<SEC-DOCUMENT>0001178913-21-003872.txt : 20211215
<SEC-HEADER>0001178913-21-003872.hdr.sgml : 20211215
<ACCEPTANCE-DATETIME>20211215091740
ACCESSION NUMBER:		0001178913-21-003872
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		3
CONFORMED PERIOD OF REPORT:	20211215
FILED AS OF DATE:		20211215
DATE AS OF CHANGE:		20211215

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			RedHill Biopharma Ltd.
		CENTRAL INDEX KEY:			0001553846
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-35773
		FILM NUMBER:		211493267

	BUSINESS ADDRESS:	
		STREET 1:		21 HA'ARBA'A STREET
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			64739
		BUSINESS PHONE:		972-3-541-3131

	MAIL ADDRESS:	
		STREET 1:		21 HA'ARBA'A STREET
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			64739
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>zk2126966.htm
<DESCRIPTION>6-K
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: ZKG
         Document created using EDGARfilings PROfile 7.7.0.0
         Copyright 1995 - 2021 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <font style="font-family: 'Times New Roman',Times,serif;">
  </font>
  <div>
    <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;">
    <div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"> <font style="font-family: 'Times New Roman',Times,serif;"><br>
        </font></div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">UNITED STATES</div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Washington, D.C.&#160;20549</div>
      <div style="text-align: center; line-height: 1.25;">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 14pt; font-weight: bold;">FORM 6-K</div>
      <div style="text-align: center; line-height: 1.25;">&#160;&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Report of Foreign Private Issuer</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Pursuant to Rule 13a-16 or 15d-16</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">of&#160;the Securities Exchange Act of 1934</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
      <div style="text-align: center; line-height: 1.25;">For the month of December 2021<br>
        Commission File No.:001-35773</div>
      <div style="text-align: center; line-height: 1.25;">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 16pt; font-weight: bold;">REDHILL BIOPHARMA LTD.</div>
      <div style="text-align: center; line-height: 1.25;">(Translation of registrant&#8217;s name into English)</div>
      <div style="text-align: center; line-height: 1.25;">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">21 Ha'arba'a Street, Tel Aviv, 6473921, Israel</div>
      <div style="text-align: center; line-height: 1.25;">(Address of principal executive offices)</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form
        40-F.&#160;&#160;</div>
      <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;"> <br>
      </div>
      <div style="text-align: center; text-indent: 14.2pt; line-height: 1.25;">Form 20-F &#9746; &#160; &#160; &#160;&#160; Form 40-F &#9744;</div>
      <div style="text-indent: 14.2pt; line-height: 1.25;">&#160;</div>
      <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">Indicate by check mark if the Registrant is&#160;submitting&#160;the Form 6-K in paper as permitted by Regulation S-T Rule
        101(b)(1): ____&#160;</div>
      <div style="text-indent: 28.35pt; line-height: 1.25;">&#160;</div>
      <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">Indicate by check mark if the Registrant is&#160;submitting&#160;the Form 6-K in paper as permitted by Regulation S-T Rule
        101(b)(7): ____</div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">Attached hereto as <a href="exhibit_99-1.htm">Exhibit
          99.1</a> and incorporated by reference herein is a press release issued by the Registrant on December 15, 2021 entitled: &#8220;<font style="font-style: italic;">RedHill Biopharma Announces Additional Insider Buying</font>&#8221;.</div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;</div>
      <div style="text-align: justify; line-height: 1.25;">This Report on Form 6-K is hereby incorporated by reference into the Company's Registration Statements on Form S-8 filed with the
        Securities and Exchange Commission on May 2, 2013 (Registration No. 333-188286), on October 29, 2015 (Registration No. 333-207654), on July 25, 2017 (Registration No. 333-219441), on May 23, 2018 (Registration No. 333-225122), on July 24, 2019
        (File No. 333-232776) on March 25, 2021 (File No. 333-254692) and on May 3, 2021 (File No. 333-255710), and its Registration Statements on Form F-3 filed with the Securities and Exchange Commission on July 24, 2019 (File No. 333-232777), on March
        30, 2021 (File No. 333-254848) and on July 29, 2021 (File No. 333-258259).</div>
      <div style="text-align: justify; line-height: 1.25;"> <br>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
        <div style="page-break-after: always;" id="DSPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">Signatures</div>
      <div style="text-indent: 28.35pt; line-height: 1.25;">&#160;</div>
      <div style="text-align: justify; line-height: 1.25;">Pursuant to the requirements of&#160;the&#160;Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its
        behalf by the undersigned, thereunto duly authorized.&#160;</div>
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><br style="line-height: 1.25;">
      </div>
      <table cellspacing="0" cellpadding="0" id="z1c0a0c2b24f248d1a11c8f7bd87b03cf" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 49.63%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 33.94%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;" colspan="2">
              <div style="line-height: 1.25;">REDHILL BIOPHARMA LTD.</div>
            </td>
            <td style="width: 16.43%; vertical-align: bottom; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 49.63%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 33.94%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;" colspan="2">
              <div style="line-height: 1.25;">(the "Registrant")</div>
            </td>
            <td style="width: 16.43%; vertical-align: bottom; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 49.63%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 3.48%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 30.46%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 16.43%; vertical-align: bottom; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 49.63%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">Date: December 15, 2021</div>
            </td>
            <td style="width: 3.48%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">By:</div>
            </td>
            <td style="width: 30.46%; vertical-align: middle; border-bottom: 2px solid rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">&#160;/s/ Dror Ben-Asher&#160;</div>
            </td>
            <td style="width: 16.43%; vertical-align: bottom; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 49.63%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 33.94%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;" colspan="2">
              <div style="line-height: 1.25;">Dror Ben-Asher&#160;</div>
            </td>
            <td style="width: 16.43%; vertical-align: bottom; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 49.63%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
            <td style="width: 33.94%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;" colspan="2">
              <div style="line-height: 1.25;">Chief Executive Officer</div>
            </td>
            <td style="width: 16.43%; vertical-align: bottom; font-family: 'Times New Roman',Times,serif;">
              <div style="line-height: 1.25;">&#160;</div>
            </td>
          </tr>

      </table>
      <div style="text-align: justify; line-height: 1.25;">&#160;</div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#160;2
        <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;"></div>
    </div>
  </div>
  <font style="font-family: 'Times New Roman',Times,serif;">
  </font>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>exhibit_99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: ZKG
         Document created using EDGARfilings PROfile 7.7.0.0
         Copyright 1995 - 2021 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;">
    <div style="text-align: right;"><u><font style="font-weight: bold;">Exhibit 99.1</font></u><br>
    </div>
    <div> <br>
    </div>
    <div>
      <div style="line-height: 1.25;"><img width="150" height="89" src="image0.jpg"></div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">
        <table cellspacing="0" cellpadding="0" border="0" id="z8843e1bdaa5044d6b21bec21e11d406c" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;">

            <tr>
              <td style="border-width: 4px 2px 2px; border-style: solid; border-color: rgb(0, 0, 0); width: 100%;">
                <div>&#160;
                  <div style="line-height: 1.25;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold;">Press Release</div>
                    <div style="text-align: center; text-indent: 42.55pt; line-height: 1.25;"> <br>
                    </div>
                  </div>
                </div>
              </td>
            </tr>

        </table>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-weight: bold;"><u>RedHill Biopharma Announces Additional Insider Buying</u></div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; line-height: 1.25;">
        <div style="line-height: 1.25;"><font style="font-weight: bold;">RALEIGH, N.C. and TEL-AVIV, Israel,
            December 15, 2021, </font><u>RedHill Biopharma Ltd.</u> (Nasdaq: <u>RDHL</u>)
          (&#8220;RedHill&#8221; or the &#8220;Company&#8221;), a specialty biopharmaceutical company, today announced that members of its board of directors and senior management, including the Company&#8217;s Chairman &amp; CEO, Mr. Dror Ben-Asher, collectively purchased
          approximately an additional 66,000 American Depositary Shares (ADSs) of RedHill since mid-October, 2021, in open-market transactions.</div>
      </div>
      <div style="text-align: justify; margin-right: 0.1pt; margin-left: 0.1pt; line-height: 1.25;"><br>
        <font style="font-weight: bold;">About RedHill Biopharma</font><br>
        RedHill Biopharma Ltd. (Nasdaq: <u>RDHL</u>) is a specialty biopharmaceutical company primarily focused on gastrointestinal and infectious diseases. RedHill promotes the gastrointestinal drugs, <font style="font-weight: bold;">Movantik</font><sup style="font-weight: bold; vertical-align: text-top; line-height: 1; font-size: smaller;">&#174; </sup>for opioid-induced constipation in adults<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup>, <font style="font-weight: bold;">Talicia</font><sup style="font-weight: bold; vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup><font style="font-weight: bold;">&#160;</font>for the treatment of <font style="font-style: italic;">Helicobacter pylori (H. pylori)</font> infection in adults<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">2</sup>, and <font style="font-weight: bold;">Aemcolo</font><sup style="font-weight: bold; vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> for the treatment of travelers&#8217; diarrhea in adults<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">3</sup>.
        RedHill&#8217;s key clinical late-stage development programs include: (i) <font style="font-weight: bold;">RHB-204</font>,<font style="font-weight: bold;">&#160;</font>with an ongoing Phase 3 study for pulmonary nontuberculous mycobacteria (NTM) disease;
        (ii) <font style="font-weight: bold;">opaganib </font><font style="font-weight: bold;">(ABC294640)</font>, a first<font style="font-weight: bold;">-</font>in<font style="font-weight: bold;">-</font>class oral SK2 selective inhibitor targeting
        multiple indications with a Phase 2/3 program for COVID-19 and Phase 2 studies for prostate cancer and cholangiocarcinoma ongoing; (iii) <font style="font-weight: bold;">RHB-107 </font>(<font style="font-weight: bold;">upamostat</font>), an oral
        serine protease inhibitor in a U.S. Phase 2/3 study as treatment for symptomatic COVID-19, and targeting multiple other cancer and inflammatory gastrointestinal diseases; (iv) <font style="font-weight: bold;">RHB-104</font>, with positive results
        from a first Phase 3 study for Crohn's disease; (v) <font style="font-weight: bold;">RHB-102</font> , with positive results from a Phase 3 study for acute gastroenteritis and gastritis and positive results from a Phase 2 study for IBS-D; and (vi)
        <font style="font-weight: bold;">RHB</font>-<font style="font-weight: bold;">106</font>, an encapsulated bowel preparation. More information about the Company is available at <u>https://www.redhillbio.com</u> / <u>https://twitter.com/RedHillBio</u>.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div id="DSPFPageBreak" style="page-break-after: always;">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: justify; line-height: 1.25; font-style: italic;">This press release contains &#8220;forward-looking statements&#8221; within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements may be preceded by the words
        &#8220;intends,&#8221; &#8220;may,&#8221; &#8220;will,&#8221; &#8220;plans,&#8221; &#8220;expects,&#8221; &#8220;anticipates,&#8221; &#8220;projects,&#8221; &#8220;predicts,&#8221; &#8220;estimates,&#8221; &#8220;aims,&#8221; &#8220;believes,&#8221; &#8220;hopes,&#8221; &#8220;potential&#8221; or similar words. Forward-looking statements are based on certain assumptions and are subject to various
        known and unknown risks and uncertainties, many of which are beyond the Company&#8217;s control and cannot be predicted or quantified, and consequently, actual results may differ materially from those expressed or implied by such forward-looking
        statements. Such risks and uncertainties associated with (i) the initiation, timing, progress and results of the Company&#8217;s research, manufacturing, pre-clinical studies, clinical trials, and other therapeutic candidate development efforts, and the
        timing of the commercial launch of its commercial products and ones it may acquire or develop in the future; (ii) the Company&#8217;s ability to advance its therapeutic candidates into clinical trials or to successfully complete its pre-clinical studies
        or clinical trials or the development of a commercial companion diagnostic for the detection of MAP; (iii) the extent and number and type of additional studies that the Company may be required to conduct and the Company&#8217;s receipt of regulatory
        approvals for its therapeutic candidates, and the timing of other regulatory filings, approvals and feedback; (iv) the manufacturing, clinical development, commercialization, and market acceptance of the Company&#8217;s therapeutic candidates and Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>;
        (v) the Company&#8217;s ability to successfully commercialize and promote Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>, and Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174; </sup>and Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>; (vi) the Company&#8217;s ability to establish and maintain corporate collaborations; (vii) the Company's ability
        to acquire products approved for marketing in the U.S. that achieve commercial success and build its own marketing and commercialization capabilities; (viii) the interpretation of the properties and characteristics of the Company&#8217;s therapeutic
        candidates and the results obtained with its therapeutic candidates in research, pre-clinical studies or clinical trials; (ix) the implementation of the Company&#8217;s business model, strategic plans for its business and therapeutic candidates; (x) the
        scope of protection the Company is able to establish and maintain for intellectual property rights covering its therapeutic candidates and its ability to operate its business without infringing the intellectual property rights of others; (xi)
        parties from whom the Company licenses its intellectual property defaulting in their obligations to the Company; (xii) estimates of the Company&#8217;s expenses, future revenues, capital requirements and needs for additional financing; (xiii) the effect
        of patients suffering adverse experiences using investigative drugs under the Company's Expanded Access Program; (xiv) competition from other companies and technologies within the Company&#8217;s industry; and (xv) the hiring and employment commencement
        date of executive managers. More detailed information about the Company and the risk factors that may affect the realization of forward-looking statements is set forth in the Company's filings with the Securities and Exchange Commission (SEC),
        including the Company's Annual Report on Form 20-F filed with the SEC on March 18, 2021. All forward-looking statements included in this press release are made only as of the date of this press release. The Company assumes no obligation to update
        any written or oral forward-looking statement, whether as a result of new information, future events or otherwise unless required by law.</div>
      <div style="text-align: justify; line-height: 1.25; font-style: italic;"> <br>
      </div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z7f2582349db14eb088b64d3dfe8e94aa">

          <tr>
            <td style="width: 53.27%; vertical-align: top;">
              <div style="line-height: 1.25; font-weight: bold;">Company contact:</div>
              <div style="line-height: 1.25;">Adi Frish</div>
              <div style="line-height: 1.25;">Chief Corporate &amp; Business Development Officer</div>
              <div style="line-height: 1.25;">RedHill Biopharma</div>
              <div style="line-height: 1.25;">+972-54-6543-112</div>
              <div style="line-height: 1.25;"><u>adi@redhillbio.com</u></div>
            </td>
            <td style="width: 46.73%; vertical-align: top;">
              <div style="line-height: 1.25; font-weight: bold;">Media contacts:</div>
              <div style="line-height: 1.25;"><font style="font-weight: bold;">U.S.:</font> Bryan Gibbs, Finn Partners</div>
              <div style="line-height: 1.25;">+1 212 529 2236</div>
              <div style="line-height: 1.25;"><u>bryan.gibbs@finnpartners.com</u></div>
              <div style="line-height: 1.25;"><font style="font-weight: bold;">UK:</font> Amber Fennell, Consilium</div>
              <div style="line-height: 1.25;">+44 (0) 7739 658 783</div>
              <div style="line-height: 1.25;"><u>fennell@consilium-comms.com</u></div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25;">Category: Corporate</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <hr noshade="noshade" align="left" style="background-color: #000000; border: 0px; height: 1px; width: 2in; margin-left: 0pt; margin-right: auto; color: #000000;">
      <div style="text-align: justify; line-height: 1.25;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">1</sup> Full prescribing information for Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> (naloxegol) is available at: www.Movantik.com.</div>
      <div style="text-align: justify; line-height: 1.25;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">2</sup> Full prescribing information for Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> (omeprazole magnesium, amoxicillin and rifabutin) is available at: www.Talicia.com.</div>
      <div style="text-align: justify; line-height: 1.25;"><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">3</sup> Full prescribing information for Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> (rifamycin) is available at: www.Aemcolo.com.</div>
      <div style="text-align: justify; line-height: 1.25;"> <br>
      </div>
      <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"> 2<br>
        <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;"></div>
    </div>
  </div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>image0.jpg
<TEXT>
begin 644 image0.jpg
M_]C_X  02D9)1@ ! 0$ W #<  #_VP!#  @&!@<&!0@'!P<)"0@*#!0-# L+
M#!D2$P\4'1H?'AT:'!P@)"XG("(L(QP<*#<I+# Q-#0T'R<Y/3@R/"XS-#+_
MVP!# 0D)"0P+#!@-#1@R(1PA,C(R,C(R,C(R,C(R,C(R,C(R,C(R,C(R,C(R
M,C(R,C(R,C(R,C(R,C(R,C(R,C(R,C+_P  1" #, 5@# 2(  A$! Q$!_\0
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M'RU8M!1115&(4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110
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M0":XCC7]U<(-TG^ZV3S]?SKN_"_Q"TGQ3?S65NDMO.HW1I/@&5>^,$\CT_\
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M?PKX:AFEA7^U+R,27$A'S*#R$'H!W]\^U=O7CW_#0.F_] *[_P"_R_X4?\-
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MX!YP6W8^E 'H=%%% !7)^%/^1F\8?]A&/_T1'765R?A3_D9O&'_81C_]$1T
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MZOI]SK=BG$6HV"!IMO82Q=2?]I<Y^M=I10!R7_"P])8;8K'6IIO^>*:9-O\
MU4#]:JS6FO>-B(-1M9-%\/DYDMV<?:KL?W6V\1H>XSD_C7;T4 ,AACMX(X88
MUCBC4(B*,!0.  /2N4N427XK6L<BAD;0IE96&009H\@UUU<G-_R5JS_[ DW_
M *.CH JQVNN^"F:'3;-]9\/Y)CMD<"YLQ_=3=Q(GH,Y'3M5D?$/25&V:QUJ"
M;_GC)IDV[]%(_6NMHH XJYO_ !#XM0V6EV-WH>FR<3ZA>*$G9>XBCZ@G^\V,
M>F:ZG2M+M-%TNWTZPB$5M;IL11_,^I)Y)]35RB@#FO%%A=7FK>&9;>!Y$MM2
M\V9E'W$\MQD^V2*Z6BB@ HHHH YKPA875C+XB-U \0N-9FGAW?QQE4 8>W!_
M*J6H:7K/A[7[K7- MUOK6^PU_II<(Q<#'FQ$\;L=0>N/R[*B@#DA\0M,C&+S
M3M;LY>\4VFRD_FH(/YU'+XLUG5AY'AOP[>;VX^V:I&;>"/\ VMI^=_H *[&B
M@#@M1\#72>$=32"?^T?$%Y)%<S7,V$\]XW5P@[*N%( Z#-='HFN76JR21W.A
M:CIK1H"6N@FQCZ*58Y_(5M44 <WX$L;K3?"%M:WD#PSK-<,4?J T\C#\P0?Q
MKI*** .;UNQNKCQCX6NX8'>"UDN3/(.B!H2JY^IXKI*** "N;\86-U?0Z*+6
M!Y3#J]M-)M_A16^9C["NDHH **** .;\?6-UJ7@?5+.R@>>XEC4)&G5OG4_T
MK8U73;;6=*NM-O$W6]S&8W ZX/<>XZU<HH XBRU;Q!X4A73];TN[U6TA&R#4
M]/3S'=!T\V/.X,!U(SFK1^(>D$;8;+6IY?\ GE'IDV[]5 _6NMHH X>X@\1^
M-1]FN;:30=!?_7*[@W=TO]WCB-3WY)_.EO+.\\,>+(M3TW1)KW2FTU+$PV17
MS("CDKA6(RI#8Z]J[>B@"M8737MC#<O:SVK2+DPS@!T]B 2,_C15FB@ HHHH
M **** "BBB@ HHHH **** "BBB@ K%DT:9_&L&N"2/R(]/>T,?.XLTBMGTQA
M:VJ* "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ H
5HHH **** "BBB@ HHHH **** /_9

end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
