law.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">After the completion of development and registration of
our patents, third parties may still manufacture or market products in infringement of our patent-protected rights. Such manufacture
or market of products in infringement of our patent-protected rights is likely to cause us damage and lead to a reduction in the
prices of our therapeutic candidates or any product we may promote or commercialize, including Donnatal<B><I><SUP>&reg;</SUP></I></B>,
EnteraGam<B><I><SUP>&reg;</SUP></I></B> and Esomeprazole Strontium Delayed-Release Capsules 49.3mg, thereby reducing our potential
profits.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition, due to the extensive time needed to develop,
test and obtain regulatory approval for our therapeutic candidates or any product we may promote or commercialize, any patents
that protect our therapeutic candidate or any product we may promote or commercialize&nbsp;may expire early during commercialization.
This may reduce or eliminate any market advantages that such patents may give us. Following patent expiration, we may face increased
competition through the entry of generic products into the market and a subsequent decline in market share and profits.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition, in some cases we may rely on our licensors
to conduct patent prosecution, patent maintenance or patent defense on our behalf. Therefore, our ability to ensure that these
patents are properly prosecuted, maintained, or defended may be limited, which may adversely affect our rights in our therapeutic
candidates and potential approval for marketing products. Any failure by our licensors or development or commercialization partners
to properly conduct patent prosecution, patent maintenance, patent enforcement, or patent defense could materially harm our ability
to obtain suitable patent protection covering our therapeutic candidates or products or ensure freedom to commercialize the products
in view of third-party patent rights, thereby materially reducing our potential profits.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We are reliant on our licensing partner, Valeant (which acquired
Salix Pharmaceuticals, Ltd.) to prosecute, maintain and defend the patents and other intellectual property rights of RHB-106 which
we have licensed to Valeant. If Valeant does not prosecute, maintain and defend the patents and other intellectual property rights
of RHB-106, it could materially harm our ability to obtain suitable patent protection covering RHB-106 or ensure freedom to commercialize
RHB-106 in view of third-party patent rights, thereby materially reducing our potential profits from RHB-106. Our out-license agreement
with Valeant is currently subject to discussion with Valeant, including renegotiation of its terms.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition, Donnatal<B><I><SUP>&reg;</SUP></I></B>, for
which we were granted certain rights to promote Donnatal<B><I><SUP>&reg;</SUP></I></B> in the U.S., and EnteraGam<B><I><SUP>&reg;</SUP></I></B>,
for which we were granted the exclusive U.S rights to EnteraGam&reg; for all indications for human use, are not protected by patents.&nbsp;&nbsp;
Our third GI-specialty product, Esomeprazole Strontium Delayed-Release Capsules 49.3mg, includes the active ingredient esomeprazole
strontium, which is protected by a process patent covering methods of preparing esomeprazole salts. If the FDA proceedings related
to Donnatal<B><I><SUP>&reg;</SUP></I></B> designed to determine its effectiveness will be ongoing, only products that receive a
New Drug Application (&ldquo;NDA&rdquo;) from the FDA, DESI products and those actively participating in the hearing process of
the FDA may be marketed. However,&nbsp;other competing products may freely enter the market, and we and our partners may not have
sufficient intellectual property rights in Donnatal<B><I><SUP>&reg;</SUP></I></B> to protect it from such competition.&nbsp;&nbsp;See
&ldquo;&ndash; Risks Related to Our Business and Regulatory Matters &ndash; Donnatal<B><I><SUP>&reg;</SUP></I></B>, EnteraGam<B><I><SUP>&reg;</SUP></I></B>
and Esomeprazole Strontium Delayed-Release Capsules 49.3mg or products which we may promote, sell or market may be withdrawn from
the market at any time due to product withdrawal requests by the FDA or other foreign regulatory authorities.&rdquo;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>If we are unable to protect the confidentiality
of our trade secrets or know-how, such proprietary information may be used by others to compete against us.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition to filing patents, we generally try to protect
our trade secrets, know-how and technology by entering into confidentiality or non-disclosure agreements with parties that have
access to them, such as our development or commercialization partners, employees, contractors and consultants. We also enter into
agreements that purport to require the disclosure and assignment to us of the rights to the ideas, developments, discoveries and
inventions of our employees, advisors, research collaborators, contractors and consultants while we employ or engage them. However,
these agreements can be difficult and costly to enforce or may not provide adequate remedies. Any of these parties may breach the
confidentiality agreements and willfully or unintentionally disclose our confidential information, or our competitors might learn
of the information in some other way. The disclosure to, or independent development by, a competitor of any trade secret, know-how
or other technology not protected by a patent could materially adversely affect any competitive advantage we may have over any
such competitor.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">To the extent that any of our employees, advisors, research
collaborators, contractors or consultants independently develop, or use independently developed, intellectual property in connection
with any of our projects, disputes may arise as to the proprietary rights to this type of information. If a dispute arises with
respect to any proprietary right, enforcement of our rights can be costly and unpredictable and a court may determine that the
right belongs to a third party.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0; text-indent: 351.35pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Legal proceedings or third-party claims of intellectual
property infringement and other challenges may require us to spend substantial time and money and could prevent us from developing
or commercializing our therapeutic candidates and any products we may promote or commercialize.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The development, manufacture, use, offer for sale, sale or
importation of our therapeutic candidates or any products that we may promote or commercialize may infringe on the claims of
third-party patents or other intellectual property rights. The nature of claims contained in unpublished patent filings
around the world is unknown to us and it is not possible to know which countries patent holders may choose for an extension
of their filings under the Patent Cooperation Treaty or other mechanisms. We may also be subject to claims based on the
actions of employees and consultants with respect to the usage or disclosure of intellectual property learned at other
employers. The cost to us of any intellectual property litigation or other infringement proceeding, even if resolved in our
favor, could be substantial. Some of our competitors may be able to sustain the costs of such litigation or proceedings more
effectively because of their substantially greater financial resources. Uncertainties resulting from the initiation and
continuation or defense of intellectual property litigation or other proceedings could have a material adverse effect on our
ability to compete in the marketplace. Intellectual property litigation and other proceedings may also absorb significant
management time. Consequently, we are unable to guarantee that we will be able to manufacture, use, offer for sale, sell or
import our therapeutic candidates or any products we may promote or commercialize in the event of an infringement action.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In the event of patent infringement claims, or to avoid
potential claims, we may choose or be required to seek a license from a third party and would most likely be required to pay license
fees or royalties or both. These licenses may not be available on acceptable terms, or at all. Even if we were able to obtain a
license, the rights may be non-exclusive, which could potentially limit our competitive advantage. Ultimately, we could be prevented
from commercializing a therapeutic candidate and any products that we may promote or commercialize or be forced to cease some aspect
of our business operations if, as a result of actual or threatened patent infringement or other claims, we are unable to enter
into licenses on acceptable terms. This inability to enter into licenses or the ability to exclude others using proprietary rights,
could have a material adverse effect on our business, financial condition and results of operations.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We may be subject to other patent-related litigation
or proceedings that could be costly to defend and uncertain in their outcome.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition to infringement claims against us, we may
become a party to other patent litigation or proceedings before regulatory agencies, including post-grant review, inter parties
review, interference or re-examination proceedings filed with the U.S. Patent and Trademark Office or opposition proceedings in
other foreign patent offices regarding intellectual property rights with respect to our therapeutic candidates or any products
that we may promote or commercialize, as well as other disputes regarding intellectual property rights with development or commercialization
partners, or others with whom we have contractual or other business relationships. Post-issuance proceedings challenging patent
claims validity are not uncommon, and we and/or our development or commercialization partners will be required to defend these
procedures as a matter of course. Such procedures may be costly, and there is a risk that we may not prevail which could harm our
business significantly.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B>Risks Related to our Ordinary Shares and ADSs</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We may be a &ldquo;passive foreign investment company&rdquo;
for U.S. federal income tax purposes, which could result in adverse U.S. federal income tax consequences to U.S. investors.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">While the determination of passive foreign investment
company, or PFIC, status is fact-specific and generally cannot be made until the close of the taxable year in question, based on
the value and composition of our assets, we may be a PFIC for U.S. federal income tax purposes for our current taxable year and
future taxable years. A non-U.S. corporation will be considered a PFIC for any taxable year if either (1) at least 75% of its gross
income for such year is passive income or (2) at least 50% of the value of its assets (based on an average of the quarterly values
of the assets during such year) is attributable to assets that produce or are held for the production of passive income. Because
the value of our assets for purposes of this determination will generally be determined by reference to the market price of the
ADSs, our PFIC status will depend in large part on the market price of the ADSs. A separate determination must be made each taxable
year as to whether we are a PFIC (after the close of each such taxable year). If we are a PFIC for any taxable year during which
a U.S. Holder (as defined in &ldquo;Material Tax Consideration &ndash; U.S. Federal Income Tax Considerations&rdquo;) holds Ordinary
Shares or ADSs, the U.S. Holder may be subject to adverse tax consequences, including (i) the treatment of all or a portion of
any gain on disposition as ordinary income, (ii) the application of an interest charge with respect to such gain and certain dividends
and (iii) compliance with certain reporting requirements. Each U.S. Holder is strongly urged to consult its own tax advisor regarding
these issues. See &ldquo;Material Tax Consideration &ndash; U.S. Federal Income Tax Considerations.&rdquo;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>The market price of our Ordinary Shares and our
ADSs are subject to fluctuation, which could result in substantial losses by our investors.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">The stock market in general and the market price of our
Ordinary Shares on the TASE and our ADSs on the NASDAQ Capital Market in particular, are subject to fluctuation, and changes in
the price of our securities may be unrelated to our operating performance. The market price of our Ordinary Shares on the TASE
and the market price of our ADSs on the NASDAQ Capital Market have fluctuated in the past, and we expect they will continue to
do so. The market price of our Ordinary Shares and ADSs are and will be subject to a number of factors, including&nbsp;but not
limited to:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="text-align: center; width: 4%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify; width: 96%">announcements of technological innovations or new therapeutic candidates or new products approved for marketing by us or others;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">announcements by us of significant acquisitions, strategic partnerships, in-licensing, out-licensing, joint ventures or capital commitments;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">expiration or terminations of licenses, research contracts or other development or commercialization agreements;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">public concern as to the safety of drugs we, our development or commercialization partners or others develop or market;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">the volatility of market prices for shares of biotechnology companies generally;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">success or failure of research and development projects;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">departure of or major events adversely affecting key personnel;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">developments concerning intellectual property rights or regulatory approvals;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">variations in our and our competitors&rsquo; results of operations;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">changes in earnings estimates or recommendations by securities analysts, if our Ordinary Shares or ADSs are covered by analysts;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">changes in government regulations or patent proceedings and decisions;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">developments by our development or commercialization partners; and</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">general market conditions and other factors, including factors unrelated to our operating performance.</TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">These factors and any corresponding price fluctuations
may materially and adversely affect the market price of our Ordinary Shares or ADSs and result in substantial losses by our investors.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Additionally, market prices for securities of biotechnology
and pharmaceutical companies historically have been very volatile. The market for these securities has from time to time experienced
significant price and volume fluctuations for reasons unrelated to the operating performance of any one company. In the past, following
periods of market volatility, shareholders have often instituted securities class action litigation. If we were involved in securities
litigation, it could have a substantial cost and divert resources and attention of management from our business, even if we are
successful.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Future sales of our Ordinary Shares or ADSs could
reduce the market price of our Ordinary Shares and ADSs</I></B>.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">All of our outstanding Ordinary Shares are registered
and available for sale in Israel. In addition, as of October 31, 2017, we had options to purchase 26,171,798 Ordinary Shares under
our Amended and Restated Award Plan (2010) outstanding and non-tradable warrants to purchase an aggregate of 2,025,458 ADSs (each
representing 10 Ordinary Shares) outstanding. In addition, our board of directors reserved up to 33,646,039 Ordinary Shares for
issuance under our Amended and Restated Award Plan (2010) (including Ordinary Shares subject to outstanding options under such
plan). Substantial sales of our Ordinary Shares or ADSs, or the perception that such sales may occur in the future, including
sales of Ordinary Shares issuable upon the exercise of options, warrants or other equity-based securities, may cause the market
price of our Ordinary Shares or ADSs to decline. Moreover, the issuance of shares underlying our options and warrants will also
have a dilutive effect on our shareholders, which could further reduce the price of our Ordinary Shares and ADSs on their respective
exchanges.&nbsp;</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Our Ordinary Shares and our ADSs are traded on different
markets and this may result in price variations.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Our Ordinary Shares have been traded on the TASE since
February 2011, and our ADSs have been listed on the NASDAQ Capital Market since December 27, 2012. Trading in our securities on
these markets takes place in different currencies (U.S. dollars on the NASDAQ Capital Market and NIS on the TASE), and at different
times (resulting from different time zones, different trading days and different public holidays in the U.S and Israel). The trading
prices of our securities on these two markets may differ due to these and other factors. Any decrease in the price of our securities
on one of these markets could cause a decrease in the trading price of our securities on the other market.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>There has been a limited market for our ADSs. We
cannot ensure investors that an active market will continue or be sustained for our ADSs on the NASDAQ Capital Market, and this
may limit the ability of our investors to sell our ADSs in the U.S.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In the past, there was limited trading in our ADSs, and
there is no assurance that an active trading market of our ADSs will continue or will be sustained. Limited or minimal trading
in our ADSs has in the past, and may in the future, lead to dramatic fluctuations in market price and investors may not be able
to liquidate their investment at all or at a price that reflects the value of the business.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">While our ADSs began trading on the NASDAQ Capital Market
in December 2012, we cannot assure you that we will maintain compliance with all of the requirements for our ADSs to remain listed.
Additionally, there can be no assurance that trading of our ADSs on such market will be sustained or desirable.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We have incurred additional increased costs as a
result of the listing of our ADSs on the NASDAQ Capital Market, and we may need to devote substantial time and resources to new
compliance initiatives and reporting requirements.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">As a public company in the U.S. and Israel, we incur additional
significant accounting, legal and other expenses as a result of the listing of our securities on both the NASDAQ Capital Market
and the TASE. These include costs associated with the reporting requirements of the Securities and Exchange Commission (&ldquo;SEC&rdquo;)
and the requirements of the NASDAQ Listing Rules, as well as requirements under Section 404 and other provisions of the Sarbanes-Oxley
Act of 2002 (&ldquo;Sarbanes-Oxley Act&rdquo;). These rules and regulations have increased our legal and financial compliance costs,
introduced new costs such as investor relations, travel costs, stock exchange listing fees and shareholder reporting, and made
some activities more time&nbsp;consuming and costly. Any future changes in the laws and regulations affecting public companies
in the U.S. and Israel, including Section 404 and other provisions of the Sarbanes-Oxley Act, the rules and regulations adopted
by the SEC and the NASDAQ Listing Rules, as well as applicable Israeli reporting requirements, will result in increased costs to
us as we respond to such changes. These laws, rules and regulations could make it more difficult and costly for us to obtain certain
types of insurance, including director and officer liability insurance, and we may be forced to accept reduced policy limits and
coverage or incur substantially higher costs to obtain the same or similar coverage. The impact of these requirements could also
make it more difficult for us to attract and retain qualified persons to serve on our board of directors, our board committees
or as executive officers and may require us to pay more for such positions.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Since we are an &ldquo;emerging growth company,&rdquo;
as defined in the JOBS Act, we may take advantage of certain temporary exemptions from various reporting requirements, including,
but not limited to, not being required to comply with the auditor attestation requirements of Section 404 of the Sarbanes Oxley
Act (and the rules and regulations of the SEC thereunder). We will remain an emerging growth company until the earliest of: (a)
the last day of our fiscal year during which we have total annual gross revenues of at least $1.07 billion; (b) the last day of
our fiscal year following the fifth anniversary of the date of the first sale of our Ordinary Shares pursuant to an effective registration
statement (in our case, December 31, 2018); (c) the date on which we have, during the previous three-year period, issued more than
$1.0 billion in non-convertible debt; or (d) the date on which we are deemed to be a &ldquo;large accelerated filer&rdquo; under
the Exchange Act, which would occur if the market value of our Ordinary Shares held by non-affiliates is $700 million or more as
of the last business day of our most recently completed fiscal quarter. When these exemptions cease to apply, we expect to incur
additional expenses and devote increased management effort toward ensuring compliance with such reporting requirements. We cannot
predict or estimate the amount of additional costs we may incur as a result of complying with these additional reporting requirements.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>As a foreign private issuer, we are permitted to
follow certain home country corporate governance practices instead of applicable SEC and NASDAQ Stock Market requirements, which
may result in less protection than is accorded to investors under rules applicable to domestic issuers.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">As a foreign private issuer, we are permitted to follow
certain home country corporate governance practices instead of those otherwise required under the NASDAQ Listing Rules for domestic
issuers. For instance, we follow home country practice in Israel with regard to, among other things, director nomination procedures
and quorum at shareholders&rsquo; meetings. In addition, we follow our home country law, instead of the NASDAQ Listing Rules, which
require that we obtain shareholder approval for certain dilutive events, such as for the establishment or amendment of certain
equity-based compensation plans, an issuance that will result in a change of control of the Company, certain transactions other
than a public offering involving issuances of a 20% or more interest in the Company and certain acquisitions of the stock or assets
of another company. Following our home country governance practices as opposed to the requirements that would otherwise apply to
a U.S. domestic issuer listed on the NASDAQ Stock Market may provide less protection than is accorded to investors under the NASDAQ
Listing Rules applicable to domestic issuers.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">In addition, as a foreign private issuer, we are exempt
from the rules and regulations under the Exchange Act related to the furnishing and content of proxy statements, and our officers,
directors and principal shareholders are exempt from the reporting and short-swing profit recovery provisions contained in Section
16 of the Exchange Act. In addition, we are not required under the Exchange Act to file annual, quarterly and current reports and
financial statements with the SEC as frequently or as promptly as domestic companies whose securities are registered under the
Exchange Act.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We may fail to maintain effective internal controls
over financial reporting, which may adversely affect investor confidence in us and, as a result, may affect the value of our Ordinary
Shares and ADSs.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We are required, pursuant to Section 404 of the Sarbanes-Oxley
Act, to furnish a report by management on, among other things, the effectiveness of our internal control over financial reporting.
Pursuant to the JOBS Act, we are classified as an &ldquo;emerging growth company,&rdquo; and we are exempt from certain reporting
requirements, including the auditor attestation requirements of Section 404 of the Sarbanes-Oxley Act.&nbsp;&nbsp;Under this exemption,
our auditor will not be required to attest to and report on management&rsquo;s assessment of our internal controls over financial
reporting during a five-year transition period commencing in 2013.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Our management report regarding our internal control over
financial reporting must include, among other things, disclosure of any material weaknesses identified by our management in our
internal control over financial reporting. The continuous process of strengthening our internal controls and complying with Section
404 is complicated and time-consuming.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We have documented and tested our internal control systems
and procedures in order for us to comply with the requirements of Section 404. While our assessment of our internal control over
financial reporting resulted in our conclusion that as of December 31, 2016, our internal control over financial reporting was
effective, we cannot predict the outcome of our testing in future periods. If we fail to maintain the adequacy of our internal
controls, we may not be able to ensure that we can conclude on an ongoing basis that we have effective internal controls over financial
reporting.&nbsp;&nbsp;Failure to maintain effective internal control over financial reporting could result in investigation or
sanctions by regulatory authorities, and could have a material adverse effect on our reputation, business, financial condition,
results of operations, and investor confidence in the accuracy and completeness of our financial reports, which would cause the
price of our Ordinary Shares and ADSs to decline.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We currently do not anticipate paying cash dividends,
and accordingly, investors must rely on the appreciation in our ADSs and our Ordinary Shares for any return on their investment.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We currently anticipate that we will retain future earnings
for the development, operation and expansion of our business and do not anticipate declaring or paying any cash dividends for the
foreseeable future. Therefore, the success of an investment in our ADSs and our Ordinary Shares will depend upon any future appreciation
in their value. There is no guarantee that our ADSs or our Ordinary Shares will appreciate in value or even maintain the price
at which our investors have purchased their securities.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Investors in our ADSs may not receive the same distributions
or dividends as those we make to the holders of our Ordinary Shares, and, in some limited circumstances, investors in our ADSs
may not receive dividends or other distributions on our Ordinary Shares and may not receive any value for them, if it is illegal
or impractical to make them available to investors in our ADSs.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">The depositary for the ADSs has agreed to pay to investors
in our ADSs the cash dividends or other distributions it or the custodian receives on Ordinary Shares or other deposited securities
underlying the ADSs, after deducting its fees and expenses. Investors in our ADSs will receive these distributions in proportion
to the number of Ordinary Shares such ADSs represent. However, the depositary is not responsible if it decides that it is unlawful
or impractical to make a distribution available to any holders of ADSs. For example, it would be unlawful to make a distribution
to a holder of ADSs if it consists of securities that require registration under the Securities Act of 1933, as amended, (the &ldquo;Securities
Act&rdquo;), but that are not properly registered or distributed under an applicable exemption from registration. In addition,
conversion into U.S. dollars from foreign currency that was part of a dividend made in respect of deposited Ordinary Shares may
require the approval or license of, or a filing with, any government or agency thereof, which may be unobtainable. In these cases,
the depositary may determine not to distribute such property and hold it as &ldquo;deposited securities&rdquo; or may seek to effect
a substitute dividend or distribution, including net cash proceeds from the sale of the dividends that the depositary deems an
equitable and practicable substitute. We have no obligation to register under U.S. securities laws any ADSs, Ordinary Shares, rights
or other securities received through such distributions. We also have no obligation to take any other action to permit the distribution
of ADSs, Ordinary Shares, rights or anything else to holders of ADSs. In addition, the depositary may deduct from such dividends
or distributions its fees and may withhold amounts on account of taxes or other governmental charges to the extent the depositary
believes it is required to make such withholding. This means that investors in our ADSs may not receive the same distributions
or dividends as those we make to the holders of our Ordinary Shares, and, in some limited circumstances, investors in our ADSs
may not receive any value for such distributions or dividends if it is illegal or impractical for us to make them available to
investors in our ADSs. These restrictions may cause a material decline in the value of the ADSs.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"><B><I>Holders of ADSs must act through the depositary to exercise their rights
as our shareholders.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Holders of our ADSs do not have the same rights as our
shareholders and may only exercise the voting rights with respect to the underlying Ordinary Shares in accordance with the provisions
of the deposit agreement for the ADSs. Under Israeli law, the minimum notice period required to convene a shareholders&rsquo; meeting
is no less than 35 or 21 calendar days, depending on the proposals on the agenda for the shareholders&rsquo; meeting. When a shareholders&rsquo;
meeting is convened, holders of our ADSs may not receive sufficient notice of a shareholders&rsquo; meeting to permit them to withdraw
their Ordinary Shares to allow them to cast their vote with respect to any specific matter. In addition, the depositary and its
agents may not be able to send voting instructions to holders of our ADSs or carry out their voting instructions in a timely manner.
We will make all reasonable efforts to cause the depositary to extend voting rights to holders of our ADSs in a timely manner,
but we cannot assure holders that they will receive the voting materials in time to ensure that they can instruct the depositary
to vote their ADSs. Furthermore, the depositary and its agents are not responsible for any failure to carry out any instructions
to vote, for the manner in which any vote is cast or for the effect of any such vote. As a result, holders of our ADSs may not
be able to exercise their right to vote and they may lack recourse if their ADSs are not voted as they requested. In addition,
in the capacity as an ADS holder, they are not able to call a shareholders&rsquo; meeting.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>The depositary for our ADSs gives us a discretionary
proxy to vote our Ordinary Shares underlying ADSs if a holder of our ADSs does not give voting instructions, except in limited
circumstances, which could adversely affect their interests.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Under the deposit agreement for the ADSs, the depositary
gives us a discretionary proxy to vote our Ordinary Shares underlying ADSs at shareholders&rsquo; meetings if a holder of our
ADSs does not give voting instructions, unless:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="font-size: 10pt; text-align: center; width: 4%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; vertical-align: middle; text-align: justify; width: 96%">we have instructed the depositary that we do not wish a discretionary proxy to be given;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt; text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; vertical-align: middle; text-align: justify">we have informed the depositary that there is substantial opposition as to a matter to be voted on at the meeting; or</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt; text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; vertical-align: middle; text-align: justify">we have informed the depositary that a matter to be voted on at the meeting would have a material adverse impact on shareholders.</TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">The effect of this discretionary proxy is that a holder of our ADSs cannot
prevent our Ordinary Shares underlying such ADSs from being voted, absent the situations described above, and it may make it more
difficult for holders of our ADSs to influence our management. Holders of our Ordinary Shares are not subject to this discretionary
proxy.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"><B>Risks Related to our Operations in Israel</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>We conduct our operations in Israel and therefore
our results may be adversely affected by political, economic and military instability in Israel and the region.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We are incorporated under the laws of the State of Israel,
our principal offices are located in central Israel and some of our officers, employees and directors are residents of Israel.
Accordingly, political, economic and military conditions in Israel and the surrounding region may directly affect our business.
Since the establishment of the State of Israel in 1948, a number of armed conflicts have taken place between Israel and its Arab
neighbors. Any hostilities involving Israel or the interruption or curtailment of trade within Israel or between Israel and its
trading partners could adversely affect our operations and results of operations and could make it more difficult for us to raise
capital. During the summer of 2014, Israel was engaged in an armed conflict with Hamas in Gaza, which involved missile strikes
against civilian targets in various parts of Israel and negatively affected business conditions in Israel. In addition, recent
political uprisings and conflicts in various countries in the Middle East, are affecting the political stability of those countries.
It is not clear how this instability will develop and how it will affect the political and security situation in the Middle East.
This instability has raised concerns regarding security in the region and the potential for armed conflict. In addition, Iran has
threatened to attack Israel, and is also believed to have a strong influence among extremist groups in the region, such as Hamas
in Gaza and Hezbollah in Lebanon. Additionally, the Islamic State of Iraq and Levant (ISIL), a violent jihadist group, is involved
in hostilities in Iraq and Syria. Although ISIL&rsquo;s activities have not directly affected the political and economic conditions
in Israel, ISIL&rsquo;s stated purpose is to take control of the Middle East, including Israel. &nbsp;The tension between Israel
and Iran or these groups may escalate in the future and turn violent, which could affect the Israeli economy in general and us
in particular. Any armed conflicts, terrorist activities or political instability in the region could adversely affect business
conditions and could harm our results of operations. Parties with whom we do business have sometimes declined to travel to Israel
during periods of heightened unrest or tension, forcing us to make alternative arrangements when necessary. In addition, the political
and security situation in Israel may result in parties with whom we have agreements involving performance in Israel claiming that
they are not obligated to perform their commitments under those agreements pursuant to force majeure provisions in such agreements.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Our commercial insurance does not cover losses that may
occur as a result of events associated with the security situation in the Middle East. Although the Israeli government currently
covers the reinstatement value of direct damages that are caused by terrorist attacks or acts of war, there is no assurance that
this government coverage will be maintained, or if maintained, will be sufficient to compensate us fully for damages incurred.
Any losses or damages incurred by us could have a material adverse effect on our business. Any armed conflicts or political instability
in the region would likely negatively affect business conditions and could harm our results of operations.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">The State of Israel and Israeli companies have been subject
to economic boycotts. These restrictions and boycotts may have a material adverse impact on our operating results, financial condition
or the expansion of our business.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Our operations may be disrupted as a result of the
obligation of management or personnel to perform military service.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Some of our employees in Israel, including members of
our senior management, may be called to active duty in the event of a military conflict. There have also been periods of significant
call-ups of military reservists, and it is possible that there will be military reserve duty call-ups in the future. Our operations
could be disrupted by the absence of employees. Such disruption could have a material adverse effect on our business, financial
condition and results of operations.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0"><B><I>Because a certain portion of our expenses is incurred in currencies other
than the U.S. dollar, our results of operations may be harmed by currency fluctuations and inflation.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Our reporting and functional currency is the U.S. dollar.
Most of the royalty payments from our agreements with our development or commercialization partners are payable in U.S. dollars,
and we expect our revenues from future licensing and co-promotion agreements to be denominated mainly in U.S. dollars or in Euros.
We pay a substantial portion of our expenses in U.S. dollars; however, a portion of our expenses, including salaries of the employees
in Israel and payment to part of the service providers in Israel and other territories, are paid in NIS and in other currencies.
In addition, a portion of our financial assets is held in NIS and in other currencies. As a result, we are exposed to the currency
fluctuation risks. For example, if the NIS strengthens against the U.S. dollar, our reported expenses in U.S. dollars may be higher.
In addition, if the NIS weakens against the U.S. dollar, the U.S. dollar value of our financial assets held in NIS will decline.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Provisions of the RedHill Biopharma Ltd. Amended
and Restated Award Plan (the &ldquo;2010 Award Plan&rdquo;), Israeli law and our articles of association may delay, prevent or
otherwise impede a merger with, or an acquisition of, our Company, or an acquisition of a significant portion of our shares, which
could prevent a change of control, even when the terms of such a transaction are favorable to us and our shareholders.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Our 2010 Award Plan provides that all options granted
by us will be fully accelerated upon a &ldquo;hostile takeover&rdquo; of the Company. A &ldquo;hostile takeover&rdquo; is defined
in our 2010 Award Plan as an event in which any person, entity or group that was not an &ldquo;interested party&rdquo;, as defined
in the Israeli Securities Law &ndash; 1968, on the date of the&nbsp;initial public offering of our Ordinary Shares on the TASE,
will become a &ldquo;controlling&nbsp;shareholder&rdquo; as defined in the Israel Securities Law, 1968, or a &ldquo;holder,&rdquo;
as defined in the Israel Securities Law, 1968, of 25% or more of the voting rights in the Company or any merger or consolidation
involving the Company, in each case without a resolution by the board of directors of the Company supporting the transaction. In
addition, if a &ldquo;Significant Event&rdquo; occurs and following which the employment of a grantee with the Company or a related
company is terminated by the Company or a related company other than for &ldquo;Cause&rdquo;, and unless the applicable agreement
provides otherwise or the board of directors determines otherwise, all the outstanding options held by or for the benefit of any
such grantee will be accelerated and immediately vested and exercisable. A &ldquo;Significant Event&rdquo; is defined in our 2010
Award Plan as a consolidation or merger of the Company with or into another corporation approved by the board of directors of the
Company in which the Company is the continuing or surviving corporation or in which the continuing or surviving corporation assumes
the option or substitutes it with an appropriate option in the surviving corporation.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">The Israeli Companies Law, 1999, or the Israeli Companies
Law, regulates mergers, requires tender offers for acquisitions of shares or voting rights above specified thresholds, requires
special approvals for transactions involving directors, officers or significant shareholders and regulates other matters that may
be relevant to these types of transactions. For example, a merger may not be consummated unless at least 50 days have passed from
the date that a merger proposal was filed by each merging company with the Israel Registrar of Companies and at least 30 days from
the date that the shareholders of both merging companies approved the merger. In addition, a majority of each class of securities
of the target company must approve a merger. Moreover, the Israeli Companies Law provides that certain purchases of securities
of a public company are subject to tender offer rules. As a general rule, the Israeli Companies Law prohibits any acquisition of
shares or voting power in a public company that would result in the purchaser holding 25% or more, or more than 45% of the voting
power in the company, if there is no other person holding 25% or more, or more than 45% of the voting power in a company, respectively,
without conducting a special tender offer. The Israeli Companies Law further provides that a purchase of shares or voting power
of a public company or a class of shares of a public company, which will result in the purchaser&rsquo;s holding 90% or more of
the company&rsquo;s shares, class of shares or voting rights, is prohibited unless the purchaser conducts a full tender offer for
all of the company&rsquo;s shares or class of shares. The purchaser will be allowed to purchase all of the company&rsquo;s shares
or class of shares (including those shares held by shareholders who did not respond to the offer), if either (i) the shareholders
who do not accept the offer hold less than 5% of the issued and outstanding share capital of the company or of the applicable class,
and more than half of the shareholders who do not have a personal interest in the offer accept the offer, or (ii) the shareholders
who do not accept the offer hold less than 2% of the issued and outstanding share capital of the company or of the applicable class.
The shareholders, including those who indicated their acceptance of the tender offer (except if otherwise detailed in the tender
offer document), may, at any time within six months following the completion of the tender offer, petition the court to alter the
consideration for the acquisition. At the request of an offeree of a full tender offer which was accepted, the court may determine
that the consideration for the shares purchased under the tender offer was lower than their fair value and compel the offeror to
pay to the offerees the fair value of the shares. Such application to the court may be filed as a class action. In addition, the
Israeli Companies Law provides for certain limitations on a shareholder that holds more than 90% of the company&rsquo;s shares,
or class of shares.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Pursuant to our articles of association, the size of our
board of directors may be no less than five persons and no more than eleven, including any external directors whose appointment
is required under law. The directors who are not external directors are divided into three classes, as nearly equal in number as
possible. At each annual general meeting, the term of one class of directors expires, and the directors of such class are re-nominated
to serve an additional three-year term that expires at the annual general meeting held in the third year following such election
(other than any director originally nominated for election by virtue of the nomination right granted to any investor who purchased,
in the Company's public offering which closed on December 27, 2016, together with its affiliates, at least $15 million of ADSs
and warrants (excluding the proceeds, if any, from the exercise of warrants, whose term of office may expire earlier depending
on the beneficial ownership by the investor of the Company's shares). This process continues indefinitely. Such provisions of our
articles of association make it more difficult for a third party to effect a change in control or takeover attempt that our management
and board of directors oppose.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Furthermore, Israeli tax considerations may, in certain
circumstances, make potential transactions unappealing to us or to some of our shareholders. For example, Israeli tax law does
not recognize tax-free share exchanges to the same extent as U.S. tax law. With respect to mergers, Israeli tax law allows for
tax deferral in certain circumstances but makes the deferral contingent on the fulfillment of numerous conditions, including a
holding period of two years from the date of the transaction during which sales and dispositions of shares of the participating
companies are restricted. Moreover, with respect to certain share swap transactions, the tax deferral is limited in time, and when
such time expires, the tax becomes payable even if no actual disposition of the shares has occurred.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">These and other similar provisions could delay, prevent
or impede an acquisition of us or our merger with another company, or an acquisition of a significant portion of our shares, even
if such an acquisition or merger would be beneficial to us or to our shareholders.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>It may be difficult to enforce a U.S. judgment against
us and our directors and officers in Israel or the U.S., or to serve process on our directors&nbsp;and officers.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We are incorporated in Israel. Most of our directors and
executive officers reside outside of the U.S., and most of our assets and most of the assets of our directors and executive officers
are located outside of the U.S. Therefore, a judgment obtained against us or most of our executive officers and our directors in
the U.S., including one based on the civil liability provisions of the U.S. federal securities laws, may not be collectible in
the U.S. and may not be enforced by an Israeli court. It may also be difficult to effect service of process on these persons in
the U.S. or to assert U.S. securities law claims in original actions instituted in Israel.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>The obligations and responsibilities of our shareholders
are governed by Israeli law which may differ in some respects from the obligations and responsibilities of shareholders of U.S.
companies.</I></B> &nbsp; <B><I>Israeli law may impose obligations and responsibilities on a shareholder of an Israeli company
that are not imposed upon shareholders of corporations in the U.S.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We are incorporated under Israeli law. The obligations
and responsibilities of the holders of our Ordinary Shares are governed by our articles of association and Israeli law. These obligations
and responsibilities differ in some respects from the obligations and responsibilities of shareholders in typical U.S.-based corporations.&nbsp;&nbsp;In
particular, a shareholder of an Israeli company has a duty to act in good faith toward the company and other shareholders and to
refrain from abusing its power in the company, including, among other things, in voting at the general meeting of shareholders
on matters such as amendments to a company&rsquo;s articles of association, increases in a company&rsquo;s authorized share capital,
mergers and acquisitions and interested party transactions requiring shareholder approval. In addition, a shareholder who knows
that it possesses the power to determine the outcome of a shareholder vote or to appoint or prevent the appointment of a director
or executive officer in the company has a duty of fairness toward the company. There is limited case law available to assist us
in understanding the implications of these provisions that govern shareholders&rsquo; actions. These provisions may be interpreted
to impose additional obligations and responsibilities on holders of our Ordinary Shares that are not typically imposed on shareholders
of U.S. corporations.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"><B><I>Claims for indemnification by our directors and
officers may reduce our available funds to satisfy successful shareholder claims against us and may reduce the amount of money
available to us.</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">The Israeli Companies Law and our articles of association
permit us to indemnify our directors and officers for acts performed by them in their capacity as directors and officers. The Israeli
Companies Law provides that a company may not exempt or indemnify a director or an officer nor enter into an insurance contract,
which would provide coverage for any monetary liability incurred as a result of: (a) a breach by the director or officer of his
duty of loyalty, except for insurance and indemnification where the director or officer acted in good faith and had a reasonable
basis to believe that the act would not prejudice the company; (b) a breach by the director or officer of his duty of care if the
breach was done intentionally or recklessly, except if the breach was solely as a result of negligence; (c) any act or omission
done with the intent to derive an illegal personal benefit; or (d) any fine, civil fine, monetary sanctions, or forfeit imposed
on the officer or director. Our articles of association provide that the Company may exempt or indemnify a director or an officer
to the maximum extent permissible under law.&nbsp;&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">We have issued letters of indemnification to our directors
and officers, pursuant to which we have agreed to indemnify them in advance for any liability or expense imposed on or incurred
by them in connection with acts they perform in their capacity as a director or officer, subject to applicable law. The amount
of the advance indemnity is limited to the higher of 25% of our then shareholders&rsquo; equity, per our most recent annual financial
statements, or $5 million.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0.2pt 0pt 0">Our indemnification obligations limit the personal liability
of our directors and officers for monetary damages for breach of their duties as directors by shifting the burden of such losses
and expenses to us. Although we have obtained directors' and officers' liability insurance, certain liabilities or expenses covered
by our indemnification obligations may not be covered by such insurance or the coverage limitation amounts may be exceeded. As
a result, we may need to use a significant amount of our funds to satisfy our indemnification obligations, which could severely
harm our business and financial condition and limit the funds available to who may choose to bring a claim against our Company.
These provisions and resultant costs may also discourage us from bringing a lawsuit against directors and officers for breaches
of their duties, and may similarly discourage the filing of derivative litigation by our shareholders against the directors and
officers even though such actions, if successful, might otherwise benefit our security holders.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0.2pt 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>Risks Related to this Offering</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>We will have broad discretion in how to use the net proceeds
of this offering, and we may not use these proceeds in a manner desired by our investors.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We will have broad discretion as to the use of the net proceeds
from this offering and could use them for purposes other than those contemplated at the time of this offering.&nbsp;Accordingly,
you will be relying on the judgment of our management with regard to the use of these net proceeds, and you will not have the opportunity
as part of your investment decision to assess whether the proceeds are being used appropriately. Our needs may change as the business
and the industry that we address evolves.&nbsp;As a result, the proceeds to be received in this offering may be used in a manner
significantly different from our current expectations. It is possible that the proceeds will be invested in a way that does not
yield a favorable, or any, return. The failure of our management to use such funds effectively could have a material adverse effect
on our business, financial condition, operating results and cash flow.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>You will experience immediate dilution in book value of any
ADSs you purchase.</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Because the price per ADS being offered is substantially higher
than our net tangible book value per ADS, you will suffer substantial dilution in the net tangible book value of any ADSs you purchase
in this offering. After giving effect to the sale by us of&nbsp;4,090,909 ADSs in this offering, based on a public offering price
of $5.50&nbsp;per ADS, and after deducting the underwriting discount and estimated offering expenses payable by us in connection
with this offering, the as adjusted net tangible book value of our ADSs would be $63.4 million, or approximately $2.98 per ADS,
as of June 30, 2017.&nbsp;If you purchase ADSs in this offering, you will suffer immediate and substantial dilution of as adjusted
net tangible book value of approximately $2.52&nbsp;per ADS. If the underwriters exercise their option to purchase additional ADSs,
you will experience additional dilution. See &ldquo;Dilution&rdquo; on page S-44 for a more detailed discussion of the dilution
you will incur in connection with this offering.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>ADSs representing a substantial percentage of our outstanding
shares may be sold in this offering, which could cause the price of our ADSs and Ordinary Shares</I> to <I>decline</I>.</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Pursuant to this offering, we will sell 4,090,909&nbsp;ADSs representing&nbsp;40,909,090
Ordinary Shares, or approximately 24% of our outstanding Ordinary Shares as of October 31, 2017. These sales and any future sales
of a substantial number of ADSs in the public market, or the perception that such sales may occur, could materially adversely affect
the price of our ADSs and Ordinary Shares. We cannot predict the effect, if any, that market sales of those ADSs or the availability
of those ADSs for sale will have on the market price of our ADSs and Ordinary Shares.&nbsp;</P>



<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"></P>



<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B><A NAME="a_007"></A>USE OF PROCEEDS </B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We estimate that the net proceeds from the sale of&nbsp;4,090,909
of our ADSs representing&nbsp;40,909,090 Ordinary Shares in this offering will be approximately $20.6 million after deducting underwriting
discounts and commissions and estimated offering expenses payable by us in connection with this offering. If the underwriters&rsquo;
option to purchase additional ADSs is exercised in full, we estimate that we will receive net proceeds of approximately $23.7 million,
after deducting underwriter discounts and commissions and estimated offering expenses payable by us in connection with this offering.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>



<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">We currently intend to use the net proceeds from the sale of our ADSs in this offering
to fund clinical development programs, for potential acquisitions, to support commercial operations and for general corporate purposes.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The amounts and timing of our actual expenditures will depend upon
numerous factors, including the progress of our development and commercialization efforts, the status of and results from our clinical
trials, whether or not we enter into strategic collaborations or partnerships, and our operating costs and expenditures. Accordingly,
our management will have significant flexibility in applying the net proceeds of this offering. In addition, while we have not
entered into any binding agreements or commitments relating to any significant transaction as of the date of this prospectus supplement,
we may use a portion of the net proceeds to pursue acquisitions, joint ventures and other strategic transactions.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B><A NAME="a_008"></A>DILUTION<SUP></SUP></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">If you invest in our ADSs, your interest will be diluted immediately
to the extent of the difference between the public offering price per ADS and the as-adjusted net tangible book value per ADS after
this offering.&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The net tangible book value of our ADSs as of June 30, 2017 was
approximately $42.8 million, or approximately $2.49 per ADS.&nbsp;Net tangible book value per ADS represents the amount of our
total tangible assets less total liabilities divided by the total number of our Ordinary Shares outstanding as of June 30, 2017
and multiplying such amount by 10 (one ADS represents 10 Ordinary Shares).&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">After giving effect to the sale of our ADSs offered by this prospectus
supplement at the public offering price of $5.50 per ADS, and after deducting the underwriting discount and estimated offering
expenses payable by us in connection with this offering, our as adjusted net tangible book value as of June 30, 2017 would have
been approximately $63.4 million, or approximately $2.98 per ADS. This represents an immediate increase in net tangible book value
of approximately $0.49&nbsp;per ADS to our existing security holders and an immediate dilution in as-adjusted net tangible book
value of approximately $2.52 per ADS to purchasers of our ADSs in this offering, as illustrated by the following table:</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="width: 83%; border-top: black 1pt solid; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 1%; border-top: black 1pt solid">&nbsp;</TD>
    <TD STYLE="width: 1%; border-top: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-top: black 1pt solid; text-align: justify; width: 6%">&nbsp;</TD>
    <TD STYLE="border-top: black 1pt solid; text-align: justify; width: 1%">&nbsp;</TD>
    <TD STYLE="border-top: black 1pt solid; text-align: justify; width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 6%; border-top: black 1pt solid; text-align: right">&nbsp;</TD>
    <TD STYLE="width: 1%; border-top: black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,238,255)">
    <TD STYLE="vertical-align: bottom">Public offering price per ADS&#9;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: top; text-align: right"><P STYLE="margin: 0pt 0">5.50&nbsp;</P>


</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: White">
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,238,255)">
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">Net tangible book value per ADS as of June 30, 2017&#9;</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right">2.49</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: right"><FONT STYLE="font-size: 10pt">&nbsp;&nbsp;</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: White">
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,238,255)">
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">Increase in net tangible book value per ADS attributable to this offering</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right">0.49</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: White">
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,238,255)">
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">As-adjusted net tangible book value per ADS as of June 30, 2017 after giving effect to this offering </FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt"></FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: left; border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="vertical-align: top; text-align: right; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt 0">2.98&nbsp;</P>


</TD>
    <TD STYLE="vertical-align: top; text-align: left; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="background-color: White">
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: right">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="background-color: rgb(204,238,255)">
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">Dilution per ADS to the new investors purchasing our ADSs in this offering&#9;</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 2.25pt double">$</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 2.25pt double; text-align: right">2.52</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 2.25pt double">&nbsp;</TD></TR>
<TR STYLE="background-color: White">
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; text-align: right">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">If the underwriters exercise in full their option to purchase&nbsp;613,316
additional ADSs at the public offering price of $5.50 per ADS, the as-adjusted net tangible book value after this offering would
be approximately $3.04 per ADS, representing an increase in net tangible book value of approximately $0.55 per ADS to existing
security holders and immediate dilution in net tangible book value of approximately $2.46&nbsp;per ADS to new investors purchasing
our ADSs in this offering at the public offering price.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The number of Ordinary Shares to be outstanding after this offering
is based on 171,640,344 Ordinary Shares outstanding as of June 30, 2017, and excludes as of such date (i) 24,056,798 Ordinary Shares
issuable upon the exercise of outstanding options to purchase 24,056,798 Ordinary Shares at a weighted average exercise price of
$1.05 per share (equivalent to 2,405,679 ADSs at a weighted average exercise price of $10.5 per ADS), and (ii) 20,254,580 Ordinary
Shares issuable upon the exercise of outstanding non-tradable warrants to purchase 20,254,580 Ordinary Shares at an exercise price
of $1.333 per share (equivalent to 2,025,458 ADSs at a weighted average exercise price of $13.33 per ADS).</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The as-adjusted information discussed above is illustrative only.
Our net tangible book value following the completion of the offering is subject to further adjustment based on the actual offering
price of our ADSs and other terms of this offering determined at pricing.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>



<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt">&nbsp;</DIV>
    <!-- Field: /Page -->

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><A NAME="a_009"></A><B>CAPITALIZATION AND INDEBTEDNESS</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">The following table sets forth our total capitalization as of June 30, 2017:</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; width: 4%; text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; width: 96%">on an actual basis; and</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; text-align: center; vertical-align: top">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt"><P STYLE="margin: 0pt 0">on an as-adjusted basis to reflect the sale of&nbsp;&nbsp;4,090,909 ADSs representing&nbsp;40,909,090&nbsp;Ordinary
Shares in this offering at the public offering price of $5.50&nbsp;per ADS and the receipt by us of net proceeds of approximately
$20.6&nbsp;million, after deducting the underwriting discounts and commissions and the estimated offering expenses payable by us
in connection with this offering.</P>


</TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The information set forth in the following table should be read
in conjunction with and is qualified in its entirety by reference to the audited and unaudited financial statements and notes thereto
incorporated by reference in this prospectus supplement and the accompanying prospectus.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><B>As of June 30, 2017</B></FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD><FONT STYLE="font-size: 10pt"><I>(In thousands, except share data)</I></FONT></TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><I>Actual</I></FONT></TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><I>As Adjusted</I></FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><B>(unaudited)</B></FONT></TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 72%"><FONT STYLE="font-size: 10pt">Derivative financial instruments&#9;</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 11%; text-align: right"><FONT STYLE="font-size: 10pt">2,622</FONT></TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="width: 11%; text-align: right"><P STYLE="margin: 0pt 0">2,622</P>


</TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD><FONT STYLE="font-size: 10pt">Ordinary shares, par value NIS 0.01 per share&#9;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">458</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><P STYLE="margin: 0pt 0">574</P>


</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD><FONT STYLE="font-size: 10pt">Additional paid-in capital&#9;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">156,587</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right"><P STYLE="margin: 0pt 0">177,101</P>


</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD><FONT STYLE="font-size: 10pt">Accumulated deficit&#9;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><FONT STYLE="font-size: 10pt">(108,242</FONT></TD>
    <TD STYLE="border-bottom: black 1pt solid"><FONT STYLE="font-size: 10pt">)</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1pt solid; text-align: right"><P STYLE="margin: 0pt 0">(108,242</P>


</TD>
    <TD STYLE="border-bottom: black 1pt solid">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD><FONT STYLE="font-size: 10pt">Total shareholders&rsquo; equity&#9;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><FONT STYLE="font-size: 10pt">48,803</FONT></TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="text-align: right"><P STYLE="margin: 0pt 0">69,433</P>


</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: right">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD><FONT STYLE="font-size: 10pt">Total capitalization&#9;</FONT></TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><FONT STYLE="font-size: 10pt">51,425</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="border-bottom: black 2.25pt double"><FONT STYLE="font-size: 10pt">$</FONT></TD>
    <TD STYLE="border-bottom: black 2.25pt double; text-align: right"><P STYLE="margin: 0pt 0">72,055</P>


</TD>
    <TD STYLE="border-bottom: black 2.25pt double">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The number of shares in the above table is based on 171,640,344
Ordinary Shares outstanding as of June 30, 2017, and excludes as of such date (i) 24,056,798 Ordinary Shares issuable upon the
exercise of outstanding options to purchase 24,056,798 Ordinary Shares at a weighted average exercise price of $1.05 per share
(equivalent to 2,405,679 ADSs at a weighted average exercise price of $10.5 per ADS), and (ii) 20,254,580 Ordinary Shares issuable
upon the exercise of outstanding non-tradable warrants to purchase 20,254,580 Ordinary Shares at an exercise price of $1.333 per
share (equivalent to 2,025,458 ADSs at a weighted average exercise price of $13.33 per ADS).</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><FONT STYLE="font-variant: small-caps"><B><A NAME="a_010"></A>PRICE RANGE OF OUR ORDINARY
SHARES </B></FONT></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Our Ordinary Shares have been trading on the TASE under the symbol
&ldquo;RDHL&rdquo; since February 3, 2011. Prior to that date, there was no public market for our Ordinary Shares. U.S. dollar
per Ordinary Share amounts are calculated using the U.S. dollar representative rate of exchange on the date to which the high or
low market price is applicable, as reported by the Bank of Israel. The following table lists the high and low closing prices for
our Ordinary Shares for the periods indicated as reported by the TASE.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="7" STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1.1pt solid">NIS</TD><TD STYLE="font-size: 10pt; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="7" STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1.1pt solid">$U.S.</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="7" STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1.1pt solid">Price per Ordinary <BR> Share</TD><TD STYLE="font-size: 10pt; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="7" STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1.1pt solid">Price per Ordinary <BR> Share</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt; font-weight: bold; border-bottom: Black 1.1pt solid; text-align: left">Annual</TD><TD STYLE="font-size: 10pt; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1.1pt solid">High</TD><TD STYLE="font-size: 10pt; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1.1pt solid">Low</TD><TD STYLE="font-size: 10pt; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1.1pt solid">High</TD><TD STYLE="font-size: 10pt; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt; text-align: center; border-bottom: Black 1.1pt solid">Low</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 52%; font-size: 10pt; text-align: left">2016</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 9%; font-size: 10pt; text-align: right">6.05</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 9%; font-size: 10pt; text-align: right">3.32</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 9%; font-size: 10pt; text-align: right">1.58</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 9%; font-size: 10pt; text-align: right">0.86</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">2015</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">7.80</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4.34</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">2.03</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.12</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">2014</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">6.80</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.00</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.96</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.78</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">2013</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4.29</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.23</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.15</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.92</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">2012</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4.19</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.71</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.08</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.45</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">2011 (beginning on February 3, 2011)&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.80</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.82</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.05</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.49</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">Quarter</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">2017</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Fourth Quarter (through November 7, 2017)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.80</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">2.72</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.07</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.77</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Third Quarter</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.75</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">2.85</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.05</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.81</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Second quarter</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.79</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.00</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.04</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.86</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">First quarter</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4.17</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.38</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.08</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.92</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">2016</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Fourth quarter</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.51</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.73</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.45</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.98</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Third quarter&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">6.05</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4.21</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.58</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.09</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Second quarter&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.29</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.90</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.41</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.01</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">First quarter&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.14</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.32</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.32</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.86</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">2015</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Fourth quarter&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.42</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4.34</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.39</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.12</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Third quarter&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">7.10</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4.62</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.88</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.19</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Second quarter&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">7.80</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.52</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">2.03</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.41</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">First quarter&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">6.16</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">4.89</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.57</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.26</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">Most Recent Six Months</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">November 2017 (through November 7, 2017)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.16</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">2.72</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.90</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.77</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left"><P STYLE="margin: 0pt 0">October 2017</P>


</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.80</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.04</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.07</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.87</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">September 2017 &#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.33</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">2.85</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.94</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.81</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">August 2017 &#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.27</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.00</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.90</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.84</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">July 2017&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.75</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">2.93</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.05</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.82</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">June 2017&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.53</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.00</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.00</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.86</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">May 2017&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.65</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">3.41</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1.02</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0.94</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><FONT STYLE="background-color: white">On&nbsp;November 7, 2017,
the last reported sales price of our Ordinary Shares on the TASE was NIS 2.72 per share, or $0.77 per share (based on the exchange
rate reported by the Bank of Israel for such date).&nbsp;On&nbsp;November 7, 2017, the exchange rate of the NIS to the U.S. dollar
was $1.00 = NIS 3.516, as reported by the Bank of Israel.&nbsp;</FONT></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><FONT STYLE="font-variant: small-caps"><B><A NAME="a_011"></A>PRICE RANGE OF OUR ADSs
</B></FONT></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">Our ADSs have been trading on The NASDAQ under the symbol &ldquo;RDHL&rdquo; since December
26, 2012.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">The following table sets forth, for the periods indicated, the reported high and low
closing sale prices of our ADSs on The NASDAQ in U.S. dollars.&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="7" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1.1pt solid">$U.S.</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="7" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1.1pt solid">Price per ADS</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1.1pt solid">High</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1.1pt">&nbsp;</TD>
    <TD NOWRAP COLSPAN="3" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1.1pt solid">Low</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">Annual</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="width: 68%; font-size: 10pt; text-align: left">2016</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 12%; font-size: 10pt; text-align: right">16.29</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 12%; font-size: 10pt; text-align: right">8.21</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">2015</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">19.79</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">11.05</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">2014</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">19.20</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">8.03</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">2013</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">13.60</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">8.31</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">Quarter</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">2017</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left"><P STYLE="margin: 0pt 0">Fourth Quarter (through November 7, 2017)</P>


</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">10.81</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">7.50</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Third Quarter</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">10.81</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">8.18</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Second quarter</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">10.38</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">8.44</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">First Quarter</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">10.88</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">9.30</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">Quarter</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">2016</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Fourth quarter</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">14.47</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">9.65</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Third quarter&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">16.29</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">10.80</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Second quarter&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">13.79</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">10.00</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">First quarter&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">12.61</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">8.21</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">2015</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Fourth quarter&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">13.72</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">11.05</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Third quarter&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">18.46</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">12.16</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Second quarter&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">19.79</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">14.03</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">First quarter&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">15.92</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">12.52</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; font-weight: bold; text-align: left">Most Recent Six Months</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">November 2017 (through November 7, 2017)</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">8.90</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">7.50</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left"><P STYLE="margin: 0pt 0">October 2017</P>


</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">10.81</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">8.71</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">September 2017&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">10.81</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">8.25</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">August 2017&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">9.30</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">8.36</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">July 2017&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">10.50</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">8.18</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">June 2017&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">9.47</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">8.44</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">May 2017&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">10.31</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">9.38</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">On&nbsp;November 7, 2017, the last reported sales price of our ADSs on The NASDAQ was $7.50 per ADS.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><A NAME="a_012"></A><B>DIVIDEND POLICY</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We have never declared or paid any cash dividends to our shareholders.
We currently anticipate that we will retain future earnings for the development, operation and expansion of our business and do
not anticipate declaring or paying any cash dividends for the foreseeable future.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B><A NAME="a_013"></A>MATERIAL TAX CONSIDERATIONS</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><B>Taxation</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><B>Israeli Tax Considerations</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><B><I>General</I></B></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The following is a summary of the material tax consequences under
Israeli law concerning the purchase, ownership and disposition of Ordinary Shares and ADSs of our company.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">This discussion does not purport to constitute a complete analysis
of all potential tax consequences applicable to investors upon purchasing, owning or disposing of Ordinary Shares and ADSs of our
company. In particular, this discussion does not take into account the specific circumstances of any particular investor (such
as tax-exempt entities, financial institutions, certain financial companies, broker-dealers, investors that own, directly or indirectly,
10% or more of our outstanding voting rights, all of whom are subject to special tax regimes not covered under this discussion).
To the extent that issues discussed herein are based on legislation which has yet to be subject to judicial or administrative interpretation,
there can be no assurance that the views expressed herein will accord with any such interpretation in the future.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Potential investors are urged to consult their own tax advisors
as to the Israeli or other tax consequences of the purchase, ownership and disposition of the Ordinary Shares or ADSs being offered
hereby, including, in particular, the effect of any foreign, state or local taxes.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>General Corporate Tax Structure in Israel</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The Israeli corporate tax rate applicable to Israeli resident companies
is 24% in 2017 (to be reduced to 23% in 2018 and thereafter).</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>Taxation of Shareholders</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>Capital Gains</I></B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Capital gains tax is imposed on the disposal of capital assets by
an Israeli resident and on the disposal of such assets by a non-Israeli resident if those assets are either (i) located in Israel;
(ii) are shares or a right to a share in an Israeli resident corporation, or (iii) represent, directly or indirectly, rights to
assets located in Israel, unless an exemption is available or unless an applicable double tax treaty between Israel and the seller&rsquo;s
country of residence provides otherwise. The Israeli Income Tax Ordinance distinguishes between &ldquo;Real Gain&rdquo; and the
&ldquo;Inflationary Surplus.&rdquo; Real Gain is the excess of the total capital gain over Inflationary Surplus computed generally
on the basis of the increase in the Israeli Consumer Price Index between the date of purchase and the date of disposition. Inflationary
Surplus is not subject to tax.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Real Gain accrued by individuals on the sale of the Ordinary Shares
or ADSs will be taxed at the rate of 25%. However, if the individual shareholder is a &ldquo;Controlling Shareholder&rdquo; (<I>i.e</I>.,
a person who holds, directly or indirectly, alone or together with another, 10% or more of one of the Israeli resident company&rsquo;s
means of control) at the time of sale or at any time during the preceding 12 month period, such gain will be taxed at the rate
of 30%.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Corporate and individual shareholders dealing in securities in Israel
are taxed at the tax rates applicable to business income which is 24% in 2017 for corporations (to be reduced to 23% in 2018 and
thereafter), and a marginal tax rate of up to 47% in 2017 for individuals, not including excess tax (as discussed below).</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Notwithstanding the foregoing, capital gains generated from the
sale of our Ordinary Shares or ADSs by a non-Israeli shareholder may be exempt from Israeli tax under the Israeli Income Tax Ordinance
provided that the following cumulative conditions are met: (i) the Ordinary Shares or ADSs were purchased upon or after the registration
of the Ordinary Shares or ADSs on the stock exchange and (ii) the seller does not have a permanent establishment in Israel to which
the generated capital gain is attributed. However, non-Israeli resident corporations will not be entitled to the foregoing exemption
if Israeli residents: (i)&nbsp;have a 25% or more interest in such non-Israeli corporation or (ii)&nbsp;are the beneficiaries of,
or are entitled to, 25% or more of the income or profits of such non-Israeli corporation, whether directly or indirectly. In addition,
such exemption would not be available to a person whose gains from selling or otherwise disposing of the Ordinary Shares or ADSs
are deemed to be business income.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">In addition, the sale of the Ordinary Shares or ADSs may be exempt
from Israeli capital gains tax under the provisions of an applicable double tax treaty. For example, the Convention between the
Government of the U.S. and the Government of the State of Israel with respect to Taxes on Income (the &ldquo;U.S.- Israel Double
Tax Treaty&rdquo;) exempts a U.S. resident (for purposes of the treaty) from Israeli capital gains tax in connection with the sale
of the Ordinary Shares or ADSs, provided that: (i) the U.S. resident owned, directly or indirectly, less than 10% of the voting
power of the company at any time within the 12 month period preceding such sale; (ii) the U.S. resident, being an individual, is
present in Israel for a period or periods of less than 183 days during the taxable year; and (iii) the capital gain from the sale
was not derived through a permanent establishment of the U.S. resident in Israel; however, under the U.S-Israel Double Tax Treaty,
the taxpayer would be permitted to claim a credit for such taxes against the U.S. federal income tax imposed with respect to such
sale, subject to the limitations under U.S. law applicable to foreign tax credits. The U.S-Israel Double Tax Treaty does not relate
to U.S. state or local taxes.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Payers of consideration for the Ordinary Shares or ADSs, including
the purchaser, the Israeli stockbroker or the financial institution through which the Ordinary Shares or ADSs are held, are obligated,
subject to certain exemptions, to withhold tax upon the sale of Ordinary Shares or ADSs.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Upon the sale of traded securities, a detailed return, including
a computation of the tax due, must be filed and an advanced payment must be paid to the Israeli Tax Authority on January 31 and
July 31 of every tax year in respect of sales of traded securities made within the previous six months. However, if all tax due
was withheld at source according to applicable provisions of the Israeli Income Tax Ordinance and regulations promulgated thereunder,
such return need not be filed and no advance payment must be paid. Capital gains are also reportable on annual income tax returns.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><B><I>Dividends</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Dividends distributed by a company to a shareholder who is an Israeli
resident individual will be generally subject to income tax at a rate of 25%. However, a 30% tax rate will generally apply if the
dividend recipient is a Controlling Shareholder, as defined above, at the time of distribution or at any time during the preceding
12 month period. If the recipient of the dividend is an Israeli resident corporation, such dividend will generally not be subject
to tax provided that the income from which such dividend is distributed, derived or accrued within Israel.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Dividends distributed by an Israeli resident company to a
non-Israeli resident (either an individual or a corporation) are generally subject to Israeli withholding tax on the receipt
of such dividends at the rate of 25% (30% if the dividend recipient is a Controlling Shareholder at the time of distribution
or at any time during the preceding 12 month period). These rates may be reduced under the provisions of an applicable double
tax treaty. For example, under the U.S.-Israel Double Tax Treaty, the following tax rates will apply in respect of dividends
distributed by an Israeli resident company to a U.S. resident: (i) if the U.S. resident is a corporation which holds during
that portion of the taxable year which precedes the date of payment of the dividend and during the whole of its prior taxable
year (if any), at least 10% of the outstanding shares of the voting stock of the Israeli resident paying corporation and not
more than 25% of the gross income of the Israeli resident paying corporation for such prior taxable year (if any) consists of
certain types of interest or dividends the tax rate is 12.5%; (ii) if both the conditions mentioned in clause (i) above are
met and the dividend is paid from an Israeli resident company&rsquo;s income which was entitled to a reduced tax rate under
The Law for the Israeli Encouragement of Capital Investments, 1959, the tax rate is 15%; and (iii) in all other cases, the
tax rate is 25%. The aforementioned rates under the U.S.-Israel Double Tax Treaty will not apply if the dividend income is
attributed to a permanent establishment of the U.S. resident in Israel.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B><I>Excess Tax</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Individual holders who are subject to tax in Israel (whether any
such individual is an Israeli resident or non-Israeli resident) and who have taxable income that exceeds a certain threshold in
a tax year (NIS 640,000 for 2017, linked to the Israeli Consumer Price Index), will be subject to an additional tax at the rate
of 3% on his or her taxable income for such tax year that is in excess of such amount. For this purpose, taxable income includes
taxable capital gains from the sale of securities and taxable income from interest and dividends, subject to the provisions of
an applicable double tax treaty.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>U.S. Federal Income Tax Considerations</B></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The following is a summary of the material U.S. federal income tax
consequences relating to the ownership and disposition of our Ordinary Shares and ADSs by U.S. Holders, as defined below. This
summary addresses solely U.S. Holders who acquire ADSs pursuant to this offering and who hold Ordinary Shares or ADSs, as applicable,
as capital assets for U.S. federal income tax purposes. This summary is based on current provisions of the Internal Revenue Code
of 1986, as amended (&ldquo;Code&rdquo;), current and proposed Treasury regulations promulgated thereunder, and administrative
and judicial decisions as of the date hereof, all of which are subject to change, possibly on a retroactive basis. In addition,
this section is based in part upon representations of the Depositary and the assumption that each obligation in the deposit agreement
and any related agreement will be performed in accordance with its terms. This summary does not address all U.S. federal income
tax matters that may be relevant to a particular holder or all tax considerations that may be relevant with respect to an investment
in our Ordinary Shares or ADSs.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">This summary does not address tax considerations applicable to a
holder of our Ordinary Shares or ADSs that may be subject to special tax rules including, without limitation, the following:</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR>
    <TD STYLE="text-align: center; width: 4%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify; width: 96%">dealers or traders in securities, currencies or notional principal contracts;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">financial institutions;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">insurance companies;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">real estate investment trusts;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">banks;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">persons subject to the alternative minimum tax;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">tax-exempt organizations;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">traders that have elected mark-to-market accounting;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">investors that hold Ordinary Shares or ADSs as part of a &ldquo;straddle&rdquo;, &ldquo;hedge&rdquo;, or &ldquo;conversion transaction&rdquo; with other investments;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">regulated investment companies;</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">persons that actually or constructively own 10 percent or more of our voting shares; and</TD></TR>
<TR>
    <TD STYLE="text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="vertical-align: middle; text-align: justify">persons whose functional currency is not the U.S. dollar.</TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">This summary does not address the effect of any U.S. federal taxation
other than U.S. federal income taxation. In addition, this summary does not address any state, local, or foreign tax consequences
to a holder of our Ordinary Shares or ADSs.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>You are urged to consult your own tax advisor regarding the foreign
and U.S. federal, state, and local and other tax consequences of an investment in our Ordinary Shares or ADSs.</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">For purposes of this summary, a &ldquo;U.S. Holder&rdquo; means a beneficial owner of
an Ordinary Share or ADSs that is for U.S. federal income tax purposes:</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 48px; text-align: center; vertical-align: top">&bull;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">an individual who is a citizen or resident of the U.S.;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top">&bull;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">a corporation (or other entity taxable as a corporation for U.S. federal income tax purposes) created or organized in the U.S. or under the laws of the U.S. or any political subdivision thereof;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top">&bull;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">an estate, the income of which is subject to U.S. federal income tax regardless of its source; or</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; vertical-align: top">&bull;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">a trust (1) if (a) a court within the U.S. is able to exercise primary supervision over the administration of the trust and (b) one or more U.S. persons have the authority to control all substantial decisions of the trust or (2) that has a valid election in effect under applicable U.S. Treasury regulations to be treated as a U.S. person.</FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">If an entity that is classified as a partnership for U.S. federal
tax purposes holds Ordinary Shares or ADSs, the U.S. federal tax treatment of its partners will generally depend upon the status
of the partners and the activities of the partnership. Entities that are classified as partnerships for U.S. federal tax purposes
and persons holding Ordinary Shares or ADSs through such entities should consult their own tax advisors.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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    <!-- Field: /Page -->

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><B><I>Taxation of ADSs</I></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><I>Exchange of ADSs for Ordinary Shares</I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">In general, for U.S. federal income tax purposes, if you hold ADSs,
you will be treated as the holder of the underlying Ordinary Shares represented by those ADSs. Accordingly, gain or loss generally
will not be recognized if you exchange ADSs for the underlying Ordinary Shares represented by those ADSs or ADSs for Ordinary Shares.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I>Distributions</I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Subject to the discussion under &ldquo;Passive Foreign Investment
Companies&rdquo; below, the gross amount of any distribution, including the amount of any Israeli taxes withheld from such distribution
(see &ldquo;Israeli Tax Considerations&rdquo;), actually or constructively received by a U.S. Holder with respect to our Ordinary
Shares (or, in the case of ADSs, received by the Depositary) will be taxable to the U.S. Holder as foreign source dividend income
to the extent of our current and accumulated earnings and profits as determined under U.S. federal income tax principles. The U.S.
Holder will not be eligible for any dividends received deduction in respect of the dividends paid by us. Distributions in excess
of earnings and profits will be non-taxable to the U.S. Holder to the extent of the U.S. Holder&rsquo;s adjusted tax basis in its
Ordinary Shares or ADSs. Distributions in excess of such adjusted tax basis will generally be taxable to the U.S. Holder as capital
gain from the sale or exchange of property as described below under &ldquo;Sale or Other Disposition of Ordinary Shares or ADSs.&rdquo;
If we do not report to a U.S. Holder the portion of a distribution that exceeds earnings and profits, the distribution will generally
be taxable as a dividend. The amount of any distribution of property other than cash will be the fair market value of that property
on the date of distribution.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Under the Code, certain dividends received by non-corporate U.S.
Holders will be subject to a maximum federal income tax rate of 20%. This reduced income tax rate is only applicable to dividends
paid by a &ldquo;qualified foreign corporation&rdquo; that is not a PFIC for the year in which the dividend is paid or for the
preceding taxable year, and only with respect to Ordinary Shares or ADSs held by a qualified U.S. Holder (i.e., a non-corporate
holder) for a minimum holding period (generally 61 days during the 121-day period beginning 60 days before the ex-dividend date).
As discussed below, however, we believe we may be a &ldquo;passive foreign investment company&rdquo; (see &ldquo;Passive Foreign
Investment Companies&rdquo; below) for our current taxable year and future taxable years. Accordingly, dividends paid by us to
non-corporate U.S. Holders may not be eligible for the reduced income tax rate applicable to qualified dividends. You should consult
your own tax advisor regarding the availability of this preferential tax rate under your particular circumstances.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The amount of any distribution paid in a currency other than U.S.
dollars (a &ldquo;foreign currency&rdquo;), including the amount of any withholding tax thereon, will be included in the gross
income of a U.S. Holder in an amount equal to the U.S. dollar value of the foreign currency calculated by reference to the exchange
rate in effect on the date of the U.S. Holder&rsquo;s (or, in the case of ADSs, the Depositary&rsquo;s) receipt of the dividend,
regardless of whether the foreign currency is converted into U.S. dollars. If the foreign currency is converted into U.S. dollars
on the date of receipt, a U.S. Holder generally should not be required to recognize a foreign currency gain or loss in respect
of the dividend. If the foreign currency received in the distribution is not converted into U.S. dollars on the date of receipt,
a U.S. Holder will have a basis in the foreign currency equal to its U.S. dollar value on the date of receipt. Any gain or loss
on a subsequent conversion or other disposition of the foreign currency will be treated as U.S. source ordinary income or loss.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Subject to certain conditions and limitations, any Israeli taxes
withheld on dividends may be creditable against a U.S. Holder&rsquo;s U.S. federal income tax liability, subject to generally applicable
limitations. The rules relating to foreign tax credits and the timing thereof are complex. U.S. Holders should consult their own
tax advisors regarding the availability of a foreign tax credit in their particular situation.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><I>Sale or Other Disposition of Ordinary Shares or ADSs</I></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Subject to the discussion under &ldquo;Passive Foreign Investment
Companies&rdquo; below, if a U.S. Holder sells or otherwise disposes of its Ordinary Shares or ADSs, gain or loss will be recognized
for U.S. federal income tax purposes in an amount equal to the difference between the amount realized on the sale or other disposition
and such holder&rsquo;s adjusted basis in the Ordinary Shares or ADSs. Such gain or loss generally will be a capital gain or loss,
and will be a long-term capital gain or loss if the holder had held the Ordinary Shares or ADSs for more than one year at the time
of the sale or other disposition. Long-term capital gains realized by non-corporate U.S. Holders are generally subject to a preferential
U.S. federal income tax rate. In general, gain or loss recognized by a U.S. Holder on the sale or other disposition or our Ordinary
Shares or ADSs will be U.S. source gain or loss for purposes of the foreign tax credit limitation. As discussed below in &ldquo;Passive
Foreign Investment Companies,&rdquo; however, we may be a PFIC for our current taxable year and future taxable years. If we are
a PFIC, any such gain will be subject to the PFIC rules, as discussed below, rather than being taxed as a capital gain.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">If a U.S. Holder receives foreign currency upon a sale or exchange
of Ordinary Shares or ADSs, gain or loss will be recognized in the manner described above under &ldquo;Distributions.&rdquo; However,
if such foreign currency is converted into U.S. dollars on the date received by the U.S. Holder, the U.S. Holder generally should
not be required to recognize any foreign currency gain or loss on such conversion.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">As discussed above under the heading &ldquo;Israeli Tax Considerations-Taxation
of Shareholders,&rdquo; a U.S. Holder who holds Ordinary Shares or ADSs through an Israeli broker or other Israeli intermediary
may be subject to Israeli withholding tax on any capital gains recognized on a sale or other disposition of the Ordinary Shares
or ADSs if the U.S. Holder does not obtain approval of an exemption from the Israeli Tax Authorities or claim any allowable refunds
or reductions. U.S. Holders are advised that any Israeli tax paid under circumstances in which an exemption from (or a refund of
or a reduction in) such tax was available will not be creditable for U.S. federal income tax purposes. U.S. Holders are advised
to consult their Israeli broker or intermediary regarding the procedures for obtaining an exemption or reduction.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><I>Medicare Tax on Unearned Income</I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Certain U.S. Holders that are individuals, estates or trusts are
required to pay an additional 3.8% tax on their net investment income, which would include dividends paid on the Ordinary Shares
or ADSs and capital gains from the sale or other disposition of the Ordinary Shares or ADSs.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I>Passive Foreign Investment Companies</I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Based on the value and composition of our assets, we may be a PFIC
for U.S. federal income tax purposes for our current taxable year and future taxable years. A non-U.S. corporation is considered
a PFIC for any taxable year if either:</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 48px; text-align: center; vertical-align: top">&bull;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">at least 75% of its gross income for such taxable year is passive income, or</FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 48px; text-align: center; vertical-align: top">&bull;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">at least 50% of the value of its assets (based on an average of the quarterly values of the assets during a taxable year) is attributable to assets that produce or are held for the production of passive income.</FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">For purposes of the above calculations, if a non-U.S. corporation
owns, directly or indirectly, 25% or more of the total value of the outstanding shares of another corporation, it will be treated
as if it (a)&nbsp;held a proportionate share of the assets of such other corporation and (b)&nbsp;received directly a proportionate
share of the income of such other corporation. Passive income generally includes dividends, interest, rents, royalties and capital
gains, but generally excludes rents and royalties which are derived in the active conduct of a trade or business and which are
received from a person other than a related person.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">A separate determination must be made each taxable year as to whether
we are a PFIC (after the close of each such taxable year). Because the value of our assets for purposes of the asset test will
generally be determined by reference to the market price of our Ordinary Shares, our PFIC status will depend in large part on the
market price of the Ordinary Shares, which may fluctuate significantly. Based on our retention of a significant amount of cash
and cash equivalents, and depending on the market price of our Ordinary Shares, we may be a PFIC for the current taxable year and
future taxable years.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">If we are a PFIC for any year during which you hold the ADSs or
Ordinary Shares, we generally will continue to be treated as a PFIC with respect to you for all succeeding years during which you
hold the ADSs or Ordinary Shares, unless we cease to be a PFIC and you make a &ldquo;deemed sale&rdquo; election with respect to
the ADSs or Ordinary Shares you hold. If such election is made, you will be deemed to have sold the ADSs or Ordinary Shares you
hold at their fair market value on the last day of the last taxable year in which we qualified as a PFIC, and any gain from such
deemed sale would be subject to the consequences described below. After the deemed sale election, the ADSs or Ordinary Shares with
respect to which the deemed sale election was made will not be treated as shares in a PFIC unless we subsequently become a PFIC.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">For each taxable year for which we are treated as a PFIC with respect
to you, you will be subject to special tax rules with respect to any &ldquo;excess distribution&rdquo; you receive and any gain
you realize from a sale or other disposition (including a pledge) of the ADSs or Ordinary Shares, unless you make a &ldquo;mark-to-market&rdquo;
election as discussed below. Distributions you receive in a taxable year that are greater than 125% of the average annual distributions
you received during the shorter of the three preceding taxable years or your holding period for the ADSs or Ordinary Shares will
be treated as an excess distribution. Under these special tax rules, if you receive any excess distribution or realize any gain
from a sale or other disposition of the ADSs or Ordinary Shares:</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 48px; text-align: center; vertical-align: top">&bull;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">the excess distribution or gain will be allocated ratably over your holding period for the ADSs or Ordinary Shares,</FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 48px; text-align: center; vertical-align: top">&bull;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">the amount of excess distribution or gain allocated to the current taxable year, and any taxable year before the first taxable year in which we were a PFIC, will be included in gross income (as ordinary income) for the current tax year, and</FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 48px; text-align: center; vertical-align: top">&bull;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">the amount allocated to each other year will be subject to the highest tax rate in effect for that year
and the interest charge generally applicable to underpayments of tax will be imposed on the resulting tax attributable thereto</FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The tax liability for amounts allocated to years before the year
of disposition or &ldquo;excess distribution&rdquo; cannot be offset by any net operating losses for such years, and gains (but
not losses) realized on the sale of the ADSs or Ordinary Shares cannot be treated as capital, even if you hold the ADSs or Ordinary
Shares as capital assets.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">If we are treated as a PFIC with respect to you for any taxable
year, to the extent any of our subsidiaries, if any, are also PFICs, you will be deemed to own your proportionate share of any
such lower-tier PFIC, and you may be subject to the rules described in the preceding two paragraphs with respect to the shares
of such lower-tier PFICs you would be deemed to own. As a result, you may incur liability for any &ldquo;excess distribution&rdquo;
described above if we receive a distribution from such lower-tier PFICs or if any shares in such lower-tier PFICs are disposed
of (or deemed disposed of). You should consult your own tax advisor regarding the application of the PFIC rules to any of our subsidiaries.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Alternatively, a U.S. Holder of &ldquo;marketable stock&rdquo; (as
defined below) in a PFIC may make a mark-to-market election for such stock to elect out of the general tax treatment for PFICs
discussed above. If you make a mark-to-market election for the ADSs, you will include in income for each year we are a PFIC an
amount equal to the excess, if any, of the fair market value of the ADSs as of the close of your taxable year over your adjusted
basis in such ADSs. You are allowed a deduction for the excess, if any, of the adjusted basis of the ADSs over their fair market
value as of the close of the taxable year. However, deductions are allowable only to the extent of any net mark-to-market gains
on the ADSs included in your income for prior taxable years. Amounts included in your income under a mark-to-market election, as
well as gain on the actual sale or other disposition of the ADSs, are treated as ordinary income. Ordinary loss treatment also
applies to the deductible portion of any mark-to-market loss on the ADSs, as well as to any loss realized on the actual sale or
disposition of the ADSs to the extent the amount of such loss does not exceed the net mark-to-market gains previously included
for the ADSs. Your basis in the ADSs will be adjusted to reflect any such income or loss amounts. If you make a valid mark-to-market
election, the tax rules that apply to distributions by corporations which are not PFICs would apply to distributions by us, except
the lower applicable tax rate for qualified dividend income would not apply. If we cease to be a PFIC when you have a mark-to-market
election in effect, gain or loss realized by you on the sale of the ADSs will be a capital gain or loss and taxed in the manner
described above under &ldquo;Sale or Other Disposition of Ordinary Shares or ADSs.&rdquo;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The mark-to-market election is available only for &ldquo;marketable
stock,&rdquo; which is stock that is traded in other than de minimis quantities on at least 15 days during each calendar quarter,
or regularly traded, on a qualified exchange or other market, as defined in applicable U.S. Treasury regulations. Any trades that
have as their principal purpose meeting this requirement will be disregarded. The ADSs are listed on The NASDAQ and, accordingly,
provided the ADSs are regularly traded, if you are a holder of ADSs, the mark-to-market election would be available to you if we
are a PFIC. Once made, the election cannot be revoked without the consent of the IRS unless the ADSs cease to be marketable stock.
If we are a PFIC for any year in which the U.S. Holder owns ADSs but before a mark-to-market election is made, the interest charge
rules described above will apply to any mark-to-market gain recognized in the year the election is made. If any of our subsidiaries,
if any, are or become PFICs, the mark-to-market election will not be available with respect to the shares of such subsidiaries
that are treated as owned by you. Consequently, you could be subject to the PFIC rules with respect to income of the lower-tier
PFICs the value of which already had been taken into account indirectly via mark-to-market adjustments. A U.S. Holder should consult
its own tax advisors as to the availability and desirability of a mark-to-market election, as well as the impact of such election
on interests in any lower-tier PFICs.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">In certain circumstances, a U.S. Holder of stock in a PFIC can make
a &ldquo;qualified electing fund election&rdquo; to mitigate some of the adverse tax consequences of holding stock in a PFIC by
including in income its share of the corporation&rsquo;s income on a current basis. However, we do not currently intend to prepare
or provide the information that would enable you to make a qualified electing fund election.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Unless otherwise provided by the U.S. Treasury, each U.S. shareholder
of a PFIC is required to file an annual report containing such information as the U.S. Treasury may require. A U.S. Holder&rsquo;s
failure to file the annual report will cause the statute of limitations for such U.S. Holder&rsquo;s U.S. federal income tax return
to remain open with regard to the items required to be included in such report until three years after the U.S. Holder files the
annual report, and, unless such failure is due to reasonable cause and not willful neglect, the statute of limitations for the
U.S. Holder&rsquo;s entire U.S. federal income tax return will remain open during such period. U.S. Holders should consult their
own tax advisors regarding the requirements of filing such information returns under these rules, taking into account the uncertainty
as to whether we are currently treated as or may become a PFIC.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">YOU ARE STRONGLY URGED TO CONSULT YOUR OWN TAX ADVISOR REGARDING
THE IMPACT OF OUR POTENTIAL PFIC STATUS ON YOUR INVESTMENT IN THE ADSs AS WELL AS THE APPLICATION OF THE PFIC RULES TO YOUR INVESTMENT
IN THE ADSs.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><I>Backup Withholding and Information Reporting</I></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Payments of dividends with respect to Ordinary Shares or ADSs and
the proceeds from the sale, retirement, or other disposition of Ordinary Shares or ADSs made by a U.S. paying agent or other U.S.
intermediary will be reported to the IRS and to the U.S. Holder as may be required under applicable U.S. Treasury regulations.
We, or an agent, a broker, or any paying agent, as the case may be, may be required to withhold tax (backup withholding), currently
at the rate of 28%, if a non-corporate U.S. Holder that is not otherwise exempt fails to provide an accurate taxpayer identification
number and comply with other IRS requirements concerning information reporting. Certain U.S. Holders (including, among others,
corporations and tax-exempt organizations) are not subject to backup withholding. Any amount of backup withholding withheld may
be used as a credit against your U.S. federal income tax liability provided that the required information is furnished to the IRS.
U.S. Holders should consult their own tax advisors as to their qualification for exemption from backup withholding and the procedure
for obtaining an exemption.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">U.S. Holders may be required to file certain U.S. information reporting
returns with the IRS with respect to an investment in our Ordinary Shares or ADSs, including, among others, IRS Form 8938 (Statement
of Specified Foreign Financial Assets). As described above under &lsquo;&lsquo;Passive Foreign Investment Companies,&rdquo; each
U.S. Holder who is a shareholder of a PFIC must file an annual report containing certain information. U.S. Holders paying more
than $100,000 for our Ordinary Shares or ADSs may be required to file IRS Form 926 (Return by a U.S. Transferor of Property to
a Foreign Corporation) reporting this payment. Substantial penalties may be imposed upon a U.S. Holder that fails to comply with
the required information reporting.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">U.S. Holders should consult their own tax advisors regarding the
backup withholding tax and information reporting rules.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">EACH PROSPECTIVE INVESTOR IS URGED TO CONSULT ITS OWN TAX ADVISOR
REGARDING THE TAX CONSEQUENCES OF AN INVESTMENT IN OUR ORDINARY SHARES OR ADSs IN LIGHT OF SUCH INVESTOR&rsquo;S PARTICULAR CIRCUMSTANCES.</P>


<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B><A NAME="a_014"></A>UNDERWRITING</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">Subject to the terms and conditions set forth
in the underwriting agreement, dated November 8, 2017, among us and Cantor Fitzgerald &amp; Co., 499 Park Avenue, New York, New
York 10022 and Nomura Securities International, Inc., Worldwide Plaza, 309 West 49th Street, New York, New York 10019 as representatives
of the underwriters named below (the &ldquo;Representatives&rdquo;), we have agreed to sell to the underwriters, and each of the
underwriters has agreed, severally and not jointly, to purchase from us, the ADSs shown opposite its name below:</P>



<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 85%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; font-weight: bold; border-bottom: Black 1pt solid">Underwriter</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Number of ADSs</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 84%; font-size: 10pt; text-align: left">Cantor Fitzgerald &amp; Co.&#9;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 16%; font-size: 10pt; text-align: right">2,045,457</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Nomura Securities International, Inc.&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,227,272</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">SMBC Nikko Securities America, Inc.&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">409,090</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">H.C. Wainwright &amp; Co., LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">204,545</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; padding-bottom: 1pt">Roth Capital Partners, LLC&#9;</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: right">204,545</TD><TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; padding-bottom: 2.25pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Total&#9;</TD><TD STYLE="font-size: 10pt; padding-bottom: 2.25pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 2.25pt double; font-size: 10pt; text-align: right">4,090,909</TD><TD STYLE="border-bottom: Black 2.25pt double; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>



<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">The underwriting agreement provides that the obligations of the several
underwriters are subject to certain conditions precedent such as the receipt by the underwriters of officers&rsquo; certificates
and legal opinions and approval of certain legal matters by their counsel. The underwriting agreement provides that the underwriters
will purchase all of the ADSs if any of them are purchased. We have agreed to indemnify the underwriters and certain of their controlling
persons against certain liabilities, including liabilities under the Securities Act, and to contribute to payments that the underwriters
may be required to make in respect of those liabilities.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">The underwriters are offering the ADSs subject to their acceptance
of the ADSs from us and subject to prior sale. The underwriters reserve the right to withdraw, cancel or modify offers to the public
and to reject orders in whole or in part. In addition, the underwriters have advised us that they do not intend to confirm sales
to any account over which they exercise discretionary authority. The underwriters may offer and sell the ADSs through certain of
their respective affiliates or selling agents.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">Three of our directors have agreed to purchase 209,090 ADSs in the aggregate in this offering. The underwriters
will receive the same underwriting discount on any ADSs purchased by these persons as they will on the other ADSs sold to the public
in this offering.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>Settlement</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">We expect to deliver the ADSs against payment
for the notes on or about November&nbsp;13, 2017, which will be the third business day following the date of the pricing of the
ADSs (such settlement cycle being referred to as T+3). Under Rule&nbsp;15c6-1&nbsp;of the Exchange Act, trades in secondary market
generally are required to settle in two business days, unless the parties to any such trade expressly agree otherwise. Accordingly,
purchasers who wish to trade ADSs prior to the second business day before the settlement date will be required, by virtue of the
fact that the ADSs initially will settle in T+3, to specify alternative settlement arrangements to prevent a failed settlement.
Purchasers of the ADSs who wish to trade the ADSs prior to the date of delivery hereunder should consult their own advisors.</P>



<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>



<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Option to Purchase Additional ADSs</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">We have granted to the underwriters an option,
exercisable 30 days from the date of this prospectus supplement, to purchase, from time to time, in whole or in part, up to an
aggregate of&nbsp;613,636&nbsp;ADSs from us at the public offering price set forth on the cover page of this prospectus supplement,
less underwriting discounts and commissions. If the underwriters exercise this option, each underwriter will be obligated, subject
to certain conditions, to purchase a number of additional ADSs approximately proportionate to that underwriter&rsquo;s initial
purchase commitment as indicated in the table above.</P>



<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Commission and Expenses</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">The underwriters have advised us that they
propose to offer the ADSs to the public at the public offering price set forth on the cover page of this prospectus supplement
and to certain dealers, which may include the underwriters, at that price less a concession not in excess of $0.198 per ADS. After
the initial offering, the Representatives may change the offering price and other selling terms.</P>



<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">The following table shows the public offering price, the underwriting
discounts and commissions that we are to pay the underwriters and the proceeds, before expenses, to us in connection with this
offering. Such amounts are shown assuming both no exercise and full exercise of the underwriters&rsquo; option to purchase additional
ADSs.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Per ADS</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Total</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Without<BR> Option to <BR> Purchase <BR> Additional <BR> ADSs</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">With<BR> Option to <BR> Purchase <BR> Additional <BR> ADSs</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Without<BR> Option to <BR> Purchase <BR> Additional <BR> ADSs</TD><TD STYLE="font-size: 10pt; font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-size: 10pt; font-weight: bold; text-align: center; border-bottom: Black 1pt solid">With<BR> Option to <BR> Purchase <BR> Additional <BR> ADSs</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="font-size: 10pt">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 48%; font-size: 10pt">Public offering price&#9;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">5.50</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">5.50</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">22,500,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">$</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">25,874,998</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Underwriting discounts and commissions&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">0.33</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">0.33</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">1,350,000</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">1,552,500</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left">Proceeds to us, before expenses&#9;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">5.17</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">5.17</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">21,150,000</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">$</TD><TD STYLE="font-size: 10pt; text-align: right">24,322,498</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
</TABLE>



<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">We estimate expenses payable by us in
connection with this offering, other than the underwriting discounts and commissions referred to above, will be approximately
$0.5 million. This amount includes an additional fee we may elect to pay certain of the underwriters based on their efforts
and results of the offering of up to 1% of the aggregate gross proceeds we receive from this offering. Banks and brokers in
non-U.S. jurisdictions who raise capital in connection with this offering in such non-U.S. jurisdictions may be paid up to
$65,000. We have also granted Cantor the right to participate in future financings by us. Such additional fees and right are
deemed underwriting compensation for this offering by FINRA. In no event shall the total underwriter compensation, including
such additional fees and right, together with the underwriting discounts and commissions, exceed 8% of the offering
proceeds, which excludes any proceeds from the sales made under the option to purchase additional ADSs. The underwriters have
agreed to reimburse us for $40,000 for certain expenses relating to this offering.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"></P>



<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"></P>



<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Listing</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">Our ADSs are listed on the NASDAQ under the trading symbol &ldquo;RDHL&rdquo;
and our Ordinary Shares currently trade on the TASE in Israel under the symbol &ldquo;RDHL&rdquo;.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>No Sales of Similar Securities</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">We, our officers and our directors have agreed, subject to certain
specified exceptions, not to directly or indirectly, for a period of 90 days after the date of the underwriting agreement:</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&bull;</TD><TD STYLE="text-align: justify"><P STYLE="margin: 0pt 0">sell, offer, contract or grant any option to sell (including any short sale), pledge, transfer, establish
an open &ldquo;put equivalent position&rdquo; within the meaning of Rule 16a-1(h) under the Securities Exchange Act of 1934, as
amended, or otherwise dispose of, any Ordinary Shares or ADSs, options or warrants to acquire Ordinary Shares or ADSs, or securities
exchangeable or exercisable for or convertible into Ordinary Shares or ADSs currently or hereafter owned either of record or beneficially,</P>


</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&bull;</TD><TD STYLE="text-align: justify"><P STYLE="margin: 0pt 0">enter into any swap, hedge or other agreement or transaction that transfers, in whole or in part, the
economic consequence of ownership of Ordinary Shares or ADSs, or securities exchangeable or exercisable for or convertible into
Ordinary Shares or ADSs, or</P>


</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&bull;</TD><TD STYLE="text-align: justify">publicly announce an intention to do any of the foregoing for a period of 90 days after the date of this prospectus supplement
without the prior written consent of the underwriters.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">In addition, we and each such person agrees
that, without the prior written consent of the underwriters, we or such other person will not, during the restricted period, make
any demand for, or exercise any right with respect to, the registration of any Ordinary Shares or ADSs or any security convertible
into or exercisable or exchangeable for Ordinary Shares or ADSs.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">The restrictions in the immediately preceding paragraph do not apply
in certain circumstances, including, with respect to directors and officers:</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&bull;</TD><TD STYLE="text-align: justify">dispositions solely in connection with the &ldquo;cashless&rdquo; exercise of stock options,</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&bull;</TD><TD STYLE="text-align: justify"><P STYLE="margin: 0pt 0">transfers of Ordinary Shares or ADSs or any security convertible into or exercisable or exchangeable for
Ordinary Shares or ADSs acquired in open market transactions after the completion of this offering,</P>


</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&bull;</TD><TD STYLE="text-align: justify">transfers pursuant to a bona fide third-party tender offer, merger, consolidation or other similar transaction made to all
holders of our capital stock involving a change of control,</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&bull;</TD><TD STYLE="text-align: justify">transfers to certain affiliates,</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&bull;</TD><TD STYLE="text-align: justify">transfers by gift, will or intestate, or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&bull;</TD><TD STYLE="text-align: justify">transfers pursuant to a so-called &ldquo;living trust&rdquo; or other revocable trust.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">In our case, the restrictions described above do not apply in certain
circumstances, including:</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&bull;</TD><TD STYLE="text-align: justify">certain issuances pursuant to stock option plans, stock purchase or other equity incentive plans,</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&bull;</TD><TD STYLE="text-align: justify">issuances upon exercise of stock options issued under such stock option or other equity incentive plans,</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&bull;</TD><TD STYLE="text-align: justify"><P STYLE="margin: 0pt 0">issuances upon the exercise of outstanding warrants, convertible debentures and other outstanding instruments
convertible into or exercisable or exchangeable for Ordinary Shares or ADSs, or</P>


</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; text-align: justify">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.75in; text-align: justify"></TD><TD STYLE="width: 0.25in; text-align: justify">&bull;</TD><TD STYLE="text-align: justify"><P STYLE="margin: 0pt 0">issuances connection with strategic partnering transactions in an amount not to exceed 10% of our outstanding
Ordinary Shares or ADSs.</P>


</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font-size: 10pt; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">The Representatives may, in their sole discretion and at any time
or from time to time before the termination of the 90-day period release all or any portion of the securities subject to lock-up
agreements.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Market Making, Stabilization and Other Transactions</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">The underwriters may make a market in the ADSs as permitted by applicable
laws and regulations. However, the underwriters are not obligated to do so, and the underwriters may discontinue any market-making
activities at any time without notice in their sole discretion. Accordingly, no assurance can be given as to the liquidity of the
trading market for the ADSs, that you will be able to sell any of the ADSs held by you at a particular time or that the prices
that you receive when you sell will be favorable.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">The underwriters have advised us that they, pursuant to Regulation
M under the Securities Exchange Act of 1934, as amended, may engage in short sale transactions, stabilizing transactions, syndicate
covering transactions or the imposition of penalty bids in connection with this offering. These activities may have the effect
of stabilizing or maintaining the market price of the ADSs at a level above that which might otherwise prevail in the open market.
Establishing short sales positions may involve either &ldquo;covered&rdquo; short sales or &ldquo;naked&rdquo; short sales.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&ldquo;Covered&rdquo; short sales are sales made in an amount not
greater than the underwriters&rsquo; option to purchase additional ADSs in this offering. The underwriters may close out any covered
short position by either exercising their option to purchase additional ADSs or purchasing our ADSs in the open market. In determining
the source of ADSs to close out the covered short position, the underwriters will consider, among other things, the price of ADSs
available for purchase in the open market as compared to the price at which they may purchase ADSs through the option to purchase
additional ADSs.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">&ldquo;Naked&rdquo; short sales are sales in
excess of the option to purchase additional ADSs. The underwriters must close out any naked short position by purchasing shares
in the open market. A naked short position is more likely to be created if the underwriters are concerned that there may be downward
pressure on the price of the ADSs in the open market after pricing that could adversely affect investors who purchase ADSs in this
offering.</P>



<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">A stabilizing bid is a bid for the purchase of ADSs on behalf of
the underwriters for the purpose of fixing or maintaining the price of the ADSs. A syndicate covering transaction is the bid for
or the purchase of ADSs on behalf of the underwriters to reduce a short position incurred by the underwriters in connection with
the offering. Similar to other purchase transactions, the underwriters&rsquo; purchases to cover the syndicate short sales may
have the effect of raising or maintaining the market price of our ADSs or preventing or retarding a decline in the market price
of our ADSs. As a result, the price of our ADSs may be higher than the price that might otherwise exist in the open market. A penalty
bid is an arrangement permitting the underwriters to reclaim the selling concession otherwise accruing to a syndicate member in
connection with the offering if the ADSs originally sold by such syndicate member are purchased in a syndicate covering transaction
and therefore have not been effectively placed by such syndicate member.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">Neither we, nor any of the underwriters make any representation or
prediction as to the direction or magnitude of any effect that the transactions described above may have on the price of our ADSs.
The underwriters are not obligated to engage in these activities and, if commenced, may end any of these activities at any time.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Passive Market Making</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">The underwriters may also engage in passive market making transactions
in our ADSs on the NASDAQ in accordance with Rule&nbsp;103 of Regulation&nbsp;M during a period before the commencement of offers
or sales of our ADSs in this offering and extending through the completion of distribution. A passive market maker must display
its bid at a price not in excess of the highest independent bid of that security. However, if all independent bids are lowered
below the passive market maker&rsquo;s bid that bid must then be lowered when specified purchase limits are exceeded. Passive market
making may cause the price of our ADSs to be higher than the price that otherwise would exist in the open market in the absence
of those transactions. The underwriters are not required to engage in passive market making and, if commenced, may end passive
market making activities at any time.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Electronic Distribution</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">A prospectus in electronic format may be made
available by e-mail or on the web sites or through online services maintained by one or more of the underwriters, selling group
members (if any) or their affiliates. The underwriters may agree with us to allocate a specific number of ADSs for sale to online
brokerage account holders. Any such allocation for online distributions will be made by the underwriters on the same basis as other
allocations. Other than the prospectus in electronic format, the information on the underwriters&rsquo; web sites and any information
contained in any other web site maintained by any of the underwriters is not part of this prospectus supplement, has not been approved
and/or endorsed by us or the underwriters and should not be relied upon by investors.</P>



<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Other Activities and Relationships </B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">The underwriters and certain of their respective affiliates are full
service financial institutions engaged in a wide range of activities for their own accounts and the accounts of customers, which
may include, among other things, corporate finance, mergers and acquisitions, merchant banking, equity and fixed income sales,
trading and research, derivatives, foreign exchange, futures, asset management, custody, clearance and securities lending. The
underwriters and certain of their affiliates have, from time to time, performed, and may in the future perform, various investment
banking and financial advisory services for us and our affiliates, for which they received or will receive customary fees and expenses.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">In addition, in the ordinary course of their
business, the underwriters and their respective affiliates may, directly or indirectly, hold long or short positions, trade and
otherwise conduct such activities in or with respect to debt or equity securities and/or bank debt of, and/or derivative products.
Such investment and securities activities may involve our securities and instruments. The underwriters and their respective affiliates
may also make investment recommendations or publish or express independent research views in respect of such securities or instruments
and may at any time hold, or recommend to clients that they acquire, long or short positions in such securities and instruments.</P>



<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Stamp Taxes</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">If you purchase ADSs offered in this prospectus supplement, you may
be required to pay stamp taxes and other charges under the laws and practices of the country of purchase, in addition to the offering
price listed on the cover page of this prospectus supplement.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt">&nbsp;</DIV>
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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><A NAME="a_015"></A><B>NOTICE TO INVESTORS</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Canada</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-indent: 0.5in; text-align: justify">This prospectus supplement constitutes an &ldquo;exempt offering
document&rdquo; as defined in and for the purposes of applicable Canadian securities laws. No prospectus has been filed with any
securities commission or similar regulatory authority in Canada in connection with the offer and sale of the ADSs. No securities
commission or similar regulatory authority in Canada has reviewed or in any way passed upon this prospectus supplement or on the
merits of the ADSs and any representation to the contrary is an offence.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-indent: 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-indent: 0.5in; text-align: justify"><B>Canadian investors are advised that this prospectus supplement
has been prepared in reliance on section 3A.3 of National Instrument 33-105 <I>Underwriting Conflicts</I> (&ldquo;NI 33-105&rdquo;).
Pursuant to section 3A.3 of NI 33-105, this prospectus supplement is exempt from the requirement that the Company and the underwriter(s)
provide Canadian investors with certain conflicts of interest disclosure pertaining to &ldquo;connected issuer&rdquo; and/or &ldquo;related
issuer&rdquo; relationships that may exist between the Company and the underwriter(s) as would otherwise be required pursuant to
subsection 2.1(1) of NI 33-105.</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-indent: 0.5in; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"><B>Resale Restrictions</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-indent: 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-indent: 0.5in; text-align: justify">The offer and sale of the ADSs in Canada is being made on a private
placement basis only and is exempt from the requirement that the Company prepares and files a prospectus under applicable Canadian
securities laws. Any resale of the ADSs acquired by a Canadian investor in this offering must be made in accordance with applicable
Canadian securities laws, which may vary depending on the relevant jurisdiction, and which may require resales to be made in accordance
with Canadian prospectus requirements, pursuant to a statutory exemption from the prospectus requirements, in a transaction exempt
from the prospectus requirements or otherwise under a discretionary exemption from the prospectus requirements granted by the applicable
local Canadian securities regulatory authority. These resale restrictions may under certain circumstances apply to resales of the
ADSs outside of Canada.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"><B>Representations of Purchasers</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-indent: 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-indent: 0.5in; text-align: justify">Each Canadian investor who purchases the ADSs will be deemed to have
represented to the Company and the underwriter(s) that the investor (i) is purchasing the ADSs as principal, or is deemed to be
purchasing as principal in accordance with applicable Canadian securities laws, for investment only and not with a view to resale
or redistribution; (ii) is an &ldquo;accredited investor&rdquo; as such term is defined in section 1.1 of National Instrument 45-106
<I>Prospectus Exemptions </I>(&ldquo;NI 45-106&rdquo;) or, in Ontario, as such term is defined in section 73.3(1) of the <I>Securities
Act </I>(Ontario); and (iii) is a &ldquo;permitted client&rdquo; as such term is defined in section 1.1 of National Instrument
31-103 <I>Registration Requirements, Exemptions and Ongoing Registrant Obligations</I>.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"><B>Taxation and Eligibility for Investment</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-indent: 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-indent: 0.5in; text-align: justify">Any discussion of taxation and related matters contained in this
prospectus supplement does not purport to be a comprehensive description of all of the tax considerations that may be relevant
to a Canadian investor when deciding to purchase the ADSs and, in particular, does not address any Canadian tax considerations.
No representation or warranty is hereby made as to the tax consequences to a resident, or deemed resident, of Canada of an investment
in the ADSs or with respect to the eligibility of the ADSs for investment by such investor under relevant Canadian federal and
provincial legislation and regulations.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"><B>Rights of Action for Damages or Rescission</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-indent: 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-indent: 0.5in; text-align: justify">Securities legislation in certain of the Canadian jurisdictions provides
certain purchasers of securities pursuant to an offering memorandum (such as this prospectus supplement), including where the distribution
involves an &ldquo;eligible foreign security&rdquo; as such term is defined in Ontario Securities Commission Rule 45-501 <I>Ontario
Prospectus and Registration Exemptions</I> and in Multilateral Instrument 45-107 <I>Listing Representation and Statutory Rights
of Action Disclosure Exemptions</I>, as applicable, with a remedy for damages or rescission, or both, in addition to any other
rights they may have at law, where the offering memorandum, or other offering document that constitutes an offering memorandum,
and any amendment thereto, contains a &ldquo;misrepresentation&rdquo; as defined under applicable Canadian securities laws. These
remedies, or notice with respect to these remedies, must be exercised or delivered, as the case may be, by the purchaser within
the time limits prescribed under, and are subject to limitations and defences under, applicable Canadian securities legislation.
In addition, these remedies are in addition to and without derogation from any other right or remedy available at law to the investor.</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify"><B>Language of Documents</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-indent: 0.5in; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-indent: 0.5in; text-align: justify">Upon receipt of this document, each Canadian investor hereby confirms
that it has expressly requested that all documents evidencing or relating in any way to the sale of the securities described herein
(including for greater certainty any purchase confirmation or any notice) be drawn up in the English language only. <I>Par la r&eacute;ception
de ce document, chaque investisseur Canadien confirme par les pr&eacute;sentes qu&rsquo;il a express&eacute;ment exig&eacute; que
tous les documents faisant foi ou se rapportant de quelque mani&egrave;re que ce soit &agrave; la vente des valeurs mobili&egrave;res
d&eacute;crites aux pr&eacute;sentes (incluant, pour plus de certitude, toute confirmation d'achat ou tout avis) soient r&eacute;dig&eacute;s
en anglais seulement.</I></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Australia</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">This prospectus is not a disclosure document for the purposes of
Australia&rsquo;s Corporations Act 2001 (Cth) of Australia, or Corporations Act, has not been lodged with the Australian Securities
&amp; Investments Commission and is only directed to the categories of exempt persons set out below. Accordingly, if you receive
this prospectus in Australia:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.25in; margin: 0pt 0; text-align: justify">You confirm and warrant that you are either:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="font-size: 10pt; text-align: center; width: 4%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; vertical-align: middle; text-align: justify; width: 96%">a &ldquo;sophisticated investor&rdquo; under section 708(8)(a) or (b) of the Corporations Act;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt; text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; vertical-align: middle; text-align: justify">a &ldquo;sophisticated investor&rdquo; under section 708(8)(c) or (d) of the Corporations Act and that you have provided an accountant&rsquo;s certificate to the company which complies with the requirements of section 708(8)(c)(i) or (ii) of the Corporations Act and related regulations before the offer has been made; or</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt; text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; vertical-align: middle; text-align: justify">a &ldquo;professional investor&rdquo; within the meaning of section 708(11)(a) or (b) of the Corporations Act.</TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B></B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-indent: 0.25in; margin: 0pt 0; text-align: justify">To the extent that you are unable to confirm or warrant that you
are an exempt sophisticated investor or professional investor under the Corporations Act any offer made to you under this prospectus
is void and incapable of acceptance.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.25in; margin: 0pt 0; text-align: justify">You warrant and agree that you will not offer any of the ADSs issued
to you pursuant to this prospectus for resale in Australia within 12 months of those securities being issued unless any such resale
offer is exempt from the requirement to issue a disclosure document under section 708 of the Corporations Act.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>European Economic Area</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.25in; margin: 0pt 0; text-align: justify">In relation to each member state of the European Economic Area which
has implemented the Prospectus Directive, each referred to herein as a Relevant Member State, with effect from and including the
date on which the Prospectus Directive is implemented in that Relevant Member State, referred to herein as the Relevant Implementation
Date, no offer of any securities which are the subject of the offering contemplated by this prospectus has been or will be made
to the public in that Relevant Member State other than any offer where a prospectus has been or will be published in relation to
such securities that has been approved by the competent authority in that Relevant Member State or, where appropriate, approved
in another Relevant Member State and notified to the relevant competent authority in that Relevant Member State in accordance with
the Prospectus Directive, except that with effect from and including the Relevant Implementation Date, an offer of such securities
may be made to the public in that Relevant Member State:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="font-size: 10pt; text-align: justify; width: 4%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; vertical-align: middle; text-align: justify; width: 96%">to any legal entity which is a &ldquo;qualified investor&rdquo; as defined in the Prospectus Directive;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt; text-align: justify; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; vertical-align: middle; text-align: justify">to fewer than 100 or, if the Relevant Member State has implemented the relevant provision of the 2010 PD Amending Directive, 150, natural or legal persons (other than qualified investors as defined in the Prospectus Directive), as permitted under the Prospectus Directive, subject to obtaining the prior consent of the representatives of the underwriters for any such offer; or</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt; text-align: justify; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; vertical-align: middle; text-align: justify">in any other circumstances falling within Article 3(2) of the Prospectus Directive,</TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">provided that no such offer of securities shall require the Company or any of the underwriters
to publish a prospectus pursuant to Article 3 of the Prospectus Directive or supplement a prospectus pursuant to Article 16 of
the Prospectus Directive.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">For the purposes of this provision, the expression an &ldquo;offer
to the public&rdquo; in relation to any securities in any Relevant Member State means the communication in any form and by any
means of sufficient information on the terms of the offer and the securities to be offered so as to enable an investor to decide
to purchase or subscribe the securities, as the same may be varied in that Relevant Member State by any measure implementing the
Prospectus Directive in that Relevant Member State and the expression &ldquo;Prospectus Directive&rdquo; means Directive 2003/71/EC
(and amendments thereto, including the 2010 PD Amending Directive, to the extent implemented in the Relevant Member State), and
includes any relevant implementing measure in the Relevant Member State and the expression &ldquo;2010 PD Amending Directive&rdquo;
means Directive 2010/73/EU.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Hong Kong</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">No securities have been offered or sold, and no securities may be
offered or sold, in Hong Kong, by means of any document, other than to persons whose ordinary business is to buy or sell shares
or debentures, whether as principal or agent; or to &ldquo;professional investors&rdquo; as defined in the Securities and Futures
Ordinance (Cap. 571) of Hong Kong and any rules made under that Ordinance; or in other circumstances which do not result in the
document being a &ldquo;prospectus&rdquo; as defined in the Companies Ordinance (Cap. 32) of Hong Kong or which do not constitute
an offer to the public within the meaning of the Companies Ordinance (Cap.32) of Hong Kong. No document, invitation or advertisement
relating to the securities has been issued or may be issued or may be in the possession of any person for the purpose of issue
(in each case whether in Hong Kong or elsewhere), which is directed at, or the contents of which are likely to be accessed or read
by, the public of Hong Kong (except if permitted under the securities laws of Hong Kong) other than with respect to securities
which are or are intended to be disposed of only to persons outside Hong Kong or only to &ldquo;professional investors&rdquo; as
defined in the Securities and Futures Ordinance (Cap. 571) of Hong Kong and any rules made under that Ordinance.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">This prospectus has not been registered with the Registrar of Companies
in Hong Kong. Accordingly, this prospectus may not be issued, circulated or distributed in Hong Kong, and the securities may not
be offered for subscription to members of the public in Hong Kong. Each person acquiring the securities will be required, and is
deemed by the acquisition of the securities, to confirm that he is aware of the restriction on offers of the securities described
in this prospectus and the relevant offering documents and that he is not acquiring, and has not been offered any securities in
circumstances that contravene any such restrictions.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Japan</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">The offering has not been and will not be registered under the Financial
Instruments and Exchange Law of Japan (Law No. 25 of 1948 of Japan, as amended), or FIEL, and the Initial Purchaser will not offer
or sell any securities, directly or indirectly, in Japan or to, or for the benefit of, any resident of Japan (which term as used
herein means, unless otherwise provided herein, any person resident in Japan, including any corporation or other entity organized
under the laws of Japan), or to others for re-offering or resale, directly or indirectly, in Japan or to a resident of Japan, except
pursuant to an exemption from the registration requirements of, and otherwise in compliance with, the FIEL and any other applicable
laws, regulations and ministerial guidelines of Japan.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Singapore</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">This prospectus has not been and will not be lodged or registered
with the Monetary Authority of Singapore. Accordingly, this prospectus and any other document or material in connection with the
offer or sale, or the invitation for subscription or purchase of the securities may not be issued, circulated or distributed, nor
may the securities be offered or sold, or be made the subject of an invitation for subscription or purchase, whether directly or
indirectly, to the public or any member of the public in Singapore other than (i) to an institutional investor under Section 274
of the Securities and Futures Act, Chapter 289 of Singapore, or the SFA, (ii) to a relevant person as defined under Section 275(2),
or any person pursuant to Section 275(1A) of the SFA, and in accordance with the conditions, specified in Section 275 of the SFA,
or (iii) otherwise pursuant to, and in accordance with the conditions of any other applicable provision of the SFA.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.25in; margin: 0pt 0; text-align: justify">Where the securities are subscribed or purchased under Section 275
of the SFA by a relevant person which is:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="font-size: 10pt; text-align: center; width: 4%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; vertical-align: middle; text-align: justify; width: 96%">a corporation (which is not an accredited investor as defined under Section 4A of the SFA) the sole business of which is to hold investments and the entire share capital of which is owned by one or more individuals, each of whom is an accredited investor; or</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt; text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; vertical-align: middle; text-align: justify">a trust (where the trustee is not an accredited investor) whose sole purpose is to hold investments and each beneficiary is an accredited investor,&nbsp;</TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">shares, debentures and units of shares and debentures of that corporation or the beneficiaries&rsquo;
rights and interest in that trust shall not be transferable for six months after that corporation or that trust has acquired the
Offer Shares under Section 275 of the SFA except:</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"></P>

<TABLE BORDER="0" CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="font-size: 10pt; text-align: center; width: 4%; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; vertical-align: middle; text-align: justify; width: 96%">to an institutional investor under Section 274 of the SFA or to a relevant person defined in Section 275(2) of the SFA, or to any person pursuant to an offer that is made on terms that such shares, debentures and units of shares and debentures of that corporation or such rights and interest in that trust are acquired at a consideration of not less than $200,000 (or its equivalent in a foreign currency) for each transaction, whether such amount is to be paid for in cash or by exchange of securities or other assets, and further for corporations, in accordance with the conditions, specified in Section 275 of the SFA;</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt; text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; vertical-align: middle; text-align: justify">where no consideration is given for the transfer; or</TD></TR>
<TR>
    <TD STYLE="font-size: 10pt; text-align: center; vertical-align: top">&bull;&nbsp;</TD>
    <TD STYLE="font-size: 10pt; vertical-align: middle; text-align: justify">where the transfer is by operation of law.</TD></TR>
</TABLE>


<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0 0pt 0.5in"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0 0pt 0.5in">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Switzerland</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">The securities may not be publicly offered in Switzerland and will
not be listed on the SIX Swiss Exchange, or SIX, or on any other stock exchange or regulated trading facility in Switzerland. This
prospectus has been prepared without regard to the disclosure standards for issuance prospectuses under art. 652a or art. 1156
of the Swiss Code of Obligations or the disclosure standards for listing prospectuses under art. 27 ff. of the SIX Listing Rules
or the listing rules of any other stock exchange or regulated trading facility in Switzerland. Neither this prospectus nor any
other offering or marketing material relating to the securities or the offering may be publicly distributed or otherwise made publicly
available in Switzerland.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">Neither this prospectus nor any other offering or marketing material
relating to the offering, the Company or the securities have been or will be filed with or approved by any Swiss regulatory authority.
In particular, this prospectus will not be filed with, and the offer of securities will not be supervised by, the Swiss Financial
Market Supervisory Authority FINMA, or FINMA, and the offer of securities has not been and will not be authorized under the Swiss
Federal Act on Collective Investment Schemes, or CISA. The investor protection afforded to acquirers of interests in collective
investment schemes under the CISA does not extend to acquirers of securities.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>Israel</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">This document does not constitute a prospectus under the Israeli
Securities Law, 5728-1968, or the Securities Law, and has not been filed with or approved by the Israel Securities Authority. In
the State of Israel, this document is being distributed only to, and is directed only at, and any offer of the ADSs is directed
only at, investors listed in the first addendum, or the Addendum, to the Israeli Securities Law, consisting primarily of joint
investment in trust funds, provident funds, insurance companies, banks, portfolio managers, investment advisors, members of the
Tel Aviv Stock Exchange, underwriters, venture capital funds, entities with equity in excess of NIS 50 million and &ldquo;qualified
individuals&rdquo;, each as defined in the Addendum (as it may be amended from time to time), collectively referred to as qualified
investors (in each case purchasing for their own account or, where permitted under the Addendum, for the accounts of their clients
who are investors listed in the Addendum). Qualified investors will be required to submit written confirmation that they fall within
the scope of the Addendum, are aware of the meaning of same and agree to it.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify"><B>United Kingdom</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">This prospectus is only being distributed to, and is only directed
at, persons in the United Kingdom that are</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">qualified investors (as defined in the Prospectus Directive) that are also (i) investment
professionals falling within Article 19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005, as
amended, referred to herein as the Order, and/or (ii) high net worth entities falling within Article 49(2)(a) to (d) of the Order
and other persons to whom it may lawfully be communicated. Each such person is referred to herein as a Relevant Person.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font-size: 10pt; text-indent: 0.5in; margin: 0pt 0; text-align: justify">This prospectus and its contents are confidential and should not
be distributed, published or reproduced (in whole or in part) or disclosed by recipients to any other persons in the United Kingdom.
Any person in the United Kingdom that is not a Relevant Person should not act or rely on this document or any of its contents.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B></B></P>

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<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><A NAME="a_016"></A><B>LEGAL MATTERS</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Certain matters concerning this offering will be passed
upon for us by Haynes and Boone, LLP, New York, New York.&nbsp;The validity of the securities being offered by this
prospectus will be passed upon for us by Gross, Kleinhendler, Hodak, Halevy, Greenberg &amp; Co., Tel Aviv, Israel. Legal
counsel to the underwriters are Covington &amp; Burling LLP, New York, New York, with respect to the U.S. law, and <FONT STYLE="background-color: white">Gornitzky
&amp; Co.</FONT>, Tel Aviv, Israel, with respect to Israeli law. Members of Covington &amp; Burling LLP are the beneficial
owner of an aggregate of less than 1% of our ordinary shares. </P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><A NAME="a_017"></A><B>EXPERTS</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The financial statements of RedHill Biopharma Ltd. incorporated
in this prospectus supplement by reference to the Annual Report on Form 20-F for the year ended December 31, 2016 have been so
incorporated in reliance on the report of Kesselman &amp; Kesselman, Certified Public Accountants (Isr.), a member firm of PricewaterhouseCoopers
International Limited, an independent registered public accounting firm, given on the authority of said firm as experts in auditing
and accounting.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B><A NAME="a_018"></A>WHERE</B>&nbsp;<B>YOU</B>&nbsp;<B>CAN</B>&nbsp;<B>FIND</B>&nbsp;<B>MORE</B>&nbsp;<B>INFORMATION</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We are subject to the informational requirements of the Securities
Exchange Act of 1934, as amended, and in accordance therewith file annual and special reports with, and furnish other information
to, the SEC. You may read and copy the registration statement and any other documents we have filed at the SEC, including any exhibits
and schedules, at the SEC&rsquo;s public reference room at 100 F Street N.E., Washington, D.C. 20549. You may call the SEC at 1-800-SEC-0330
for further information on this public reference room. In addition, the SEC maintains a web site that contains reports and other
information regarding issuers that file electronically with the SEC. You may access the SEC's website at <U>http://www.sec.gov</U>.
These SEC filings are also available to the public on the Israel Securities Authority&rsquo;s Magna website at www.magna.isa.gov.il
and from commercial document retrieval services.</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify">This prospectus supplement is part of the registration statement on Form F-3 filed with
the SEC in connection with this offering and does not contain all of the information included in the registration statement. Whenever
a reference is made in this prospectus supplement to any of our contracts or other documents, the reference may not be complete
and, for a copy of the contract or document, you should refer to the exhibits that are a part of the registration statement.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><A NAME="a_070"></A><B>INCORPORATION OF INFORMATION BY REFERENCE</B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">The SEC allows us to &ldquo;incorporate by reference&rdquo; information
into this prospectus supplement, which means that we can disclose important information to you by referring you to other documents
which we have filed or will file with the SEC. We are incorporating by reference in this prospectus supplement the documents listed
below and all amendments or supplements we may file to such documents, as well as any future filings we may make with the SEC on
Form 20-F under the Securities Exchange Act of 1934, as amended before the time that all of the securities offered by this prospectus
have been sold or de-registered:</P>



<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 48px; text-align: center"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">the description of our Ordinary Shares contained in our Registration Statement on Form 20-F filed with the SEC on December 26, 2012;</FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 48px; text-align: center"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></TD>
    <TD><FONT STYLE="font-size: 10pt">our Annual Report on Form 20-F for the fiscal year ended December 31, 2016, filed with the SEC on February 23, 2017; and</FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 48px; text-align: center"><FONT STYLE="font-family: Symbol; font-size: 10pt">&middot;</FONT></TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Current Reports on Form 6-K filed on February 23, 2017 (two
    reports), March 7, 2017, March 13, 2017, March 21, 2017, March 22, 2017, March 29, 2017, March 30, 2017, April 3, 2017, April
    4, 2017, April 5, 2017, April 13, 2017, April 18, 2017, April 19, 2017, April 20, 2017, April 24, 2017, April 25, 2017, May
    3, 2017, May 4, 2017, May 11, 2017, June 6, 2017, June 13, 2017, June 14, 2017, June 15, 2017, June 19, 2017, July 12, 2017,
    July 17, 2017, July 18, 2017, July 25, 2017, July 31, 2017, August 10, 2017, August 17, 2017, August 31, 2017, September 7,
    2017, September 13, 2017, September 18, 2017, September 18, 2017 (two reports), September 28, 2017, October 2, 2017, October
    3, 2017, October 10, 2017, October 19, 2017, October 20, 2017, October 23, 2017, October 26, 2017, November 1, 2017, November
    6, 2017 (two reports), November 7, 2017 and November 8, 2017.</FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">In addition, any reports on Form 6-K submitted to the SEC prior
to the termination of the offering that we specifically identify in such forms as being incorporated by reference into the registration
statement of which this prospectus supplement forms a part.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">Certain statements in and portions of this prospectus supplement
update and replace information in the above listed documents incorporated by reference. Likewise, statements in or portions of
a future document incorporated by reference in this prospectus supplement may update and replace statements in and portions of
this prospectus supplement or the above listed documents.</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0">We will provide you without charge, upon your written or oral request,
a copy of any of the documents incorporated by reference in this prospectus supplement, other than exhibits to such documents which
are not specifically incorporated by reference into such documents. Please direct your written or telephone requests to RedHill
Biopharma Ltd., 21 Ha'arba'a Street, Tel Aviv 6473921, Israel, Attn: Micha Ben Chorin, telephone number +972 (3) 541-3131. You
may also obtain information about us by visiting our website at <I>www.redhillbio.com</I>. Information contained in our website
is not part of this prospectus supplement.</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>PROSPECTUS</B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>$120,000,000 of</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">American Depositary Shares representing Ordinary Shares,</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">Ordinary Shares,</P>

<P STYLE="font-size: 10pt; text-align: center; text-indent: 0.5in; margin: 0pt 0">Warrants to Purchase American Depositary Shares,</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">Subscription Rights and/or Units</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">Offered by the Company</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B><img src="logo.jpg"></B></P>

<P STYLE="font-size: 10pt; text-align: center; text-indent: 0.5in; margin: 0pt 0; color: red">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>REDHILL BIOPHARMA LTD. </B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">We may offer to the public from time to time
in one or more series or issuances American Depositary Shares (&quot;ADSs&quot;), ordinary shares, warrants, subscription rights
and/or units consisting of two or more of these classes or series of securities. Each ADS represents 10 ordinary shares.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">We refer to the ADSs, ordinary shares, warrants,
subscription rights and units collectively as &ldquo;securities&rdquo; in this prospectus.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">Each time we sell securities pursuant to this
prospectus, we will provide a supplement to this prospectus that contains specific information about the offeror, the offering
and the specific terms of the securities offered. This prospectus may not be used to consummate a sale of securities by us unless
accompanied by the applicable prospectus supplement. You should read this prospectus and the applicable prospectus supplement carefully
before you invest in our securities.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 20pt; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">We may, from time to time, offer to sell the
securities, through public or private transactions, directly or through underwriters, agents or dealers, on or off the Nasdaq Capital
Market or Tel Aviv Stock Exchange (the &quot;TASE&quot;), as applicable, at prevailing market prices or at privately negotiated
prices. If any underwriters, agents or dealers are involved in the sale of any of these securities, the applicable prospectus supplement
will set forth the names of the underwriter, agent or dealer and any applicable fees, commissions or discounts.</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 20pt; margin: 0pt 0; background-color: white">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">Our ordinary shares are traded on the TASE,
and our ADSs are traded on the Nasdaq Capital Market under the symbol &ldquo;RDHL.&rdquo; The last reported sale price for our
ADSs on February 24, 2016 as quoted on the Nasdaq Capital Market was $9.38 per ADS, and the last reported sale price for our ordinary
shares on February 24, 2016 as quoted on the TASE was NIS 3.68 per share, or $0.94 per share (based on the exchange rate reported
by the Bank of Israel for such date).</P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"><B>Investing in these securities involves a
high degree of risk. Please carefully consider the risks discussed in this prospectus under &ldquo;Risk Factors&rdquo; beginning
on page 3 and the &ldquo;Risk Factors&rdquo; in &ldquo;Item 3: Key Information- Risk Factors&rdquo; of our most recent Annual Report
on Form 20-F incorporated by reference in this prospectus and in any applicable prospectus supplement for a discussion of the factors
you should consider carefully before deciding to purchase these securities. </B></P>

<P STYLE="font-size: 10pt; text-align: justify; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"><B>Neither the Securities and Exchange Commission
nor any state securities commission has approved or disapproved of the securities being offered by this prospectus, or determined
if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense. </B></P>

<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">The date of this prospectus is March 11, 2016</P>

<P STYLE="font-size: 10pt; text-align: center; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin: 0pt 0"></P>

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<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>TABLE OF CONTENTS </B></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><U>Page</U></P>



<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%">
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="width: 90%; text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_019">ABOUT THIS PROSPECTUS</A></TD>
    <TD STYLE="width: 10%; text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_019">2</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_020">REDHILL BIOPHARMA LTD.</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_020">2</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_021">RISK FACTORS</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_021">3</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_022">FORWARD-LOOKING STATEMENTS</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_022">3</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_023">CAPITALIZATION</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_023">4</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_024">PRICE RANGE OF OUR ORDINARY SHARES</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_024">4</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_025">PRICE RANGE OF OUR ADSs</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_025">5</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_026">USE OF PROCEEDS</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_026">6</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_027">DESCRIPTION OF ORDINARY SHARES</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_027">6</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_028">DESCRIPTION OF AMERICAN DEPOSITARY SHARES</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_028">6</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_029">DESCRIPTION OF WARRANTS</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_029">7</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_030">DESCRIPTION OF SUBSCRIPTION RIGHTS</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_030">7</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_031">DESCRIPTION OF UNITS</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_031">8</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_032">PLAN OF DISTRIBUTION</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_032">8</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_033">LEGAL MATTERS</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_033">11</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_034">EXPERTS</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_034">11</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_035">WHERE YOU CAN FIND MORE INFORMATION</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_035">11</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_036">INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_036">12</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_037">ENFORCEABILITY OF CIVIL LIABILITIES</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_037">12</A></TD></TR>
<TR STYLE="text-align: left; vertical-align: bottom; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="text-align: left; padding-top: 6pt; padding-bottom: 6pt; padding-left: 0in"><A HREF="#a_038">OFFERING EXPENSES</A></TD>
    <TD STYLE="text-align: right; padding-top: 6pt; padding-bottom: 6pt"><A HREF="#a_038">13</A></TD></TR>
</TABLE>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_019"></A>ABOUT THIS PROSPECTUS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">This prospectus is
part of a registration statement that we filed with the Securities and Exchange Commission, or SEC, utilizing a &ldquo;shelf&rdquo;
registration process. Under this process, we may offer and sell our securities under this prospectus.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Under this shelf process,
we may sell the securities described in this prospectus in one or more offerings up to a total price to the public of $120,000,000.
The offer and sale of securities under this prospectus may be made from time to time, in one or more offerings, in any manner described
under the section in this prospectus entitled &ldquo;Plan of Distribution.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">This prospectus provides
you with a general description of the securities we may offer. Each time we sell securities we will provide a prospectus supplement
that will contain specific information about the terms of that offering. The prospectus supplement may also add, update or change
information contained in this prospectus, and may also contain information about any material federal income tax considerations
relating to the securities covered by the prospectus supplement. You should read both this prospectus and any prospectus supplement
together with additional information under the headings &ldquo;Where You Can Find More Information&rdquo; and &ldquo;Incorporation
of Certain Documents by Reference.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">This summary may not
contain all of the information that may be important to you. You should read this entire prospectus, including the financial statements
and related notes and other financial data incorporated by reference in this prospectus, before making an investment decision.
This summary contains forward-looking statements that involve risks and uncertainties. Our actual results may differ significantly
from the results discussed in the forward-looking statements. Factors that might cause or contribute to such differences include
those discussed in &ldquo;Risk Factors&rdquo; and &ldquo;Forward-Looking Statements.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_020"></A>REDHILL BIOPHARMA LTD.</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Overview</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Our legal and commercial
name is RedHill Biopharma Ltd. We were incorporated on August 3, 2009 and were registered as a private company limited by shares
under the laws of the State of Israel. Our ordinary shares are traded on TASE under the symbol &ldquo;RDHL&rdquo; and our ADSs
are traded on the Nasdaq Capital Market under the symbol &quot;RDHL&quot;. Each ADS represents 10 ordinary shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We are an emerging
biopharmaceutical company focused primarily on the development and acquisition of late clinical-stage, proprietary, orally administered,
small molecule drugs for the treatment of inflammatory and gastrointestinal diseases, including cancer. In particular, we acquire
or in-license and develop patent-protected new formulations and combinations of existing drugs in advanced stages of development.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Depending on the specific
development program, our therapeutic candidates are designed to provide improvements over existing drugs by improving their safety
profile, reducing side effects, lowering the number of administrations, using a more convenient administration form, providing
a cost advantage and/or exhibiting greater efficacy. Where applicable, we intend to seek U.S. Food and Drug Administration approval
for the commercialization of certain of our therapeutic candidates through the alternative Section 505(b)(2) regulatory path under
the Federal Food, Drug, and Cosmetic Act of 1938, as amended, and in corresponding regulatory paths in other foreign jurisdictions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify"></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">Our current pipeline consists of nine late
clinical development therapeutic candidates, including one therapeutic candidate (RP101) for which we have an option to acquire.
Our current product pipeline includes: (i) <B>RHB-105</B> - an oral combination therapy for the treatment of Helicobacter pylori
infection with successful top-line results from a first Phase III study; (ii) <B>RHB-104</B> - an oral combination therapy for
the treatment of Crohn's disease with an ongoing first Phase III study; (iii) <B>BEKINDA&reg; (RHB-102)</B> - a once-daily oral
pill formulation of ondansetron with an ongoing Phase III study in the U.S. for acute gastroenteritis and gastritis; (iv) <B>RHB-106
</B>- an encapsulated bowel preparation licensed to Salix Pharmaceuticals, Ltd.; (v) <B>YELIVA&reg; (ABC294640)</B> - an orally-administered
first-in-class SK2 selective inhibitor targeting multiple oncology, inflammatory and gastrointestinal indications with a Phase
I/II study initiated for refractory/relapsed diffuse large B-cell lymphoma (DLBCL); (vi) <B>MESUPRON</B> - a Phase II-stage first-in-class
uPA inhibitor, administered by oral capsule, targeting gastrointestinal and other solid tumors; (vii) <B>RP101</B> - currently
subject to an option-to-acquire by RedHill, RP101 is a Phase II-stage first-in-class Hsp27 inhibitor, administered by oral tablet,
targeting pancreatic and other gastrointestinal cancers; (viii) <B>RIZAPORT&reg; (RHB-103)</B> - an oral thin film formulation
of rizatriptan for acute migraines, with a U.S. NDA currently under discussion with the FDA and marketing authorization received
in Germany in October 2015; and (ix) <B>RHB-101</B> - a once-daily oral pill formulation of the cardio drug carvedilol.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: justify"></P>






<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">We generate our pipeline of therapeutic candidates
by identifying, rigorously validating and in-licensing or acquiring products that are consistent with our products strategy and
that we believe exhibit a relatively high probability of therapeutic and commercial success. With the exception of Rizaport<SUP>&reg;</SUP>
which was approved for marketing in Germany, our therapeutic candidates have not yet been approved for marketing and, to date,
there have been no meaningful sales. We intend to commercialize our therapeutic candidates through licensing and other commercialization
arrangements with pharmaceutical companies on a global and territorial basis. We may also evaluate, on a case by case basis, co-development
and similar arrangements and the independent commercialization of our therapeutic candidates in the U.S.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Corporate Information</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Our principal executive
offices are located at 21 Ha&rsquo;arba&rsquo;a Street, Tel Aviv, Israel and our telephone number is +972 (3) 541-3131. Our web
site address is http://www.redhillbio.com. The information on our web site does not constitute part of this prospectus. Our registered
agent in the United States is Puglisi &amp; Associates. The address of Puglisi &amp; Associates is 850 Library Avenue, Suite 204,
Newark Delaware 19715.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_021"></A>RISK FACTORS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">An investment in our
securities involves a high degree of risk. Our business, financial condition or results of operations could be adversely affected
by any of these risks. You should carefully consider the risk factors discussed under the caption &quot;Item 3: Key Information<B>-
</B>Risk Factors&quot; in our Annual Report on Form 20-F for the year ended December 31, 2015, and in any other filing we make
with the SEC subsequent to the date of this prospectus, each of which are incorporated herein by reference, and in any supplement
to this prospectus, before making your investment decision. The risks and uncertainties we have described are not the only ones
we face. Additional risks and uncertainties not presently known to us or that we currently deem immaterial may also affect our
operations. Past financial performance may not be a reliable indicator of future performance, and historical trends should not
be used to anticipate results or trends in future periods. If any of these risks actually occurs, our business, business prospects,
financial condition or results of operations could be seriously harmed. This could cause the trading price of our ordinary shares
(directly or in the form of ADSs) to decline, resulting in a loss of all or part of your investment. Please also read carefully
the section below entitled &ldquo;Forward-Looking Statements.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_022"></A>FORWARD-LOOKING STATEMENTS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">This prospectus,
including the information incorporated by reference into this prospectus, contains, and any prospectus supplement may contain,
statements that are forward-looking statements within the meaning of Private Securities Litigation Reform Act of 1995. We caution
you that any forward-looking statements presented in this prospectus or any prospectus supplement, or which management may make
orally or in writing from time to time, are based on management&rsquo;s beliefs and assumptions made by, and information currently
available to, management. Such statements may be preceded by the words &quot;intends,&quot; &quot;may,&quot; &quot;will,&quot;
&quot;plans,&quot; &quot;expects,&quot; &quot;anticipates,&quot; &quot;projects,&quot; &quot;predicts,&quot; &quot;estimates,&quot;
&quot;aims,&quot; &quot;believes,&quot; &quot;hopes,&quot; &quot;potential&quot; or similar words. These statements are not guarantees
of future performance, are based on certain assumptions and our current and best understanding of the regulatory status and are
subject to various known and unknown risks and uncertainties, many of which are beyond our control, and cannot be predicted or
quantified and consequently, actual results may differ materially from those expressed or implied by such forward-looking statements.
Such risks and uncertainties include, without limitation, risks and uncertainties associated with: &nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 28.35pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">the initiation, timing, progress and results of our research, manufacturing, preclinical studies,
clinical trials and other therapeutic candidate development efforts, as well as the extent and number of additional studies that
we may be required to conduct;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">our ability to advance our therapeutic candidates into clinical trials or to successfully complete
our preclinical studies or clinical trials;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">our receipt of regulatory clarity and approvals for our therapeutic candidates, and the timing
of other regulatory filings and approvals;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt">&nbsp;</DIV>
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<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">the research, manufacturing, clinical development, commercialization and market acceptance of our
therapeutic candidates;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">our ability to establish and maintain corporate collaborations;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">our ability to acquire products approved for marketing in the U.S. that achieve commercial success
and build our own marketing and commercialization capabilities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">the interpretation of the properties and characteristics of our therapeutic candidates and of the
results obtained with our therapeutic candidates in research, manufacturing, preclinical studies or clinical trials;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">the implementation of our business model, strategic plans for our business and therapeutic candidates;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">the scope of protection we are able to establish and maintain for intellectual property rights
covering our therapeutic candidates and our ability to operate our business without infringing upon the intellectual property rights
of others;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">estimates of our expenses, future revenues, capital requirements and our need for additional financing;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">competitive companies, technologies and our industry; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">the impact of the political and security situation in Israel on our business.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We caution you to carefully
consider these risks and not to place undue reliance on our forward-looking statements. Except as required by law, we assume no
responsibility for updating any forward-looking statements.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_023"></A>CAPITALIZATION</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The table below sets
forth our total capitalization as of December 31, 2015. The financial data in the following table should be read in conjunction
with our financial statements and notes thereto incorporated by reference herein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD NOWRAP>&nbsp;</TD><TD NOWRAP STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" NOWRAP STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">As of December 31, <BR>
2015</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">Actual</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center">(in thousands)</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD><TD>&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 85%; text-align: left">Total debt (1)</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 12%; text-align: right">6,751</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD>Ordinary shares,&nbsp;&nbsp;par value NIS 0.01 per share&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">343</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">Additional paid-in capital&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">120,621</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD>Warrants</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,057</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">Accumulated deficit&#9;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">(61,944</TD><TD STYLE="text-align: left">)</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left; padding-bottom: 1pt">Total shareholders&rsquo; equity&#9;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: right">60,077</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left; padding-bottom: 2.25pt">Total capitalization&#9;</TD><TD STYLE="padding-bottom: 2.25pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 2.25pt double; text-align: left">$</TD><TD STYLE="border-bottom: Black 2.25pt double; text-align: right">66,828</TD><TD STYLE="border-bottom: Black 2.25pt double; text-align: left">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in"><FONT STYLE="font-size: 10pt">(1)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">Represents $5,514 thousand under current liabilities, mainly accounts
payable</FONT> <FONT STYLE="font-size: 10pt">and accrued expenses.</FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><A NAME="a_024"></A>PRICE RANGE OF OUR ORDINARY SHARES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Our ordinary shares have been trading on
the TASE under the symbol &quot;RDHL&quot; since February 3, 2011. Prior to that date, there was no public market for our ordinary
shares. U.S. dollar per ordinary share amounts are calculated using the U.S. dollar representative rate of exchange on the date
to which the high or low market price is applicable, as reported by the Bank of Israel. The following table lists the high and
low closing prices for our ordinary shares for the periods indicated as reported by the TASE.<FONT STYLE="font-size: 10pt"> </FONT>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: center; border-bottom: Black 1pt solid">NIS</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: center; border-bottom: Black 1pt solid">$U.S.</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: left; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: center; border-bottom: Black 1pt solid">Price per Ordinary Share</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: center; border-bottom: Black 1pt solid">Price per Ordinary Share</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="padding-bottom: 1pt; text-align: left">Annual</TD><TD STYLE="padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: center">High</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: center">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: center">Low</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: center">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: center">High</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: center">&nbsp;</TD><TD STYLE="padding-bottom: 1pt; text-align: center">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; text-align: center">&nbsp;</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: center">Low</TD><TD STYLE="border-bottom: Black 1pt solid; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 56%; text-align: left">2015</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">7.80</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">4.34</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">2.03</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 8%; text-align: right">1.12</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">2014</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">6.80</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3.00</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.96</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.78</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">2013</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4.29</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3.23</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.15</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.92</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">2012</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4.19</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.71</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.08</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.45</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">2011 (beginning on February 3, 2011)</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3.80</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.82</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.05</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.49</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-weight: bold; text-align: left">Quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left"><B>2015</B></TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD STYLE="font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold; text-align: right">&nbsp;</TD><TD STYLE="font-weight: bold; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">Fourth quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5.42</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4.34</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.39</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.12</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">Third quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">7.10</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4.62</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.88</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.19</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">Second quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">7.80</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5.52</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">2.03</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.41</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">First quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">6.16</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4.89</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.57</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.26</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left"><B>2014</B></TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD STYLE="font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold; text-align: right">&nbsp;</TD><TD STYLE="font-weight: bold; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">Fourth quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5.38</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3.00</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.38</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.78</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">Third quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5.89</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4.18</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.72</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.20</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">Second quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">6.80</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4.80</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.96</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.39</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">First quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5.04</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3.96</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.44</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.14</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-weight: bold; text-align: left">Most Recent Six Months</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">February 2016 (through February 22, 2016)</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3.88</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3.32</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.98</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.86</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">January 2016</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5.14</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">3.86</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.32</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">0.97</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">December 2015</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5.01</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4.56</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.29</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.17</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">November 2015</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5.42</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4.34</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.39</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.12</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">October 2015</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5.19</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4.57</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.34</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.18</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">September 2015</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5.91</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5.00</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.53</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.27</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">August 2015</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">5.65</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">4.62</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.50</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1.19</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in"><FONT STYLE="background-color: white">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="background-color: white">On
February 22, 2016, the last reported sales price of our ordinary shares on the TASE was NIS 3.73 per share, or $0.95 per share
(based on the exchange rate reported by the Bank of Israel for such date).&nbsp;&nbsp;On February 22, 2016 the exchange rate of
the NIS to the U.S. dollar was $1.00 = NIS 3.907, as reported by the Bank of Israel.&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_025"></A><B>PRICE RANGE OF OUR ADSs</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-size: 10pt">Our ADSs have
been trading on the Nasdaq Capital Market under the symbol &ldquo;RDHL&rdquo; since December 27,</FONT><FONT STYLE="font-family: Times New Roman, Times, Serif">
</FONT><FONT STYLE="font-size: 10pt">2012.</FONT></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt">&nbsp;</DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt"></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-size: 10pt">The
following table sets forth, for the periods indicated, the reported high and low closing sale prices of our ADSs on the Nasdaq
Capital Market in U.S. dollars.&nbsp; </FONT>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: center; border-bottom: Black 1pt solid"><B>$U.S.</B></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="text-align: center; border-bottom: Black 1pt solid"><B>Price per ADS</B></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-weight: bold; text-align: left; padding-bottom: 1pt">&nbsp;</TD><TD STYLE="font-weight: bold; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-weight: bold; text-align: center; border-bottom: Black 1pt solid">High</TD><TD STYLE="padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: center; border-bottom: Black 1pt solid"><B>Low</B></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-weight: bold; text-align: left">Annual</TD><TD>&nbsp;</TD>
    <TD COLSPAN="3">&nbsp;</TD><TD>&nbsp;</TD>
    <TD COLSPAN="3">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 70%; text-align: left">2015</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 12%; text-align: right">19.79</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">&nbsp;</TD><TD STYLE="width: 12%; text-align: right">11.05</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">2014</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">19.20</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">8.03</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">2013</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">13.60</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">8.31</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-weight: bold; text-align: left">Quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left"><B>2015</B></TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD STYLE="font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold; text-align: right">&nbsp;</TD><TD STYLE="font-weight: bold; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">Fourth quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">13.72</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">11.05</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">Third quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">18.46</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">12.16</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">Second quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">19.79</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">14.03</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">First quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">15.92</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">12.52</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left"><B>2014</B></TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD STYLE="font-weight: bold; text-align: left">&nbsp;</TD><TD STYLE="font-weight: bold; text-align: right">&nbsp;</TD><TD STYLE="font-weight: bold; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">Fourth quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">13.40</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">8.03</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">Third quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">17.35</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">12.14</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">Second quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">19.20</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">14.01</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">First quarter</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">14.50</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">12.38</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-weight: bold; text-align: left">Most Recent Six Months</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">&nbsp;</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">February 2016 (through February 22, 2016)</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">9.43</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">8.21</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">January 2016</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">12.61</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">9.75</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">December 2015</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">12.90</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">11.64</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">November 2015</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">13.70</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">11.05</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">October 2015</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">13.72</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">11.31</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">September 2015</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">15.28</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">12.78</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">August 2015</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">14.63</TD><TD STYLE="text-align: left">&nbsp;</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">12.16</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">On <FONT STYLE="background-color: white">February
22, 2016</FONT>, the last reported sales price of our ADSs on the Nasdaq Capital Market was $9.37 per ADS.&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_026"></A>USE OF PROCEEDS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Unless otherwise indicated
in an accompanying prospectus supplement, the net proceeds from the sale of securities will be used for general corporate purposes,
including research and development related purposes in connection with our therapeutic candidates, and for potential acquisitions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in"><A NAME="a_027"></A>DESCRIPTION OF
ORDINARY SHARES</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">A description of our
ordinary shares, par value NIS 0.01 per share, can be found in Item 10B of the Registration Statement on Form 20-F filed with the
SEC on December 26, 2012.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>


<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_028"></A>DESCRIPTION OF AMERICAN DEPOSITARY
SHARES</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">A description of our
ADSs, each of which represents 10 of our ordinary shares, can be found in Item 12 of the Registration Statement on Form 20-F filed
with the SEC on December 26, 2012.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt">&nbsp;</DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_029"></A>DESCRIPTION OF WARRANTS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We may issue warrants
to purchase ADS and/or ordinary shares. Warrants may be issued independently or together with any other securities and may be attached
to, or separate from, such securities. Each series of warrants will be issued under a separate warrant agreement to be entered
into between us and a warrant agent. The warrant agent will act solely as our agent and will not assume any obligation or relationship
of agency for or with holders or beneficial owners of warrants. The terms of any warrants to be issued and a description of the
material provisions of the applicable warrant agreement will be set forth in the applicable prospectus supplement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The applicable
prospectus supplement will describe the following terms of any warrants in respect of which this prospectus is being delivered:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">the title of such warrants;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">the aggregate number of such warrants;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">the price or prices at which such warrants will be issued and exercised;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">the currency or currencies in which the price of such warrants will be payable;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">the securities purchasable upon exercise of such warrants;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">the date on which the right to exercise such warrants shall commence and the date on which such
right shall expire;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">if applicable, the minimum or maximum amount of such warrants which may be exercised at any one
time;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">if applicable, the designation and terms of the securities with which such warrants are issued
and the number of such warrants issued with each such security;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">if applicable, the date on and after which such warrants and the related securities will be separately
transferable;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">information with respect to book-entry procedures, if any;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">any material Israeli and United States federal income tax consequences;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify">the anti dilution provisions of the warrants, if any; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 37pt"></TD><TD STYLE="width: 18pt">&bull;</TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">any other terms of such warrants, including terms, procedures and
limitations relating to the exchange and exercise of such warrants. </FONT></TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Amendments and Supplements to Warrant Agreement</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We and the warrant
agent may amend or supplement the warrant agreement for a series of warrants without the consent of the holders of the warrants
issued thereunder to effect changes that are not inconsistent with the provisions of the warrants and that do not materially and
adversely affect the interests of the holders of the warrants.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_030"></A>DESCRIPTION OF SUBSCRIPTION RIGHTS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We may issue subscription
rights to purchase our ordinary shares and/or our ADSs. These subscription rights may be issued independently or together with
any other security offered hereby and may or may not be transferable by the shareholder receiving the subscription rights in such
offering. In connection with any offering of subscription rights, we may enter into a standby arrangement with one or more underwriters
or other purchasers pursuant to which the underwriters or other purchasers may be required to purchase any securities remaining
unsubscribed for after such offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 28.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The prospectus
supplement relating to any subscription rights we offer, if any, will, to the extent applicable, include specific terms relating
to the offering, including some or all of the following:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 28.35pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">the price, if any, for the subscription rights;&nbsp;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">the exercise price payable for each ordinary share and/or ADS upon the exercise of the subscription
rights;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">the number of subscription rights to be issued to each shareholder;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt">&nbsp;</DIV>
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<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">the number and terms of the ordinary shares and/or ADSs which may be purchased per each subscription
right;&nbsp;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">the extent to which the subscription rights are transferable;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">any other terms of the subscription rights, including the terms, procedures and limitations relating
to the exchange and exercise of the subscription rights;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">the date on which the right to exercise the subscription rights shall commence, and the date on
which the subscription rights shall expire;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">the extent to which the subscription rights may include an over-subscription privilege with respect
to unsubscribed securities;&nbsp;and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">if applicable, the material terms of any standby underwriting or purchase arrangement which may
be entered into by us in connection with the offering of subscription rights.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The description in
the applicable prospectus supplement of any subscription rights we offer will not necessarily be complete and will be qualified
in its entirety by reference to the applicable subscription right agreement, which will be filed with the SEC if we offer subscription
rights. For more information on how you can obtain copies of the applicable subscription right agreement if we offer subscription
rights, see &ldquo;Where You Can Find More Information; Incorporation of Information by Reference&rdquo; beginning on page&nbsp;11.
We urge you to read the applicable subscription right agreement and any applicable prospectus supplement in their entirety.</P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 28.35pt">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_031"></A>DESCRIPTION OF UNITS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We may issue units
comprised of one or more of the other securities that may be offered under this prospectus, in any combination. Each unit will
be issued so that the holder of the unit is also the holder of each security included in the unit. Thus, the holder of a unit will
have the rights and obligations of a holder of each included security. The unit agreement under which a unit is issued may provide
that the securities included in the unit may not be held or transferred separately at any time, or at any time before a specified
date.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 28.35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The prospectus supplement relating to
any units we offer, if any, will, to the extent applicable, include specific terms relating to the offering, including some or
all of the following:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 28.35pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">the material terms of the units and of the securities comprising the units, including whether and
under what circumstances those securities may be held or transferred separately;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">any material provisions relating to the issuance, payment, settlement, transfer or exchange of
the units or of the securities comprising the units; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">any material provisions of the governing unit agreement that differ from those described above.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The description in
the applicable prospectus supplement of any units we offer will not necessarily be complete and will be qualified in its entirety
by reference to the applicable unit agreement, which will be filed with the SEC if we offer units. For more information on how
you can obtain copies of the applicable unit agreement if we offer units, see &ldquo;Where You Can Find More Information; Incorporation
of Information by Reference&rdquo; beginning on page&nbsp;11. We urge you to read the applicable unit agreement and any applicable
prospectus supplement in their entirety.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 28.35pt">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_032"></A>PLAN OF DISTRIBUTION</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The securities
being offered by this prospectus may be sold:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">through agents;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">to or through one or more underwriters on a firm commitment or agency basis;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">through put or call option transactions relating to the securities;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">through broker-dealers;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">directly to purchasers, through a specific bidding or auction process, on a negotiated basis or
otherwise;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">through any other method permitted pursuant to applicable law; or</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">through a combination of any such methods of sale.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt">&nbsp;</DIV>
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<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">At any time a
particular offer of the securities covered by this prospectus is made, a revised prospectus or prospectus supplement, if required,
will be distributed which will set forth the aggregate amount of securities covered by this prospectus being offered and the terms
of the offering, including the name or names of any underwriters, dealers, brokers or agents, any discounts, commissions, concessions
and other items constituting compensation from us and any discounts, commissions or concessions allowed or reallowed or paid to
dealers. Such prospectus supplement, and, if necessary, a post-effective amendment to the registration statement of which this
prospectus is a part, will be filed with the SEC to reflect the disclosure of additional information with respect to the distribution
of the securities covered by this prospectus. In order to comply with the securities laws of certain states, if applicable, the
securities sold under this prospectus may only be sold through registered or licensed broker-dealers. In addition, in some states
the securities may not be sold unless they have been registered or qualified for sale in the applicable state or an exemption from
registration or qualification requirements is available and is complied with.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The distribution
of securities may be effected from time to time in one or more transactions, including block transactions and transactions on the
Nasdaq Capital Market or any other organized market where the securities may be traded. The securities may be sold at a fixed price
or prices, which may be changed, or at market prices prevailing at the time of sale, at prices relating to the prevailing market
prices or at negotiated prices. The consideration may be cash or another form negotiated by the parties. Agents, underwriters or
broker-dealers may be paid compensation for offering and selling the securities. That compensation may be in the form of discounts,
concessions or commissions to be received from us or from the purchasers of the securities. Any dealers and agents participating
in the distribution of the securities may be deemed to be underwriters, and compensation received by them on resale of the securities
may be deemed to be underwriting discounts. If any such dealers or agents were deemed to be underwriters, they may be subject to
statutory liabilities under the Securities Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Agents may from
time to time solicit offers to purchase the securities. If required, we will name in the applicable prospectus supplement any agent
involved in the offer or sale of the securities and set forth any compensation payable to the agent. Unless otherwise indicated
in the prospectus supplement, any agent will be acting on a best efforts basis for the period of its appointment. Any agent selling
the securities covered by this prospectus may be deemed to be an underwriter, as that term is defined in the Securities Act, of
the securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">If underwriters
are used in a sale, securities will be acquired by the underwriters for their own account and may be resold from time to time in
one or more transactions, including negotiated transactions, at a fixed public offering price or at varying prices determined at
the time of sale, or under delayed delivery contracts or other contractual commitments. Securities may be offered to the public
either through underwriting syndicates represented by one or more managing underwriters or directly by one or more firms acting
as underwriters. If an underwriter or underwriters are used in the sale of securities, an underwriting agreement will be executed
with the underwriter or underwriters, as well as any other underwriter or underwriters, with respect to a particular underwritten
offering of securities, and will set forth the terms of the transactions, including compensation of the underwriters and dealers
and the public offering price, if applicable. The prospectus and prospectus supplement will be used by the underwriters to resell
the securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">If a dealer is
used in the sale of the securities, we or an underwriter will sell the securities to the dealer, as principal. The dealer may then
resell the securities to the public at varying prices to be determined by the dealer at the time of resale. To the extent required,
we will set forth in the prospectus supplement the name of the dealer and the terms of the transactions.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We may directly
solicit offers to purchase the securities and may make sales of securities directly to institutional investors or others. These
persons may be deemed to be underwriters within the meaning of the Securities Act with respect to any resale of the securities.
To the extent required, the prospectus supplement will describe the terms of any such sales, including the terms of any bidding
or auction process, if used.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Agents, underwriters
and dealers may be entitled under agreements which may be entered into with us to indemnification by us against specified liabilities,
including liabilities incurred under the Securities Act, or to contribution by us to payments they may be required to make in respect
of such liabilities. If required, the prospectus supplement will describe the terms and conditions of the indemnification or contribution.
Some of the agents, underwriters or dealers, or their affiliates may be customers of, engage in transactions with or perform services
for us or our subsidiaries.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Any person participating
in the distribution of securities registered under the registration statement that includes this prospectus will be subject to
applicable provisions of the Securities Exchange Act of 1934, as amended, or the Exchange Act, and the applicable SEC rules and
regulations, including, among others, Regulation M, which may limit the timing of purchases and sales of any of our securities
by that person. Furthermore, Regulation M may restrict the ability of any person engaged in the distribution of our securities
to engage in market-making activities with respect to our securities. These restrictions may affect the marketability of our securities
and the ability of any person or entity to engage in market-making activities with respect to our securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Certain persons
participating in an offering may engage in over-allotment, stabilizing transactions, short-covering transactions, penalty bids
and other transactions that stabilize, maintain or otherwise affect the price of the offered securities. These activities may maintain
the price of the offered securities at levels above those that might otherwise prevail in the open market, including by entering
stabilizing bids, effecting syndicate covering transactions or imposing penalty bids, each of which is described below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">A stabilizing bid means the placing of any bid, or the effecting of any purchase, for the purpose
of pegging, fixing or maintaining the price of a security.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">A syndicate covering transaction means the placing of any bid on behalf of the underwriting syndicate
or the effecting of any purchase to reduce a short position created in connection with the offering.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 10pt">A penalty bid means an arrangement that permits the managing underwriter
to reclaim a selling concession from a syndicate member in connection with the offering when offered securities originally sold
by the syndicate member are purchased in syndicate covering transactions. </FONT></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">These transactions
may be effected on an exchange or automated quotation system, if the securities are listed on that exchange or admitted for trading
on that automated quotation system, or in the over-the-counter market or otherwise.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">If so indicated
in the applicable prospectus supplement, we will authorize agents, underwriters or dealers to solicit offers from certain types
of institutions to purchase offered securities from us at the public offering price set forth in such prospectus supplement pursuant
to delayed delivery contracts providing for payment and delivery on a specified date in the future. Such contracts will be subject
only to those conditions set forth in the prospectus supplement and the prospectus supplement will set forth the commission payable
for solicitation of such contracts.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">In addition, ordinary
shares or ADSs may be issued upon conversion of or in exchange for debt securities or other securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Any underwriters
to whom offered securities are sold for public offering and sale may make a market in such offered securities, but such underwriters
will not be obligated to do so and may discontinue any market making at any time without notice. The offered securities may or
may not be listed on a national securities exchange. No assurance can be given that there will be a market for the offered securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Any securities
that qualify for sale pursuant to Rule 144 or Regulation S under the Securities Act, may be sold under Rule 144 or Regulation S
rather than pursuant to this prospectus.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">To the extent
that we make sales to or through one or more underwriters or agents in at-the-market offerings, we will do so pursuant to the terms
of a distribution agreement between us and the underwriters or agents. If we engage in at-the-market sales pursuant to a distribution
agreement, we will sell our ordinary shares or ADSs to or through one or more underwriters or agents, which may act on an agency
basis or on a principal basis. During the term of any such agreement, we may sell ordinary shares or ADSs on a daily basis in exchange
transactions or otherwise as we agree with the underwriters or agents. The distribution agreement will provide that any ordinary
shares or ADSs sold will be sold at prices related to the then prevailing market prices for our ordinary shares or ADSs. Therefore,
exact figures regarding proceeds that will be raised or commissions to be paid cannot be determined at this time and will be described
in a prospectus supplement. Pursuant to the terms of the distribution agreement, we also may agree to sell, and the relevant underwriters
or agents may agree to solicit offers to purchase, blocks of our ordinary shares, ADSs or warrants. The terms of each such distribution
agreement will be set forth in more detail in a prospectus supplement to this prospectus.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 24.5pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">In connection with offerings
made through underwriters or agents, we may enter into agreements with such underwriters or agents pursuant to which we receive
our outstanding securities in consideration for the securities being offered to the public for cash. In connection with these arrangements,
the underwriters or agents may also sell securities covered by this prospectus to hedge their positions in these outstanding securities,
including in short sale transactions. If so, the underwriters or agents may use the securities received from us under these arrangements
to close out any related open borrowings of securities.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 35pt">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We may enter into derivative
transactions with third parties or sell securities not covered by this prospectus to third parties in privately negotiated transactions.
If the applicable prospectus supplement indicates, in connection with those derivatives, such third parties (or affiliates of such
third parties) may sell securities covered by this prospectus and the applicable prospectus supplement, including in short sale
transactions. If so, such third parties (or affiliates of such third parties) may use securities pledged by us or borrowed from
us or others to settle those sales or to close out any related open borrowings of shares, and may use securities received from
us in settlement of those derivatives to close out any related open borrowings of shares. The third parties (or affiliates of such
third parties) in such sale transactions will be underwriters and, if not identified in this prospectus, will be identified in
the applicable prospectus supplement (or a post-effective amendment).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 35pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We may loan or pledge
securities to a financial institution or other third party that in turn may sell the securities using this prospectus. Such financial
institution or third party may transfer its short position to investors in our securities or in connection with a simultaneous
offering of other securities offered by this prospectus or in connection with a simultaneous offering of other securities offered
by this prospectus.</P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 35pt">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_033"></A>LEGAL MATTERS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Certain legal matters
with respect to Israeli law and with respect to the validity of the offered securities under Israeli law will be passed upon for
us by Gross, Kleinhendler, Hodak, Halevy, Greenberg &amp; Co.<B> </B>Certain legal matters with respect to U.S. federal securities
law will be passed upon for us by Haynes and Boone, LLP.</P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_034"></A>EXPERTS</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The financial statements
of RedHill Biopharma Ltd. incorporated in this prospectus by reference to the Annual Report on Form 20-F for the year ended December
31, 2015 have been so incorporated in reliance on the report of Kesselman &amp; Kesselman, Certified Public Accountants (Isr.),
a member firm of PricewaterhouseCoopers International Limited, an independent registered public accounting firm, given on the authority
of such firm as experts in auditing and accounting.</P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_035"></A>WHERE YOU CAN FIND MORE INFORMATION</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We have filed with
the SEC a registration statement on Form F-3 under the Securities Act, with respect to the securities offered by this prospectus.
However, as is permitted by the rules and regulations of the SEC, this prospectus, which is part of our registration statement
on Form F-3, omits certain non-material information, exhibits, schedules and undertakings set forth in the registration statement.
For further information about us, and the securities offered by this prospectus, please refer to the registration statement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We
are subject to the reporting requirements of the Exchange Act that are applicable to a foreign private issuer. In accordance with
the Exchange Act, we file reports, including annual reports on Form 20-F by April 30 of each year. We also furnish to the SEC under
cover of Form 6-K material information required to be made public in Israel, filed with and made public by any stock exchange or
distributed by us to our shareholders.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The
registration statement on Form F-3 of which this prospectus forms a part, including the exhibits and schedules thereto, and reports
and other information filed by us with the SEC may be inspected without charge and copied at prescribed rates at the SEC&rsquo;s
Public Reference Room at 100 F Street, N.E., Washington, D.C. 20549. Copies of this material are also available by mail from the
Public Reference Section of the SEC, at 100 F. Street, N.E., Washington D.C. 20549, at prescribed rates. The public may obtain
information on the operation of the Public Reference Room by calling the SEC at 1-800-SEC-0330. The SEC maintains an Internet site
that contains reports, proxy and information statements, and other information regarding issuers, such as us, that file electronically
with the SEC (<I>http://www.sec.gov</I>).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">As
a foreign private issuer, we are exempt from the rules under the Exchange Act prescribing the furnishing and content of proxy statements
to shareholders and our officers, directors and principal shareholders are exempt from the &ldquo;short-swing profits&rdquo; reporting
and liability provisions contained in Section 16 of the Exchange Act and related Exchange Act rules.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_036"></A>INCORPORATION OF CERTAIN DOCUMENTS
BY REFERENCE</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We file annual and
special reports and other information with the SEC (File Number 001-35464). These filings contain important information which does
not appear in this prospectus. The SEC allows us to &ldquo;incorporate by reference&rdquo; information into this prospectus, which
means that we can disclose important information to you by referring you to other documents which we have filed or will file with
the SEC. We are incorporating by reference in this prospectus the documents listed below and all amendments or supplements we may
file to such documents, as well as any future filings we may make with the SEC on Form 20-F under the Exchange Act before the time
that all of the securities offered by this prospectus have been sold or de-registered:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">our Registration Statement on Form 20-F filed with the SEC on December 26, 2012; and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">our Annual Report on Form 20-F for the fiscal year ended on December 31, 2015, filed with the SEC
on February 25, 2016</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">In addition, any reports
on Form 6-K submitted to the SEC by the registrant pursuant to the Exchange Act after the date of the initial registration statement
and prior to effectiveness of the registration statement that we specifically identify in such forms as being incorporated by reference
into the registration statement of which this prospectus forms a part and all subsequent annual reports on Form 20-F filed after
the effective date of this registration statement and prior to the termination of this offering and any reports on Form 6-K subsequently
submitted to the SEC or portions thereof that we specifically identify in such forms as being incorporated by reference into the
registration statement of which this prospectus forms a part, shall be considered to be incorporated into this prospectus by reference
and shall be considered a part of this prospectus from the date of filing or submission of such documents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Certain statements
in and portions of this prospectus update and replace information in the above listed documents incorporated by reference. Likewise,
statements in or portions of a future document incorporated by reference in this prospectus may update and replace statements in
and portions of this prospectus or the above listed documents.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-size: 10pt">We
will provide you without charge, upon your written or oral request, a copy of any of the documents incorporated by reference in
this prospectus, other than exhibits to such documents which are not specifically incorporated by reference into such documents.
Please direct your written or telephone requests to RedHill Biopharma Ltd., 21 Ha'arba'a Street, Tel Aviv 64739, Israel, Attn:
Dror Ben-Asher, telephone number +972 (3) 541-3131. You may also obtain information about us by visiting our website at <I>www.redhillbio.com</I>.
Information contained in our website is not part of this prospectus</FONT>.</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_037"></A>ENFORCEABILITY OF CIVIL LIABILITIES</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We are incorporated
under the laws of the State of Israel. Service of process upon us and upon our directors and officers and the Israeli experts named
in this prospectus, substantially all of whom reside outside the United States, may be difficult to obtain within the United States.
Furthermore, because substantially all of our assets and substantially all of our directors and officers are located outside the
United States, any judgment obtained in the United States against us or any of our directors and officers may not be collectible
within the United States.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">It may be difficult
to assert U.S.&nbsp;securities law claims in original actions instituted in Israel. Israeli courts may refuse to hear a claim based
on a violation of U.S.&nbsp;securities laws because Israel is not the most appropriate forum to bring such a claim. In addition,
even if an Israeli court agrees to hear a claim, it may determine that Israeli law and not U.S.&nbsp;law is applicable to the claim.
If U.S.&nbsp;law is found to be applicable, the content of applicable U.S.&nbsp;law must be proved as a fact which can be a time-consuming
and costly process. Certain matters of procedure will also be governed by Israeli law.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Subject to specified
time limitations and legal procedures, Israeli courts may enforce a United States judgment in a civil matter which, subject to
certain exceptions, is non-appealable, including judgments based upon the civil liability provisions of the Securities Act and
the Exchange Act and including a monetary or compensatory judgment in a non-civil matter, provided that:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">the judgments are obtained after due process before a court of competent jurisdiction, according
to the laws of the state in which the judgment is given and the rules of private international law currently prevailing in Israel;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">the prevailing law of the foreign state in which the judgments were rendered allows the enforcement
of judgments of Israeli courts (however, the Israeli courts may waive this requirement following a request by the attorney general);</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">adequate service of process has been effected and the defendant has had a reasonable opportunity
to be heard and to present his or her evidence;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">the judgments are not contrary to public policy, and the enforcement of the civil liabilities set
forth in the judgment does not impair the security or sovereignty of the State of Israel;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">the judgments were not obtained by fraud and do not conflict with any other valid judgment in the
same matter between the same parties;</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">an action between the same parties in the same matter is not pending in any Israeli court at the
time the lawsuit is instituted in the foreign court;&nbsp;and</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.25in">&bull;</TD><TD STYLE="text-align: justify">the obligations under the judgment are enforceable according to the laws of the State of Israel
and according to the law of the foreign state in which the relief was granted.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">We have irrevocably
appointed Puglisi &amp; Associates<B> </B>as our agent to receive service of process in any action against us in any United States
federal or state court arising out of this offering or any purchase or sale of securities in connection with this offering.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 35.3pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">If a foreign judgment
is enforced by an Israeli court, it generally will be payable in Israeli currency, which can then be converted into non-Israeli
currency and transferred out of Israel. The usual practice in an action before an Israeli court to recover an amount in a non-Israeli
currency is for the Israeli court to issue a judgment for the equivalent amount in Israeli currency at the rate of exchange in
force on the date of the judgment, but the judgment debtor may make payment in foreign currency. Pending collection, the amount
of the judgment of an Israeli court stated in Israeli currency ordinarily will be linked to the Israeli consumer price index plus
interest at the annual statutory rate set by Israeli regulations prevailing at the time. Judgment creditors must bear the risk
of unfavorable exchange rates.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><A NAME="a_038"></A>OFFERING EXPENSES</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The following is a
statement of expenses in connection with the distribution of the securities registered. All amounts shown are estimates except
the SEC registration fee. The estimates do not include expenses related to offerings of particular securities. Each prospectus
supplement describing an offering of securities will reflect the estimated expenses related to the offering of securities under
that prospectus supplement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 35.3pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 35.3pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 35.3pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 85%; text-align: left">SEC registration fees</TD><TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 1%; text-align: left">$</TD><TD STYLE="width: 12%; text-align: right"><P STYLE="margin: 0pt 0"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">7,943.83</FONT></P>


</TD><TD STYLE="width: 1%; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="text-align: left">Legal fees and expenses</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">10,000</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="text-align: left">Accountants fees and expenses</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">2,000</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD>Miscellaneous</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD><TD STYLE="text-align: right">1,000</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD>Total</TD><TD>&nbsp;</TD>
    <TD STYLE="text-align: left">$</TD><TD STYLE="text-align: right"><P STYLE="margin: 0pt 0">20,943.83</P>


</TD><TD STYLE="text-align: left">&nbsp;</TD></TR>
</TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
<!-- Field: Page; Sequence: 79; Value: 2 -->
    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 4pt solid"><P STYLE="margin-top: 0pt; text-align: center; margin-bottom: 0pt"><!-- Field: Sequence; Type: Arabic; Name: PageNo -->13<!-- Field: /Sequence -->&nbsp;</P></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 12pt">&nbsp;</DIV>
    <!-- Field: /Page -->




<P STYLE="margin: 0"><FONT STYLE="font-size: 14pt">&nbsp;</FONT></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B></B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><FONT STYLE="font-size: 14pt"><B>4,090,909 American Depositary Shares
Representing 40,909,090 Ordinary Shares</B></FONT></P>



<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><img src="logo.jpg"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 24pt; text-align: center; margin: 0pt 0"><B>RedHill Biopharma Ltd.</B></P>

<P STYLE="font-size: 18pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">___________________________________</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><FONT STYLE="font-size: 16pt"><B>PROSPECTUS SUPPLEMENT</B></FONT></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">___________________________________</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 6pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 75pt; text-align: right">&nbsp;</TD><TD STYLE="width: 5pt"></TD><TD STYLE="text-align: justify">&nbsp;</TD>
</TR></TABLE>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">Joint Book-Running Managers</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 70%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 50%; text-align: center"><FONT STYLE="font-size: 24pt"><B>Cantor</B></FONT></TD>
    <TD STYLE="width: 50%; text-align: center"><FONT STYLE="font-size: 24pt"><B>Nomura</B></FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp; <FONT STYLE="font-size: 10pt">Lead Manager</FONT></P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp; <FONT STYLE="font-size: 12pt"><B>SMBC
Nikko</B></FONT></P>


<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"><I>Co-Managers</I></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; font: 10pt Times New Roman, Times, Serif; width: 70%">
<TR STYLE="vertical-align: top; text-align: left">
    <TD STYLE="width: 50%; text-align: center"><FONT STYLE="font-size: 11pt"><B>H.C. Wainwright &amp; Co.</B></FONT></TD>
    <TD STYLE="width: 50%; text-align: center"><FONT STYLE="font-size: 11pt"><B>Roth Capital Partners</B></FONT></TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>

<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0">November&nbsp;8, 2017</P>



<P STYLE="font-size: 10pt; text-align: center; margin: 0pt 0"></P>



<P STYLE="font-size: 10pt; text-align: center; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: center; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<!-- Field: Rule-Page --><DIV ALIGN="CENTER" STYLE="margin-top: 3pt; margin-bottom: 3pt"><DIV STYLE="font-size: 1pt; border-top: Black 4pt solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="font-size: 10pt; text-align: center; text-indent: 0.5in; margin: 0pt 0"></P>

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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
