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CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY - USD ($) $ in Thousands | Ordinary shares | Additional paid-in capital | Accumulated deficit | Total
--- | --- | --- | --- | ---
Balance at beginning of period at Dec. 31, 2017 | $ 575 | $ 177,434 | $ (132,944) | $ 45,065
Share-based compensation to employees and service providers |  |  | 2,678 | 2,678
Issuance of ordinary shares | 190 | 41,712 |  | 41,902
Exercise of options into ordinary shares | 2 | 359 |  | 361
Comprehensive loss |  |  |  | (38,820)
Balance at end of period at Dec. 31, 2018 | 767 | 219,505 | (169,086) | 51,186
Share-based compensation to employees and service providers |  |  | 3,027 | 3,027
Issuance of ordinary shares | 195 | 47,893 |  | 48,088
Exercise of options into ordinary shares |  | 5 |  | 5
Comprehensive loss |  |  | (42,304) | (42,304)
Balance at end of period at Dec. 31, 2019 | 962 | 267,403 | (208,363) | 60,002
Share-based compensation to employees and service providers |  |  | 4,202 | 4,202
Issuance of ordinary shares | 84 | 23,783 |  | 23,867
Exercise of options into ordinary shares |  | 52 |  | 52
Share-based compensation in consideration for intangible assets | 8 | 1,906 |  | 1,914
Comprehensive loss |  |  | (76,173) | (76,173)
Balance at end of period at Dec. 31, 2020 | $ 1,054 | $ 293,144 | $ (280,334) | $ 13,864

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