<SEC-DOCUMENT>0001178913-22-004270.txt : 20221206
<SEC-HEADER>0001178913-22-004270.hdr.sgml : 20221206
<ACCEPTANCE-DATETIME>20221206060428
ACCESSION NUMBER:		0001178913-22-004270
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20221206
DATE AS OF CHANGE:		20221206

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			RedHill Biopharma Ltd.
		CENTRAL INDEX KEY:			0001553846
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-258259
		FILM NUMBER:		221446624

	BUSINESS ADDRESS:	
		STREET 1:		21 HA'ARBA'A STREET
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			64739
		BUSINESS PHONE:		972-3-541-3131

	MAIL ADDRESS:	
		STREET 1:		21 HA'ARBA'A STREET
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			64739
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>zk2228857.htm
<DESCRIPTION>424B5
<TEXT>
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        <hr align="center" style="border: none; border-bottom: 1px solid black; border-top: 4px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
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    <div style="text-align: right; line-height: 1.25; font-weight: bold;"> <br>
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    <div style="text-align: right; line-height: 1.25; font-weight: bold;">Filed Pursuant to Rule 424(b)(5)</div>
    <div style="text-align: right; line-height: 1.25; font-weight: bold;">Registration No. 333-258259</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">PROSPECTUS SUPPLEMENT</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">(To prospectus dated August 9, 2021)</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">21,775,000 Units Each Consisting of</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">One American Depositary Share and One Warrant to Purchase One American Depositary Share</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">10,225,000 Pre-Funded Units Each Consisting of</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">One Pre-Funded Warrant to Purchase One American Depositary Share and One Warrant to Purchase One </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">American Depositary Share</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;"><img width="362" height="214" src="image0.jpg"></div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif; font-size: 12pt; font-weight: bold; background-color: rgb(255, 255, 255); color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">RedHill Biopharma Ltd.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">We are offering 21,775,000 units, each consisting of one American Depositary Share (&#8220;ADS&#8221;) and one warrant to purchase one ADS (the &#8220;Warrants&#8221;) at a combined public offering price of $0.25 for each
      unit pursuant to this prospectus supplement and accompanying prospectus. Each ADS represents 10 of our ordinary shares, par value NIS 0.01 per share (&#8220;Ordinary Shares&#8221;). The ADSs and Warrants are immediately separable and will be issued separately in
      this offering. The Warrants have an exercise price of $0.25 per ADS, are exercisable immediately and will expire five years from the date of issuance.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">We are also offering10,225,000 pre-funded units, or, each, a pre-funded unit, in lieu of the units that would otherwise result in ownership in excess of 4.99% (or, at the election of the purchaser,
      9.99%) of our outstanding Ordinary Shares, with each pre-funded unit consisting of a pre-funded warrant to purchase&#160;one ADS (a &#8220;Pre-funded Warrant&#8221;), and one Warrant. The purchase price of each pre-funded unit will equal the price per unit, minus
      $0.001, and the exercise price of each pre-funded warrant included in the pre-funded unit will be $0.001 per ADS. The pre-funded units have no stand-alone rights and will not be certificated or issued as stand-alone securities. The Pre-funded
      Warrants and Warrants are immediately separable and will be issued separately in this offering. There can be no assurance that we will sell any of the pre-funded units being offered. The Pre-funded Warrants offered hereby will be immediately
      exercisable and may be exercised on the date of issuance at any time until exercised in full.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">The ADSs are listed on The Nasdaq Global Market (&#8220;Nasdaq&#8221;) under the symbol &#8220;RDHL.&#8221; On December 2, 2022, the last reported sale price of the ADSs on Nasdaq was $0.266 per ADS.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">There is no established public trading market for the Warrants or Pre-funded Warrants, and we do not expect a market to develop. We do not intend to apply for listing of the Warrants or Pre-funded
      Warrants on any securities exchange or nationally recognized trading system. Without an active trading market, the liquidity of the Warrants and Pre-funded Warrants will be limited.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">The ADSs issuable from time to time upon exercise of the Pre-funded Warrants and Warrants are also being offered by this prospectus supplement and accompanying prospectus. We refer to the ADSs
      issuable upon exercise of the Pre-funded Warrants and Warrants, the ADSs and Warrants being offered hereby, collectively, as the &#8220;securities&#8221;.</div>
    <div style="text-align: justify; line-height: 1.25;"> <br>
    </div>
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    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">The offering is being underwritten on a firm commitment basis. The underwriter may offer the securities from time to time for sale in one or more transactions on Nasdaq, in the over-the-counter
      market, through negotiated transactions or otherwise at market prices prevailing at the time of sale, at prices related to prevailing market prices or at negotiated prices, subject to receipt and acceptance by it and subject to its right to reject
      any order in whole or in part. See &#8220;Underwriting.&#8221;</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
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        <tr>
          <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#8203;</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#8203;</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; border-bottom: #000000 solid 2px;" colspan="2">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Per Unit</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; border-bottom: #000000 solid 2px;" colspan="2">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Per Pre-Funded Unit</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; border-bottom: #000000 solid 2px;" colspan="2">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">Total</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 32%; padding-bottom: 2px;">
            <div style="line-height: 1.25;">Public Offering price</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 32%; padding-bottom: 2px;">
            <div style="text-align: center; line-height: 1.25;">&#8203;</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
            <div style="line-height: 1.25;">0.25</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
            <div style="line-height: 1.25;">0.249</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
            <div style="line-height: 1.25;">7,989,775</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; width: 32%; padding-bottom: 2px;">
            <div style="line-height: 1.25;">Underwriting discounts and commissions</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 32%; padding-bottom: 2px;">
            <div style="text-align: center; line-height: 1.25;">&#8203;</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
            <div style="line-height: 1.25;">0.0125</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
            <div style="line-height: 1.25;">0.0125</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
            <div style="line-height: 1.25;">399,489</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 32%; padding-bottom: 4px;">
            <div style="line-height: 1.25;">Proceeds, before expenses and fees, to us</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 32%; padding-bottom: 4px;">
            <div style="text-align: center; line-height: 1.25;">&#8203;</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;" colspan="1" class="cftcurrcell">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;" colspan="1" class="cftnumcell">
            <div style="line-height: 1.25;">0.2375</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftfncell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;" colspan="1" class="cftcurrcell">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;" colspan="1" class="cftnumcell">
            <div style="line-height: 1.25;">0.2365</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftfncell">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
          <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;" colspan="1" class="cftcurrcell">
            <div style="line-height: 1.25;">$</div>
          </td>
          <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;" colspan="1" class="cftnumcell">
            <div style="line-height: 1.25;">7,590,286</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftfncell">&#160;</td>
        </tr>

    </table>
    <div style="line-height: 1.25;">&#8203;&#160;</div>
    <div style="text-align: justify; line-height: 1.25;">We have agreed to reimburse the underwriter for certain offering related expenses. See &#8220;Underwriting&#8221; for details and information regarding the compensation to be paid to the underwriter.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Investing in our securities involves a high degree of risk. Please read &#8220;Risk Factors&#8221; beginning on page S-10 of this prospectus supplement, on page 11 of the accompanying
      prospectus and in the documents incorporated by reference into this prospectus supplement.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25; font-weight: bold;">None of the United States Securities and Exchange Commission, any state securities commission or any other regulatory body, has approved or disapproved of these securities or
      passed upon the adequacy or accuracy of this prospectus supplement or the accompanying prospectus. Any representation to the contrary is a criminal offense.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Delivery of the units and/or pre-funded units is expected to be made on or about&#160;December 6, 2022.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Aegis Capital Corp.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;">Prospectus supplement dated&#160;December 2, 2022.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;">&#160;</div>
    <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;">Table Of Contents</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <table cellspacing="0" cellpadding="0" id="z7c0b4f77985f485c9100f6f6720605d0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 10%; vertical-align: top;">
            <div style="text-align: right; line-height: 1.25; font-weight: bold;">Page</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: bottom;" colspan="2">
            <div style="line-height: 1.25; font-weight: bold;">PROSPECTUS SUPPLEMENT</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#ABOUTTHISPROSPECTUSSUPPLE111">ABOUT THIS PROSPECTUS SUPPLEMENT</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-1</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#CAU111TIONARYNOTEREGARDINGFO">CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-2</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#Sum11maryofRiskFactors">PROSPECTUS SUPPLEMENT SUMMARY</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-5</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#RISKFACT11ORS">RISK FACTORS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-10</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#USEOFPROCEEDS11">USE OF PROCEEDS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-13</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#DILUTION222">DILUTION</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-14</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#CAPITALIZATIO11NANDINDEBTED">CAPITALIZATION AND INDEBTEDNESS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-15</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#DIVI11DENDPOLICY">DIVIDEND POLICY</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-16</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#DE111SCRIPTIONOFSECURITIESWE">DESCRIPTION OF SECURITIES WE ARE OFFERING</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-17</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#MATERIALTAXCONSI11DERATIONS">MATERIAL TAX CONSIDERATIONS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-22</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#UNDERWRITING11">UNDERWRITING</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-35</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#EXPENSES11">EXPENSES</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-40</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#LEGALMATTERS1">LEGAL MATTERS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-41</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#EXPERTS1">EXPERTS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-42</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#WHEREYOUCA1NFINDMOREINFORM">WHERE YOU CAN FIND MORE INFORMATION</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-43</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#INCORPORA1TIONOFCERTAINDOC">INCORPORATION OF INFORMATION BY REFERENCE</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">S-44</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="line-height: 1.25;">&#160;</div>
          </td>
        </tr>

    </table>
    <div style="line-height: 1.25; font-variant: small-caps; font-weight: bold;">PROSPECTUS</div>
    <table cellspacing="0" cellpadding="0" id="z563dbd5354a84634ba83067723628bb7" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#ROSPECTUS">ABOUT THIS PROSPECTUS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">2</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#REDHILLBIOPHARMALTD.">REDHILL BIOPHARMA LTD.</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">3</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#RISKFACTORS1">RISK FACTORS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">11</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#FORWARD-LOOKINGSTATEMENTS">FORWARD-LOOKING STATEMENTS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">11</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#CAPITALIZATION">CAPITALIZATION</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">12</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#OFFERANDLISTINGDETAILS">OFFER AND LISTING DETAILS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">12</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#USEOFPROCEEDS1">USE OF PROCEEDS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">13</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFORDINARYSHAR1">DESCRIPTION OF ORDINARY SHARES</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">13</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFAMERICANDEPO1">DESCRIPTION OF AMERICAN DEPOSITARY SHARES</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">13</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFWARRANTS1">DESCRIPTION OF WARRANTS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">13</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFSUBSCRIPTION">DESCRIPTION OF SUBSCRIPTION RIGHTS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">14</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFUNITS">DESCRIPTION OF UNITS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">14</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#PLANOFDISTRIBUTION1">PLAN OF DISTRIBUTION</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">15</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#LEGALMATTERS1">LEGAL MATTERS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">17</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#EXPERTS1">EXPERTS</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">18</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#WHEREYOUCA1NFINDMOREINFORM">WHERE YOU CAN FIND MORE INFORMATION</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">18</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#INCORPORA1TIONOFCERTAINDOC">INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">18</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#ENFORCEABILITYOFCIVILLIAB">ENFORCEABILITY OF CIVIL LIABILITIES</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">19</div>
          </td>
        </tr>
        <tr>
          <td style="width: 90%; vertical-align: bottom;">
            <div style="line-height: 1.25;"><a href="#OFFERINGEXPENSES">OFFERING EXPENSES</a></div>
          </td>
          <td style="width: 10%; vertical-align: bottom;">
            <div style="text-align: right; line-height: 1.25;">20</div>
          </td>
        </tr>

    </table>
    <div style="text-align: center; line-height: 1.25; font-variant: small-caps; font-weight: bold;">&#160;</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <!--PROfilePageNumberReset%Num%1%S - %%-->
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="ABOUTTHISPROSPECTUSSUPPLE111"><!--Anchor--></a>ABOUT THIS PROSPECTUS SUPPLEMENT</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">This prospectus supplement and the accompanying prospectus form part of the registration statement (No. 333- 258259) that we filed with the Securities and Exchange Commission (&#8220;SEC&#8221;), using a &#8220;shelf&#8221;
      registration process. This document comprises two parts. The first part is this prospectus supplement, which describes the specific terms of this offering and also adds to and updates information contained in the accompanying base prospectus and the
      documents incorporated by reference herein. The second part, the accompanying base prospectus, gives more general information, some of which may not apply to this offering. Generally, when we refer to this prospectus, we are referring to both parts
      of this document combined. If the description of the offering varies between this prospectus supplement and the accompanying prospectus or the documents incorporated herein or therein by reference filed prior to the date of this prospectus
      supplement, you should rely on the information contained in this prospectus supplement. However, if any statement in one of these documents is inconsistent with a statement in another document having a later date - for example, a document
      incorporated by reference in the accompanying prospectus - the statement in the document having the later date modifies or supersedes the earlier statement.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">Neither we nor the underwriter has authorized anyone to provide information different from that contained in this prospectus supplement, the accompanying prospectus and any free writing prospectus
      that we have authorized for use in this offering. If anyone provides you with different or inconsistent information, you should not rely on it. Neither we nor the underwriter take any responsibility for, and can provide no assurance as to the
      reliability of, any other information that others may give you. You should not assume that the information contained in this prospectus supplement or the accompanying prospectus, or any document incorporated by reference in this prospectus supplement
      or the accompanying prospectus, is accurate as of any date other than the date on the front cover of the applicable document. Neither the delivery of this prospectus supplement, the accompanying prospectus and any free writing prospectus that we have
      authorized for use in this offering, nor the sale of the securities means that information contained in this prospectus supplement, the accompanying prospectus and any free writing prospectus that we have authorized for use in this offering, is
      correct after their respective dates. Our business, financial condition, results of operations and prospects may have changed since that date. It is important for you to read and consider all information contained in this prospectus supplement and
      the accompanying prospectus, including the information incorporated by reference into this prospectus supplement, the accompanying prospectus and any free writing prospectus that we have authorized for use in connection with this offering in making
      your investment decision.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">Before purchasing any securities, you should carefully read both this prospectus supplement and the accompanying prospectus, together with the additional information described under the headings,
      &#8220;Where You Can Find More Information&#8221; and &#8220;Incorporation of Information by Reference,&#8221; on page S-43 of this prospectus supplement.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">Unless the context otherwise requires, all references to &#8220;RedHill,&#8221; &#8220;we,&#8221; &#8220;us,&#8221; &#8220;our,&#8221; the &#8220;Company&#8221; and similar designations refer to RedHill Biopharma Ltd. and its wholly-owned subsidiary, RedHill
      Biopharma Inc. (&#8220;RedHill US&#8221;) The term &#8220;NIS&#8221; refers to New Israeli Shekels, the lawful currency of the State of Israel, and the terms &#8220;dollar,&#8221; &#8220;US$&#8221; or &#8220;$&#8221; refer to U.S. dollars, the lawful currency of the United States (&#8220;U.S.&#8221;). Our functional and
      presentation currency is the U.S. dollar. Foreign currency transactions in currencies other than the U.S. dollar are translated in this prospectus supplement into U.S. dollars using exchange rates in effect at the date of the transactions.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">We further note that the representations, warranties and covenants made by us in any agreement that is filed as an exhibit to any document that is incorporated by reference herein were made solely
      for the benefit of the parties to such agreement, including, in some cases, for the purpose of allocating risk among the parties to such agreements, and should not be deemed to be a representation, warranty or covenant to you. Moreover, such
      representations, warranties or covenants were accurate only as of the date when made. Accordingly, such representations, warranties, and covenants should not be relied on as accurately representing the current state of our affairs.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">This prospectus supplement and the accompanying prospectus do not constitute an offer to sell, or a solicitation of an offer to purchase, the securities offered by this prospectus supplement and the
      accompanying prospectus in any jurisdiction where it is unlawful to make such offer or solicitation.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">We are offering to sell, and seeking offers to buy, and the underwriter is soliciting offers to buy, securities only in jurisdictions where offers and sales are permitted. The distribution of this
      prospectus supplement and the accompanying prospectus and the offering of the securities in certain jurisdictions may be restricted by law. Persons outside the U.S. who come into possession of this prospectus supplement and the accompanying
      prospectus must inform themselves about, and observe any restrictions relating to, the offering of the securities and the distribution of this prospectus supplement and the accompanying prospectus outside the U.S. This prospectus supplement and the
      accompanying prospectus do not constitute, and may not be used in connection with, an offer to sell, or a solicitation of an offer to buy, any securities offered by this prospectus supplement and the accompanying prospectus by any person in any
      jurisdiction in which it is unlawful for such person to make such an offer or solicitation.</div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25;"><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 1</font></div>
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="CAU111TIONARYNOTEREGARDINGFO"><!--Anchor--></a>CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">This prospectus supplement, the accompanying prospectus, and the information incorporated by reference herein and therein may include forward-looking statements. These statements involve known and
      unknown risks, uncertainties and other factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. In
      some cases, you can identify forward-looking statements by terms, including &#8220;anticipates,&#8221; &#8220;believes,&#8221; &#8220;could,&#8221; &#8220;estimates,&#8221; &#8220;expects,&#8221; &#8220;intends,&#8221; &#8220;may,&#8221; &#8220;plans,&#8221; &#8220;potential,&#8221; &#8220;predicts,&#8221; &#8220;projects,&#8221; &#8220;should,&#8221; &#8220;will,&#8221; &#8220;would,&#8221; and similar expressions
      intended to identify forward-looking statements. Forward-looking statements reflect our current views with respect to future events and are based on assumptions and are subject to risks and uncertainties. In addition, certain sections of this
      prospectus supplement, the accompanying prospectus, and the information incorporated by reference herein contain information obtained from independent industry and other sources that we have not independently verified. You should not put undue
      reliance on any forward-looking statements. Unless we are required to do so under U.S. federal securities laws or other applicable laws, we do not intend to update or revise any forward-looking statements.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">Our ability to predict our operating results or the effects of various events on our operating results is inherently uncertain. Therefore, we caution you to consider carefully the matters described
      under the caption &#8220;Risk Factors&#8221; on page S-10 of this prospectus supplement, and certain other matters discussed in this prospectus supplement, the accompanying prospectus, and the information incorporated by reference herein and therein, and other
      publicly available sources. Such factors and many other factors beyond our control could cause our actual results, performance or achievements to be materially different from any future results, performance or achievements that may be expressed or
      implied by the forward-looking statements.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">Factors that could cause our actual results to differ materially from those expressed or implied in such forward-looking statements include, but are not limited to:</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z800975a4bdc940c2839dc3ade32dc4f5" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">estimates of our expenses, future revenues, capital requirements and our needs for additional financing;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z6e8b75e651184c87aa19c7d09a8da258" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our ability to obtain additional financing;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z586f8743c80e4a1e9cedf157bcce7a5a" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">the commercialization and market acceptance of our commercial products;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="ze0dfa15341734bc69b7d1a3479040bff" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our ability to generate sufficient revenues from our commercial products, including obtaining commercial insurance and government reimbursement;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zbacd86af072a4ae4a77bf3b09817cfa8" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our ability to advance our therapeutic candidates into clinical trials or to successfully complete our preclinical studies or clinical trials, and to complete the development of such
                therapeutic candidates and obtain approval for marketing by the Food and Drug Administration (&#8220;FDA&#8221;) or other regulatory authorities;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zf2b1420071bb4fc0b9b571f2fe385746" class="DSPFListTable">

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            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our reliance on third parties to satisfactorily conduct key portions of our commercial operations, including manufacturing and other supply chain functions, market analysis services, safety
                monitoring, regulatory reporting and sales data analysis and the risk that those third parties may not perform such functions satisfactorily;</div>
            </td>
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    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z504e702bda8c487cba6e17075bb61008" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our ability to maintain an appropriate sales and marketing infrastructure;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zc51f39ec00c842fcaf67f8985b2b8c3f" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our ability to establish and maintain corporate collaborations;</div>
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          </tr>

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    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z886a46d2f948484f9b0c02c472195fa5" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">that our current commercial products or commercial products that we may commercialize or promote in the future may be withdrawn from the market by regulatory authorities and our need to
                comply with continuing laws, regulations and guidelines to maintain clearances and approvals for those products;</div>
            </td>
          </tr>

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    </div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25;"><br>
    </div>
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      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 2</font></div>
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25; text-align: center;"><br style="line-height: 1.25;">
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zbfa0ea0b45cf4eb68ef02fb72b32d682" class="DSPFListTable">

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            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
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            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our exposure to significant drug product liability claims;</div>
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          </tr>

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    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z943131772bff46deae2620b6db3636d9" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
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            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">the initiation and completion of any postmarketing studies or trials;</div>
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      </table>
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    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zf29bb9cc33e44204a00a78ba56bece48" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our ability to acquire products approved for marketing in the U.S. that achieve commercial success and to maintain our own marketing and commercialization capabilities;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <div>
        <div>
          <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z6eaa56bf739a436f9d19d82235f005c3" class="DSPFListTable">

              <tr style="vertical-align: top;">
                <td style="vertical-align: top; width: 27pt;">
                  <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="line-height: 1.25;">&#8226;</font></div>
                </td>
                <td style="align: left; vertical-align: top; width: auto;">
                  <div style="text-align: justify; line-height: 1.25;">our estimates of the markets, their size, characteristics and their potential for our commercial products and therapeutic candidates and our ability to serve those markets;</div>
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      </div>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="za5d2fdd94233419c8b7ef54298fbaba5" class="DSPFListTable">

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              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
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              <div style="text-align: justify; line-height: 1.25;">the successful commercialization of products we in-license or acquire;</div>
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    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zd84950b249c44d879c3c4acf470f51a6" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our inability to enforce claims relating to a breach of a representation and warranty by a counterparty;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="za9dbce14ae444c93a0a9b8743f606344" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">the hiring and continued employment of executives, sales personnel, and contractors;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zaa99028902314562a033233454e61fd3" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our receipt and timing of regulatory clarity and approvals for our commercial products and therapeutic candidates, and the timing of other regulatory filings and approvals;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="ze99bfcc6f5f34f60b237499ed4746ddf" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">the initiation, timing, progress, and results of our research, development, manufacturing, preclinical studies, clinical trials, and other commercial efforts and therapeutic candidate
                development, as well as the extent and number of additional studies that we may be required to conduct;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zedf3732648f440edaa7ab786eaed6e25" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our ability to advance our therapeutic candidates into clinical trials or to successfully complete our preclinical studies or clinical trials, including developing a commercial companion
                diagnostic for the detection of Mycobacterium avium paratuberculosis (&#8220;MAP&#8221;);</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z5367ef80386b49049915ee33168da5a6" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our reliance on third parties to conduct key portions of our clinical trials, including data management services and the risk that those third parties may not perform such functions
                satisfactorily;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z01e4b035da964e62b2112a1fa987a571" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our reliance on third parties to manufacture and supply our therapeutic candidates and their respective active pharmaceutical ingredients with the requisite quality and manufacturing
                standards in sufficient quantities and within the required timeframes and at an acceptable cost;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z7b6c2ce8d99840c3a5655c65e8428f82" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">the research, manufacturing, clinical development, commercialization, and market acceptance of our therapeutic candidates;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z90a446653f904ad782cc025397d981f2" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">the interpretation of the properties and characteristics of our commercial products or therapeutic candidates and of the results obtained in research, preclinical studies or clinical
                trials;</div>
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          </tr>

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    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z554a45276d964b9ba660ce4f762aebc4" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">the implementation of our business model, strategic plans for our business, commercial products, and therapeutic candidates;</div>
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    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zdbf09f05f40745ebabe3ed492f963c7c" class="DSPFListTable">

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            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
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            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">heightened attention on the problems associated with opioids;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zf63b47a2fd7e47daaeb45be23fb32207" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">the impact of other companies and technologies that compete with us within our industry;</div>
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          </tr>

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    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="ze92a4a9c53e645ae95aa870b8aeeb43a" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">the scope of protection we are able to establish and maintain for intellectual property rights covering our commercial products and therapeutic candidates, including from existing or future
                claims of infringement, and our ability to operate our business without infringing or violating the intellectual property rights of others;</div>
            </td>
          </tr>

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    <div>
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          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">parties from whom we license or acquire our intellectual property defaulting in their obligations toward us;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z233ef2757e8341e19ec8f31de9f515d0" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">the failure by a licensor or a partner of ours to meet their respective obligations under our acquisition, in-license or other development or commercialization agreements or renegotiate the
                obligations under such agreements, or if other events occur that are not within our control, such as bankruptcy of a licensor or a partner;</div>
            </td>
          </tr>

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    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z2ca913b3db744ed28081f34971a8f1de" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our reliance on the actions of third parties, including sublicensors and their other sublicensees, to maintain our rights under our in-licenses which are sublicenses;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zccd2d13aba004f248a10e84e1bc2f346" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">the effect of a potential occurrence of patients suffering serious adverse events using investigative drugs under our Expanded Access Program;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z9db71eaf487c4746a62e0648b5f7030b" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our ability to implement network systems and controls that are effective at preventing cyber-attacks, malware intrusions, malicious viruses and ransomware threats;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z246f27e9e40a444189d0c367bd9918d1" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">our ability to resolve the disputes regarding the alleged events of default under our term loan facility, if not resolved, could harm our financial condition which could materially
                adversely affect our financial performance;</div>
            </td>
          </tr>

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    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z7bcee7678ffa48b797096c7e9c31a930" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: left; line-height: 1.25;">our ability to regain and maintain compliance with the Nasdaq&#8217;s listing standards;</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zbd2ee244a7b546569f6aeff9863a3348" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">the effects of the economic and business environment, including unforeseeable events and the changing market conditions caused by the COVID-19 global pandemic; and</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zb2dcedc81dfc4cd9a770fe75fdc4a73d" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">the impact on our business of the political and security situation in Israel, the U.S. and other places in which we operate.</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;"><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 3</font></div>
      <div style="page-break-after: always;" class="BRPFPageBreak">
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    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="Sum11maryofRiskFactors"><!--Anchor--></a>Summary of Risk Factors</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">The following is a summary of some of the principal risks we face. The list below is not exhaustive, and investors should read the &#8220;Risk Factors&#8221; section, including the &#8220;Item 3. Key Information -
      Risk Factors&#8221; in our Annual Report on Form 20-F for the year-ended December 31, 2021, in full.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div>
      <div>
        <div>
          <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="za9d397a906684dfa93e48b6afd902f76" class="DSPFListTable">

              <tr style="vertical-align: top;">
                <td style="vertical-align: top; width: 27pt;">
                  <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="line-height: 1.25;">&#8226;</font></div>
                </td>
                <td style="align: left; vertical-align: top; width: auto;">
                  <div style="text-align: justify; line-height: 1.25;">Our pursuit of treatments for SARS-CoV-2 (the virus that causes COVID-19) infection in patients entails a high level of uncertainty. We cannot assure you that either opaganib
                    (ABC294640; Yeliva&#174;) (&#8220;opaganib&#8221;) or RHB-107 will prove to be a safe and effective treatment for COVID-19, or will be approved for marketing or Emergency Use Authorization or be granted with Expanded Access clearance by the FDA or other
                    regulatory authorities. In addition, we cannot assure that we will be able to complete the development of opaganib or RHB-107.</div>
                </td>
              </tr>

          </table>
        </div>
      </div>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z5e8037fb00564865b4999f9215ce3f01" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">If we are successful in developing a COVID-19 therapeutic, we may need to devote significant resources to our manufacturing scale-up and large-scale deployment, including for use by the
                U.S. or other governments. If one of our COVID-19 therapeutic candidates is approved for marketing or for Emergency Use, we may also need to devote significant resources to further expand our U.S. and non-U.S. sales and marketing activities
                and increase or maintain personnel to accommodate sales in the U.S. and outside the U.S.</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="za7a40f9c4d544d6690acdda120090a35" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">The ongoing COVID-19 pandemic may continue to adversely affect our business, revenues, results of operations and financial condition.</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z3be3db6b4019422cb3a89d1a68c11833" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">Our current working capital is not sufficient to commercialize our current commercial products or to complete the research and development with respect to any or all of our therapeutic
                candidates. We may need to raise additional capital to achieve our strategic objectives and to execute our business plans, and our failure to raise sufficient capital or on favorable terms would significantly impair our ability to fund the
                commercialization of our current commercial products, therapeutic candidates, or the products we may commercialize or promote in the future, attract development or commercial partners or retain key personnel, and to fund operations and
                develop our therapeutic candidates.</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zbb4ca0955aab42acbfaef630178e5b85" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">Our long-term capital requirements are subject to numerous risks.</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z054f906f7bde4f2f85d086d5ef0b8e0d" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">Our term loan facility imposes significant operating and financial restrictions on us, which may prevent us from capitalizing on business opportunities and may restrict our operational
                flexibility, and our failure to comply with the restrictive covenants in our term loan facility could have a material adverse effect on our business.</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zcc955fa3d89646b8be784fdcc960a577" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">Our failure to satisfy financial covenants and/or repayment requirements under our term loan facility could harm our financial condition which could materially adversely affect our
                financial performance.</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z4345586f49cb46e1afc971096816eb57" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">We may be unable to generate sufficient cash flow to make the required payments under the term loan facility or to adhere to other requirements under the term loan facility.</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z234bb9f37d5b4041bab17aa2a21bd911" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">The indebtedness under our term loan facility is secured by substantially all of the current and future assets of RedHill US, all of our assets related in any material respect to Talicia&#174;,
                and all of the equity interests of RedHill US As a result of these security interests, such assets would only be available to satisfy claims of our general creditors or to holders of our equity securities if we were to become insolvent to
                the extent the value of such assets exceeded the amount of our indebtedness and other obligations. In addition, the existence of these security interests may adversely affect our financial flexibility.</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="ze76a73d29b3244ad83455f1929843453" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">We may be unable to comply with commitments and agreements between us and our commercial partners.</div>
            </td>
          </tr>

      </table>
    </div>
    <div>
      <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zfc4b10eb5f3e49919c0ab9f273f6dcfc" class="DSPFListTable">

          <tr style="vertical-align: top;">
            <td style="vertical-align: top; width: 27pt;">
              <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
            </td>
            <td style="align: left; vertical-align: top; width: auto;">
              <div style="text-align: justify; line-height: 1.25;">If we or our future development or commercialization partners are unable to obtain or maintain the FDA or other foreign regulatory clearance and approval for our commercial products or
                therapeutic candidates, we or our commercialization partners will be unable to commercialize our current commercial products, products we may commercialize or promote in the future or our therapeutic candidates, upon approval, if any.</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="text-align: center; line-height: 1.25;"><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 4</font></div>
      <div style="page-break-after: always;" class="BRPFPageBreak">
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    </div>
    <div style="line-height: 1.25;">
      <div style="border: #000000 2px solid; padding: 5px; width: 99%;">
        <div>&#160;
          <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="PROSPE11CTUSSUPPLEMENTSUMMA"><!--Anchor--></a>PROSPECTUS SUPPLEMENT SUMMARY</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-style: italic;">This summary highlights selected information about us, this offering and information contained in greater detail elsewhere in this prospectus supplement, the accompanying
            prospectus, any free writing prospectus that we have authorized for use, and in the documents incorporated by reference. This summary is not complete and does not contain all of the information that you should consider before investing in the
            ADSs. You should carefully read and consider this entire prospectus supplement, the accompanying prospectus and the documents, including financial statements and related notes, and information incorporated by reference into this prospectus
            supplement, including the financial statements and &#8220;Risk Factors&#8221; starting on page S-10 of this prospectus supplement, before making an investment decision. If you invest in our securities, you are assuming a high degree of risk.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Our Business</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">We are a specialty biopharmaceutical company, primarily focused on gastrointestinal (&#8220;GI&#8221;) and infectious diseases. Our primary goal is to become a leading specialty biopharmaceutical company
            through our commercial presence in the U.S. that supports commercialization of our current and potentially additional products approved for marketing in the U.S., and potential future commercialization of our therapeutic candidates, if
            approved.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">We are currently focused primarily on the commercialization in the U.S. of the GI-related products, Movantik&#174; (naloxegol), Talicia&#174; (omeprazole, amoxicillin, and rifabutin) and Aemcolo&#174;
            (rifamycin).</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">In addition, we continue to develop our pipeline of clinical-stage therapeutic candidates. We look for opportunities to leverage our commercial presence and capabilities in the U.S. to support
            the potential future launch of our therapeutic candidates currently under development, if approved by the FDA, or any FDA-approved products that we may acquire the rights to in the future.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Our current pipeline consists of five therapeutic candidates, most of which are in late-stage clinical development. We generate our pipeline of therapeutic candidates by identifying, validating
            and in-licensing or acquiring products that are consistent with our product and corporate strategy and that have the potential to exhibit a favorable probability of therapeutic and commercial success. We have one product that we primarily
            developed internally which has been approved for marketing and, to date, none of our therapeutic candidates has generated meaningful revenues. We have out-licensed one of our commercial products, Talicia&#174;, and one of our clinical-stage
            therapeutic candidates, opaganib, for specific territories outside the U.S. and we plan to commercialize our therapeutic candidates, upon approval, if any, through licensing and other commercialization arrangements outside the U.S. with
            pharmaceutical companies on a global and territorial basis or, in the case of commercialization in the U.S., independently with our dedicated commercial operations or in potential partnership with other commercial-stage companies. We also
            evaluate, on a case-by-case basis, co-development, co-promotion, licensing, acquisitions and similar arrangements.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Recent Events</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;"><u>Aemcolo</u></font><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;"><u>&#174;</u></sup><font style="font-weight: bold;"><u> Exclusivity Extension</u></font></div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">The U.S. FDA Exclusivity Board confirmed the granting of five years NCE data exclusivity plus an additional five years&#8217; exclusivity for Aemcolo under the FDA&#8217;s Generating Antibiotic Incentives
            Now Act Qualified Infectious Disease Product designation, extending regulatory exclusivity through to 2028.</div>
        </div>
        <div>&#160;</div>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">&#160;</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 5</font></div>
      <div style="page-break-after: always;" class="BRPFPageBreak">
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    </div>
    <br>
    <br>
    <div style="line-height: 1.25;">
      <div style="border: #000000 2px solid; padding: 5px; width: 99%;">
        <div>&#160;
          <div style="text-align: justify; line-height: 1.25; font-weight: bold;"><u>Notice of Events of Default</u></div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">On September 13, 2022, we received a notice from HCR Collateral Management, LLC (&#8220;HCR&#8221;), asserting certain events of default under the Credit Agreement, resulting in the outstanding obligations
            under the credit agreement, dated as of February 23, 2020 (as amended, the &#8220;Credit Agreement&#8221;), now bearing interest at the default rate under the Credit Agreement. We disagree with the assertions made by HCR and are engaged with HCR in good
            faith in order to establish a consensual business resolution to this dispute. We are continuing operating our business as usual, while also concurrently evaluating strategic alternatives to satisfy our outstanding obligations under the Credit
            Agreement through the potential sale of Movantik.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">
            <div style="line-height: 1.25; color: #000000; font-family: 'Times New Roman', serif;">In addition to the previously reported breach of the 60 days quarterly reporting covenant in connection with the second
              quarter financial statements, the Company did not maintain&#160; minimum net sales of $75.0 million for the trailing four fiscal quarter period ending on September 30,
              2022.</div>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">On November 14, 2022, we announced that we reached a non-binding agreement in principle with HCR with respect to the terms of a transfer of our rights in Movantik to HCR in exchange for the
            extinguishment of all our obligations (including all principal, interest, revenue interest, prepayment premiums and exit fees) under the Credit Agreement. We would retain substantially all pre-closing liabilities relating to Movantik and HCR
            would assume substantially all post-closing liabilities. It is expected that we would provide transition services to HCR to ensure a seamless process so that patient care will not be interrupted. Subject to certain approvals, the definitive
            agreements are expected to be signed and the transaction is expected to close by year-end, but there can be no assurance that the parties will enter into definitive agreements or that the transaction will be completed.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Discussions regarding RHB-204 out-licensing in multiple territories and the in-licensing of a new revenue-generating GI product are advancing.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-weight: bold;"><u>Termination Notice</u></div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">On November 3, 2022, the Company received a termination notice from SVB Securities LLC (&#8220;SVB Securities&#8221;), with respect to itself, in connection with the Sales Agreement dated July 29, 2022, by
            and among the Company, SVB Securities and Cantor Fitzgerald &amp; Co.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-weight: bold;"><u>Oral Opaganib in Radioprotection</u></div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">On November 14, 2022, we announced the publication of a new paper in the <font style="font-style: italic;">International Journal of Molecular Sciences</font>, describing the collective results
            of eight U.S. government-funded in vivo studies by RedHill and Apogee Biotechnology Corporation (&#8220;Apogee&#8221;), as well as additional experiments, establishing opaganib&#8217;s potential nuclear radiation protection capabilities. The publication
            highlights observations from numerous studies undertaken in both protection against radiation toxicity and cancer radiotherapy settings. In the relevant study models, opaganib was associated with protection of normal tissue, including
            gastrointestinal, from radiation damage due to ionizing radiation exposure or cancer radiotherapy, as well as improvement of antitumor activity, response to chemoradiation, and enhancement of tolerability and survival. Additional independent
            studies demonstrate the radioprotective capacity of opaganib in bone marrow, with opaganib showing enhanced survival in mice which were irradiated with both lethal and half-lethal whole-body radiation.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-weight: bold;"><u>Kukbo Proceedings</u></div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">
            <div style="line-height: 1.25; color: rgb(0, 0, 0); font-family: 'Times New Roman',serif;">On September 2, 2022, the
                Company filed a lawsuit against Kukbo CO. Ltd. (&#8220;Kukbo&#8221;) and in
              the process of seeking a default judgment against Kukbo in a United States
                court, as a result of Kukbo&#8217;s default in delivering to the Company $5 million under the Subscription Agreement, dated October 25, 2021, in
              exchange for ADSs, and a further payment of $1.5 million due under the Exclusive License Agreement, dated March 14, 2022. In parallel, the lawsuit is being
                translated into Korean and planned to be sent to the Korean Central Authority for filing in South Korea.</div>
            <div style="text-align: left; line-height: 1.25; color: #000000; font-family: 'Times New Roman', serif;"> <br>
            </div>
            <div style="text-align: left; line-height: 1.25; color: #000000; font-family: 'Times New Roman', serif;">
              <div style="line-height: 1.25; color: #000000;">On November 24, 2022, the Company received a letter from Kukbo regarding the pending lawsuit. According to the letter
                received, Kukbo asserts that it intends to defend its case and bring a counterclaim against the Company. The Company strongly believes in the merits of its lawsuit against Kukbo and will continue to decisively pursue a favorable judgment.
                The Company notes that Kukbo did not file a response in the U.S. court within the required timeframe.</div>
            </div>
          </div>
        </div>
        <div>&#160;</div>
      </div>
    </div>
    <div style="line-height: 1.25;">&#160;</div>
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      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 6</font></div>
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    </div>
    <br>
    <div>
      <div style="border: #000000 2px solid; padding: 5px; width: 99%;">
        <div>&#160;
          <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Nasdaq Notification</div>
          <div style="text-align: justify; line-height: 1.25; font-weight: bold;"> <br>
          </div>
          <div style="text-align: justify; line-height: 1.25;">On October 12, 2022, we received a letter from the Listing Qualifications Department of Nasdaq indicating that, based upon the closing bid price of the ADSs for the 30 consecutive business day
            period prior to October 12, 2022, we did not meet the minimum bid price of $1.00 per ADS required for continued listing on Nasdaq pursuant to Nasdaq Listing Rule 5550(a)(2). The letter also indicated that we will be provided with a compliance
            period of 180 calendar days, or until April 10, 2023 (the &#8220;Compliance Period&#8221;), in which to regain compliance pursuant to Nasdaq Listing Rule 5810(c)(3)(A).</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">In order to regain compliance with Nasdaq&#8217;s minimum bid price requirement, the ADSs must maintain a minimum closing bid price of $1.00 per ADS for at least ten consecutive business days during
            the Compliance Period. In the event we do not regain compliance by the end of the Compliance Period, we may be eligible for additional time to regain compliance. To qualify, we will be required to meet the continued listing requirement for the
            market value of our publicly held securities and all other initial listing standards for Nasdaq, with the exception of the bid price requirement, and will need to provide written notice of its intention to cure the deficiency during the second
            compliance period, by effecting a reverse stock split if necessary. If we meet these requirements, we may be granted an additional 180 calendar days to regain compliance. However, if it appears to Nasdaq that we will be unable to cure the
            deficiency, or if we are not otherwise eligible for the additional cure period, Nasdaq will provide notice that the ADSs will be subject to delisting.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Corporate Information</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">We were incorporated as a limited liability company under the laws of the State of Israel on August 3, 2009. Our principal executive offices are located at 21 Ha&#8217;arba&#8217;a Street, Tel-Aviv, Israel
            and our telephone number is +972 (3) 541-3131. Our web site address is http://www.redhillbio.com. The information on, or that can be accessed through, our website does not constitute part of this prospectus. Our registered agent in the U.S. is
            RedHill US The address of RedHill US is 8041 Arco Corporate Drive, Suite 200, Raleigh, NC 27617, U.S.A.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
        </div>
      </div>
    </div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 7</font></div>
      <div class="BRPFPageBreak" style="page-break-after: always;">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div><br>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;">
        <div style="border: #000000 2px solid; padding: 5px; width: 99%;">
          <div>&#160;
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 100%; vertical-align: top;" colspan="3">
                    <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="THEOFF11ERING"><!--Anchor--></a>THE OFFERING</div>
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">Units offered by us</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="line-height: 1.25;">21,775,000 units, each consisting of one ADS and one Warrant to purchase one ADS. The units have no stand-alone rights and will not be certificated or issued as stand-alone securities. The ADSs and
                      Warrants are immediately separable and will be issued separately in this offering.</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">Pre-funded units offered by us</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="text-align: justify; line-height: 1.25;">We are also offering 10,225,000 pre-funded units, each consisting of one Pre-funded Warrant to purchase one ADS and one Warrant to purchase one ADS. The pre-funded units have no
                      stand-alone rights and will not be certificated or issued as stand-alone securities. The Pre-funded Warrants and Warrants are immediately separable and will be issued separately in this offering.</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">Warrants</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="text-align: justify; line-height: 1.25;">Each Warrant has an exercise price of $0.25 per ADS, is immediately exercisable and will expire on the five year anniversary of the original issuance date. This offering also relates
                      to the offering of the ADSs issuable upon exercise of the Warrants. See &#8220;Description of Securities We Are Offering&#8221; on page S-17 of this prospectus supplement.</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">Pre-funded Warrants</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="line-height: 1.25;">Each Pre-funded Warrant has an exercise price of $0.001 per ADS, is immediately exercisable and may be exercised at any time until exercised in full. This offering also relates to the offering of the ADSs
                      issuable upon exercise of the Pre-funded Warrants. See &#8220;Description of Securities We Are Offering&#8221; on page S-17 of this prospectus supplement.</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">Ordinary Shares to be outstanding after this offering</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="line-height: 1.25;">964,290,334 Ordinary Shares (assuming exercise of the Pre-funded Warrants and that none of the Warrants issued in this offering are exercised).</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">The ADSs</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="text-align: justify; line-height: 1.25;">Each ADS represents 10 Ordinary Shares. The ADSs will be delivered by The Bank of New York Mellon, as depositary (the &#8220;Depositary&#8221;).</div>
                    <div style="line-height: 1.25;">&#160;</div>
                    <div style="text-align: justify; line-height: 1.25;">The Depositary, as depositary, or its nominee, will be the holder of the Ordinary Shares underlying your ADSs and you will have rights as provided in the Deposit Agreement, dated as
                      of December 26, 2012, among us, the Depositary and all owners and holders from time to time of ADSs issued thereunder (the &#8220;Deposit Agreement&#8221;), a form of which has been filed as Exhibit 1 to the Registration Statement on Form F-6
                      filed by the Depositary with the SEC on December 6, 2012.</div>
                    <div style="line-height: 1.25;">&#160;</div>
                    <div style="text-align: justify; line-height: 1.25;">Subject to the terms of the Deposit Agreement and in compliance with the relevant requirements set out in the prospectus, you may turn in your ADSs to the Depositary for cancellation
                      and withdrawal of the Ordinary Shares underlying your ADSs. The Depositary will charge you fees for such cancellations pursuant to the Deposit Agreement.</div>
                    <div style="line-height: 1.25;">&#160;</div>
                    <div style="text-align: justify; line-height: 1.25;">You should carefully read the &#8220;Description of American Depositary Shares&#8221; section of the accompanying prospectus and the Deposit Agreement to better understand the terms of the ADSs.</div>
                  </td>
                </tr>

            </table>
            <div style="line-height: 1.25;"><br style="line-height: 1.25;">
            </div>
          </div>
        </div>
      </div>
      <div style="text-align: center; line-height: 1.25;"><br>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
        <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 8</font></div>
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      </div>
      <div style="line-height: 1.25;">
        <div style="border: #000000 2px solid; padding: 5px; width: 99%;">
          <div>
            <div> <br>
            </div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">Use of proceeds</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="text-align: justify; line-height: 1.25;">We intend to use the net proceeds from the offering, together with our existing cash and cash equivalents, for working capital, acquisitions and general corporate purposes. See &#8220;Use
                      of Proceeds.&#8221;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">Risk factors</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="text-align: justify; line-height: 1.25;">Before deciding to invest in our securities, you should carefully consider the risks related to our business, the offering, the ADSs and our Ordinary Shares, and our location in
                      Israel. See &#8220;Risk Factors&#8221; on page S-10 of this prospectus supplement and under similar headings in other documents incorporated by reference into this prospectus supplement and the accompanying prospectus.</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">Dividend policy</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="text-align: justify; line-height: 1.25;">We have never declared or paid any cash dividends to our shareholders, and we currently do not expect to declare or pay any cash dividends in the foreseeable future. See &#8220;Dividend
                      Policy.&#8221;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">Nasdaq Global Market symbol</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="text-align: justify; line-height: 1.25;">Our ADSs are listed on Nasdaq under the symbol &#8220;RDHL.&#8221;</div>
                    <div style="line-height: 1.25;">&#160;</div>
                    <div style="text-align: justify; line-height: 1.25;">There is no established trading market for the Pre-funded Warrants or the Warrants, and we do not expect a trading market to develop. We do not intend to list the Pre-funded Warrants
                      or Warrants on any securities exchange or nationally recognized trading system. Without a trading market, the liquidity of the Pre-funded Warrants and the Warrants will be extremely limited.</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">Depositary</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="text-align: justify; line-height: 1.25;">The Bank of New York Mellon</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 27.98%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 1%; vertical-align: bottom;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td style="width: 71.02%; vertical-align: top;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 100%; vertical-align: top;" colspan="3">
                    <div style="text-align: justify; line-height: 1.25;">The number of Ordinary Shares to be outstanding immediately after the offering, as shown above, is based on 640,422,174 Ordinary Shares outstanding as of September 30, 2022. As of
                      September 30, 2022, we had (i) 54,998,320 Ordinary Shares issuable upon the exercise of outstanding options to purchase 54,998,320 Ordinary Shares at a weighted average exercise price of $0.64 per share (equivalent to 5,499,832 ADSs
                      at a weighted average exercise price of $6.39 per ADS), (ii) 13,204,225 ADSs issuable upon the exercise of certain warrants with an exercise price of $1.48 per ADS issued to the investor in the private placement that closed on May 11,
                      2022, and (iii) 3,559,728 outstanding Restricted Share Units (&#8220;RSUs&#8221;), each RSU representing one ADS. The number of Ordinary Shares to be outstanding immediately after the offering does not include the ADSs we agreed to issue to Kukbo
                      for second tranche of $5 million pursuant to the Subscription Agreement.</div>
                    <div style="line-height: 1.25;">&#160;</div>
                    <div style="text-align: justify; line-height: 1.25;">Unless otherwise stated, outstanding share information throughout this prospectus supplement excludes such outstanding securities and assumes (i) no exercise of the outstanding
                      options or warrants described above, (ii) no vesting of the RSUs described above and (iii) an aggregate of 386,816 ADSs sold under our existing &#8220;at-the-market&#8221; equity offering program established with Cantor Fitzgerald &amp; Co.
                      Except as otherwise indicated, the information in this prospectus supplement, including the number of Ordinary Shares that will be outstanding after this offering, and assumes the exercise of the Pre-funded Warrants and no exercise of
                      the Warrants offered and sold in this offering.</div>
                    <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
                  </td>
                </tr>

            </table>
          </div>
        </div>
      </div>
      <br>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
        <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 9</font></div>
        <div style="page-break-after: always;" class="BRPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="RISKFACT11ORS"><!--Anchor--></a>RISK FACTORS</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-style: italic;">You should carefully consider the risks described below and in our annual report on Form 20-F for the year ended December 31, 2021, as well as the other information included or
        incorporated by reference in this prospectus supplement and the accompanying prospectus, including our financial statements and the related notes, before you decide to buy our securities. The risks and uncertainties described below and incorporated
        by reference in this prospectus supplement are not the only risks facing us. We may face additional risks and uncertainties not currently known to us or that we currently deem to be immaterial. Any of the risks described below or incorporated by
        reference in this prospectus supplement, and any such additional risks, could materially adversely affect our business, financial condition or results of operations. In such case, you may lose all or part of your original investment.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Risks Related to The ADSs</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">U.S. holders of ADSs may suffer adverse tax consequences if we were characterized as a passive foreign investment company.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">Based on the current composition of our gross income and assets and on reasonable assumptions and projections, we believe we should not be treated as a passive foreign investment company (a
        &#8220;PFIC&#8221;), for U.S. federal income tax purposes for 2022. However, there can be no assurance that this will be the case in 2022 or in future taxable years. If we were characterized as a PFIC, U.S. holders of the ADSs may suffer adverse tax
        consequences such as (i) having gains realized on the sale of the ADSs treated as ordinary income rather than capital gain, not qualifying for the preferential rate otherwise applicable to dividends received in respect of the ADSs by individuals
        who are U.S. holders, and (ii) having interest charges apply to certain distributions by us and upon certain sales of the ADSs.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
        <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 10</font></div>
        <div style="page-break-after: always;" class="BRPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="text-align: center; line-height: 1.25;"><br>
      </div>
      <div style="line-height: 1.25; font-weight: bold;">Risks Related to the Offering</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">We will have broad discretion in how to use the net proceeds of this offering, and we may not use these proceeds in a manner desired by our investors.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">We will have broad discretion as to the use of the net proceeds from this offering and could use them for purposes other than those contemplated at the time of this offering. Accordingly, you will
        be relying on the judgment of our management with regard to the use of these net proceeds, and you will not have the opportunity as part of your investment decision to assess whether the proceeds are being used appropriately. Our needs may change
        as the business and the industry that we address evolves. As a result, the proceeds to be received in this offering may be used in a manner significantly different from our current expectations. It is possible that the proceeds will be invested in
        a way that does not yield a favorable, or any, return. The failure of our management to use such funds effectively could have a material adverse effect on our business, financial condition, operating results and cash flow.</div>
      <div style="line-height: 1.25">&#160;</div>
      <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">You may experience immediate and substantial dilution in book value of any ADSs included as part of the units or that may be issued upon the exercise of any
        Pre-Funded warrants included in the pre-funded units you purchase.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">The effective offering price of the ADSs included as part of the units or that may be issued upon the exercise of any Pre-funded Warrants included in the pre-funded units being offered hereby is
        substantially higher than the net tangible book value per ADS. Therefore, if you purchase securities in this offering, you will pay a price per ADS included as part of the units or that may be issued upon the exercise of any Pre-funded Warrants
        included in the pre-funded units that substantially exceeds our net tangible book value per ADS included as part of the units or that may be issued upon the exercise of any Pre-funded Warrants included in the pre-funded units after this offering.
        To the extent outstanding options or warrants are exercised, you will incur further dilution. Based on the effective offering price of $0.25 per unit or $0.249 per pre-funded unit, you will experience immediate dilution of $1.23 per ADS included as
        part of the units or that may be issued upon the exercise of any Pre-funded Warrants included in the pre-funded units, representing the difference between our as adjusted net tangible book value per ADS as of September 30, 2022 after giving effect
        to this offering and the effective offering price. See &#8220;Dilution&#8221; on page S-14 for a more detailed discussion of the dilution you will incur in connection with this offering.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">Future sales of the ADSs, including any ADSs issuable upon the exercise of the Pre-funded Warrants and Warrants, or the perception that future sales may occur, may cause the
        market price of the ADSs to decline, even if our business is doing well.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">Sales by the ADS holders of a substantial number of ADSs in the public market could occur in the future. These sales, or the perception in the market that the holders of a large number of ADSs
        intend to sell shares, may cause the market price of the ADSs and Ordinary Shares to decline. In addition, we will be issuing in this offering units consisting of one ADS and one Warrant and pre-funded units consisting of one Pre-funded Warrant and
        one Warrant. To the extent that holders of Pre-Funded Warrants or Warrants sell the ADSs issued upon the exercise of the units or pre-funded units, the market price of the ADSs may decrease due to the additional selling pressure in the market. The
        risk of dilution from issuances of ADSs underlying the Pre-Funded Warrants or Warrants may cause shareholders to sell their ADSs, which could cause a further decline in the market price.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 11</font></div>
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div><br>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">You may experience future dilution as a result of future equity offerings.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">To raise additional capital, we may in the future offer additional ADSs, Ordinary Shares or other securities convertible into or exchangeable for the ADSs or Ordinary Shares at prices that may not
        be the same as the price per share in this offering. We may sell ADSs, Ordinary Shares or other securities in any other offering at a price per share that is less than the price per share paid by investors in this offering, and investors purchasing
        shares or other securities in the future could have rights superior to the rights of ADSs holders. The price per share at which we sell additional ADSs, Ordinary Shares or securities convertible or exchangeable into ADSs or Ordinary Shares, in
        future transactions may be higher or lower than the price per ADS paid by investors in this offering.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25; font-style: italic; font-weight: bold;">The Warrants included in the units being offered may not have value.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">The Warrants included in the units being offered by us in this offering have an exercise price of $0.25 per ADS, subject to certain adjustments, and expire five years from the date of issuance. In
        the event that the applicable volume weighted average price of our common stock does not exceed the exercise price of the Warrants during the period when they are exercisable, the Warrants may not have any value.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">There is no public market for the Pre-funded Warrants or Warrants included in the units and/or pre-funded units in this offering being offered in this
        offering.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">There is no established public trading market for the Pre-funded Warrants or Warrants included in the units and pre-funded units being offered in this offering, and we do not expect a market to
        develop. In addition, we do not intend to apply to list the Pre-funded Warrants or Warrants on any securities exchange or nationally recognized trading system, including Nasdaq. Without an active market, the liquidity of the Pre-funded Warrants and
        Warrants will be limited.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">Holders of the Pre-funded Warrants or Warrants included in the units and/or pre-funded units purchased in this offering will have no rights as ADS holders
        until such holders exercise such Pre-funded Warrants or Warrants and acquire the ADSs.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">Until holders of Pre-Funded Warrants or Warrants included in the units and/or pre-funded units purchased in this offering acquire the ADSs upon exercise thereof, holders of such Pre-funded Warrants
        and Warrants will have no rights with respect to the ADSs underlying such Pre-funded Warrants and Warrants. Upon exercise of the Pre-Funded Warrants and Warrants included in the units and/or pre-funded units purchased in this offering, such holders
        will be entitled to exercise the rights of an ADS holder only as to matters for which the record date occurs after the exercise date.</div>
      <div style="line-height: 1.25;">&#160;</div>
      <div style="text-align: center; line-height: 1.25;"><br>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
        <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 12</font></div>
        <div style="page-break-after: always;" class="BRPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="USEOFPROCEEDS11"><!--Anchor--></a>USE OF PROCEEDS</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">We estimate that the net proceeds from the sale of ADSs representing Ordinary Shares in this offering will be approximately $7.3 million, after deducting underwriting discounts and commissions and
        estimated offering expenses payable by us in connection with this offering. These estimates exclude the proceeds, if any, from the exercise of Warrants and Pre-funded Warrants included in the units and/or pre-funded units sold in this offering.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">We intend to use the net proceeds from this offering, together with our existing cash and cash equivalents, for working capital, acquisitions and general corporate purposes.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
      <div style="text-align: justify; line-height: 1.25;">The amounts and timing of our actual expenditures will depend upon numerous factors, including the progress of our development and commercialization efforts, the status of and results from our
        clinical trials, whether or not we enter into strategic collaborations or partnerships, and our operating costs and expenditures. Accordingly, our management will have significant flexibility in applying the net proceeds of this offering. In
        addition, while we have not entered into any binding agreements or commitments relating to any significant transaction as of the date of this prospectus supplement that we expect to use the net proceeds from this offering, we may use a portion of
        the net proceeds to pursue acquisitions, joint ventures and other strategic transactions.</div>
      <div style="text-align: justify; line-height: 1.25;"> <br>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
        <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 13</font></div>
        <div style="page-break-after: always;" class="BRPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
    </div>
    <div>
      <div>&#160;<br>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DILUTION222"><!--Anchor--></a>DILUTION</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">If you invest in our securities, your interest will be diluted immediately to the extent of the difference between the effective public offering price per ADS included in the units or that may be
          issued upon the exercise of any Pre-funded Warrants included in the pre-funded units and our as-adjusted net tangible book value per ADS after this offering.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">Our net tangible book value as of September 30, 2022 was approximately $(101.5) million, or approximately $(1.58) per ADS. Net tangible book value represents the amount of our total tangible
          assets minus total liabilities, net of leases presented as right-of-use assets, lease liabilities and payable in respect of intangible assets purchase.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">After giving effect to the sale of units offered by us in this offering (which includes the issuance and sale of (i) 21,755,000 ADSs and (ii) Pre-funded Warrants to purchase up to 10,225,000
          ADSs), and the concurrent issuance of Warrants to purchase up to an aggregate of 32,000,000 ADSs, and after deducting underwriting discounts and commissions and estimated offering expenses payable by us, and assuming full exercise of the
          Pre-funded Warrants to be issued in this offering, but no exercise of the Warrants to be issued, our as-adjusted net tangible book value as of September 30, 2022 would have been approximately $(94.2) million, or $(0.98) per ADS. This represents
          an immediate increase in net tangible book value of $0.60 per ADS to our existing shareholders and an immediate dilution in net tangible book value of approximately $1.23 per ADS to purchasers of the units in this offering, as illustrated by the
          following table:</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000; width: 100%;" id="zb531b97523f245858be6b19253da6a2b" class="cfttable">

            <tr>
              <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF;">
                <div style="line-height: 1.25;">Offering price per unit</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: middle; background-color: #CCEEFF;" colspan="2">&#160;</td>
              <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom;" colspan="1" class="cftcurrcell">
                <div style="line-height: 1.25;">$</div>
              </td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">0.25</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: bottom; width: 76%;">
                <div style="line-height: 1.25;">Net tangible book value per ADS as of September 30, 2022</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
                <div style="line-height: 1.25;">$</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">(1.58</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">
                <div style="line-height: 1.25;">)</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 76%; padding-bottom: 2px;">
                <div style="line-height: 1.25;">Increase in net tangible book value per ADS attributable this offering</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 solid 2px;" colspan="1" class="cftcurrcell">
                <div style="line-height: 1.25;">$</div>
              </td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 solid 2px;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">0.60</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftcurrcell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; padding-bottom: 2px;" colspan="1" class="cftnumcell">&#160;</td>
              <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: bottom; width: 76%; padding-bottom: 2px;">
                <div style="line-height: 1.25;">As-adjusted net tangible book value per ADS at September 30, 2022, after giving effect to this offering</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftcurrcell">
                <div style="line-height: 1.25;">$</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">(0.98</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">
                <div style="line-height: 1.25;">)</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftcurrcell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; padding-bottom: 2px;" colspan="1" class="cftnumcell">&#160;</td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 76%; padding-bottom: 4px;">
                <div style="line-height: 1.25;">Dilution per ADS to new investors in this offering</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftcurrcell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; padding-bottom: 4px;" colspan="1" class="cftnumcell">&#160;</td>
              <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftfncell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; padding-bottom: 4px; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; border-bottom: #000000 double 4px;" colspan="1" class="cftcurrcell">
                <div style="line-height: 1.25;">$</div>
              </td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%; border-bottom: #000000 double 4px;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">1.23</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%; padding-bottom: 4px;" colspan="1" class="cftfncell">&#160;</td>
            </tr>

        </table>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">The above discussion and table are based on 640,422,174 Ordinary Shares outstanding as of September 30, 2022. As of September 30, 2022, we had (i) 54,998,320 Ordinary Shares issuable upon the
          exercise of outstanding options to purchase 54,998,320 Ordinary Shares at a weighted average exercise price of $0.64 per share (equivalent to 5,499,832 ADSs at a weighted average exercise price of $6.39 per ADS), (ii) 13,204,225 ADSs issuable
          upon the exercise of certain warrants with an exercise price of $1.48 per ADS issued to the investor in the private placement that closed on May 11, 2022, and (iii) 3,559,728 outstanding RSUs, each RSU representing one ADS. The number of Ordinary
          Shares to be outstanding immediately after the offering does not include the ADSs we agreed to issue to Kukbo for second tranche of $5 million pursuant to the Subscription Agreement.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">Except as otherwise indicated herein, outstanding share information throughout this prospectus supplement excludes such outstanding securities and assumes (i) no exercise of the outstanding
          options or warrants described above, (ii) no vesting of the RSUs described above and (iii) an aggregate of 386,816 ADSs sold under our existing &#8220;at-the-market&#8221; equity offering program established with Cantor Fitzgerald &amp; Co. Except as
          otherwise indicated, the information in this prospectus supplement, including the number of Ordinary Shares that will be outstanding after this offering, and assumes the exercise of the Pre-funded Warrants and no exercise of the Warrants offered
          and sold in this offering.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">The as-adjusted information discussed above is illustrative only. Our net tangible book value following the completion of the offering is subject to further adjustment based on the actual
          offering price of the units and other terms of this offering determined at pricing.</div>
        <div style="line-height: 1.25;">&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 14</font></div>
          <div style="page-break-after: always;" class="BRPFPageBreak">
            <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
        </div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="CAPITALIZATIO11NANDINDEBTED"><!--Anchor--></a>CAPITALIZATION AND INDEBTEDNESS</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="line-height: 1.25;">The following table sets forth our total capitalization as of September 30, 2022:</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <table cellspacing="0" cellpadding="0" id="z45ef951cb291434f98b0000f4ca89640" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

            <tr>
              <td style="width: 3%; vertical-align: top;">
                <div style="line-height: 1.25;">&#160;</div>
              </td>
              <td style="width: 2%; vertical-align: top;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: 95%; vertical-align: bottom;">
                <div style="line-height: 1.25;">on an actual basis;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%; vertical-align: top;">
                <div style="line-height: 1.25;">&#160;</div>
              </td>
              <td style="width: 2%; vertical-align: top;">
                <div style="line-height: 1.25;">&#160;</div>
              </td>
              <td style="width: 95%; vertical-align: bottom;">
                <div style="line-height: 1.25;">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="width: 3%; vertical-align: top;">
                <div style="line-height: 1.25;">&#160;</div>
              </td>
              <td style="width: 2%; vertical-align: top;">
                <div style="line-height: 1.25;">&#8226;</div>
              </td>
              <td style="width: 95%; vertical-align: bottom;">
                <div style="text-align: justify; line-height: 1.25;">on an as-adjusted basis to reflect the sale of units in this offering, after deducting underwriting discounts and commissions and estimated offering expenses payable by us in connection
                  with this offering.</div>
              </td>
            </tr>

        </table>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">The information set forth in the following table should be read in conjunction with and is qualified in its entirety by reference to the audited and unaudited financial statements and notes
          thereto incorporated by reference in this prospectus supplement and the accompanying prospectus.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000; width: 100%;" id="z75d5730fb0c947c581e2a08eac7c5386" class="cfttable">

            <tr>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 2px;">
                <div style="line-height: 1.25;">&#160;</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: top; border-bottom: #000000 solid 2px;" colspan="6">
                <div style="text-align: center; line-height: 1.25; font-weight: bold;">As of September 30, 2022</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 2px;">
                <div style="line-height: 1.25; font-style: italic;">(In thousands, except share data)</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; border-bottom: #000000 solid 2px;" colspan="2">
                <div style="text-align: center; line-height: 1.25; font-style: italic;">Actual</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; border-bottom: #000000 solid 2px;" colspan="2">
                <div style="text-align: center; line-height: 1.25; font-style: italic;">As-Adjusted</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;">
                <div style="line-height: 1.25;">&#160;</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom;" colspan="2">&#160;</td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: top;" colspan="2">&#160;</td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom;" colspan="1" class="cftfncell">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 76%;">
                <div style="line-height: 1.25;">Total debt (1)</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
                <div style="line-height: 1.25;">$</div>
              </td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">203,219</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
                <div style="line-height: 1.25;">$</div>
              </td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">211,209</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: bottom; width: 76%;">
                <div style="line-height: 1.25;">Ordinary shares, par value NIS 0.01 per share</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">1,834</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">2,472</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 76%;">
                <div style="line-height: 1.25;">Additional paid-in capital</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">383,407</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">382,769</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: bottom; width: 76%;">
                <div style="line-height: 1.25;">Accumulated deficit</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">431,268</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">431,997</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 76%;">
                <div style="line-height: 1.25;">Total shareholders&#8217; equity</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
                <div style="line-height: 1.25;">$</div>
              </td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">(46,027</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">
                <div style="line-height: 1.25;">)</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
                <div style="line-height: 1.25;">$</div>
              </td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">(46,756</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">
                <div style="line-height: 1.25;">)</div>
              </td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: bottom; width: 76%;">
                <div style="line-height: 1.25;">&#160;</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">&#160;</td>
              <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            </tr>
            <tr>
              <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 76%;">
                <div style="line-height: 1.25;">Total capitalization and indebtedness</div>
              </td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
                <div style="line-height: 1.25;">$</div>
              </td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">157,192</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
              <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
                <div style="line-height: 1.25;">$</div>
              </td>
              <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                <div style="line-height: 1.25;">164,452</div>
              </td>
              <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
            </tr>

        </table>
        <div style="text-align: justify; line-height: 1.25;"> <br>
        </div>
        <div>
          <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zee82eac1f4ad43a182b1749fe6426e40" class="DSPFListTable">

              <tr style="vertical-align: top;">
                <td style="vertical-align: top; width: 27pt;">
                  <div style="text-align: center; line-height: 1.25;">(1)</div>
                </td>
                <td style="align: left; vertical-align: top; width: auto;">
                  <div style="text-align: justify; line-height: 1.25;">Includes $193.5 million reported as current liabilities, which mainly consist of borrowing, allowance for deductions from revenue and accrued expenses, and $9.7 million reported as
                    non-current liabilities, which mainly consist of lease liabilities and derivative financial instruments.</div>
                </td>
              </tr>

          </table>
        </div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">The above discussion and table are based on 640,422,174 Ordinary Shares outstanding as of September 30, 2022. As of September 30, 2022, we had (i) 54,998,320 Ordinary Shares issuable upon the
          exercise of outstanding options to purchase 54,998,320 Ordinary Shares at a weighted average exercise price of $0.64 per share (equivalent to 5,499,832 ADSs at a weighted average exercise price of $6.39 per ADS), (ii) 13,204,225 ADSs issuable
          upon the exercise of certain warrants with an exercise price of $1.48 per ADS issued to the investor in the private placement that closed on May 11, 2022, and (iii) 3,559,728 outstanding RSUs, each RSU representing one ADS. The number of Ordinary
          Shares to be outstanding immediately after the offering does not include the ADSs we agreed to issue to Kukbo for second tranche of $5 million pursuant to the Subscription Agreement.</div>
        <div style="line-height: 1.25;">&#160;</div>
      </div>
      <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
        <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 15</font></div>
        <div style="page-break-after: always;" class="BRPFPageBreak">
          <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
      </div>
      <div><br>
        <br>
        <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DIVI11DENDPOLICY"><!--Anchor--></a>DIVIDEND POLICY</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">We have never declared or paid any cash dividends to our shareholders. We currently anticipate that we will retain future earnings for the development, operation and expansion of our business and
          do not anticipate declaring or paying any cash dividends for the foreseeable future.</div>
        <div style="line-height: 1.25;">&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 16</font></div>
          <div style="page-break-after: always;" class="BRPFPageBreak">
            <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
        </div>
        <div style="text-align: center; line-height: 1.25;"><br>
        </div>
        <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DE111SCRIPTIONOFSECURITIESWE"><!--Anchor--></a>DESCRIPTION OF SECURITIES WE ARE OFFERING</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: center; line-height: 1.25; font-weight: bold;">Units</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">Each unit consists of one ADS and a warrant to purchase one ADS at an exercise price equal to $0.25. The ADSs and Warrants may be transferred separately immediately upon issuance. This prospectus
          supplement also relates to the offering of ADSs issuable upon exercise, if any, of the Warrants issued in this offering.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: center; line-height: 1.25; font-weight: bold;">Pre-funded Units</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">We are offering the pre-funded units at a price equal to the price per unit, minus $0.001, and the exercise price of each Pre-funded Warrant included in the pre-funded unit will be $0.001 per
          ADS. Each pre-funded unit consists of one Pre-funded Warrant to purchase one ADS and one Warrant to purchase one ADS. The Pre-funded Warrants and Warrants may be transferred separately immediately upon issuance. This prospectus supplement also
          relates to the offering of ADSs issuable upon exercise, if any, of the Pre-funded Warrants issued in this offering.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;"><font style="font-style: italic;">Authorized Share Capital</font>. Our authorized share capital is 1,600,000,000 shares, consisting of (i) 1,594,000,000 registered Ordinary Shares of NIS 0.01 par
          value each, and (ii) 6,000,000 preferred shares of NIS 0.01 par value each, and as of November 30, 2022, we had 644,290,334 Ordinary Shares outstanding (which would be represented by 64,429,033 of the ADSs) and no preferred shares outstanding.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: center; line-height: 1.25; font-weight: bold;">American Depositary Shares</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">The material terms and provisions of the ADSs and other outstanding securities convertible into or exercisable for ADSs are described in the accompanying prospectus and Exhibit 2.3, Description
          of Share Capital, to our annual report on Form 20-F for the year ended December 31, 2021, which are incorporated by reference into this prospectus supplement.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: center; line-height: 1.25; font-weight: bold;">Pre-funded&#160;Warrants</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">The following summary of certain terms and provisions of the Pre-funded Warrants included in the pre-funded units that are being offered hereby is not complete and is subject to, and qualified in
          its entirety by, the provisions of the Pre-funded Warrants, the form of which is or shall be filed as an exhibit to a Report on Form 6-K which shall be incorporated by reference into the registration statement of which this prospectus forms a
          part. Prospective investors should carefully review the terms and provisions of the form of Pre-funded Warrants for a complete description of the terms and conditions of the Pre-funded Warrants.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">The purpose of the Pre-funded Warrants is to enable investors that may have restrictions on their ability to beneficially own more than 4.99% (or, upon election of the holder, 9.99%) of our
          outstanding Ordinary Shares following the consummation of this offering the opportunity to make an investment in the Company without triggering their ownership restrictions, by receiving Pre-funded Warrants in lieu of ADSs which would result in
          such ownership of more than 4.99% (or 9.99%), and receive the ability to exercise their option to purchase the shares underlying the Pre-funded Warrants at such nominal price at a later date.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 17</font></div>
          <div style="page-break-after: always;" class="BRPFPageBreak">
            <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
        </div>
        <br>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Duration and Exercise Price</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">Each Pre-funded Warrant included in a pre-funded unit offered hereby has an initial exercise price per ADS equal to $0.001. Pre-funded Warrants are immediately exercisable and may be exercised at
          any time until the Pre-funded Warrants are exercised in full. The exercise price and number of ADSs issuable upon exercise is subject to appropriate adjustment in the event of share dividends, share splits, reorganizations or similar events
          affecting our Ordinary Shares and the exercise price.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Exercisability</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">The Pre-funded Warrants are exercisable, at the option of each holder, in whole or in part, by delivering to us a duly executed exercise notice accompanied by payment in full for the number of
          ADSs purchased upon such exercise (except in the case of a cashless exercise as discussed below). Purchasers of the Pre-funded Warrants included in the pre-funded units in this offering may elect to deliver their exercise notice following the
          pricing of the offering and prior to the issuance of the Pre-funded Warrants at closing to have their Pre-funded Warrants exercised immediately upon issuance and receive ADSs underlying the Pre-funded Warrants upon closing of this offering. A
          holder (together with its affiliates) may not exercise any portion of the Pre-funded Warrants to the extent that the holder would own more than 4.99% of the outstanding Ordinary Shares (or, at the election of the purchaser, 9.99%), except that
          upon at least 61 days&#8217; prior notice from the holder to us, a holder with a 4.99% ownership blocker may increase the amount of ownership of outstanding shares after exercising the holder&#8217;s Pre-funded Warrants up to 9.99% of our outstanding
          Ordinary Shares. No fractional ADSs will be issued in connection with the exercise of a Pre-funded Warrant. In lieu of fractional shares, we may, at our election, either pay a cash adjustment in respect of such final fraction in an amount equal
          to such fraction multiplied by the exercise price of the Pre-funded Warrant or round up to the next whole ADS.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Cashless Exercise</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">In lieu of making the cash payment otherwise contemplated to be made to us upon such exercise in payment of the aggregate exercise price, the holder may elect instead to receive upon such
          exercise (either in whole or in part) the net number of ADSs determined according to a formula set forth in the Pre-funded Warrants.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Transferability</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">Subject to applicable laws, a&#160;Pre-funded&#160;Warrant may be transferred at the option of the holder upon surrender of the&#160;Pre-funded&#160;Warrant to us together with the appropriate instruments of
          transfer.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Exchange Listing</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">There is no trading market available for the Pre-funded Warrants on any securities exchange or nationally recognized trading system. We do not intend to list the Pre-funded Warrants on any
          securities exchange or nationally recognized trading system, nor do we have any obligation to do so.</div>
        <div style="text-align: justify; line-height: 1.25;"> <br>
        </div>
      </div>
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        <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 18</font></div>
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      </div>
      <div><br>
        <br>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Right as a Shareholder</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">Except as otherwise provided in the&#160;Pre-funded&#160;Warrants or by virtue of such holder&#8217;s ownership of the ADSs or Ordinary Shares, the holders of the&#160;Pre-funded&#160;Warrants do not have the rights or
          privileges of holders of the ADSs or Ordinary Shares, including any voting rights, until they exercise their&#160;Pre-funded&#160;Warrants.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Fundamental Transaction</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">If, at any time while the Pre-funded Warrants are outstanding, (1) we, directly or indirectly, consolidate or merge with or into another person, (2) we, directly or indirectly, sell, lease,
          license, assign, transfer, convey or otherwise dispose of all or substantially all of our assets, (3) any direct or indirect purchase offer, tender offer or exchange offer (whether by us or another person) is completed pursuant to which holders
          of our Ordinary Shares (including any Ordinary Shares underlying ADSs)&#160; are permitted to sell, tender or exchange their Ordinary Shares for other securities, cash or property and has been accepted by the holders of 50% or more of our outstanding
          Ordinary Shares or 50% or more of the voting power of the common equity of the Company&#160; (including any Ordinary Shares underlying ADSs), (4) we, directly or indirectly, effect any reclassification, reorganization or recapitalization of our
          Ordinary Shares or any compulsory share exchange pursuant to which our Ordinary Shares are converted into or exchanged for other securities, cash or property, or (5) we, directly or indirectly, consummate a stock or share purchase agreement or
          other business combination with another person whereby such other person acquires more than 50% of our outstanding Ordinary Shares (including any Ordinary Shares underlying ADSs) or 50% or more of the voting power of the common equity of the
          Company, each, a &#8220;Fundamental Transaction&#8221;, then upon any subsequent exercise of the Pre-funded Warrants, a holder thereof will have the right to receive the same amount and kind of securities, cash or property as it would have been entitled to
          receive upon the occurrence of such Fundamental Transaction if it had been, immediately prior to such Fundamental Transaction, the holder of the number of ADSs then issuable upon exercise of the Pre-funded Warrant, and any additional
          consideration payable as part of the Fundamental Transaction.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="Warrants11"><!--Anchor--></a>Warrants</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">The following summary of certain terms and provisions of the Warrants included in a unit that are being offered hereby is not complete and is subject to, and qualified in its entirety by, the
          provisions of the Warrants, the form of which is or shall be filed as an exhibit to a Report on Form 6-K which shall be incorporated by reference into the registration statement of which this prospectus supplement forms a part. Prospective
          investors should carefully review the terms and provisions of the form of Warrants for a complete description of the terms and conditions of the Warrants.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: center; line-height: 1.25;"><br>
        </div>
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        </div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Duration and Exercise Price</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">Each Warrant offered hereby has an exercise price per share equal to $0.25&#160;per ADS. The Warrants are immediately exercisable and expire on the five year anniversary of the original issuance date.
          The exercise price and number of ADSs issuable upon exercise is subject to appropriate adjustment in the event of share dividends, share splits, reorganizations or similar events affecting our Ordinary Shares and the exercise price.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Exercisability</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">The Warrants are exercisable, at the option of each holder, in whole or in part, by delivering to us a duly executed exercise notice accompanied by payment in full for the number of ADSs
          purchased upon such exercise. In lieu of fractional shares, we may, at our election, either pay a cash adjustment in respect of such final fraction in an amount equal to such fraction multiplied by the exercise price of the Warrant or round up to
          the next whole ADS.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Transferability</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">Subject to applicable laws, a Warrant may be transferred at the option of the holder upon surrender of the Warrant to us together with the appropriate instruments of transfer.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Exchange Listing</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">There is no trading market available for the Warrants on any securities exchange or nationally recognized trading system. We do not intend to list the Warrants on any securities exchange or
          nationally recognized trading system, nor do we have any obligation to do so.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Right as a Shareholder</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">Except as otherwise provided in the Warrants or by virtue of such holder&#8217;s ownership of the ADSs or Ordinary Shares, the holders of the Warrants do not have the rights or privileges of holders of
          the ADSs or Ordinary Shares, including any voting rights, until they exercise their Warrants.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Fundamental Transaction</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">If, at any time while the Warrants are outstanding, (1) we, directly or indirectly, consolidate or merge with or into another person, (2) we, directly or indirectly, sell, lease, license, assign,
          transfer, convey or otherwise dispose of all or substantially all of our assets, (3) any direct or indirect purchase offer, tender offer or exchange offer (whether by us or another person) is completed pursuant to which holders of our Ordinary
          Shares (including any Ordinary Shares underlying ADSs)&#160; are permitted to sell, tender or exchange their Ordinary Shares for other securities, cash or property and has been accepted by the holders of 50% or more of our outstanding Ordinary Shares
          or 50% or more of the voting power of the common equity of the Company&#160; (including any Ordinary Shares underlying ADSs), (4) we, directly or indirectly, effect any reclassification, reorganization or recapitalization of our Ordinary Shares or any
          compulsory share exchange pursuant to which our Ordinary Shares are converted into or exchanged for other securities, cash or property, or (5) we, directly or indirectly, consummate a stock or share purchase agreement or other business
          combination with another person whereby such other person acquires more than 50% of our outstanding Ordinary Shares (including any Ordinary Shares underlying ADSs) or 50% or more of the voting power of the common equity of the Company, each, a
          &#8220;Fundamental Transaction&#8221;, then upon any subsequent exercise of the Warrants, a holder thereof will have the right to receive the same amount and kind of securities, cash or property as it would have been entitled to receive upon the occurrence
          of such Fundamental Transaction if it had been, immediately prior to such Fundamental Transaction, the holder of the number of ADSs then issuable upon exercise of the Warrant, and any additional consideration payable as part of the Fundamental
          Transaction. Notwithstanding anything to the contrary, in the event of a Fundamental Transaction, the holder will have the right to require us or a successor entity to repurchase its remaining unexercised Warrants at the Black Scholes value;
          provided, however, that if the Fundamental Transaction is not within our control, including not approved by our board of directors, then the holder shall only be entitled to receive the same type or form of consideration (and in the same
          proportion), at the Black Scholes value of the unexercised portion of its Warrants, that is being offered and paid to the holders of our Ordinary Shares in connection with the Fundamental Transaction.</div>
        <div style="text-align: justify; line-height: 1.25;"> <br>
        </div>
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          <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 20</font></div>
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        </div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Share Combination Event Adjustment</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">If at any time and from time to time on or after the date of issuance there occurs any share split, share dividend, share combination recapitalization or other similar transaction involving the
          Ordinary Shares (each, a &#8220;Share Combination Event&#8221;, and such date thereof, the &#8220;Share Combination Event Date&#8221;) and the lowest daily volume weighted average price during the 5 consecutive trading days commencing on the Share Combination Event Date
          (the &#8220;Event Market Price&#8221;) (provided if the Share Combination Event is effective after close of Trading on the primary trading market, then commencing on the next Trading Day which period shall be the &#8220;Share Combination Adjustment Period&#8221;) is
          less than the exercise price then in effect (after giving effect to the adjustment in the Warrant upon a stock dividend, stock split or similar transaction), then at the close of trading on the primary trading market on the last day of the Share
          Combination Adjustment Period, the exercise price then in effect on such 5th trading Day shall be reduced (but in no event increased) to the Event Market Price and the number of Warrant Shares issuable hereunder shall be increased such that the
          aggregate exercise Price payable hereunder, after taking into account the decrease in the eexercise price, shall be equal to the aggregate exercise price on the date of issuance. For the avoidance of doubt, if the adjustment in the immediately
          preceding sentence would otherwise result in an increase in the exercise price hereunder, no adjustment shall be made, and if the Warrant is exercised, on any given exercise date during the Share Combination Adjustment Period, solely with respect
          to such portion of the Warrant exercised on such applicable exercise date, such applicable Share Combination Adjustment Period shall be deemed to have ended on, and included, the trading day immediately prior to such exercise date and the Event
          Market Price on such applicable exercise date will be the lowest daily volume weighted average price of the Ordinary Shares immediately prior to the Share Combination Event Date and ending on, and including the Trading Day immediately prior to
          such exercise date.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: center; line-height: 1.25;"><br>
        </div>
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        </div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="MATERIALTAXCONSI11DERATIONS"><!--Anchor--></a>MATERIAL TAX CONSIDERATIONS</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Israeli Tax Considerations</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">General</div>
        <div style="text-align: justify; line-height: 1.25;"><br>
          The following is a summary of the material tax consequences under Israeli law concerning the purchase, ownership and disposition of units and/or pre-funded units consisting of American Depositary Shares, representing Ordinary Shares, Pre-funded
          Warrants and Warrants (collectively, the &#8220;Shares&#8221;) by persons who acquired the Shares in this offering.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">This discussion does not purport to constitute a complete analysis of all potential tax consequences applicable to investors upon purchasing, owning or disposing of our Shares. In particular,
          this discussion does not take into account the specific circumstances of any particular investor (such as tax-exempt entities, financial institutions, certain financial companies, broker-dealers, investors that own, directly or indirectly, 10% or
          more of our outstanding voting rights, all of whom are subject to special tax regimes not covered under this discussion). To the extent that issues discussed herein are based on legislation that has yet to be subject to judicial or administrative
          interpretation, there can be no assurance that the views expressed herein will accord with any such interpretation in the future.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">Potential investors are urged to consult their own tax advisors as to the Israeli or other tax consequences of the purchase, ownership, and disposition of the Shares, including, in particular,
          the effect of any foreign, state or local taxes.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">General Corporate Tax Structure in Israel</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">Israeli companies are generally subject to corporate tax on their taxable income at the rate of 23% for the 2022 tax year.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">Taxation of Shareholders</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">Capital Gains</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">Capital gains tax is imposed on the disposition of capital assets by an Israeli resident and on the disposition of such assets by a non-Israeli resident if those assets are either (i) located in
          Israel; (ii) are shares or a right to a share in an Israeli resident corporation, or (iii) represent, directly or indirectly, rights to assets located in Israel, unless an exemption is available or unless an applicable double tax treaty between
          Israel and the seller&#8217;s country of residence provides otherwise. The Israeli Income Tax Ordinance distinguishes between &#8220;Real Gain&#8221; and the &#8220;Inflationary Surplus&#8221;. &#8220;Real Gain&#8221; is the excess of the total capital gain over Inflationary Surplus
          generally computed on the basis of the increase in the Israeli Consumer Price Index between the date of purchase and the date of disposition. Inflationary Surplus is not subject to tax.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">Real Gain accrued by individuals on the sale of the Shares will be taxed at the rate of 25%. However, if the individual shareholder is a &#8220;Controlling Shareholder&#8221; (i.e., a person who holds,
          directly or indirectly, alone or together with another, 10% or more of one of the Israeli resident company&#8217;s means of control) at the time of sale or at any time during the preceding 12-month period, such gain will be taxed at the rate of 30%.</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div style="text-align: justify; line-height: 1.25;">Corporate and individual shareholders dealing in securities in Israel are taxed at the tax rates applicable to business income (23% in 2019 and thereafter), and a marginal tax rate of up to 50%
          in 2022 for individuals, including an excess tax (as discussed below).</div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
        <div>Notwithstanding the foregoing, capital gains generated from the sale of our Shares by a non-Israeli shareholder may be exempt from Israeli tax under the Israeli Income Tax Ordinance provided&#160; that seller does not have a permanent establishment
          in Israel to which the generated capital gain is attributed. However, non-Israeli resident corporations will not be entitled to the foregoing exemption if Israeli residents: (i) have a 25% or more interest in such non-Israeli corporation or (ii)
          are the beneficiaries of, or are entitled to, 25% or more of the income or profits of such non-Israeli corporation, whether directly or indirectly. In addition, such exemption would not be available to a person whose gains from selling or
          otherwise disposing of the securities are deemed to be business income.<br>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
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            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 22</font></div>
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          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">In addition, the sale of the Shares may be exempt from Israeli capital gains tax under the provisions of an applicable double tax treaty. For example, the Convention Between the Government of
            the United States of America and the Government of the State of Israel with Respect to Taxes on Income, or the U.S.-Israel Double Tax Treaty, exempts a U.S. resident (for purposes of the U.S.-Israel Double Tax Treaty) from Israeli capital gain
            tax in connection with the sale of the Shares, provided that: (i) the U.S. resident owned, directly or indirectly, less than 10% of the voting power of the company at any time within the 12-month period preceding such sale; (ii) the U.S.
            resident, being an individual, is present in Israel for a period or periods of less than 183 days during the taxable year; and (iii) the capital gain from the sale was not derived through a permanent establishment of the U.S. resident in
            Israel; however, under the U.S.-Israel Double Tax Treaty, the taxpayer should be permitted to claim a credit for such taxes against the U.S. federal income tax imposed with respect to such sale, exchange or disposition, subject to the
            limitations under U.S. law applicable to foreign tax credits. The U.S.-Israel Double Tax Treaty does not relate to U.S. state or local taxes.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Payers of consideration for the Ordinary Shares, including the purchaser, the Israeli stockbroker or the financial institution through which the Shares are held, are obligated, subject to
            certain exemptions, to withhold tax upon the sale of Shares at a rate of 25% of the consideration for individuals and corporations.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Upon the sale of traded securities, a detailed return, including a computation of the tax due, must be filed and an advance payment must be paid to the Israeli Tax Authority on January 31 and
            July 31 of every tax year in respect of sales of traded securities made within the previous six months. However, if all tax due was withheld at source according to applicable provisions of the Israeli Income Tax Ordinance and regulations
            promulgated thereunder, such return need not be filed, and no advance payment must be paid. Capital gains are also reportable on annual income tax returns.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">Exercise of Warrants and Certain Adjustments to the Warrants</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Investors will generally not recognize gain or loss for Israeli tax purposes on the exercise of a Warrant and related receipt of an ordinary share (unless, for instance, cash is received in
            lieu of the issuance of a fractional ordinary share). Nevertheless, the Israeli income tax treatment and the tax consequences of a cashless exercise of Warrants into ordinary shares is unclear. Furthermore, the exercise terms of the Warrants
            may be adjusted in certain circumstances. An adjustment to the number of ordinary shares that will be issued on the exercise of the Warrants or an adjustment to the exercise price of a Warrant may be treated as a taxable event under Israeli tax
            law even if such holder does not receive any cash or other property in connection with the adjustment. Investors should consult their tax advisors regarding the proper treatment of any exercise of and/or adjustments to the Warrants.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">Dividends</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Dividends distributed by a company to a shareholder who is an Israeli resident individual will generally be subject to income tax at a rate of 25%. However, a 30% tax rate will apply if the
            dividend recipient is a Controlling Shareholder, as defined above, at the time of distribution or at any time during the preceding 12-month period. If the recipient of the dividend is an Israeli resident corporation, such dividend will
            generally be exempt from Israeli income tax provided that the income from which such dividend is distributed, derived or accrued within Israel.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
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            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 23</font></div>
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          </div>
          <br>
          <div style="text-align: justify; line-height: 1.25;">Dividends distributed by an Israeli resident company to a non-Israeli resident (either an individual or a corporation) are generally subject to Israeli withholding tax on the receipt of such
            dividends at the rate of 25% (30% if the dividend recipient is a Controlling Shareholder at the time of distribution or at any time during the preceding 12-month period). These rates may be reduced under the provisions of an applicable double
            tax treaty. For example, under the U.S.-Israel Double Tax Treaty, the following tax rates will apply in respect of dividends distributed by an Israeli resident company to a U.S. resident: (i) if the U.S. resident is a corporation that holds
            during that portion of the taxable year which precedes the date of payment of the dividend and during the whole of its prior taxable year (if any), at least 10% of the outstanding shares of the voting stock of the Israeli resident paying
            corporation and not more than 25% of the gross income of the Israeli resident paying corporation for such prior taxable year (if any) consists of certain types of interest or dividends the tax rate is 12.5%; (ii) if both the conditions
            mentioned in clause (i) above are met and the dividend is paid from an Israeli resident company&#8217;s income which was entitled to a reduced tax rate under The Law for the Encouragement of Capital Investments, 1959, the tax rate is 15%; and (iii)
            in all other cases, the tax rate is 25%. The aforementioned rates under the U.S.-Israel Double Tax Treaty will not apply if the dividend income is attributed to a permanent establishment of the U.S. resident in Israel.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">Excess Tax</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Individual holders who are subject to tax in Israel (whether any such individual is an Israeli resident or non-Israeli resident) and who have taxable income that exceeds a certain threshold in
            a tax year (NIS 663,240 for 2022, linked to the Israeli Consumer Price Index) will be subject to an additional tax at the rate of 3% on his or her taxable income for such tax year that is in excess of such amount. For this purpose, taxable
            income includes taxable capital gains from the sale of securities and taxable income from interest and dividends, subject to the provisions of an applicable double tax treaty.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">Estate and Gift Tax</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Israel does not currently impose estate or gift taxes if the Israeli Tax Authority is satisfied that the gift was made in good faith and on condition that the recipient of the gift is not a
            non-Israeli resident.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">Foreign Exchange Regulations</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Non-residents of Israel who hold our Shares are able to receive any dividends, and any amounts payable upon the dissolution, liquidation and winding up of our affairs, repayable in non-Israeli
            currency at the rate of exchange prevailing at the time of conversion. However, Israeli income tax is generally required to have been paid or withheld on these amounts. In addition, the statutory framework for the potential imposition of
            currency exchange control has not been eliminated and may be restored at any time by administrative action.</div>
          <div style="line-height: 1.25;">&#160;</div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 24</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <br>
          <div style="text-align: justify; line-height: 1.25;">Notwithstanding the foregoing, capital gains generated from the sale of our Shares by a non-Israeli shareholder may be exempt from Israeli tax under the Israeli Income Tax Ordinance provided
            that the following cumulative conditions are met: (i) the Shares were purchased upon or after the registration of the Shares on the stock exchange (this condition may not apply to shares purchased on or after January 1, 2009) and (ii) the
            seller does not have a permanent establishment in Israel to which the generated capital gain is attributed. However, non-Israeli resident corporations will not be entitled to the foregoing exemption if Israeli residents: (i) have a 25% or more
            interest in such non-Israeli corporation or (ii) are the beneficiaries of, or are entitled to, 25% or more of the income or profits of such non-Israeli corporation, whether directly or indirectly. In addition, such exemption would not be
            available to a person whose gains from selling or otherwise disposing of the securities are deemed to be business income.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">In addition, the sale of the Shares may be exempt from Israeli capital gains tax under the provisions of an applicable double tax treaty. For example, the Convention Between the Government of
            the United States of America and the Government of the State of Israel with Respect to Taxes on Income, or the U.S.-Israel Double Tax Treaty, exempts a U.S. resident (for purposes of the U.S.-Israel Double Tax Treaty) from Israeli capital gain
            tax in connection with the sale of the Shares, provided that: (i) the U.S. resident owned, directly or indirectly, less than 10% of the voting power of the company at any time within the 12-month period preceding such sale; (ii) the U.S.
            resident, being an individual, is present in Israel for a period or periods of less than 183 days during the taxable year; and (iii) the capital gain from the sale was not derived through a permanent establishment of the U.S. resident in
            Israel; however, under the U.S.-Israel Double Tax Treaty, the taxpayer would be permitted to claim a credit for such taxes against the U.S. federal income tax imposed with respect to such sale, exchange or disposition, subject to the
            limitations under U.S. law applicable to foreign tax credits. The U.S.-Israel Double Tax Treaty does not relate to U.S. state or local taxes.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Payers of consideration for the Ordinary Shares, including the purchaser, the Israeli stockbroker or the financial institution through which the Shares are held, are obligated, subject to
            certain exemptions, to withhold tax upon the sale of Shares at a rate of 25% of the consideration for individuals and corporations.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Upon the sale of traded securities, a detailed return, including a computation of the tax due, must be filed and an advance payment must be paid to the Israeli Tax Authority on January 31 and
            July 31 of every tax year in respect of sales of traded securities made within the previous six months. However, if all tax due was withheld at source according to applicable provisions of the Israeli Income Tax Ordinance and regulations
            promulgated thereunder, such return need not be filed, and no advance payment must be paid. Capital gains are also reportable on annual income tax returns.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: center; line-height: 1.25;"><br>
          </div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 25</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Material U.S. Federal Income Tax Considerations</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">The following is a summary of the material U.S. federal income tax consequences relating to the acquisition, ownership, and disposition of the ADSs and Warrants by U.S. Holders, as defined
            below. This summary addresses solely U.S. Holders who acquire ADSs, Pre-funded Warrants and Warrants pursuant to this offering and who hold ADSs, Pre-funded Warrants and Warrants, including ADSs from the exercise of such Pre-funded Warrants and
            Warrants, as capital assets for tax purposes. This summary is based on current provisions of the Internal Revenue Code of 1986, as amended (the &#8220;Code&#8221;), current and proposed U.S. Treasury regulations promulgated thereunder, and administrative
            and judicial decisions as of the date hereof, all of which are subject to change, possibly on a retroactive basis. In addition, this section is based in part upon representations of the depositary and the assumption that each obligation in the
            Deposit Agreement and any related agreement will be performed in accordance with its terms. This summary does not address all U.S. federal income tax matters that may be relevant to a particular holder or all tax considerations that may be
            relevant with respect to an investment in the ADSs, Pre-funded Warrants or Warrants.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">This summary does not address tax considerations applicable to a holder of the ADSs, Pre-funded Warrants or Warrants that may be subject to special tax rules including, without limitation, the
            following:</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z71df7983a21f4bac89bcc0af8d5a6f92" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">dealers or traders in securities, currencies, or notional principal contracts;</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z8a239c54913f407cbef2605184adee38" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">banks, insurance companies, and other financial institutions;</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z2916817660a44c94946fb654ae772547" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">real estate investment trusts or regulated investment companies;</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z578d3cc4dfd74849a7eb9fdbd1532389" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">persons or corporations subject to an alternative minimum tax;</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z186357059b234073bfd94e5f02c6ee4c" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">tax-exempt organizations;</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z0c35c3cf85674e839614ead4d8e7e9ce" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">traders that have elected mark-to-market accounting;</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="za5e14af48bcb4c449a0fcacfab300065" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">corporations that accumulate earnings to avoid U.S. tax;</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z1a6b4a1091f94ca8a7d28dece26d2d48" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">pension plans;</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zeaff6865379c4c75a708a1f93ad703bd" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">investors that hold the ADSs, Pre-funded Warrants or Warrants as part of a &#8220;straddle,&#8221; &#8220;hedge,&#8221; or &#8220;conversion transaction&#8221; with other investments;</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zb2f6026ed487449f9141442274167f93" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">persons that actually or constructively own 10 percent or more of our Ordinary Shares&#160; outstanding by vote or by value;</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z0b723d3761fc4947ba26b11cfa974064" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">persons that are treated as partnerships or other pass-through entities for U.S. federal income purposes; and</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z3fe8314c5cd441118eb7d62a35bb91be" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">U.S. Holders whose functional currency is not the U.S. dollar.</div>
                  </td>
                </tr>

            </table>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">This summary does not address the effect of any U.S. federal taxation other than U.S. federal income taxation. In addition, this summary does not include any discussion of state, local, or
            foreign tax consequences to a holder of the ADSs, Pre-funded Warrants or Warrants.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: center; line-height: 1.25;"><br>
          </div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 26</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-weight: bold;">You are urged to consult your own tax advisor regarding the foreign and U.S. federal, state, and local income and other tax consequences of an investment in the ADSs,
            Pre-funded Warrants and Warrants, including the potential effects of any proposed legislation, if enacted.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">For purposes of this summary, a &#8220;U.S. Holder&#8221; means a beneficial owner of an ADS, Pre-funded Warrant or Warrant that is for U.S. federal income tax purposes:</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z613da7f5d7c34499855d878ca6ab25b4" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">an individual who is a citizen or resident of the U.S.;</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z48a6ac540fa44bcf8d0e77139c0d9648" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">a corporation (or other entity taxable as a corporation for U.S. federal income tax purposes) created or organized in the U.S. or under the laws of the U.S., any state thereof, or the
                      District of Columbia;</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z44a352a9629845849dfb92befcc3695b" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">an estate, the income of which is subject to U.S. federal income tax regardless of its source; or</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z3a4d7b05d38d4dac9df2fa36a8ce3502" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">a trust (1) if (a) a court within the U.S. is able to exercise primary supervision over the administration of the trust and (b) one or more U.S. persons have the authority to control
                      all substantial decisions of the trust or (2) that has a valid election in effect under applicable U.S. Treasury regulations to be treated as a U.S. person.</div>
                  </td>
                </tr>

            </table>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">If an entity or arrangement that is classified as a partnership for U.S. federal tax purposes holds ADSs, Pre-funded Warrants or Warrants, the U.S. federal tax treatment of its partners will
            generally depend upon the status of the partners and the activities of the partnership. Entities or arrangements that are classified as partnerships for U.S. federal tax purposes and persons holding ADSs, Pre-funded Warrants or Warrants through
            such entities should consult their own tax advisors.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">In general, and assuming that all obligations under the Deposit Agreement will be satisfied in accordance with the terms of the Deposit Agreement, if you hold ADSs, you will be treated as the
            holder of the underlying Ordinary Shares represented by those ADSs for U.S. federal income tax purposes. Accordingly, gain or loss generally will not be recognized if you exchange ADSs for the underlying Ordinary Shares represented by those
            ADSs.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 27</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
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          </div>
          <br>
          <div style="text-align: justify; line-height: 1.25; font-style: italic;"><u>General Treatment of ADSs and Warrants and Allocation of Purchase Price</u></div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">For U.S. federal income tax purposes, a U.S. Holder&#8217;s acquisition of an ADS and Warrant will be treated as the acquisition of a &#8220;Unit&#8221; consisting of one ADS and a Warrant to purchase one ADS.
            The purchase price for each Unit will be allocated between these two components in proportion to their relative fair market values at the time the unit is purchased by a U.S. Holder. This allocation of the purchase price for each Unit will
            establish a U.S. Holder&#8217;s initial tax basis for U.S. federal income tax purposes in the ADS and the Warrant included in each Unit. Each U.S. Holder should consult its own tax advisor regarding the allocation of the purchase price for a Unit.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">Taxation of Warrants</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-style: italic;">Exercise of Warrants</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">A U.S. Holder will not be required to recognize taxable gain or loss upon the exercise of a Warrant for ADSs, except with respect to cash received in lieu of a fractional ADS. The U.S. Holder&#8217;s
            adjusted tax basis in the ADSs received upon exercise generally will be an amount equal to the sum of the holder&#8217;s tax basis in the Warrant plus the exercise price of the Warrant, less any portion of the tax basis attributable to the receipt of
            cash in lieu of a fractional ADS. Except as provided under the heading &#8220;&#8211; Passive Foreign Investment Companies&#8221; below, the holding period for the ADSs received upon exercise of the Warrant will begin on the date of exercise of the Warrant. A
            U.S. Holder&#8217;s receipt of cash in lieu of a fractional ADS will generally be treated as if such U.S. Holder had received the fractional ADS upon exercise of the Warrant and then received such cash in redemption of such ADS. For more information
            regarding the tax considerations related to the ownership and disposition of our ADSs acquired upon exercise of the Warrant, see the discussion below regarding &#8220;&#8211; Taxation of ADSs.&#8221;</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-style: italic;">Lapse of Warrants</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Except as provided under the heading &#8220;&#8211; Passive Foreign Investment Companies&#8221; below, if a<font style="font-style: italic;">&#160;</font>Warrant is allowed to lapse unexercised, a U.S. Holder will
            recognize a capital loss in an amount equal to its tax basis in the Warrant. Such loss will be long-term capital loss if the Warrant has been held for more than one year as of the date the Warrant lapsed. The deductibility of capital losses is
            subject to limitation.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-style: italic;">Disposition of Warrants</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Except as provided under the heading &#8220;&#8211; Passive Foreign Investment Companies&#8221; below, upon the sale, exchange, or other disposition of our Warrants, a U.S. Holder will recognize capital gain or
            loss in an amount equal to the difference between such U.S. Holder&#8217;s tax basis in the sold Warrants and the amount realized on the disposition of such Warrants (or its U.S. dollar equivalent determined by reference to the spot rate of exchange
            on the date of disposition, if the amount realized is denominated in a foreign currency). The gain or loss realized on the sale, exchange, or other disposition of Warrants will be long-term capital gain or loss if the U.S. Holder has a holding
            period in the warrants of more than one year at the time of the disposition. The deductibility of capital losses is subject to limitation.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 28</font></div>
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          </div>
          <br>
          <div style="text-align: justify; line-height: 1.25; font-style: italic;">Certain Adjustments to Warrants</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Under Section 305 of the Code, an adjustment to the number of ADSs that will be issued on the exercise of the Warrants, or an adjustment to the exercise price of the Warrants, may be treated as
            a constructive distribution to a U.S. Holder of the Warrants if, and to the extent that, such adjustment has the effect of increasing such U.S. Holder&#8217;s proportionate interest in our "earnings and profits" or assets, depending on the
            circumstances of such adjustment (for example, if such adjustment is to compensate for a distribution of cash or other property to our shareholders). For more information regarding the tax considerations related to distributions, see the
            discussion below regarding &#8220;&#8211; Taxation of ADSs.&#8221;</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-style: italic;">Distributions</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">We do not expect to make any distribution with respect to the ADSs. But if we make any such distributions, subject to the discussion under &#8220;&#8211; Passive Foreign Investment Companies&#8221; below, the
            gross amount of any distribution actually or constructively received by a U.S. Holder (through the Depositary) with respect to an ADS will generally be taxable to the U.S. Holder as foreign-source dividend income to the extent of our current
            and accumulated earnings and profits as determined under U.S. federal income tax principles. The amount distributed will include the amount of any Israeli taxes withheld from such distribution, as described above under the caption &#8220;Material Tax
            Considerations-Israeli Tax Considerations.&#8221; A U.S. Holder will not be eligible for any dividends received deduction in respect of the dividends paid by us, which deduction is otherwise available to a corporate U.S. Holder in respect of
            dividends received from a domestic corporation. Distributions in excess of earnings and profits will be non-taxable to the U.S. Holder to the extent of the U.S. Holder&#8217;s adjusted tax basis in its ADSs and Pre-funded Warrants. Distributions in
            excess of such adjusted tax basis will generally be taxable to a U.S. Holder as capital gain from the sale or exchange of property as described below under &#8220;-Sale or Other Disposition of ADSs and Pre-funded Warrants.&#8221; If we do not report to a
            U.S. Holder the portion of a distribution that exceeds earnings and profits, then the distribution will generally be taxable as a dividend. The amount of any distribution of property other than cash will be the fair market value of that
            property on the date of distribution.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Under the Code, certain qualified dividends received by non-corporate U.S. Holders will be subject to U.S. federal income tax at the preferential long-term capital gains of, currently, a
            maximum of 20%. This preferential income tax rate is applicable only to dividends paid by a &#8220;qualified foreign corporation&#8221; that is not a PFIC for the year in which the dividend is paid or for the preceding taxable year, and only with respect
            to ADSs and Pre-funded Warrants held by a qualified U.S. Holder (i.e., a non-corporate holder) for a minimum holding period (generally 61 days during the 121-day period beginning 60 days before the ex-dividend date) and certain other holding
            period requirements are met. If such holding period requirements are met, dividends we pay with respect to the ADSs and Pre-funded Warrants generally will be qualified dividend income. However, if we were a PFIC, dividends paid by us to
            individual U.S. Holders would not be eligible for the reduced income tax rate applicable to qualified dividends. As discussed below in &#8220;&#8211; Passive Foreign Investment Companies,&#8221; we do not anticipate being treated as a PFIC for this year;
            however, there can be no assurance that we will not be treated as a PFIC for our current taxable or future taxable years. You should consult your own tax advisor regarding the availability of this preferential tax rate under your particular
            circumstances.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 29</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <div style="text-align: center; line-height: 1.25;"><br>
          </div>
          <div style="text-align: justify; line-height: 1.25;">The amount of any distribution paid in a currency other than U.S. dollars (a &#8220;foreign currency&#8221;), including the amount of any withholding tax thereon, will be included in the gross income of a
            U.S. Holder in an amount equal to the U.S. dollar value of the foreign currency calculated by reference to the exchange rate in effect on the date of the U.S. Holder&#8217;s (or, in the case of ADSs, the depositary&#8217;s) receipt of the dividend,
            actively or constructively, regardless of whether the foreign currency is converted into U.S. dollars. If the foreign currency is converted into U.S. dollars on the date of receipt, a U.S. Holder generally should not be required to recognize a
            foreign currency gain or loss in respect of the dividend. If the foreign currency received in the distribution is not converted into U.S. dollars on the date of receipt, a U.S. Holder will have a basis in the foreign currency equal to its U.S.
            dollar value on the date of receipt. Any gain or loss on a subsequent conversion or other disposition of the foreign currency will be treated as U.S. source ordinary income or loss and will not be eligible for the preferential rate applicable
            to qualified dividend income.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25;">Subject to certain conditions and limitations, any Israeli taxes withheld on dividends may be creditable against a U.S. Holder&#8217;s U.S. federal income tax liability, subject to generally applicable limitations. The
            rules relating to foreign tax credits and the timing thereof are complex. You should consult your own tax advisors regarding the availability of a foreign tax credit in your particular situation.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25; font-style: italic;">Sale, Exchange, or Other Disposition of ADSs and Pre-funded Warrants</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Subject to the discussion under &#8220;&#8211; Passive Foreign Investment Companies&#8221; below, a U.S. Holder that sells or otherwise disposes of its ADSs or Pre-funded Warrants will recognize gain or loss for
            U.S. federal income tax purposes in an amount equal to the difference between the amount realized on the sale or other disposition and such U.S. Holder&#8217;s adjusted basis in the ADSs and Pre-funded Warrants. Such gain or loss generally will be
            capital gain or loss and will be a long-term capital gain or loss if the U.S. Holder&#8217;s holding period of the ADSs and Pre-funded Warrants exceeds one year at the time of the sale or other disposition. Long-term capital gains realized by
            non-corporate U.S. Holders are generally subject to a preferential U.S. federal income tax rate. In general, gain or loss recognized by a U.S. Holder on the sale or other disposition or the ADSs or Pre-funded Warrants will be U.S. source gain
            or loss for purposes of the foreign tax credit limitation. However, if we are a PFIC, any such gain will be subject to the PFIC rules, as discussed below, rather than being taxed as a capital gain. As discussed below in &#8220;-Passive Foreign
            Investment Companies,&#8221; we do not anticipate being a PFIC for this year; however, there can be no assurance that we will not be treated as a PFIC for our current taxable year and future taxable years.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">If a U.S. Holder receives foreign currency upon a sale or exchange of ADSs or Pre-funded Warrants, gain or loss will be recognized in the manner described above under &#8220;&#8211; Distributions.&#8221;
            However, if such foreign currency is converted into U.S. dollars on the date received by the U.S. Holder, the U.S. Holder generally should not be required to recognize any foreign currency gain or loss on such conversion.</div>
          <br>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 30</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">As discussed above under the heading &#8220;Material Tax Considerations-Israeli Tax Considerations-Taxation of Shareholders,&#8221; a U.S. Holder who holds ADSs or Pre-funded Warrants through an Israeli
            broker or other Israeli intermediary may be subject to Israeli withholding tax on any capital gains recognized on a sale or other disposition of the ADSs or Pre-funded Warrants if the U.S. Holder does not obtain approval of an exemption from
            the Israeli Tax Authorities or does not claim any allowable refunds or reductions. Any Israeli tax paid under circumstances in which an exemption from (or a refund of or a reduction in) such tax was available will not be creditable for U.S.
            federal income tax purposes. U.S. Holders are advised to consult their Israeli broker or intermediary regarding the procedures for obtaining an exemption or reduction.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-style: italic;">Medicare Tax on Unearned Income</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Non-corporate U.S. Holders whose income exceeds certain thresholds are required to pay an additional 3.8% tax on their net investment income, which includes dividends paid on the ADSs and
            Pre-funded Warrants and capital gains from the sale or other disposition of the ADSs and Pre-funded Warrants.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-style: italic;">Passive Foreign Investment Companies</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Although we do not anticipate being treated as a PFIC for this year, we cannot give assurance that based on the value and composition of our assets, we will not be treated as a PFIC for U.S.
            federal income tax purposes for our current taxable year or future taxable years. We will be considered a PFIC for any taxable year if:</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z09d40bea62694e53a1794d808b422384" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">at least 75% of our gross income for such taxable year is passive income; or</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="za673f3fbe22f48f5afe83fa161095f8e" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">at least 50% of the value of our assets (based on an average of the fair market values of the assets determined at the end of each quarter during a taxable year) is attributable to
                      assets that produce or are held for the production of passive income.</div>
                  </td>
                </tr>

            </table>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">For purposes of the above calculations, if we own, directly or indirectly, 25% or more of the total value of the outstanding shares of another corporation, we will be treated as if we (a) held
            a proportionate share of the assets of such other corporation and (b) received a proportionate share of the income of such other corporation directly. Passive income generally includes, among other things, dividends, interest, rents, royalties
            and certain capital gain, but generally excludes rents and royalties that are derived in the active conduct of a trade or business and which are received from a person other than a related person.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25;">A separate determination must be made each taxable year as to whether we are a PFIC (after the close of each such taxable year). Because the value of our assets for purposes of the asset test will generally be
            determined by reference to the market price of the ADSs and Pre-funded Warrants, our PFIC status will depend in large part on the market price of the ADSs and Pre-funded Warrants, which may fluctuate significantly.</div>
          <div style="line-height: 1.25;"> <br>
          </div>
        </div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 31</font></div>
          <div style="page-break-after: always;" class="BRPFPageBreak">
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        </div>
        <div><br>
          <br>
          <div style="text-align: justify; line-height: 1.25;">If we are a PFIC for any year during which a U.S. Holder holds ADSs and Pre-funded Warrants or Warrants, we generally will be treated as a PFIC with respect to such U.S. Holder for all
            succeeding years during which such U.S. Holder holds the ADSs and Pre-funded Warrants or Warrants, unless we cease to be a PFIC and such U.S. Holder makes a &#8220;deemed sale&#8221; election with respect to the ADSs and Pre-funded Warrants or Warrants
            such U.S. Holder holds. For this purpose, a U.S. Holder will be treated as holding ADSs acquired through the exercise of a Warrant for the period during which the Warrant was held. A U.S. Holder that makes such an election will be deemed to
            have sold the ADSs and Pre-funded Warrants or Warrants it holds at their fair market value on the last day of the last taxable year in which we qualified as a PFIC, and any gain from such deemed sale will be subject to the U.S. federal income
            tax treatment described below. After the deemed sale election, the ADSs and Pre-funded Warrants or Warrants with respect to which the deemed sale election was made will not be treated as shares in a PFIC unless we subsequently become a PFIC.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">For each taxable year for which we are treated as a PFIC with respect to a U.S. Holder, such U.S. Holder will be subject to special tax rules with respect to any &#8220;excess distribution&#8221; it
            receives and any gain it realizes from a sale or other disposition (including a pledge) of the ADSs and Pre-funded Warrants or Warrants, unless it makes a &#8220;mark-to-market&#8221; election or a &#8220;qualified electing fund&#8221; election discussed below.
            Distributions a U.S. Holder receives in a taxable year that are greater than 125% of the average annual distributions it received during the shorter of the three preceding taxable years or its holding period for the ADSs and Pre-funded Warrants
            or Warrants will be treated as an excess distribution. Under these special tax rules, if a U.S. Holder receives any excess distribution or realizes any gain from a sale or other disposition of the ADSs and Pre-funded Warrants or Warrants:</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z8aa73a3e2b6a48979943aa93037b1991" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">the excess distribution or gain will be allocated ratably over the U.S. Holder&#8217;s holding period for the ADSs and Pre-funded Warrants or Warrants;</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z92e1c3c14e27451ebe5cf8a627c78b30" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">the amount of excess distribution or gain allocated to the current taxable year, and any taxable year before the first taxable year in which we were a PFIC, must be included in the
                      U.S. Holder&#8217;s gross income (as ordinary income) for the tax year of the sale or disposition; and</div>
                  </td>
                </tr>

            </table>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z7175bf6a7ed14fd98dd4df482dc20a65" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">&#8226;</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">the amount allocated to each other year will be subject to the highest marginal tax rate in effect with respect to such U.S. Holder for that year and the interest charge generally
                      applicable to underpayments of tax will be imposed on the resulting tax attributable to such amounts allocated to each other year.</div>
                  </td>
                </tr>

            </table>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">The tax liability for amounts allocated to years before the year of disposition or &#8220;excess distribution&#8221; cannot be offset by any losses for such years. Additionally, any gains realized on the
            sale of the ADSs and Pre-funded Warrants or Warrants cannot be treated as capital gains.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">If we are treated as a PFIC with respect to a U.S. Holder for any taxable year, to the extent any of our subsidiaries are also PFICs, such U.S. Holder will be deemed to own its proportionate
            share of any such subsidiaries that are PFICs, and such U.S. Holder may be subject to the rules described in the preceding two paragraphs with respect to the shares of such subsidiaries that are PFICs it will be deemed to own. As a result, a
            U.S. Holder may incur liability for any &#8220;excess distribution&#8221; described above if we receive a distribution from such subsidiaries that are PFICs or if we dispose of, or are deemed to dispose of, any shares in such subsidiaries that are PFICs.
            You should consult your own tax advisor regarding the application of the PFIC rules to any of our subsidiaries.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: center; line-height: 1.25;"><br>
          </div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 32</font></div>
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          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Alternatively, a U.S. Holder of &#8220;marketable stock&#8221; (as defined below) in a PFIC may make a mark-to-market election for such stock to elect out of the general tax treatment for PFICs discussed
            above. If a U.S. Holder makes a mark-to-market election for the ADSs and Pre-funded Warrants, such U.S. Holder will include in income for each year we are a PFIC an amount equal to the excess, if any, of the fair market value of the ADSs and
            Pre-funded Warrants as of the close of such U.S. Holder&#8217;s taxable year over such U.S. Holder&#8217;s adjusted basis in such ADSs and Pre-funded Warrants. A U.S. Holder is allowed a deduction for the excess, if any, of the adjusted basis of the ADSs
            and Pre-funded Warrants over their fair market value as of the close of the taxable year. However, deductions are allowable only to the extent of any net mark-to-market gains on the ADSs and Pre-funded Warrants included in a U.S. Holder&#8217;s
            income for prior taxable years. Amounts included in a U.S. Holder&#8217;s income under a mark-to-market election, as well as gain on the actual sale or other disposition of the ADSs and Pre-funded Warrants, are treated as ordinary income. Ordinary
            loss treatment also applies to the deductible portion of any mark-to-market loss on the ADSs and Pre-funded Warrants, as well as to any loss realized on the actual sale or disposition of the ADSs and Pre-funded Warrants to the extent the amount
            of such loss does not exceed the net mark-to-market gains previously included for the ADSs and Pre-funded Warrants. A U.S. Holder&#8217;s basis in the ADSs and Pre-funded Warrants will be adjusted to reflect any such income or loss amounts. If a U.S.
            Holder makes a valid mark-to-market election, the tax rules that apply to distributions by corporations that are not PFICs will apply to distributions by us, except the lower applicable tax rate for qualified dividend income will not apply. If
            we cease to be a PFIC when a U.S. Holder has a mark-to-market election in effect, gain or loss realized by such U.S. Holder on the sale of the ADSs or Pre-funded Warrants will be a capital gain or loss and taxed in the manner described above
            under &#8220;&#8211; Sale, Exchange, or Other Disposition of ADSs and Pre-funded Warrants.&#8221;</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">The mark-to-market election is available only for &#8220;marketable stock,&#8221; which is a stock that is traded in other than de minimis quantities on at least 15 days during each calendar quarter, or
            regularly traded, on a qualified exchange or another market, as defined in applicable U.S. Treasury regulations. Any trades that have as their principal purpose meeting this requirement will be disregarded. The ADSs are listed on the Nasdaq
            Global Market and, accordingly, provided the ADSs are regularly traded, the mark-to-market election will be available to a U.S. Holder of ADSs if we are a PFIC. Once made, the election cannot be revoked without the consent of the IRS unless the
            ADSs and Pre-funded Warrants cease to be marketable stock. If we are a PFIC for any year in which the U.S. Holder owns the ADSs and Pre-funded Warrants but before a mark-to-market election is made, the interest charge rules described above will
            apply to any mark-to-market gain recognized in the year the election is made. If any of our subsidiaries are or become PFICs, the mark-to-market election will not be available with respect to the shares of such subsidiaries that are treated as
            owned by a U.S. Holder. Consequently, a U.S. Holder could be subject to the PFIC rules with respect to income of the lower-tier PFICs the value of which already had been taken into account indirectly via mark-to-market adjustments. The
            mark-to-market election will not be available for Warrants. You should consult your own tax advisors as to the availability and desirability of a mark-to-market election, as well as the impact of such election on interests in any lower-tier
            PFICs.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">In certain circumstances, a U.S. Holder of stock in a PFIC can make a &#8220;qualified electing fund&#8221; election to mitigate some of the adverse tax consequences of holding stock in a PFIC by including
            in income its share of the corporation&#8217;s income on a current basis. However, we do not currently intend to prepare or provide the information that would enable a U.S. Holder to make a qualified electing fund election. The qualified electing
            fund election will not be available for Warrants.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Unless otherwise provided by the U.S. Treasury, each U.S. shareholder of a PFIC is required to file an annual information return on IRS Form 8621 (Information Return by a Shareholder of a
            Passive Foreign Investment Company or Qualifying Electing Fund) containing such information as the U.S. Treasury may require. A U.S. Holder&#8217;s failure to file such annual information return could result in the imposition of penalties and the
            extension of the statute of limitations with respect to U.S. federal income tax. You should consult your own tax advisors regarding the requirements of filing such information returns under these rules, taking into account the uncertainty as to
            whether we are currently treated as or may become a PFIC.</div>
          <div style="line-height: 1.25;">&#160;</div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 33</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-weight: bold;">YOU ARE STRONGLY URGED TO CONSULT YOUR OWN TAX ADVISOR REGARDING THE IMPACT AND APPLICATION OF THE PFIC RULES ON YOUR INVESTMENT IN THE ADSs, PRE-FUNDED WARRANTS AND
            WARRANTS.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-style: italic;">Backup Withholding and Information Reporting</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Payments of dividends with respect to ADSs Pre-funded Warrants or Warrants and the proceeds from the sale, retirement, or other disposition of ADSs and Pre-funded Warrants or Warrants made by a
            U.S. paying agent or other U.S. intermediary will generally be reported to the IRS and to the U.S. Holder as may be required under applicable U.S. Treasury regulations. We, or an agent, a broker, or any paying agent, as the case may be, may be
            required to withhold tax (backup withholding), currently at the rate of 24%, if a non-corporate U.S. Holder that is not otherwise exempt fails to provide an accurate taxpayer identification number and comply with other IRS requirements
            concerning information reporting. Certain U.S. Holders (including, among others, corporations and tax-exempt organizations) are not subject to backup withholding. Backup withholding is not an additional tax. Any amount of backup withholding
            withheld may be used as a credit against your U.S. federal income tax liability or may be refunded provided that the required information is timely furnished to the IRS. U.S. Holders should consult their own tax advisors as to their
            qualification for exemption from backup withholding and the procedure for obtaining an exemption.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">You should consult your own tax advisors regarding the backup withholding tax and information reporting rules.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25;"><font style="font-style: italic;">Foreign Asset Reporting</font>&#160;</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Certain U.S. Holders who are individuals are required to report information relating to an interest in the ADSs or Warrants, subject to certain exceptions (including an exception for shares
            held in accounts maintained by financial institutions) by filing IRS Form 8938 (Statement of Specified Foreign Financial Assets) with their federal income tax return. U.S. Holders are urged to consult their tax advisors regarding their
            information reporting obligations, if any, with respect to their ownership and disposition of the ADSs and Warrants.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25; font-weight: bold;">EACH PROSPECTIVE INVESTOR IS URGED TO CONSULT ITS OWN TAX ADVISOR REGARDING THE TAX CONSEQUENCES OF AN INVESTMENT IN THE ADSs AND PRE-FUNDED WARRANTS IN LIGHT OF SUCH
            INVESTOR&#8217;S PARTICULAR CIRCUMSTANCES.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 34</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <br>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="UNDERWRITING11"><!--Anchor--></a>UNDERWRITING</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">We have entered into an underwriting agreement with Aegis Capital Corp. (the &#8220;underwriter&#8221; or &#8220;Aegis&#8221;), with respect to the units and pre-funded units being offered hereby. Subject to the terms
            and conditions set forth in the underwriting agreement, dated December 2, 2022, between us and Aegis Capital Corp. (the &#8220;underwriter&#8221; or &#8220;Aegis&#8221;) as the exclusive underwriter of this offering, we have agreed to sell to the underwriter, and the
            underwriter has agreed to purchase from us the number of units and pre-funded units shown opposite its name below:</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <table cellspacing="0" cellpadding="0" id="z0377dc7f813d43f5a6c7a089cc714a8a" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

              <tr>
                <td style="width: 75.82%; vertical-align: bottom; border-bottom: #000000 2px solid;">
                  <div style="line-height: 1.25; font-weight: bold;">Name</div>
                </td>
                <td style="width: 0.82%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 10.44%; vertical-align: bottom; border-bottom: #000000 2px solid;" colspan="2">
                  <div style="text-align: center; line-height: 1.25; font-weight: bold;">Number of<br>
                    Units</div>
                </td>
                <td nowrap="nowrap" style="width: 0.82%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 0.82%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 10.44%; vertical-align: bottom; border-bottom: #000000 2px solid;" colspan="2">
                  <div style="text-align: center; line-height: 1.25; font-weight: bold;">Number of Pre-Funded Units</div>
                </td>
                <td nowrap="nowrap" style="width: 0.83%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="width: 75.82%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">Aegis Capital Corp.</div>
                </td>
                <td style="width: 0.82%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 0.82%; vertical-align: bottom; background-color: #CCEEFF; border-bottom: #000000 2px solid;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 9.62%; vertical-align: bottom; background-color: #CCEEFF; border-bottom: #000000 2px solid;">
                  <div style="text-align: right; line-height: 1.25;">21,775,000</div>
                </td>
                <td nowrap="nowrap" style="width: 0.82%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 0.82%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 0.82%; vertical-align: bottom; background-color: #CCEEFF; border-bottom: #000000 2px solid;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 9.62%; vertical-align: bottom; background-color: #CCEEFF; border-bottom: #000000 2px solid;">
                  <div style="text-align: right; line-height: 1.25;">10,225,000</div>
                </td>
                <td nowrap="nowrap" style="width: 0.83%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="width: 75.82%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">Total</div>
                </td>
                <td style="width: 0.82%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 0.82%; vertical-align: bottom; border-bottom: #000000 4px double;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 9.62%; vertical-align: bottom; border-bottom: #000000 4px double;">
                  <div style="text-align: right; line-height: 1.25;">21,775,000</div>
                </td>
                <td nowrap="nowrap" style="width: 0.82%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 0.82%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 0.82%; vertical-align: bottom; border-bottom: #000000 4px double;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 9.62%; vertical-align: bottom; border-bottom: #000000 4px double;">
                  <div style="text-align: right; line-height: 1.25;">10,225,000</div>
                </td>
                <td nowrap="nowrap" style="width: 0.83%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
              </tr>

          </table>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">The underwriting agreement provides that the obligations of the underwriter are subject to certain conditions precedent such as the receipt by the underwriter of officers&#8217; certificates and
            legal opinions and approval of certain legal matters by their counsel. The underwriting agreement provides that the underwriter will purchase all of the units and pre-funded units if any of them are purchased. We have agreed to indemnify the
            underwriter against specified liabilities, including liabilities under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), and to contribute to payments the underwriter may be required to make in respect thereof.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">The underwriter is offering the units and pre-funded units subject to prior sale, when, as and if issued to and accepted by them, subject to approval of legal matters by its counsel and other
            conditions specified in the underwriting agreement. The underwriter reserves the right to withdraw, cancel or modify offers to the public and to reject orders in whole or in part.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25; font-weight: bold;">Underwriting Discounts and Expenses</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">The underwriter has advised us that it proposes to offer the units and pre-funded units to the public at the public offering price per ADS set forth on the cover page of this prospectus
            supplement.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: center; line-height: 1.25;"><br>
          </div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 35</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">The following table summarizes the underwriting discounts and proceeds, before expenses, to us:</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000; width: 100%;" id="z2b234fe482cc4f58b593428986a0c5c3" class="cfttable">

              <tr>
                <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;">
                  <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
                </td>
                <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
                <td valign="bottom" style="vertical-align: bottom; border-bottom: #000000 solid 2px;" colspan="2">
                  <div style="text-align: center; line-height: 1.25; font-weight: bold;">Per Unit</div>
                </td>
                <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
                <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftguttercell">&#160;</td>
                <td valign="bottom" style="vertical-align: bottom; border-bottom: #000000 solid 2px;" colspan="2">
                  <div style="text-align: center; line-height: 1.25; font-weight: bold;">Per Pre-Funded Unit</div>
                </td>
                <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 2px;" colspan="1" class="cftfncell">&#160;</td>
              </tr>
              <tr>
                <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 76%;">
                  <div style="line-height: 1.25;">Public offering price</div>
                </td>
                <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
                <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
                  <div style="line-height: 1.25;">$</div>
                </td>
                <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                  <div style="line-height: 1.25;">0.25</div>
                </td>
                <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
                <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
                <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
                  <div style="line-height: 1.25;">$</div>
                </td>
                <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                  <div style="line-height: 1.25;">0.249</div>
                </td>
                <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
              </tr>
              <tr>
                <td valign="bottom" style="vertical-align: bottom; width: 76%;">
                  <div style="line-height: 1.25;">Underwriting discounts and commissions (5.0%)</div>
                </td>
                <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
                <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
                  <div style="line-height: 1.25;">$</div>
                </td>
                <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                  <div style="line-height: 1.25;">0.0125</div>
                </td>
                <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
                <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftguttercell">&#160;</td>
                <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
                  <div style="line-height: 1.25;">$</div>
                </td>
                <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                  <div style="line-height: 1.25;">0.0125</div>
                </td>
                <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
              </tr>
              <tr>
                <td valign="bottom" style="vertical-align: bottom; background-color: #CCEEFF; width: 76%;">
                  <div style="line-height: 1.25;">Proceeds, before expenses, to us</div>
                </td>
                <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
                <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
                  <div style="line-height: 1.25;">$</div>
                </td>
                <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                  <div style="line-height: 1.25;">0.2375</div>
                </td>
                <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
                <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1" class="cftguttercell">&#160;</td>
                <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftcurrcell">
                  <div style="line-height: 1.25;">$</div>
                </td>
                <td valign="bottom" style="background-color: #CCEEFF; vertical-align: bottom; text-align: right; width: 9%;" colspan="1" class="cftnumcell">
                  <div style="line-height: 1.25;">0.2365</div>
                </td>
                <td valign="bottom" nowrap="nowrap" style="background-color: #CCEEFF; vertical-align: bottom; width: 1%;" colspan="1" class="cftfncell">&#160;</td>
              </tr>

          </table>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">In addition, we have also agreed to pay all expenses in connection with the offering, including the following expenses: (a) all filing fees and expenses relating to the registration of the
            shares with SEC; (b) all FINRA public offering filing fees; (c) all fees and expenses relating to the listing of our equity or equity-linked securities on Nasdaq; (d) all fees, expenses and disbursements relating to the registration,
            qualification or exemption of the shares under the securities laws of such foreign jurisdictions as Aegis may reasonably designate; (e) the costs of all mailing and printing of the offering documents; (f) transfer and/or stamp taxes, if any,
            payable upon the transfer of shares from us to the underwriter; (g) the fees and expenses of our accountants; and (h) the reasonable and documented out-of-pocket costs, fees and expenses of counsel to Aegis up to an aggregate maximum amount of
            $50,000, if the offering closes.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">We estimate the expenses of this offering payable by us, not including underwriting discounts, including amounts for which we agreed to reimburse the underwriter for certain of its expenses,
            will be approximately $330,000. In accordance with Financial Industry Regulatory Authority, Inc. Rule 5110, these reimbursed fees to the underwriter and expenses are deemed underwriting compensation for this offering.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25; font-weight: bold;">Lock-Up Agreements</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Pursuant to certain &#8220;lock-up&#8221; agreements, our executive officers and directors have agreed, subject to certain exceptions, not to (i) sell, offer to sell, contract to sell or lend, effect any
            short sale or establish or increase a Put Equivalent Position (as defined in Rule 16a-1(h) of the Exchange Act) or liquidate or decrease any Call Equivalent Position (as defined in Rule 16a-1(b) under the Exchange Act), pledge, hypothecate or
            grant any security interest in, or in any other way transfer or dispose of, in each case whether effected directly or indirectly, any ADSs, Ordinary Shares, or options or warrants or other rights to acquire ADSs or Ordinary Shares or any
            securities exchangeable or exercisable for or convertible into ADSs or Ordinary Shares, or to acquire other securities or rights ultimately exchangeable or exercisable for or convertible into ADSs or Ordinary Shares (the &#8220;Related Securities&#8221;),
            whether currently owned or subsequently acquired, (ii) enter into any swap, hedge or similar arrangement or agreement that transfers, in whole or in part, the economic risk of ownership of ADSs, Ordinary Shares or Related Securities, regardless
            of whether any such transaction is to be settled in securities, in cash or otherwise, (iii) make any demand for, or exercise any right with respect to, the registration under the Securities Act of the offer and sale of any ADSs, Ordinary Shares
            or Related Securities, or cause to be filed a registration statement, prospectus or prospectus supplement (or an amendment or supplement thereto) with respect to any such registration, or (iv) publicly announce any intention to do any of the
            foregoing, without the prior written consent of the underwriter, for a period of 90 days from the closing date of the offering.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: center; line-height: 1.25;"><br>
          </div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 36</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25; font-weight: bold;">Securities Issuance Standstill</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">We have agreed, for a period of ninety (90) days after the closing date of this offering, that we will not, without the prior written consent of the underwriter, directly or indirectly (a)&#160;
            issue, offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase, lend or otherwise transfer or dispose of any ADSs, Ordinary Shares
            or other share capital or any securities convertible into or exercisable or exchangeable for ADSs, Ordinary Shares or other share capital; (b) file or cause the filing of any registration statement under the Securities Act, with respect to any
            ADSs, Ordinary Shares or other share capital or any securities convertible into or exercisable or exchangeable for any ADSs, Ordinary Shares or other share capital (other than any Rule 462(b) registration statement filed to register securities
            to be sold to Aegis pursuant to the underwriting agreement); or (c) enter into any swap or other agreement, arrangement, hedge or transaction that transfers to another, in whole or in part, directly or indirectly, any of the economic
            consequences of ownership of any ADSs, Ordinary Shares or other share capital (all of such matters referred to collectively as the &#8220;Standstill&#8221;), whether any transaction described in clause (a) or (c) above is to be settled by delivery of ADSs,
            Ordinary Shares, other share capital, other securities, in cash or otherwise, or publicly announce any intention to do any of the foregoing; provided, however, such restrictions shall no longer be in effect immediately upon the trading price of
            the ADS reaches the price that is 15% higher than the closing price of the ADS on the closing date of this offering.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Notwithstanding the Standstill restrictions set forth above, for a period of ninety (90) days after the closing date of this offering and while such restrictions are in effect, we may, without
            the prior written consent of the underwriter:</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z6d863d3098a041ab88f7c1a4a85e0da3" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">(1)</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: left; line-height: 1.25;">issue ADSs or Ordinary Shares, Restricted Share Units and options to purchase ADSs or Ordinary Shares, pursuant to stock option plans, stock purchase or other equity incentive plans in
                      effect on the date of the underwriting agreement, provided no such equity securities shall be saleable in the public market until the expiration of the ninety (90) day period,</div>
                  </td>
                </tr>

            </table>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zd8d0d7c822894c4687aa576c7181c94f" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">(2)</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: left; line-height: 1.25;">issue ADSs or Ordinary Shares upon the vesting of Restricted Share Units outstanding on the date of the underwriting agreement, exercise of stock options outstanding on the date of the
                      underwriting agreement issued under stock option or other equity incentive plans referred to in clause (1) above, as those plans are in effect on the date of the underwriting agreement, provided no such equity securities shall be
                      saleable in the public market until the expiration of the ninety (90) day period,</div>
                  </td>
                </tr>

            </table>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="zc7515b7300a54cc3af1a5967e2a1a7ea" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">(3)</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: left; line-height: 1.25;">issue ADSs or Ordinary Shares upon the exercise of outstanding warrants, convertible securities and other outstanding instruments convertible into or exercisable or exchangeable for ADSs
                      or Ordinary Shares, outstanding or in effect on the date of the underwriting agreement, provided that no such securities shall be amended, exchanged, repurchased, repriced or otherwise altered until the expiration of the ninety (90)
                      day period,</div>
                  </td>
                </tr>

            </table>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z042b8453e083458c8333ff3bd5abd46d" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">(4)</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: left; line-height: 1.25;">issue ADSs or Ordinary Shares in connection with strategic partnering transactions or an acquisition;</div>
                  </td>
                </tr>

            </table>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">provided, however, that the aggregate number of ADSs and Ordinary Shares and options to purchase ADSs and Ordinary Shares issued under clauses (1) and (2) above shall not exceed one million
            ADSs during the period of ninety (90) days from the closing date of this offering;</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">provided, further, that the aggregate number of ADSs or Ordinary Shares issued under clause (4) above shall not exceed 15% of our outstanding ADSs or Ordinary Shares as of the date of the
            underwriting agreement,</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">provided, further, that the underwriter shall receive a signed lock-up agreement for a period of 90 days from the closing date of this offering with respect to any such ADSs or Ordinary Shares
            so issued under clause (4) above, and</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">provided no such equity securities so issued under clause (4) above shall be saleable in the public market until the expiration of the ninety (90) day period,</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" style="width: 100%; font-family: 'Times New Roman', Times, serif; font-size: 10pt;" id="z5336e1ed23c04aadb7c6b4909ed8d4b9" class="DSPFListTable">

                <tr style="vertical-align: top;">
                  <td style="vertical-align: top; width: 27pt;">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;">(5)</div>
                  </td>
                  <td style="align: left; vertical-align: top; width: auto;">
                    <div style="text-align: justify; line-height: 1.25;">file a registration statement on Form F-3 registering for resale ADSs issuable upon the exercise of certain warrants issued in a private placement in May 2022, provided no such equity
                      securities shall be amended, exchanged, repurchased, repriced or otherwise altered until the expiration of the ninety (90) day period.</div>
                  </td>
                </tr>

            </table>
          </div>
          <div style="text-align: justify; line-height: 1.25;"> <br>
          </div>
        </div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 37</font></div>
          <div style="page-break-after: always;" class="BRPFPageBreak">
            <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
        </div>
        <div><br>
          <div style="line-height: 1.25; font-weight: bold;">Electronic Offer, Sale and Distribution of Shares</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">A prospectus in electronic format may be made available on the websites maintained by the underwriter or one or more of selling group members. The underwriter may agree to allocate a number of
            ADSs to selling group members for sale to its online brokerage account holders. Internet distributions will be allocated by the underwriter and selling group members that will make internet distributions on the same basis as other allocations.
            Other than the prospectus in electronic format, the information on these websites is not part of, nor incorporated by reference into this prospectus supplement, has not been approved or endorsed by us, and should not be relied upon by
            investors.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25; font-weight: bold;">Stabilization</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">The underwriter has advised us that it, pursuant to Regulation M under the Exchange Act, and certain persons participating in the offering may engage in short sale transactions, stabilizing
            transactions, syndicate covering transactions or the imposition of penalty bids in connection with this offering. These activities may have the effect of stabilizing or maintaining the market price of the ADSs at a level above that which might
            otherwise prevail in the open market. Establishing short sales positions may involve either &#8220;covered&#8221; short sales or &#8220;naked&#8221; short sales.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">&#8220;Covered&#8221; short sales are sales made in an amount not greater than the underwriter&#8217; option to purchase additional ADSs and/or Warrants in this offering. The underwriter may close out any
            covered short position by either exercising their option to purchase additional ADSs and/or Warrants or purchasing ADSs in the open market. In determining the source of ADSs to close out the covered short position, the underwriter will
            consider, among other things, the price of ADSs available for purchase in the open market as compared to the price at which they may purchase shares through the option to purchase additional ADSS.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">&#8220;Naked&#8221; short sales are sales in excess of the option to purchase additional ADSs. The underwriter must close out any naked short position by purchasing ADSs in the open market. A naked short
            position is more likely to be created if the underwriter is concerned that there may be downward pressure on the price of our shares in the open market after pricing that could adversely affect investors who purchase in this offering.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">A stabilizing bid is a bid for the purchase of ADSs on behalf of the underwriter for the purpose of fixing or maintaining the price of the ADSs. A syndicate covering transaction is the bid for
            or the purchase of shares on behalf of the underwriter to reduce a short position incurred by the underwriter in connection with the offering. Similar to other purchase transactions, the underwriter&#8217;s purchases to cover the syndicate short
            sales may have the effect of raising or maintaining the market price of the ADSs or preventing or retarding a decline in the market price of the ADSs or our Ordinary Shares. As a result, the price of the ADSs may be higher than the price that
            might otherwise exist in the open market. A penalty bid is an arrangement permitting the underwriter to reclaim the selling concession otherwise accruing to a syndicate member in connection with the offering if the shares originally sold by
            such syndicate member are purchased in a syndicate covering transaction and therefore have not been effectively placed by such syndicate member.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Neither we nor the underwriter makes any representation or prediction as to the direction or magnitude of any effect that the transactions described above may have on the price of the ADSs. The
            underwriter is not obligated to engage in these activities and, if commenced, any of the activities may be discontinued at any time.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">The underwriter may also engage in passive market making transactions in the ADSs on Nasdaq in accordance with Rule 103 of Regulation M during a period before the commencement of offers or
            sales of our shares in this offering and extending through the completion of distribution. A passive market maker must display its bid at a price not in excess of the highest independent bid of that security. However, if all independent bids
            are lowered below the passive market maker&#8217;s bid, that bid must then be lowered when specified purchase limits are exceeded.</div>
          <div style="text-align: justify; line-height: 1.25;"> <br>
          </div>
        </div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
          <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 38</font></div>
          <div style="page-break-after: always;" class="BRPFPageBreak">
            <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
        </div>
        <div><br>
          <div style="line-height: 1.25; font-weight: bold;">Other Relationships</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">The underwriter and certain of its affiliates are full service financial institutions engaged in various activities, which may include securities trading, commercial and investment banking,
            financial advisory, investment management, investment research, principal investment, hedging, financing and brokerage activities. The underwriter and certain of its affiliates may in the future perform, various commercial and investment
            banking and financial advisory services for us and our affiliates, for which they would receive customary fees and expenses.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">In the ordinary course of their various business activities, the underwriter and certain of its affiliates may make or hold a broad array of investments and actively trade debt and equity
            securities (or related derivative securities) and financial instruments (including bank loans) for their own account and for the accounts of their customers, and such investment and securities activities may involve securities and/or
            instruments issued by us and our affiliates. The underwriter and certain of its respective affiliates may also communicate independent investment recommendations, market color or trading ideas and/or publish or express independent research
            views in respect of such securities or instruments and may at any time hold, or recommend to clients that they acquire, long and/or short positions in such securities and instruments.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25; font-weight: bold;">Offer Restrictions Outside the United States</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Other than in the United States, no action has been taken by us or the underwriter that would permit a public offering of the shares offered by this prospectus supplement in any jurisdiction
            where action for that purpose is required. The shares offered by this prospectus supplement and the accompanying prospectus may not be offered or sold, directly or indirectly, nor may this prospectus supplement or any other offering material or
            advertisements in connection with the offer and sale of any such shares be distributed or published in any jurisdiction, except under circumstances that will result in compliance with the applicable rules and regulations of that jurisdiction.
            Persons into whose possession this prospectus supplement comes are advised to inform themselves about and to observe any restrictions relating to the offering and the distribution of this prospectus supplement. This prospectus supplement does
            not constitute an offer to sell or a solicitation of an offer to buy any shares offered by this prospectus supplement in any jurisdiction in which such an offer or a solicitation is unlawful.</div>
          <div style="line-height: 1.25;">&#160;</div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 39</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <div style="text-align: center; line-height: 1.25;"><br>
          </div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="EXPENSES11"><!--Anchor--></a>EXPENSES</div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
          <div style="text-align: justify; line-height: 1.25;">The following are estimated expenses (other than underwriting discounts and commissions or agency fees and other items constituting underwriters&#8217; or agents&#8217; compensation, if any) of the
            issuance and distribution of the securities offered by this prospectus supplement, all of which will be paid by us.</div>
          <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
          <table cellspacing="0" cellpadding="0" id="zdf519864636b4e5fb75a5b781d151d9f" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

              <tr>
                <td style="width: 87.98%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">SEC registration fees</div>
                </td>
                <td style="width: 0.98%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 1.07%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">$</div>
                </td>
                <td style="width: 8.97%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="text-align: right; line-height: 1.25;">&#160;</div>
                </td>
                <td nowrap="nowrap" style="width: 1%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="width: 87.98%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">FINRA fees</div>
                </td>
                <td style="width: 0.98%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 1.07%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">$</div>
                </td>
                <td style="width: 8.97%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">-</div>
                </td>
                <td nowrap="nowrap" style="width: 1%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="width: 87.98%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">Legal fees and expenses</div>
                </td>
                <td style="width: 0.98%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 1.07%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">$</div>
                </td>
                <td style="width: 8.97%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="text-align: right; line-height: 1.25;">150,000</div>
                </td>
                <td nowrap="nowrap" style="width: 1%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="width: 87.98%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">Accountants&#8217; fees and expenses</div>
                </td>
                <td style="width: 0.98%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 1.07%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">$</div>
                </td>
                <td style="width: 8.97%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">20,000</div>
                </td>
                <td nowrap="nowrap" style="width: 1%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="width: 87.98%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">Miscellaneous</div>
                </td>
                <td style="width: 0.98%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 1.07%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">$</div>
                </td>
                <td style="width: 8.97%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="text-align: right; line-height: 1.25;">160,000</div>
                </td>
                <td nowrap="nowrap" style="width: 1%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="width: 87.98%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 0.98%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 1.07%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 8.97%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">&#160;</div>
                </td>
                <td nowrap="nowrap" style="width: 1%; vertical-align: bottom;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="width: 87.98%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">Total</div>
                </td>
                <td style="width: 0.98%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
                <td style="width: 1.07%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">$</div>
                </td>
                <td style="width: 8.97%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="text-align: right; line-height: 1.25;">330,000&#160;</div>
                </td>
                <td nowrap="nowrap" style="width: 1%; vertical-align: bottom; background-color: #CCEEFF;">
                  <div style="line-height: 1.25;">&#160;</div>
                </td>
              </tr>

          </table>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 40</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <br>
          <br>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="LEGALMATTERS11"><!--Anchor--></a>LEGAL MATTERS</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Certain matters concerning this offering will be passed upon for us by Haynes and Boone, LLP, New York, New York. The validity of the securities being offered by this prospectus will be passed
            upon for us by Gross &amp; Co., Tel-Aviv, Israel. Kaufman &amp; Canoles, P.C., is counsel to Aegis Capital Corp. in connection with this offering.</div>
          <div style="line-height: 1.25;">&#160;</div>
          <div style="text-align: center; line-height: 1.25;"><br>
          </div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 41</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="EXPERTS11"><!--Anchor--></a>EXPERTS</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">The financial statements and management&#8217;s assessment of the effectiveness of internal control over financial reporting (which is included in Management&#8217;s Annual Report on Internal Control over
            Financial Reporting) incorporated in this prospectus supplement by reference to the Annual Report on Form 20-F for the year ended December 31, 2021 have been so incorporated in reliance on the report of Kesselman &amp; Kesselman, Certified
            Public Accountants (Isr.), a member firm of PricewaterhouseCoopers International Limited, an independent registered public accounting firm, given on the authority of said firm as experts in auditing and accounting.</div>
          <div style="line-height: 1.25;">&#160;</div>
          <div style="text-align: center; line-height: 1.25;"><br>
          </div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 42</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: center; line-height: 1.25;"><a name="WHEREYOUCANFI11NDMOREINFORM"><!--Anchor--></a><font style="font-weight: bold;">WHERE</font>&#160;<font style="font-weight: bold;">YOU</font>&#160;<font style="font-weight: bold;">CAN</font>&#160;<font style="font-weight: bold;">FIND</font>&#160;<font style="font-weight: bold;">MORE</font>&#160;<font style="font-weight: bold;">INFORMATION</font></div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">We are subject to the informational requirements of the Exchange Act, and in accordance therewith file annual and special reports with, and furnish other information to, the SEC. The SEC
            maintains a website that contains reports and other information regarding issuers that file electronically with the SEC. You may access the SEC&#8217;s website at http://www.sec.gov. These SEC filings are also available to the public on the Israel
            Securities Authority&#8217;s Magna website at www.magna.isa.gov.il and from commercial document retrieval services.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">This prospectus supplement is part of the registration statement on Form F-3 filed with the SEC in connection with this offering and does not contain all of the information included in the
            registration statement. Whenever a reference is made in this prospectus supplement to any of our contracts or other documents, the reference may not be complete and, for a copy of the contract or document, you should refer to the exhibits that
            are a part of the registration statement.</div>
          <div style="line-height: 1.25;">&#160;</div>
          <div style="text-align: center; line-height: 1.25;"><br>
          </div>
          <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 43</font></div>
            <div style="page-break-after: always;" class="BRPFPageBreak">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="INCORPORAT11IONOFINFORMATIO"><!--Anchor--></a>INCORPORATION OF INFORMATION BY REFERENCE</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">The SEC allows us to &#8220;incorporate by reference&#8221; information into this prospectus supplement, which means that we can disclose important information to you by referring you to other documents
            that we have filed or will file with the SEC. We are incorporating by reference in this prospectus supplement the documents listed below and all amendments or supplements we may file to such documents, as well as any future filings we may make
            with the SEC on Form 20-F under the Securities Exchange Act of 1934, as amended before the time that all of the securities offered by this prospectus have been sold or de-registered:</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25;">
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">
                <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                    <tr>
                      <td style="width: 4%; vertical-align: top;">
                        <div style="text-align: center; line-height: 1.25;">&#8226;</div>
                      </td>
                      <td style="width: 96%; vertical-align: top;">
                        <div style="text-align: justify; line-height: 1.25;">the description of our Ordinary Shares contained in our Registration Statement on <a href="https://www.sec.gov/Archives/edgar/data/1553846/000114420412069612/0001144204-12-069612-index.htm">Form 20-F</a> filed with the SEC on December 26, 2012;</div>
                      </td>
                    </tr>
                    <tr>
                      <td style="width: 4%; vertical-align: top;">
                        <div style="text-align: center; line-height: 1.25;">&#8226;</div>
                      </td>
                      <td style="width: 96%; vertical-align: top;">
                        <div style="text-align: justify; line-height: 1.25;">our Annual Report on <a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001553846/000155837022003806/rdhl-20211231x20f.htm">Form 20-F</a> for the fiscal year ended
                          December 31, 2021, filed with the SEC on March 17, 2022; and</div>
                      </td>
                    </tr>

                </table>
                <div style="line-height: 1.25;">
                  <table cellspacing="0" cellpadding="0" style="width: 100%; text-align: left; color: rgb(0, 0, 0); font-family: 'Times New Roman', Times, serif; font-size: 10pt;">

                      <tr>
                        <td style="width: 4%; font-family: 'Times New Roman',Times,serif; vertical-align: top;">
                          <div style="text-align: center; color: rgb(0, 0, 0); line-height: 1.25;">&#8226;</div>
                        </td>
                        <td style="width: 96%; vertical-align: top;">
                          <div style="text-align: justify; line-height: 1.25; font-family: 'Times New Roman',serif;"><font style="color: rgb(0, 0, 0); font-family: 'Times New Roman',Times,serif;">Reports on Form 6-K filed on </font><font style="font-family: 'Times New Roman',Times,serif;"><a href="https://www.sec.gov/Archives/edgar/data/0001553846/000117891322000051/zk2227023.htm">January 6, 2022</a><font style="color: rgb(0, 0, 0);">, </font><a href="https://www.sec.gov/Archives/edgar/data/0001553846/000117891322000103/zk2227053.htm">January 13, 2022</a><font style="color: rgb(0, 0, 0);">, </font><a href="https://www.sec.gov/Archives/edgar/data/0001553846/000117891322000416/zk2227207.htm">February 7, 2022</a><font style="color: rgb(0, 0, 0);">, </font><a href="https://www.sec.gov/Archives/edgar/data/0001553846/000117891322000875/zk2227389.htm">March 1, 2022</a><font style="color: rgb(0, 0, 0);">, </font><a href="https://www.sec.gov/Archives/edgar/data/0001553846/000117891322001087/zk2227483.htm">March 15, 2022</a><font style="color: rgb(0, 0, 0);">, </font><a href="https://www.sec.gov/Archives/edgar/data/0001553846/000117891322001165/zk2227499.htm">March 17, 2022</a><font style="color: rgb(0, 0, 0);"> (with respect to exhibit 99.1 to the report, solely with respect to the
                                Financial results for the quarter ended December 31, 2021, Financial results for the year ended December 31, 2021 and Liquidity and Capital Resources), </font><a href="https://www.sec.gov/Archives/edgar/data/0001553846/000117891322001279/zk2227553.htm">March 30, 2022</a><font style="color: rgb(0, 0, 0);">, </font><a href="https://www.sec.gov/Archives/edgar/data/0001553846/000117891322001407/zk2227584.htm">April 5, 2022</a><font style="color: rgb(0, 0, 0);">, </font><a href="https://www.sec.gov/Archives/edgar/data/0001553846/000117891322001476/zk2227614.htm">April 11, 2022</a><font style="color: rgb(0, 0, 0);">, </font><a href="https://www.sec.gov/Archives/edgar/data/0001553846/000117891322001832/zk2227749.htm">May 9, 2022</a></font>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322001877/0001178913-22-001877-index.htm">May




                              11, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322001921/0001178913-22-001921-index.htm">May 12, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322001947/0001178913-22-001947-index.htm">May 13, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322002166/0001178913-22-002166-index.htm">May 25, 2022</a> (excluding the posters therein contained in Exhibit 99.1), <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322002257/0001178913-22-002257-index.htm">June 1, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322002442/0001178913-22-002442-index.htm">June 22, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322002461/0001178913-22-002461-index.htm">June 23, 2022</a> (as amended by Form <a href="https://www.sec.gov/Archives/edgar/data/1553846/000155837022016533/0001558370-22-016533-index.htm">6-K/A</a> filed on November 7, 2022), <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322002633/0001178913-22-002633-index.htm">July 12, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322003172/0001178913-22-003172-index.htm">August 17, 2022</a>,<a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322003251/0001178913-22-003251-index.htm"> August 26, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322003405/0001178913-22-003405-index.htm">September 13, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322003445/0001178913-22-003445-index.htm"> September 16, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322003518/0001178913-22-003518-index.htm">September 23, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322003548/0001178913-22-003548-index.htm">October, 3, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322003638/0001178913-22-003638-index.htm">October 14, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322003644/0001178913-22-003644-index.htm">October 18, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322003650/0001178913-22-003650-index.htm">October 19, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322003711/0001178913-22-003711-index.htm">October 26, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322003813/0001178913-22-003813-index.htm">November 4, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000155837022016536/0001558370-22-016536-index.htm">November 7, 2022</a>,<a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322003940/0001178913-22-003940-index.htm"> November 10, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322003947/0001178913-22-003947-index.htm">November 14, 2022</a> (<a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322003970/0001178913-22-003970-index.htm">two reports</a>), <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322004090/0001178913-22-004090-index.htm">November 17, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322004193/0001178913-22-004193-index.htm">November 29, 2022</a> and <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322004222/0001178913-22-004222-index.htm">December 1, 2022</a>, <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322004228/0001178913-22-004228-index.htm">December 2, 2022</a> and <a href="https://www.sec.gov/Archives/edgar/data/1553846/000117891322004235/0001178913-22-004235-index.htm">December 5, 2022</a>.</div>
                        </td>
                      </tr>

                  </table>
                </div>
                <br>
              </div>
            </div>
          </div>
          <div style="text-align: justify; line-height: 1.25;">In addition, any reports on Form 6-K submitted to the SEC prior to the termination of the offering that we specifically identify in such forms as being incorporated by reference into the
            registration statement of which this prospectus supplement forms a part.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">Certain statements in and portions of this prospectus supplement update and replace information in the above-listed documents incorporated by reference. Likewise, statements in or portions of a
            future document incorporated by reference in this prospectus supplement may update and replace statements in and portions of this prospectus supplement or the above-listed documents.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: justify; line-height: 1.25;">We will provide you without charge, upon your written or oral request, a copy of any of the documents incorporated by reference in this prospectus supplement, other than exhibits to such
            documents which are not specifically incorporated by reference into such documents. Please direct your written or telephone requests to RedHill Biopharma Ltd., 21 Ha'arba'a Street, Tel Aviv 6473921, Israel, Attn: Micha Ben Chorin, telephone
            number +972 (3) 541-3131. You may also obtain information about us by visiting our website at <u>www.redhillbio.com</u>. Information contained on our website is not part of this prospectus supplement.</div>
          <div style="text-align: center; line-height: 1.25;"><br>
          </div>
          <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
            <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="font-weight: normal; font-style: normal;">S - 44</font></div>
            <div class="BRPFPageBreak" style="page-break-after: always;">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25;"><br>
          </div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">PROSPECTUS</div>
          <div style="line-height: 1.25; font-weight: bold;">&#160;</div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">$200,000,000 of</div>
          <div style="text-align: center; line-height: 1.25;">American Depositary Shares representing Ordinary Shares,</div>
          <div style="text-align: center; line-height: 1.25;">Ordinary Shares,</div>
          <div style="text-align: center; line-height: 1.25;">Warrants to Purchase American Depositary Shares,</div>
          <div style="text-align: center; line-height: 1.25;">Subscription Rights and/or Units</div>
          <div style="text-align: center; line-height: 1.25;">Offered by the Company</div>
          <div style="text-align: center; line-height: 1.25;">&#160;</div>
          <div style="text-align: center; line-height: 1.25;"><img width="362" height="214" src="image0.jpg"></div>
          <div style="text-align: center; line-height: 1.25;">&#160;</div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">REDHILL BIOPHARMA LTD.</div>
          <div style="text-align: center; line-height: 1.25;">&#160;</div>
          <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">We may offer to the public from time to time in one or more series or issuances American Depositary Shares ("ADSs"), ordinary shares (&#8220;Ordinary Shares&#8221;), warrants,
            subscription rights and/or units consisting of two or more of these classes or series of securities. Each ADS represents 10 of our Ordinary Shares.</div>
          <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;</div>
          <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">We refer to the ADSs, Ordinary Shares, warrants, subscription rights and units collectively as &#8220;securities&#8221; in this prospectus.</div>
          <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;</div>
          <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Each time we sell securities pursuant to this prospectus, we will provide a supplement to this prospectus that contains specific information about the offeror, the offering
            and the specific terms of the securities offered. This prospectus may not be used to consummate a sale of securities by us unless accompanied by the applicable prospectus supplement. You should read this prospectus and the applicable prospectus
            supplement carefully before you invest in our securities.</div>
          <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;</div>
          <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">We may, from time to time, offer to sell the securities, through public or private transactions, directly or through underwriters, agents or dealers, on or off the Nasdaq
            Global Market, as applicable, at prevailing market prices or at privately negotiated prices. If any underwriters, agents or dealers are involved in the sale of any of these securities, the applicable prospectus supplement will set forth the
            names of the underwriter, agent or dealer and any applicable fees, commissions or discounts.</div>
          <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;</div>
          <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">The ADSs are traded on the Nasdaq Global Market under the symbol &#8220;RDHL.&#8221; The last reported sale price for the ADSs on August 6, 2021, as quoted on the Nasdaq Global Market
            was $7.13 per ADS.</div>
          <div style="text-align: justify; line-height: 1.25;">&#160;</div>
          <div style="text-align: justify; text-indent: 36pt; line-height: 1.25; font-weight: bold;">Investing in these securities involves a high degree of risk. Please carefully consider the risks discussed in this prospectus under &#8220;Risk Factors&#8221;
            beginning on page 11 and the &#8220;Risk Factors&#8221; in &#8220;Item 3: Key Information - Risk Factors&#8221; of our most recent Annual Report on Form 20-F incorporated by reference in this prospectus and in any applicable prospectus supplement for a discussion of
            the factors you should consider carefully before deciding to purchase these securities.</div>
          <div style="text-align: justify; line-height: 1.25; font-weight: bold;">&#160;</div>
          <div style="text-align: justify; text-indent: 36pt; line-height: 1.25; font-weight: bold;">Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of the securities being offered by this
            prospectus or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.</div>
          <div style="text-align: justify; line-height: 1.25;">&#160;</div>
          <div style="text-align: center; line-height: 1.25;">The date of this prospectus is August 9, 2021.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
            <div class="BRPFPageBreak" style="page-break-after: always;">
              <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">TABLE OF CONTENTS</div>
          <div style="text-align: right; line-height: 1.25; font-weight: bold;">Page</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <table cellspacing="0" cellpadding="0" id="z6258def0fab9403f939286062ac0b2f0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#ROSPECTUS">ABOUT THIS PROSPECTUS</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">2</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#REDHILLBIOPHARMALTD.">REDHILL BIOPHARMA LTD.</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">3</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#RISKFACTORS1">RISK FACTORS</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">11</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#FORWARD-LOOKINGSTATEMENTS">FORWARD-LOOKING STATEMENTS</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">11</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#CAPITALIZATION">CAPITALIZATION</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">12</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#OFFERANDLISTINGDETAILS">OFFER AND LISTING DETAILS</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">12</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#USEOFPROCEEDS1">USE OF PROCEEDS</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">13</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFORDINARYSHAR1">DESCRIPTION OF ORDINARY SHARES</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">13</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFAMERICANDEPO1">DESCRIPTION OF AMERICAN DEPOSITARY SHARES</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">13</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFWARRANTS1">DESCRIPTION OF WARRANTS</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">13</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFSUBSCRIPTION">DESCRIPTION OF SUBSCRIPTION RIGHTS</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">14</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#DESCRIPTIONOFUNITS">DESCRIPTION OF UNITS</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">14</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#PLANOFDISTRIBUTION1">PLAN OF DISTRIBUTION</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">15</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#LEGALMATTERS1">LEGAL MATTERS</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">17</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#EXPERTS1">EXPERTS</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">18</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#WHEREYOUCA1NFINDMOREINFORM">WHERE YOU CAN FIND MORE INFORMATION</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">18</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#INCORPORA1TIONOFCERTAINDOC">INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">18</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#ENFORCEABILITYOFCIVILLIAB">ENFORCEABILITY OF CIVIL LIABILITIES</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">19</div>
                </td>
              </tr>
              <tr>
                <td style="width: 90%; vertical-align: bottom;">
                  <div style="line-height: 1.25;"><a href="#OFFERINGEXPENSES">OFFERING EXPENSES</a></div>
                </td>
                <td style="width: 10%; vertical-align: bottom;">
                  <div style="text-align: right; line-height: 1.25;">20</div>
                </td>
              </tr>

          </table>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
          <div style="line-height: 1.25;">
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"> <br>
            </div>
            <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
              <div style="page-break-after: always;" class="BRPFPageBreak">
                <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
            </div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"> <br>
            </div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">ABOUT THIS PROSPECTUS<a name="ROSPECTUS"></a></div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">This prospectus is part of a registration statement that we filed with the Securities and Exchange Commission, or SEC, utilizing a &#8220;shelf&#8221; registration process. Under this
              process, we may offer and sell our securities under this prospectus.</div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">Under this shelf process, we may sell the securities described in this prospectus in one or more offerings up to a total price to the public of $200,000,000. The offer and
              sale of securities under this prospectus may be made from time to time, in one or more offerings, in any manner described under the section in this prospectus entitled &#8220;Plan of Distribution.&#8221;</div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">This prospectus provides you with a general description of the securities we may offer. Each time we sell securities we will provide a prospectus supplement that will
              contain specific information about the terms of that offering. The prospectus supplement may also add, update or change information contained in this prospectus, and may also contain information about any material federal income tax
              considerations relating to the securities covered by the prospectus supplement. You should read both this prospectus and any prospectus supplement together with additional information under the headings &#8220;Where You Can Find More Information&#8221;
              and &#8220;Incorporation of Certain Documents by Reference.&#8221;</div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">This summary may not contain all of the information that may be important to you. You should read this entire prospectus, including the financial statements and related
              notes and other financial data incorporated by reference in this prospectus, before making an investment decision. This summary contains forward-looking statements that involve risks and uncertainties. Our actual results may differ
              significantly from the results discussed in the forward-looking statements. Factors that might cause or contribute to such differences include those discussed in &#8220;Risk Factors&#8221; and &#8220;Forward-Looking Statements.&#8221;</div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">2</font></div>
                <div class="BRPFPageBreak" style="page-break-after: always;">
                  <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
              </div>
            </div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="REDHILLBIOPHARMALTD."></a>REDHILL BIOPHARMA LTD.</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="line-height: 1.25; font-weight: bold;">Overview</div>
            <div style="text-align: center; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">We are a specialty biopharmaceutical company, primarily focused on gastrointestinal (&#8220;GI&#8221;) and infectious diseases. Our primary goal is to become a leading specialty biopharmaceutical company through our
                    commercial presence in the U.S. that supports current commercialization of products approved for marketing and potential future commercialization of our therapeutic candidates, if approved.</div>
                </div>
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">We are currently focused primarily on the commercialization in the U.S. of the GI-related products, Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;(naloxegol),






























                Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;(omeprazole, amoxicillin, and rifabutin) and Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;(rifamycin).</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">In addition, we continue to develop our pipeline of clinical-stage therapeutic candidates, including, among others, the study of our therapeutic candidates, opaganib (ABC294640) and RHB-107 (upamostat),
                        as potential treatments for COVID-19. We look for opportunities to leverage our commercial presence and capabilities in the U.S. to support the potential future launch of our therapeutic candidates currently under development, if
                        approved by the U.S. Food and Drug Administration (&#8220;FDA&#8221;), or any FDA-approved products that we may acquire or license in the future.</div>
                    </div>
                  </div>
                </div>
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">Our therapeutic candidates are designed to exhibit greater efficacy and/or provide improvements over existing drugs in various ways, including by one or more of the following: by improving
                their safety profile, reducing side effects, lowering the number of administrations, using a more convenient administration form or providing a cost advantage. Our current pipeline consists of six therapeutic candidates, most of which are
                in late-stage clinical development.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">We generate our pipeline of therapeutic candidates by identifying, validating and in-licensing or acquiring products that are consistent with our product and corporate strategy and that
                have the potential to exhibit a favorable probability of therapeutic and commercial success. We have one product that we primarily developed internally which has been approved for marketing and, to date, none of our therapeutic candidates
                has generated meaningful revenues. We plan to commercialize our therapeutic candidates, upon approval, if any, through licensing and other commercialization arrangements outside the U.S. with pharmaceutical companies on a global and
                territorial basis or, in the case of commercialization in the U.S., independently with our dedicated commercial operations or in potential partnership with other commercial-stage companies. We also evaluate, on a case-by-case basis,
                co-development, co-promotion, licensing and similar arrangements.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25; font-weight: bold;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25; font-weight: bold;">U.S. and global COVID-19 studies with opaganib</div>
                </div>
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">Opaganib, a new chemical entity, is a proprietary, first-in-class, orally-administered, sphingosine kinase-2 (SK2) selective inhibitor with observed anticancer, anti-inflammatory, and antiviral activities,
                    targeting multiple oncology, viral, inflammatory, and gastrointestinal indications.</div>
                </div>
              </div>
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">In July 2020, we initiated a global Phase 2/3 clinical trial evaluating opaganib in hospitalized patients with severe COVID-19 pneumonia. This global multi-center, randomized, double-blind,
                        parallel-arm, placebo-controlled trial enrolled a total of 475 patients requiring hospitalization and treatment with supplemental oxygen. The study has been approved in ten countries. On July19, 2021, we announced that we had
                        completed treatment and follow-up of all 475 patients in the trial and that top-line results are expected in the coming weeks. The primary endpoint of the trial is the proportion of patients breathing room air without oxygen support
                        by Day 14. Additional important outcome measures, such as time to discharge from hospital, improvement according to the World Health Organization Ordinal Scale for Clinical Improvement and incidence of intubation and mortality, will
                        also be captured in the follow-up period of up to six weeks. The trial has received four independent DSMB recommendations to continue following unblinded safety reviews and a futility review.</div>
                    </div>
                  </div>
                </div>
              </div>
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div style="text-align: justify; line-height: 1.25;">In December 2020, we announced that our randomized, double-blind, placebo-controlled U.S. Phase 2 trial with opaganib in patients hospitalized with COVID-19 pneumonia demonstrated
                preliminary top-line positive safety and efficacy data. The trial, which was not powered for statistical significance, enrolled 40 patients requiring hospitalization and supplemental oxygen.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
              <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">3</font></div>
                <div class="BRPFPageBreak" style="page-break-after: always;">
                  <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
              </div>
              <div style="line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="text-align: justify; line-height: 1.25;">In June 2021, we announced the presentation of the findings from the 40-patient U.S. phase 2 trial, including:</div>
                </div>
              </div>
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 100%; vertical-align: top;">
                    <div style="text-align: justify; text-indent: -26.85pt; margin-left: 44.7pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif;">&#8226;&#160;&#160;&#160;&#160;&#160; &#160; &#160; 50.0% of patients treated with opaganib (n=22) reached room air by Day
                        14 compared to 22.2% in the placebo group (n=18). The benefit of reaching room air by Day 14 for patients on opaganib was maintained regardless of whether or not the patients were also receiving dexamethasone and/or remdesivir.</font></div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 100%; vertical-align: top;">
                    <div style="text-align: justify; text-indent: -26.85pt; margin-left: 44.7pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; background-color: rgb(255, 255, 255); font-weight: normal; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">&#8226;&#160;&#160;&#160;&#160;&#160; &#160; &#160; 86.4% of patients treated with opaganib were discharged from hospital by Day 14 compared to 55.6% of patients treated with placebo.</font></div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 100%; vertical-align: top;">
                    <div style="text-align: justify; text-indent: -26.85pt; margin-left: 44.7pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; background-color: rgb(255, 255, 255); font-weight: normal; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">&#8226;&#160;&#160;&#160;&#160;&#160; &#160; &#160; Median time to discharge was 6 days for the opaganib group compared to 7.5 days for the placebo group.</font></div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 100%; vertical-align: top;">
                    <div style="text-align: justify; text-indent: -26.85pt; margin-left: 44.7pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; background-color: rgb(255, 255, 255); font-weight: normal; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">&#8226;&#160;&#160;&#160;&#160; &#160; &#160;&#160; 81.8% of opaganib patients achieved a 2-point improvement in the WHO Ordinal Scale compared to 55.6% of patients in the placebo group &#8211; achieved in a median
                        time of 6 days versus 7.5 days, respectively.</font></div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 100%; vertical-align: top;">
                    <div style="text-align: justify; text-indent: -26.85pt; margin-left: 44.7pt; line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif; background-color: rgb(255, 255, 255); font-weight: normal; color: rgb(0, 0, 0); font-style: normal; font-variant: normal; text-transform: none;">&#8226;&#160;&#160;&#160;&#160;&#160; &#160; &#160; No significant differences in safety-related measures between the two groups (with diarrhea being the main treatment-emergent difference in tolerability)
                        were observed.</font></div>
                  </td>
                </tr>

            </table>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">Opaganib was originally developed by U.S.-based Apogee Biotechnology Corp. (&#8220;Apogee&#8221;) and completed multiple successful preclinical studies in oncology, inflammation, GI, and
                radioprotection models, as well as a Phase 1 clinical trial in cancer patients with advanced solid tumors and an additional Phase 1 trial in multiple myeloma.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">Opaganib received orphan drug designation from the FDA for the treatment of cholangiocarcinoma and is also being evaluated in a Phase 2a trial in advanced cholangiocarcinoma and in a Phase
                2 trial in prostate cancer.</div>
            </div>
            <div style="line-height: 1.25;">&#160;&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">Preclinical data have demonstrated both anti-inflammatory and antiviral activities of opaganib, demonstrating the potential to reduce inflammatory lung disorders, such as pneumonia, and
                mitigate pulmonary fibrotic damage. Opaganib demonstrated potent antiviral activity against SARS-CoV-2, the virus that causes COVID-19, completely inhibiting viral replication in an in vitro model of human lung bronchial tissue.
                Additionally, preclinical <font style="font-style: italic;">in vivo</font> studies have demonstrated that opaganib decreased fatality rates from influenza virus infection and ameliorated Pseudomonas aeruginosa-induced lung injury by
                reducing the levels of IL-6 and TNF-alpha in bronchoalveolar lavage fluids.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">In June 2021, we announced that preliminary results from a preclinical study with opaganib demonstrate potent inhibition of COVID-19 variants of concern by opaganib. Working with the University of
                    Louisville Center for Predictive Medicine, opaganib was studied in a 3D tissue model of human bronchial epithelial cells (EpiAirway&#8482;) to evaluate the&#160;<font style="font-style: italic;">in vitro</font>&#160;efficacy of opaganib in inhibiting
                    the&#160;<font style="font-style: italic;">Beta</font>&#160;(South African) and&#160;<font style="font-style: italic;">Gamma</font>&#160;(Brazilian) SARS-CoV-2 variants. Preliminary results showed potent inhibition of both the&#160;<font style="font-style: italic;">Beta</font>&#160;and&#160;<font style="font-style: italic;">Gamma</font>&#160;variants by opaganib at non-cytotoxic doses. Based on opaganib&#8217;s unique host-targeted mechanism and the preliminary results of this study, we believe opaganib is
                    likely to also maintain its activity against emerging variants, including the <font style="font-style: italic;">Delta</font> and <font style="font-style: italic;">Delta Plus </font>variants.</div>
                </div>
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">Under a compassionate use program, seven COVID-19 patients (as classified by the WHO ordinal scale) were treated with opaganib in a leading hospital in Israel. Analysis of treatment
                outcomes from the five patients included in the final published analysis suggested substantial benefit to patients treated with opaganib under compassionate use in both clinical outcomes and inflammatory markers as compared to a
                retrospective matched case-control group from the same hospital. All patients in the opaganib-treated group were discharged from hospital on room air without requiring intubation and mechanical ventilation, whereas 33% of the matched
                case-control group required intubation and mechanical ventilation. Median time to weaning from high-flow nasal cannula was reduced to 10 days in the opaganib-treated group, as compared to 15 days in the matched case-control group.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
              <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">4</font></div>
                <div class="BRPFPageBreak" style="page-break-after: always;">
                  <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">The development of opaganib for indications non-related to COVID-19 has been supported by grants and contracts from U.S. federal and state government agencies awarded to Apogee, including from the U.S.
                    National Cancer Institute (NCI), Biomedical Advanced Research and Development Authority (BARDA), the U.S. Department of Defense and the FDA Office of Orphan Products Development. In September 2020, Apogee was awarded a grant from
                    Pennsylvania&#8217;s COVID-19 Vaccines, Treatments and Therapies Program, which supports the rapid advancement of promising novel COVID-19 therapies.</div>
                </div>
              </div>
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div style="text-align: justify; line-height: 1.25;">In May 2021, we announced receipt of a Notice of Allowance for a U.S. patent application covering the use of opaganib for the treatment of COVID-19 with a term extending until at least
                2041. We also previously announced that we had signed collaborations with several U.S., European and Canadian suppliers, including with Cosmo Pharmaceuticals for large-scale ramp-up of opaganib manufacturing, further strengthening
                manufacturing capabilities and capacity of opaganib.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">In view of the completion of enrollment, treatment and follow up for our global Phase 2/3 clinical trial evaluating opaganib in hospitalized patients with severe COVID-19 pneumonia, we
                maintain ongoing discussions with the FDA, the European Medicines Agency (EMA) and other regulators, on potential pathways to approval for opaganib with a focus on those countries currently most affected by COVID-19. The next steps will be
                guided by the results of the global Phase 2/3 trial.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div style="text-align: justify; line-height: 1.25;">Discussions are also ongoing with potential partners who are interested in the rights to opaganib in various countries.</div>
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div style="text-align: justify; line-height: 1.25;">The regulatory path, including potential submissions of emergency use applications in those countries, is subject to the data generated by the ongoing Phase 2/3 trial, as well as the
                specific requirements in each country. The strength of the safety and efficacy data generated from the opaganib studies will be key to regulatory applications. Additional studies to support the potential of such applications and the use or
                marketing of opaganib are likely to be required. For example, the FDA has indicated we will need to complete additional studies to support applications in the U.S. Evaluations and discussions continue with the FDA, EMA and regulators in
                other countries.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Our Approved and Commercial Products in the U.S.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">We have established the headquarters of our U.S. commercial operations in Raleigh, North Carolina. Our U.S. operations promote Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;for opioid-induced constipation in adults, Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;for the treatment of <font style="font-style: italic;">H. pylori</font> infection
                    in adults and Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;for the treatment of travelers&#8217; diarrhea in adults. We also expect our U.S. operations to serve as the platform for potential launch
                    of our proprietary, late-clinical stage therapeutic candidates in the U.S., if approved by the FDA, and potential in-licensed or acquired commercial-stage products in the U.S.</div>
                </div>
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">During 2020, we expanded our sales force from approximately 40 sales representatives to approximately 100 sales representatives. We commercially launched Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;in March 2020 and initiated our commercialization activities for Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;in April 2020.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold; font-style: italic;">Movantik</font><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup></div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">In April 2020, we acquired from AstraZeneca AB (&#8220;AstraZeneca&#8221;) worldwide rights (excluding Europe and Canada) to commercialize and develop Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;(naloxegol), pursuant to a license agreement, dated February 23, 2020 (the &#8220;AstraZeneca License Agreement&#8221;), and in October 2020 we obtained the rights to commercialize and develop Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;in Israel. Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;is a proprietary once-daily oral peripherally acting
                mu-opioid receptor antagonist (PAMORA) approved by the FDA for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain, including patients with chronic pain related to prior cancer or its treatment
                who do not require frequent (e.g. weekly) opioid dosage escalation. We initiated our U.S. commercialization activities for Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;in April 2020.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">5</font></div>
                <div class="BRPFPageBreak" style="page-break-after: always;">
                  <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;received FDA approval on September 16, 2014, for the treatment of OIC in adult patients with
                chronic non-cancer pain. Its label was later updated to include patients with chronic pain related to prior cancer or its treatment who do not require frequent (e.g. weekly) opioid dosage escalation. In the AstraZeneca License Agreement, we
                agreed to assume responsibility for completing any postmarketing requirements or commitments that may be required to retain approval. Accordingly, we will be required to continue the postmarketing observational epidemiologic study to
                evaluate the major adverse cardiovascular events (MACE) of Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">In August 2020, we announced that we had replaced the 2015 Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;co-commercialization agreement with Daiichi Sankyo, Inc.
                    (Daiichi Sankyo) (assigned under the agreement with AstraZeneca), with a new royalty-bearing agreement. Under the terms of the new agreement, we bear all responsibilities and costs for commercializing Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;in the U.S. During the term of the new agreement, we pay Daiichi Sankyo a mid-teen royalty rate on net sales of Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;in the U.S., in addition to three annual lump sum payments, starting in the fourth quarter of 2021 and ending in 2023.</div>
                </div>
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">In July 2020, we amended the AstraZeneca License Agreement, whereby the parties agreed to postpone the non-contingent payment of $15.0 million by us to December 2021 and to increase the
                amount due by $0.5 million.</div>
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
            </div>
            <div style="text-align: justify; line-height: 1.25;">
              <div style="line-height: 1.25;">In July 2021, we announced that one of America&#8217;s largest payors, serving many Blue Cross and Blue Shield Plans and more than 30 million members, had added Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174; </sup>as a preferred brand with no restrictions to its National Formulary and as a preferred brand on its other commercial formularies starting July 1, 2021. Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#8217;s total commercial coverage now extends to 152 million American patient lives.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold; font-style: italic;">Talicia</font><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup><font style="font-weight: bold; font-style: italic;">&#160;(omeprazole, magnesium, amoxicillin, and rifabutin) delayed-release capsules 10 mg/250 mg/12.5 mg</font></div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;is designed to address the high resistance of <font style="font-style: italic;">H. pylori</font> bacteria to the
                    antibiotics commonly used in current standard-of-care therapies. Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#8217;s approval was supported, in part, by the results of two positive Phase 3 trials
                    in the U.S. for the treatment of <font style="font-style: italic;">H. pylori</font>-positive adult patients complaining of epigastric pain and/or discomfort. The confirmatory Phase 3 trial of Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;demonstrated 84% eradication of <font style="font-style: italic;">H. pylori</font> infection with Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;vs. 58% in the active comparator arm (p&lt;0.0001). Further, in an analysis of data from this trial, it was observed that subjects with measurable blood levels of drug at visit 3 (approximately day 13) had response
                    rates of 90.3% in the Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;arm vs. 64.7% in the active comparator arm.</div>
                </div>
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;is designed to address the high resistance of <font style="font-style: italic;">H. pylori</font>
                bacteria to the antibiotics commonly used in current standard-of-care therapies. Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#8217;s approval was supported, in part, by the results of two positive
                Phase 3 trials in the U.S. for the treatment of <font style="font-style: italic;">H. pylori</font>-positive adult patients complaining of epigastric pain and/or discomfort. The confirmatory Phase 3 trial of Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;demonstrated 84% eradication of H. pylori infection with Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;vs. 58% in
                the active comparator arm (p&lt;0.0001). Further, in an analysis of data from this trial, it was observed that subjects with measurable blood levels of drug at visit 3 (approximately day 13) had response rates of 90.3% in the Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;arm vs. 64.7% in the active comparator arm.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">We believe that Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;may offer a significant benefit over other currently approved drugs in part because
                of the resistance profile demonstrated in our Phase 3 program, which showed no bacterial resistance to rifabutin and high resistance to clarithromycin and metronidazole.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;is the first product we developed that was approved for marketing in the U.S. Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;was approved by the FDA on November 1, 2019, and we launched Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;in the
                U.S. in March 2020.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">In November 2014, Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;was granted Qualified Infectious Disease Product (QIDP) designation by the FDA. Under its QIDP
                    designation, Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;is eligible for an additional five years of U.S. market exclusivity, on top of the standard exclusivity period, for a total of eight
                    years of market exclusivity. <br>
                  </div>
                </div>
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: center; line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">In July 2021, we announced that OptumRx, part of the UnitedHealth Group - a leader in healthcare coverage serving more than 26 million Americans, had added Talicia&#160;to its Commercial Formulary as an
                    unrestricted brand for&#160;<font style="font-style: italic;">H. pylori</font>&#160;treatment, effective July 1, 2021. Patient access to Talicia now extends to greater than 8 out of 10 covered U.S. commercial lives.</div>
                </div>
              </div>
              <div style="text-align: justify; line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">6</font></div>
                <div class="BRPFPageBreak" style="page-break-after: always;">
                  <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
              </div>
              <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold; font-style: italic;">Aemcolo</font><sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup></div>
              <div style="text-align: justify; line-height: 1.25;">&#160;</div>
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>, containing 194 mg of rifamycin, is an orally administered, minimally absorbed antibiotic that is delivered to the
                    colon, approved by the FDA in 2018 for the treatment of travelers&#8217; diarrhea caused by non-invasive strains of E. coli in adults (&#8220;Travelers&#8217; Diarrhea&#8221;). In October 2019, we entered into a license agreement with a wholly-owned subsidiary
                    of Cosmo Pharmaceuticals N.V. (&#8220;Cosmo&#8221;) pursuant to which we were granted exclusive rights to commercialize Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;in the U.S. In December 2019, we
                    launched the commercialization of Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;in the U.S.</div>
                </div>
              </div>
              <div style="text-align: justify; line-height: 1.25;">&#160;</div>
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;received FDA approval on November 16, 2018, for the treatment of travelers&#8217; diarrhea caused by noninvasive
                        strains of <font style="font-style: italic;">E. coli</font> in adults. Cosmo transferred the Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;New Drug Application (NDA) and the IND to
                        RedHill Biopharma Inc., which were accepted on November 27, 2019. This acceptance also includes a commitment to complete any postmarketing requirements or commitments related to the NDA. There are two pediatric studies that are
                        required to be completed to satisfy the PREA requirements:</div>
                    </div>
                  </div>
                </div>
              </div>
              <div style="text-align: justify; line-height: 1.25;">&#160;</div>
            </div>
            <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 2%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 96%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">Conduct a randomized, placebo-controlled study to evaluate the safety, tolerability, and efficacy of Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;(rifamycin)






























                      for the treatment of travelers&#8217; diarrhea in children from 6 to 11 years of age.</div>
                  </td>
                </tr>

            </table>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">&#160;</div>
            </div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 2%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 96%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">Conduct a randomized, placebo-controlled study to evaluate the safety, tolerability, and efficacy of Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;(rifamycin)






























                      for the treatment of travelers&#8217; diarrhea in children from 12 to 17 years of age.</div>
                  </td>
                </tr>

            </table>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div style="text-align: justify; line-height: 1.25;">In October 2017, the FDA granted QIDP and Fast Track designations for Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>. With the QIDP designation,
                intended for antibacterial or antifungal drugs that treat serious or life-threatening infections, together with new chemical entity (NCE) designation, Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;enjoys




























                marketing exclusivity until 2028. Due to the significant decrease in travel as a result of the pandemic, the travelers&#8217; diarrhea market has been significantly impacted, and we have not generated meaningful revenues from the sale of Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>. We do not expect Aemcolo<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>&#160;to generate meaningful revenues until U.S.
                international travel returns to pre-COVID-19 pandemic levels, if at all, and there can be no assurance that we will generate meaningful revenues upon return of U.S. international travel to pre-pandemic levels.</div>
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div style="text-align: justify; line-height: 1.25;">RedHill has implemented plans, including re-launching active field promotion of Aemcolo&#174;, to support, and build on, the initial momentum that Aemcolo&#174; was generating pre-COVID-19 travel
                restrictions.</div>
              <div style="text-align: justify; line-height: 1.25;">&#160;</div>
              <div style="text-align: justify; line-height: 1.25;">We continue to pursue the acquisition of additional commercial products, including, without limitation, through licensing or promotion transaction, asset purchase, joint venture with,
                acquisition of, or merger with or other business combination with, companies with rights to commercial GI and other relevant assets and are continuously working to expand U.S.-managed care access and coverage to our commercial products,
                where appropriate. We plan to pursue such opportunities in the U.S. and, if available, in other jurisdictions; however, we intend to focus our commercial activities in the U.S.</div>
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Recent Developments on our Therapeutic Product Candidates</div>
              <div style="text-align: justify; line-height: 1.25;">&#160;</div>
              <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">RHB&#8209;204</div>
              <div style="text-align: justify; line-height: 1.25;">&#160;</div>
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">RHB&#8209;204 is a patented fixed-dose oral capsule containing a combination of three antibiotics developed for the treatment of pulmonary Mycobacterium avium Complex (MAC) disease in adults with nodular
                    bronchiectasis (also referred to hereafter as pulmonary nontuberculous mycobacteria (NTM) disease caused by MAC). Each capsule contains clarithromycin, clofazimine, and rifabutin, at doses distinct from RHB&#8209;104.</div>
                </div>
              </div>
              <div style="text-align: justify; line-height: 1.25;">&#160;</div>
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">In November 2020, we initiated our Phase 3 trial to evaluate the efficacy and safety of RHB-204 in adults with pulmonary NTM disease caused by MAC infection. This multi-center, randomized, double-blind,
                    two-part, placebo-controlled, parallel-group Phase 3 trial is planned to be conducted at up to 40 sites across the U.S. Study endpoints include sputum culture conversion at month six of treatment with RHB-204, compared to placebo and
                    Quality of Life questionnaire, including improvements in physical functioning, respiratory symptoms and fatigue. An interim sample size re-estimate is planned once the study reaches approximately 50% enrollment.</div>
                </div>
              </div>
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">7</font></div>
                <div class="BRPFPageBreak" style="page-break-after: always;">
                  <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
              </div>
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">In January 2017, we announced that RHB&#8209;204 had been granted QIDP designation by the FDA for the treatment of pulmonary NTM disease, including eligibility for Priority Review, Accelerated Approval and an
                        extended market exclusivity period, if approved for marketing in the U.S. In October 2020, we announced that the FDA granted RHB-204 Orphan Drug designation which, together with the QIDP designation will extend U.S. market
                        exclusivity to a total of 12 years, if RHB-204 is approved by the FDA. In January 2021, we announced that the FDA granted RHB-204 Fast Track designation, allowing RedHill access to early and frequent communications with the FDA, to
                        expedite the RHB-204 development program, and to a rolling review of an NDA.</div>
                    </div>
                  </div>
                </div>
              </div>
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div style="text-align: justify; line-height: 1.25; font-style: italic; font-weight: bold;">RHB-107</div>
              <div style="text-align: justify; line-height: 1.25;">&#160;</div>
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">RHB-107 (formerly Mesupron) (INN: upamostat) is a proprietary, first-in-class, orally-administered potent inhibitor of several serine proteases. We are developing this investigational new drug as a
                    potential treatment for symptomatic COVID-19 patients that do not require hospitalization. In addition, we believe RHB-107 has potential in targeting cancer, inflammatory lung diseases and gastrointestinal diseases. In November 2020, we
                    announced that the FDA had cleared our IND application for a U.S. Phase 2/3 trial evaluating RHB-107 in non-hospitalized patients with symptomatic COVID-19 who do not require supplemental oxygen. In December 2020, we submitted an
                    amendment to the protocol for that trial, addressing FDA comments. In February 2021, we announced that the first patient had been dosed in the trial. This multicenter, randomized, double-blind, placebo-controlled, parallel-group trial
                    will evaluate the safety and efficacy of RHB-107. The first part of the trial is designed for dose selection and is planned to enroll 60 patients. The second part of the trial is planned to enroll 250 patients and will evaluate time to
                    sustained recovery from illness as the primary endpoint. Each patient will be tested for specific viral strain. Several secondary and exploratory endpoints will also be assessed.</div>
                </div>
              </div>
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div style="text-align: justify; line-height: 1.25;">In May 2021, we announced the receipt of a notice of allowance from the USPTO covering RHB-107 as a method for the treatment of COVID-19 caused by the SARS-CoV-2 virus.</div>
              <div style="text-align: justify; line-height: 1.25;">&#160;</div>
              <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Expanded Access Program (EAP)</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">We have adopted an Expanded Access Program (&#8220;EAP&#8221;), allowing patients with life-threatening diseases potential access to our investigational new drugs that have not yet received regulatory marketing
                    approval. Expanded access (sometimes referred to as &#8220;compassionate use&#8221;) is possible outside of our clinical trials, under certain eligibility criteria, when a certain investigational new drug is needed to treat a life-threatening
                    condition and when there is some clinical evidence suggesting that the drug might be effective for that condition. Patients who qualify for our EAP do not meet the eligibility criteria or are incapable of participating in our clinical
                    trials for such therapeutic candidates or there is no clinical trial accessible to such patients. Following the adoption of the program, we continue to receive patient requests to obtain access to our investigational drugs. Subject to
                    the evaluation of eligibility and all other necessary regulatory, reporting and other conditions and approvals required in all relevant jurisdictions, we provide certain patients with an investigational new drug under the EAP.</div>
                </div>
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25; font-weight: bold;">January 2021 Underwritten Offering</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">On January 14, 2021, we closed an underwritten offering of 3,188,776 ADSs at a public offering price of $7.84 per ADS, for total net proceeds of approximately $23.1 million, after deducting underwriting
                    discounts and commissions and approximated offering expenses payable by us in connection with the offering.</div>
                </div>
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25; font-weight: bold;">March 2021 Underwritten Offering</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">On March 4, 2021, we closed an underwritten offering of 4,375,000 ADSs at a public offering price of $8.00 per ADS, for total net proceeds of approximately $32.8 million, after deducting underwriting
                        discounts and commissions and approximated offering expenses payable by us in connection with the offering. On March 11, 2021, and on March 16, 2021, the underwriter exercised its overallotment option and accordingly we issued an
                        additional 272,433 ADSs for total net proceeds of approximately $2.0 million, after deducting underwriting discounts and commissions.</div>
                    </div>
                  </div>
                </div>
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">8</font></div>
                <div class="BRPFPageBreak" style="page-break-after: always;">
                  <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
              </div>
              <div style="line-height: 1.25; font-weight: bold;">Recent Developments</div>
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="text-align: justify; line-height: 1.25;">
              <div style="line-height: 1.25;">In March 2021 we announced that RedHill Biopharma Inc., AstraZeneca AB and AstraZenca Pharmaceuticals LP and Nektar Therapeutics entered into a settlement and license agreement with MSN Pharmaceuticals, Inc.
                and MSN Laboratories PVT. LTD. (&#8220;MSN&#8221;) resolving their patent litigation in the U.S. in response to MSN&#8217;s Abbreviated New Drug Application (&#8220;ANDA&#8221;) seeking approval by the US. FDA to market a generic version of Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>. Under the terms of the settlement agreement, MSN may not sell a generic version of Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> in the U.S. until October 1, 2030 (subject to U.S. FDA approval) or earlier under certain circumstances. The parties to the settlement agreement have also agreed to file a stipulation and order of dismissal with the U.S.
                District Court for the District of Delaware which will conclude this litigation with respect to MSN. As required by law, the parties will submit the settlement agreement to the U.S. Federal Trade Commission and the U.S. Department of
                Justice for review. The settlement with MSN did not end RedHill&#8217;s ongoing litigation against the other two ANDA filers.</div>
            </div>
            <div style="line-height: 1.25;"><br style="line-height: 1.25;">
            </div>
            <div style="text-align: justify; line-height: 1.25;">
              <div style="line-height: 1.25;">In July 2021, we announced that RedHill Biopharma Inc., AstraZeneca AB and AstraZeneca Pharmaceuticals LP and Nektar Therapeutics have entered into a settlement and license agreement with Apotex, Inc. and
                Apotex Corp. (&#8220;Apotex&#8221;) resolving their patent litigation in the U.S. in response to Apotex&#8217;s Abbreviated New Drug Application (&#8220;ANDA&#8221;) seeking approval by the US. FDA to market a generic version of Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>. Under the terms of the settlement agreement, Apotex may not sell a generic version of Movantik<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup> in
                the U.S. until October 1, 2030 (subject to U.S. FDA approval) or earlier under certain circumstances. The parties to the settlement agreement also agreed to file a stipulation and order of dismissal with the U.S. District Court for the
                District of Delaware which will conclude this litigation with respect to Apotex. As required by law, the parties will submit the settlement agreement to the U.S. Federal Trade Commission and the U.S. Department of Justice for review. The
                settlement with Apotex did not end RedHill&#8217;s ongoing litigation against the other one ANDA filer.</div>
            </div>
            <div style="text-align: justify; line-height: 1.25;"><br style="line-height: 1.25;">
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: center; margin-left: 36pt; line-height: 1.25;">&#160;<font style="font-weight: bold;">Summary of Risk Factors</font></div>
              <div style="line-height: 1.25;">&#160;</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="text-indent: 36pt; line-height: 1.25;">The following is a summary of some of the principal risks we face. The list below is not exhaustive, and investors should read the &#8220;Risk Factors&#8221; section, including the &#8220;Item 3. Key
                    Information &#8211; Risk Factors&#8221; in our Annual Report on Form 20-F for the year-ended December 31, 2020, in full.</div>
                  <div style="line-height: 1.25">&#160;</div>
                </div>
              </div>
              <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                  <tr>
                    <td style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#9679;</td>
                    <td style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                      <div style="text-align: justify; line-height: 1.25;">Our pursuit of treatments for SARS-CoV-2 (the virus that causes COVID-19) infection in patients entails a high level of uncertainty. We have conducted limited testing of both
                        opaganib and RHB-107 and cannot assure you that either of them will prove to be a safe and effective treatment for COVID-19 or will be approved for marketing or Emergency Use Authorization by the FDA or other regulatory authorities.</div>
                    </td>
                  </tr>
                  <tr>
                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  </tr>
                  <tr>
                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#9679;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                      <div style="text-align: justify; line-height: 1.25;">If we are successful in developing a COVID-19 therapeutic, we may need to devote significant resources to our manufacturing scale-up and large-scale deployment, including for use by
                        the U.S. or other governments. If one of our COVID-19 therapeutic candidates is approved for marketing we may also need to devote significant resources to further expand our U.S. sales and marketing activities and increase or
                        maintain personnel to accommodate sales in the U.S.</div>
                    </td>
                  </tr>
                  <tr>
                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  </tr>
                  <tr>
                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#9679;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                      <div style="text-align: justify; line-height: 1.25;">The ongoing COVID-19 pandemic may adversely affect our business, revenues, results of operations and financial condition.</div>
                    </td>
                  </tr>
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                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  </tr>
                  <tr>
                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#9679;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                      <div style="text-align: justify; line-height: 1.25;">Our current working capital is not sufficient to commercialize our current commercial products or to complete the research and development with respect to any or all of our
                        therapeutic candidates. We may need to raise additional capital to achieve our strategic objectives and to execute our business plans, and our failure to raise sufficient capital or on favorable terms would significantly impair our
                        ability to fund the commercialization of our current commercial products, therapeutic candidates, or the products we may commercialize or promote in the future, attract development or commercial partners or retain key personnel, and
                        to fund operations and develop our therapeutic candidates.</div>
                    </td>
                  </tr>

              </table>
              <div><br>
              </div>
              <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
                <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">9</font></div>
                <div class="BRPFPageBreak" style="page-break-after: always;">
                  <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
              </div>
              <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                  <tr>
                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#9679;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                      <div style="text-align: justify; line-height: 1.25;">Our long-term capital requirements are subject to numerous risks.</div>
                    </td>
                  </tr>
                  <tr>
                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  </tr>
                  <tr>
                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#9679;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                      <div style="text-align: justify; line-height: 1.25;">Our term loan facility imposes significant operating and financial restrictions on us, which may prevent us from capitalizing on business opportunities and may restrict our
                        operational flexibility, and our failure to comply with the restrictive covenants in our term loan facility could have a material adverse effect on our business.</div>
                    </td>
                  </tr>
                  <tr>
                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  </tr>
                  <tr>
                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#9679;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                      <div style="text-align: justify; line-height: 1.25;">We may be unable to generate sufficient cash flow to make the required payments under the term loan facility or to adhere to other requirements under the term loan facility.</div>
                    </td>
                  </tr>
                  <tr>
                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  </tr>
                  <tr>
                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#9679;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                      <div style="text-align: justify; line-height: 1.25;">The indebtedness under our term loan facility is secured by substantially all of the current and future assets of RedHill Biopharma Inc., all of our assets related in any material
                        respect to Talicia<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">&#174;</sup>, and all of the equity interests of RedHill Biopharma Inc. As a result of these security interests, such assets would only be
                        available to satisfy claims of our general creditors or t holders of our equity securities if we were to become insolvent to the extent the value of such assets exceeded the amount of our indebtedness and other obligations. In
                        addition, the existence of these security interests may adversely affect our financial flexibility.</div>
                    </td>
                  </tr>
                  <tr>
                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  </tr>
                  <tr>
                    <td rowspan="1" style="width: 5%; vertical-align: middle; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                    <td rowspan="1" style="width: 2%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#9679;</td>
                    <td rowspan="1" style="width: 93%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                      <div style="text-align: justify; line-height: 1.25;">If we or our future development or commercialization partners are unable to obtain or maintain the FDA or other foreign regulatory clearance and approval for our commercial products
                        or therapeutic candidates, we or our commercialization partners will be unable to commercialize our current commercial products, products we may commercialize or promote in the future or our therapeutic candidates, upon approval, if
                        any.</div>
                    </td>
                  </tr>

              </table>
              <br>
            </div>
            <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Corporate Information</div>
            <div style="text-align: justify; line-height: 1.25;">&#160;</div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">
              <div style="text-indent: 28.35pt; line-height: 1.25;">Our principal executive offices are located at 21 Ha&#8217;arba&#8217;a Street, Tel Aviv, Israel and our telephone number is +972 (3) 541-3131. Our website address is http://www.redhillbio.com. The
                information on our web site is included as an inactive textual reference only and does not constitute part of this prospectus. Our registered agent in the United States is RedHill Biopharma Inc. The address of RedHill Biopharma Inc. is 8045
                Arco Corporate Drive, Suite 200, Raleigh, NC 27617.</div>
            </div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;&#160;</div>
            <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
              <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">10</font></div>
              <div class="BRPFPageBreak" style="page-break-after: always;">
                <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
            </div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="RISKFACTORS1"></a>RISK FACTORS</div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
            </div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25; font-style: italic;">
              <div style="text-indent: 28.35pt; line-height: 1.25; font-style: italic;">An investment in our securities involves a high degree of risk. Our business, financial condition or results of operations could be adversely affected by any of these
                risks. You should carefully consider the risk factors discussed under the caption "Item 3: Key Information&#160;<font style="font-weight: bold;">-&#160;</font>Risk Factors" in our Annual Report on Form 20-F for the year ended December 31, 2020, and
                in any other filing we make with the SEC subsequent to the date of this prospectus, each of which is incorporated herein by reference, and in any supplement to this prospectus, before making your investment decision. The risks and
                uncertainties we have described are not the only ones we face. Additional risks and uncertainties not presently known to us or that we currently deem immaterial may also affect our operations. Past financial performance may not be a
                reliable indicator of future performance, and historical trends should not be used to anticipate results or trends in future periods. If any of these risks actually occurs, our business, business prospects, financial condition or results of
                operations could be seriously harmed. This could cause the trading price of the ADSs to decline, resulting in a loss of all or part of your investment. Please also read carefully the section below entitled &#8220;Forward-Looking Statements.&#8221;</div>
            </div>
            <div style="line-height: 1.25;"><br style="line-height: 1.25;">
            </div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="FORWARD-LOOKINGSTATEMENTS"></a>FORWARD-LOOKING STATEMENTS</div>
            <div style="text-align: justify; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">
              <div style="text-indent: 28.35pt; line-height: 1.25;">This prospectus, including the information incorporated by reference into this prospectus, contains, and any prospectus supplement may include forward-looking statements within the meaning
                of the Private Securities Litigation Reform Act of 1995. These statements involve known and unknown risks, uncertainties and other factors that may cause our actual results, performance or achievements to be materially different from any
                future results, performance or achievements expressed or implied by the forward-looking statements. In some cases, you can identify forward-looking statements by terms including &#8220;anticipates,&#8221; &#8220;believes,&#8221; &#8220;could,&#8221; &#8220;estimates,&#8221; &#8220;expects,&#8221;
                &#8220;intends,&#8221; &#8220;may,&#8221; &#8220;plans,&#8221; &#8220;potential,&#8221; &#8220;predicts,&#8221; &#8220;projects,&#8221; &#8220;should,&#8221; &#8220;will,&#8221; &#8220;would,&#8221; and similar expressions intended to identify forward-looking statements. Forward-looking statements reflect our current views with respect to future
                events and are based on assumptions and subject to risks and uncertainties. You should not put undue reliance on any forward-looking statements. Unless we are required to do so under U.S. federal securities laws or other applicable laws, we
                do not intend to update or revise any forward-looking statements. Factors that could cause our actual results to differ materially from those expressed or implied in such forward-looking statements include, but are not limited to:</div>
            </div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">&#160;</div>
            <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">estimates of our expenses, future revenues, capital requirements and our needs for additional financing;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">our ability to obtain additional financing;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">our receipt and timing of regulatory clarity and approvals for our therapeutic candidates, and the timing of other regulatory filings and approvals;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the initiation, timing, progress, and results of our research, manufacturing, preclinical studies, clinical trials, and other therapeutic candidate development efforts, as well as the
                      extent and number of additional studies that we may be required to conduct;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">our ability to advance our therapeutic candidates into clinical trials or to successfully complete our preclinical studies or clinical trials;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">our reliance on third parties to conduct key portions of our clinical trials, including data management services, and the potential for those third parties to not perform
                      satisfactorily;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">our ability to establish and maintain corporate collaborations;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">that products we promote or commercialize may be withdrawn from the market by regulatory authorities and our need to comply with continuing laws, regulations and guidelines to
                      maintain clearances and approvals for our products;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">our ability to acquire products approved for marketing in the U.S. that achieve commercial success and to maintain our own marketing and commercialization capabilities;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the research, manufacturing, clinical development, commercialization, and market acceptance of our therapeutic candidates or commercial products;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the properties and characteristics of our therapeutic candidates and of the results observed with our therapeutic candidates in research, preclinical studies or clinical trials;</div>
                  </td>
                </tr>

            </table>
            <div><br>
            </div>
            <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
              <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">11</font></div>
              <div class="BRPFPageBreak" style="page-break-after: always;">
                <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
            </div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the implementation of our business model, strategic plans for our business, therapeutic candidates and commercial products;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the impact of other companies and technologies that compete with us within our industry;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">our estimates of the markets, their size, characteristics and their potential for our therapeutic candidates and commercial products and our ability to serve those markets;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the scope of protection we are able to establish and maintain for intellectual property rights covering our therapeutic candidates and our ability to operate our business without
                      infringing or violating the intellectual property rights of others;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">parties from whom we license or acquire our intellectual property defaulting in their obligations toward us;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the failure by a licensor or a partner of ours to meet their respective obligations under our acquisition, in-license or other development or commercialization agreements or
                      renegotiate the obligations under such agreements, or if other events occur that are not within our control, such as bankruptcy of a licensor or a partner;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">our ability to implement and maintain network systems and controls that are effective at preventing cyber-attacks, malware intrusions, malicious viruses and ransomware threats; and</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the impact of the political and security situation in Israel on our business.</div>
                  </td>
                </tr>

            </table>
            <div style="text-align: justify; text-indent: -14.2pt; margin-left: 42.55pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">We caution you to carefully consider these risks and not to place undue reliance on our forward-looking statements. Except as required by law, we assume no
              responsibility for updating any forward-looking statements.</div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="CAPITALIZATION"></a>CAPITALIZATION</div>
            <div style="text-align: justify; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">The table below sets forth our total capitalization as of March 31, 2021. The financial data in the following table should be read in conjunction with our financial
              statements and notes thereto incorporated by reference herein.&#160;</div>
            <div style="text-align: justify; line-height: 1.25;">&#160;</div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000; width: 100%;">

                <tr>
                  <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px;">
                    <div style="text-align: justify; line-height: 1.25;">&#160;</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
                  <td valign="bottom" colspan="2" style="vertical-align: bottom; border-bottom: #000000 solid 2px;">
                    <div style="text-align: center; line-height: 1.25; font-weight: bold;">As of March 31, 2021</div>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; padding-bottom: 2px;">&#160;</td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; ">
                    <div style="text-align: justify; line-height: 1.25;">&#160;</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom;">&#160;</td>
                  <td valign="bottom" colspan="2" style="vertical-align: bottom; ">
                    <div style="text-align: center; line-height: 1.25; font-family: 'Times New Roman',Times,serif;"><font style="font-weight: bold;">Actual</font>&#160;<font style="font-weight: bold;">U.S. dollars</font></div>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom;">&#160;</td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; ">
                    <div style="text-align: justify; line-height: 1.25;">&#160;</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom;">&#160;</td>
                  <td valign="bottom" colspan="2" style="vertical-align: bottom; ">
                    <div style="text-align: center; line-height: 1.25; font-weight: bold;">(in thousands)</div>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom;">&#160;</td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; ">
                    <div style="text-align: justify; line-height: 1.25;">&#160;</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom;">&#160;</td>
                  <td valign="bottom" colspan="2" style="vertical-align: bottom; ">&#160;</td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom;">&#160;</td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 88%;">
                    <div style="text-align: justify; line-height: 1.25;">Total debt (1)</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
                  <td valign="bottom" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; width: 1%;">
                    <div style="line-height: 1.25;">$</div>
                  </td>
                  <td valign="bottom" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; text-align: right; width: 9%;">
                    <div style="line-height: 1.25;">167,082</div>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; width: 1%;">&#160;</td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; width: 88%;">
                    <div style="text-align: justify; line-height: 1.25;">Ordinary shares, par value NIS 0.01 per share</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;">
                    <div style="line-height: 1.25;">1,309</div>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 88%;">
                    <div style="text-align: justify; line-height: 1.25;">Additional paid-in capital</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
                  <td valign="bottom" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; width: 1%;">&#160;</td>
                  <td valign="bottom" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; text-align: right; width: 9%;">
                    <div style="line-height: 1.25;">354,057</div>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; width: 1%;">&#160;</td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; width: 88%;">
                    <div style="text-align: justify; line-height: 1.25;">Accumulated deficit</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;">
                    <div style="line-height: 1.25;">(302,325</div>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%;">
                    <div style="line-height: 1.25;">)</div>
                  </td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 88%; padding-bottom: 2px;">
                    <div style="text-align: justify; line-height: 1.25;">Total shareholders&#8217; equity</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px; background-color: rgb(204, 238, 255);">&#160;</td>
                  <td valign="bottom" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
                  <td valign="bottom" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                    <div style="line-height: 1.25;">53,041</div>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; width: 88%; padding-bottom: 2px;">
                    <div style="text-align: justify; line-height: 1.25;">Total capitalization</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; border-bottom: 2px solid rgb(0, 0, 0);">
                    <div style="line-height: 1.25;">$</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%; border-bottom: 2px solid rgb(0, 0, 0);">
                    <div style="line-height: 1.25;">220,123</div>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%; padding-bottom: 2px;">&#160;</td>
                </tr>

            </table>
            <div style="line-height: 1.25;">&#160;</div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 0.23%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 4.13%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="line-height: 1.25;">(1)</div>
                  </td>
                  <td style="width: 95.64%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">
                      <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">Includes $66,629 thousand of current liabilities, which is mainly accounts payable, allowance for deductions from revenues and accrued
                        expenses and $100,453 thousand under non-current liabilities, mainly borrowing and payable in respect of intangible assets purchase.</div>
                    </div>
                  </td>
                </tr>

            </table>
            <div style="line-height: 1.25;">&#160;</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="OFFERANDLISTINGDETAILS"></a>OFFER AND LISTING DETAILS</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">The ADSs were traded on the Nasdaq Capital Market under the symbol &#8220;RDHL&#8221; from December&#160;27, 2012 to July 20, 2018, and have since that date been listed on the Nasdaq
              Global Market under the same symbol. Our Ordinary Shares were traded on the TASE under the symbol &#8220;RDHL&#8221; from February&#160;2011 to February&#160;2020, when we voluntarily delisted the Ordinary Shares from trading on the TASE, effective February&#160;13,
              2020. They are listed but are not traded on the Nasdaq Global Market in connection with the ADSs.&#160;</div>
            <div style="line-height: 1.25;">&#160;</div>
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              <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">12</font></div>
              <div class="BRPFPageBreak" style="page-break-after: always;">
                <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
            </div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="USEOFPROCEEDS1"></a>USE OF PROCEEDS</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">Unless otherwise indicated in an accompanying prospectus supplement, the net proceeds from the sale of securities will be used for general corporate purposes, including
              research and development related purposes in connection with our therapeutic candidates, for potential acquisitions and to support commercial operations.&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;"> <br>
            </div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DESCRIPTIONOFORDINARYSHAR1"></a>DESCRIPTION OF ORDINARY SHARES</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">
              <div style="text-indent: 28.35pt; line-height: 1.25;">A description of our Ordinary Shares can be found in Exhibit 2.3 to our Annual Report on Form 20-F filed with the SEC on March 18, 2021.</div>
            </div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DESCRIPTIONOFAMERICANDEPO1"></a>DESCRIPTION OF AMERICAN DEPOSITARY SHARES</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">
              <div style="text-indent: 28.35pt; line-height: 1.25;">A description of the ADSs, each of which represents 10 of our Ordinary Shares, can be found in Exhibit 2.3 to our Annual Report on Form 20-F filed with the SEC on March 18, 2021.</div>
            </div>
            <div style="text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DESCRIPTIONOFWARRANTS1"></a>DESCRIPTION OF WARRANTS</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">
              <div style="text-indent: 28.35pt; line-height: 1.25;">We may issue warrants to purchase ADS and/or Ordinary Shares. Warrants may be issued independently or together with any other securities and may be attached to, or separate from, such
                securities. We will evidence each series of warrants by warrant certificates that we may issue under a separate agreement. We may enter into a warrant agreement with a warrant agent. We may also choose to act as our own warrant agent. We
                will indicate the name and address of any such warrant agent in the applicable prospectus supplement relating to a particular series of warrants. The terms of any warrants to be issued and a description of the material provisions of the
                applicable warrant agreement will be set forth in the applicable prospectus supplement.</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">The applicable prospectus supplement will describe the following terms of any warrants in respect of which this prospectus is being delivered:</div>
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            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
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                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the title of such warrants;</div>
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                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
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                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the aggregate number of such warrants;</div>
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                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the price or prices at which such warrants will be issued and exercised;</div>
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                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the currency or currencies in which the price of such warrants will be payable;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the securities purchasable upon exercise of such warrants;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the date on which the right to exercise such warrants shall commence and the date on which such right shall expire;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">if applicable, the minimum or maximum amount of such warrants which may be exercised at any one time;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">if applicable, the designation and terms of the securities with which such warrants are issued and the number of such warrants issued with each such security;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">if applicable, the date on and after which such warrants and the related securities will be separately transferable;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">information with respect to book-entry procedures, if any;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">any material Israeli and United States federal income tax consequences;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the anti-dilution provisions of the warrants, if any; and</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">any other terms of such warrants, including terms, procedures and limitations relating to the exchange and exercise of such warrants.</div>
                  </td>
                </tr>

            </table>
            <div style="text-align: justify; line-height: 1.25;">&#160;</div>
            <div style="text-align: justify; line-height: 1.25; font-weight: bold;">Amendments and Supplements to Warrant Agreement</div>
            <div style="text-align: justify; line-height: 1.25;">&#160;</div>
            <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
              <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">13</font></div>
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            </div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">We and the warrant agent may amend or supplement the warrant agreement for a series of warrants without the consent of the holders of the warrants issued thereunder to
              effect changes that are not inconsistent with the provisions of the warrants and that do not materially and adversely affect the interests of the holders of the warrants.</div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DESCRIPTIONOFSUBSCRIPTION"></a>DESCRIPTION OF SUBSCRIPTION RIGHTS</div>
            <div style="text-align: justify; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">
              <div style="text-indent: 28.35pt; line-height: 1.25;">We may issue subscription rights to purchase our Ordinary Shares and/or ADSs. These subscription rights may be issued independently or together with any other security offered hereby and
                may or may not be transferable by the shareholder receiving the subscription rights in such offering. In connection with any offering of subscription rights, we may enter into a standby arrangement with one or more underwriters or other
                purchasers pursuant to which the underwriters or other purchasers may be required to purchase any securities remaining unsubscribed for after such offering.</div>
            </div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">The prospectus supplement relating to any subscription rights we offer, if any, will, to the extent applicable, include specific terms relating to the offering,
              including some or all of the following:</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">&#160;</div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the price, if any, for the subscription rights;&#160;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the exercise price payable for each ordinary share and/or ADS upon the exercise of the subscription rights;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the number of subscription rights to be issued to each shareholder;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">
                      <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">the number and terms of the Ordinary Shares and/or ADSs which may be purchased per each subscription right; <br>
                      </div>
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                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the extent to which the subscription rights are transferable;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">any other terms of the subscription rights, including the terms, procedures and limitations relating to the exchange and exercise of the subscription rights;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the date on which the right to exercise the subscription rights shall commence, and the date on which the subscription rights shall expire;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the extent to which the subscription rights may include an over-subscription privilege with respect to unsubscribed securities;&#160;and</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">if applicable, the material terms of any standby underwriting or purchase arrangement which may be entered into by us in connection with the offering of subscription rights.</div>
                  </td>
                </tr>

            </table>
            <div style="text-align: justify; line-height: 1.25;">&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">The description in the applicable prospectus supplement of any subscription rights we offer will not necessarily be complete and will be qualified in its entirety by
              reference to the applicable subscription right agreement, which will be filed with the SEC if we offer subscription rights. For more information on how you can obtain copies of the applicable subscription right agreement if we offer
              subscription rights, see &#8220;Where You Can Find More Information; Incorporation of Information by Reference&#8221; beginning on page 18. We urge you to read the applicable subscription right agreement and any applicable prospectus supplement in their
              entirety.</div>
            <div style="line-height: 1.25;"><br style="line-height: 1.25;">
            </div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="DESCRIPTIONOFUNITS"></a>DESCRIPTION OF UNITS</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">We may issue units comprised of one or more of the other securities that may be offered under this prospectus, in any combination. Each unit will be issued so that the
              holder of the unit is also the holder of each security included in the unit. Thus, the holder of a unit will have the rights and obligations of a holder of each included security. The unit agreement under which a unit is issued may provide
              that the securities included in the unit may not be held or transferred separately at any time, or at any time before a specified date.</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">The prospectus supplement relating to any units we offer, if any, will, to the extent applicable, include specific terms relating to the offering, including some or all
              of the following:</div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">&#160;</div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the material terms of the units and of the securities comprising the units, including whether and under what circumstances those securities may be held or transferred separately;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">any material provisions relating to the issuance, payment, settlement, transfer or exchange of the units or of the securities comprising the units; and</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">any material provisions of the governing unit agreement that differ from those described above.</div>
                  </td>
                </tr>

            </table>
            <div style="text-align: justify; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">The description in the applicable prospectus supplement of any units we offer will not necessarily be complete and will be qualified in its entirety by reference to
                the applicable unit agreement, which will be filed with the SEC if we offer units. For more information on how you can obtain copies of the applicable unit agreement if we offer units, see &#8220;Where You Can Find More Information; Incorporation
                of Information by Reference&#8221; beginning on page 18. We urge you to read the applicable unit agreement and any applicable prospectus supplement in their entirety.</div>
            </div>
            <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">&#160;</div>
            <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
              <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">14</font></div>
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                <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
            </div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="PLANOFDISTRIBUTION1"></a>PLAN OF DISTRIBUTION</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">The securities being offered by this prospectus may be sold:</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">through agents;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">to or through one or more underwriters on a firm commitment or agency basis;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">through put or call option transactions relating to the securities;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">in at the market offerings into an existing trading market in accordance with Rule 415(a)(4) of the Securities Act;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">through broker-dealers;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">directly to purchasers, through a specific bidding or auction process, on a negotiated basis or otherwise;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">through any other method permitted pursuant to applicable law; or</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">through a combination of any such methods of sale.</div>
                  </td>
                </tr>

            </table>
            <div style="text-align: justify; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">At any time a particular offer of the securities covered by this prospectus is made, a revised prospectus or prospectus supplement, if required, will be distributed
                which will set forth the aggregate amount of securities covered by this prospectus being offered and the terms of the offering, including the name or names of any underwriters, dealers, brokers or agents, any discounts, commissions,
                concessions and other items constituting compensation from us and any discounts, commissions or concessions allowed or reallowed or paid to dealers. Such prospectus supplement, and, if necessary, a post-effective amendment to the
                registration statement of which this prospectus is a part, will be filed with the SEC to reflect the disclosure of additional information with respect to the distribution of the securities covered by this prospectus. In order to comply with
                the securities laws of certain states, if applicable, the securities sold under this prospectus may only be sold through registered or licensed broker-dealers. In addition, in some states the securities may not be sold unless they have been
                registered or qualified for sale in the applicable state or an exemption from registration or qualification requirements is available and is complied with.</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">The distribution of securities may be effected from time to time in one or more transactions, including block transactions and transactions on the Nasdaq Global Market
                or any other organized market where the securities may be traded. The securities may be sold at a fixed price or prices, which may be changed, or at market prices prevailing at the time of sale, at prices relating to the prevailing market
                prices or at negotiated prices. The consideration may be cash, or another form negotiated by the parties. Agents, underwriters or broker-dealers may be paid compensation for offering and selling the securities. That compensation may be in
                the form of discounts, concessions or commissions to be received from us or from the purchasers of the securities. Any dealers and agents participating in the distribution of the securities may be deemed to be underwriters, and compensation
                received by them on resale of the securities may be deemed to be underwriting discounts. If any such dealers or agents were deemed to be underwriters, they may be subject to statutory liabilities under the Securities Act.</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">Agents may from time to time solicit offers to purchase the securities. If required, we will name in the applicable prospectus supplement any agent involved in the
                offer or sale of the securities and set forth any compensation payable to the agent. Unless otherwise indicated in the prospectus supplement, any agent will be acting on a best efforts basis for the period of its appointment. Any agent
                selling the securities covered by this prospectus may be deemed to be an underwriter, as that term is defined in the Securities Act, of the securities.</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">If underwriters are used in a sale, securities will be acquired by the underwriters for their own account and may be resold from time to time in one or more
                transactions, including negotiated transactions, at a fixed public offering price or at varying prices determined at the time of sale, or under delayed delivery contracts or other contractual commitments. Securities may be offered to the
                public either through underwriting syndicates represented by one or more managing underwriters or directly by one or more firms acting as underwriters. If an underwriter or underwriters are used in the sale of securities, an underwriting
                agreement will be executed with the underwriter or underwriters, as well as any other underwriter or underwriters, with respect to a particular underwritten offering of securities, and will set forth the terms of the transactions, including
                compensation of the underwriters and dealers and the public offering price, if applicable. The prospectus and prospectus supplement will be used by the underwriters to resell the securities.</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
              <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">15</font></div>
              <div class="BRPFPageBreak" style="page-break-after: always;">
                <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">If a dealer is used in the sale of the securities, we or an underwriter will sell the securities to the dealer, as principal. The dealer may then resell the securities
                to the public at varying prices to be determined by the dealer at the time of resale. To the extent required, we will set forth in the prospectus supplement the name of the dealer and the terms of the transactions.</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">We may directly solicit offers to purchase the securities and may make sales of securities directly to institutional investors or others. These persons may be deemed
                to be underwriters within the meaning of the Securities Act with respect to any resale of the securities. To the extent required, the prospectus supplement will describe the terms of any such sales, including the terms of any bidding or
                auction process, if used.</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">Agents, underwriters and dealers may be entitled under agreements which may be entered into with us to indemnification by us against specified liabilities, including
                liabilities incurred under the Securities Act, or to contribution by us to payments they may be required to make in respect of such liabilities. If required, the prospectus supplement will describe the terms and conditions of the
                indemnification or contribution. Some of the agents, underwriters or dealers, or their affiliates may be customers of, engage in transactions with or perform services for us or our subsidiaries.</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">Any person participating in the distribution of securities registered under the registration statement that includes this prospectus will be subject to applicable
                provisions of the Securities Exchange Act of 1934, as amended ( the &#8220;Exchange Act&#8221;), and the applicable SEC rules and regulations, including, among others, Regulation M, which may limit the timing of purchases and sales of any of our
                securities by that person. Furthermore, Regulation M may restrict the ability of any person engaged in the distribution of our securities to engage in market-making activities with respect to our securities. These restrictions may affect
                the marketability of our securities and the ability of any person or entity to engage in market-making activities with respect to our securities.</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">Certain persons participating in an offering may engage in over-allotment, stabilizing transactions, short-covering transactions, penalty bids and other transactions
                that stabilize, maintain or otherwise affect the price of the offered securities. These activities may maintain the price of the offered securities at levels above those that might otherwise prevail in the open market, including by entering
                stabilizing bids, effecting syndicate covering transactions or imposing penalty bids, each of which is described below.</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">A stabilizing bid means the placing of any bid, or the effecting of any purchase, for the purpose of pegging, fixing or maintaining the price of a security.</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">A syndicate covering transaction means the placing of any bid on behalf of the underwriting syndicate or the effecting of any purchase to reduce a short position created in connection
                      with the offering.</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">A penalty bid means an arrangement that permits the managing underwriter to reclaim a selling concession from a syndicate member in connection with the offering when offered
                      securities originally sold by the syndicate member are purchased in syndicate covering transactions.</div>
                  </td>
                </tr>

            </table>
            <div style="text-align: justify; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">These transactions may be effected on an exchange or automated quotation system, if the securities are listed on that exchange or admitted for trading on that
                automated quotation system, or in the over-the-counter market or otherwise.</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">If so indicated in the applicable prospectus supplement, we will authorize agents, underwriters or dealers to solicit offers from certain types of institutions to
                purchase offered securities from us at the public offering price set forth in such prospectus supplement pursuant to delayed delivery contracts providing for payment and delivery on a specified date in the future. Such contracts will be
                subject only to those conditions set forth in the prospectus supplement and the prospectus supplement will set forth the commission payable for solicitation of such contracts.</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
              <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">16</font></div>
              <div class="BRPFPageBreak" style="page-break-after: always;">
                <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="text-indent: 28.35pt; line-height: 1.25;">In addition, Ordinary Shares or ADSs may be issued upon conversion of or in exchange for debt securities or other securities.</div>
                </div>
              </div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">Any underwriters to whom offered securities are sold for public offering and sale may make a market in such offered securities, but such underwriters will not be
                obligated to do so and may discontinue any market making at any time without notice. The offered securities may or may not be listed on a national securities exchange. No assurance can be given that there will be a market for the offered
                securities.</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">Any securities that qualify for sale pursuant to Rule 144 or Regulation S under the Securities Act, may be sold under Rule 144 or Regulation S rather than pursuant to
                this prospectus.</div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="text-indent: 28.35pt; line-height: 1.25;">To the extent that we make sales to or through one or more underwriters or agents in at-the-market offerings, we will do so pursuant to the terms of a distribution agreement between us
                    and the underwriters or agents. If we engage in at-the-market sales pursuant to a distribution agreement, we will sell our Ordinary Shares or ADSs to or through one or more underwriters or agents, which may act on an agency basis or on
                    a principal basis. During the term of any such agreement, we may sell Ordinary Shares or ADSs on a daily basis in exchange transactions or otherwise as we agree with the underwriters or agents. The distribution agreement will provide
                    that any Ordinary Shares or ADSs sold will be sold at prices related to the then prevailing market prices for our Ordinary Shares or ADSs. Therefore, exact figures regarding proceeds that will be raised or commissions to be paid cannot
                    be determined at this time and will be described in a prospectus supplement. Pursuant to the terms of the distribution agreement, we also may agree to sell, and the relevant underwriters or agents may agree to solicit offers to
                    purchase, blocks of our Ordinary Shares, ADSs or warrants. The terms of each such distribution agreement will be set forth in more detail in a prospectus supplement to this prospectus.</div>
                </div>
              </div>
            </div>
            <div style="text-align: justify; text-indent: 24.5pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">In connection with offerings made through underwriters or agents, we may enter into agreements with such underwriters or agents pursuant to which we receive our
                outstanding securities in consideration for the securities being offered to the public for cash. In connection with these arrangements, the underwriters or agents may also sell securities covered by this prospectus to hedge their positions
                in these outstanding securities, including in short sale transactions. If so, the underwriters or agents may use the securities received from us under these arrangements to close out any related open borrowings of securities.</div>
            </div>
            <div style="text-align: justify; text-indent: 35pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">We may enter into derivative transactions with third parties or sell securities not covered by this prospectus to third parties in privately negotiated transactions.
                If the applicable prospectus supplement indicates, in connection with those derivatives, such third parties (or affiliates of such third parties) may sell securities covered by this prospectus and the applicable prospectus supplement,
                including in short sale transactions. If so, such third parties (or affiliates of such third parties) may use securities pledged by us or borrowed from us or others to settle those sales or to close out any related open borrowings of
                shares, and may use securities received from us in settlement of those derivatives to close out any related open borrowings of shares. The third parties (or affiliates of such third parties) in such sale transactions will be underwriters
                and, if not identified in this prospectus, will be identified in the applicable prospectus supplement (or a post-effective amendment).</div>
            </div>
            <div style="text-indent: 35pt; line-height: 1.25;">&#160;&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">We may loan or pledge securities to a financial institution or other third party that in turn may sell the securities using this prospectus. Such financial institution
                or third party may transfer its short position to investors in our securities or in connection with a simultaneous offering of other securities offered by this prospectus or in connection with a simultaneous offering of other securities
                offered by this prospectus.</div>
            </div>
            <div style="text-indent: 35pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="LEGALMATTERS1"></a>LEGAL MATTERS</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">Certain legal matters with respect to Israeli law and with respect to the validity of the offered securities under Israeli law will be passed upon for us by Gross
                &amp; Co. Certain legal matters with respect to U.S. federal securities law and New York law will be passed upon for us by Haynes and Boone, LLP.</div>
            </div>
            <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
            <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
              <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">17</font></div>
              <div class="BRPFPageBreak" style="page-break-after: always;">
                <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
            </div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="EXPERTS1"></a>EXPERTS</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;">
                <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">The financial statements and management&#8217;s assessment of the effectiveness of internal control over financial reporting (which is included in Management&#8217;s Report on
                  Internal Control over Financial Reporting) incorporated in this Prospectus by reference to the Annual Report on Form 20-F for the year ended December 31, 2020, have been so incorporated in reliance on the report of Kesselman &amp;
                  Kesselman, Certified Public Accountants (Isr.), a member firm of PricewaterhouseCoopers International Limited, an independent registered public accounting firm, given on the authority of said firm as experts in auditing and accounting.</div>
              </div>
            </div>
            <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="WHEREYOUCA1NFINDMOREINFORM"></a>WHERE YOU CAN FIND MORE INFORMATION</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">We have filed with the SEC a registration statement on Form F-3 under the Securities Act, with respect to the securities offered by this prospectus. However, as is
                permitted by the rules and regulations of the SEC, this prospectus, which is part of our registration statement on Form F-3, omits certain non-material information, exhibits, schedules and undertakings set forth in the registration
                statement. For further information about us, and the securities offered by this prospectus, please refer to the registration statement.</div>
            </div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">We are subject to the reporting requirements of the Exchange Act that are applicable to a foreign private issuer. In accordance with the Exchange Act, we file reports,
                including annual reports on Form 20-F by April 30 of each year. We also furnish to the SEC under cover of Form 6-K material information required to be made public in Israel, filed with and made public by any stock exchange or distributed by
                us to our shareholders.</div>
            </div>
            <div style="text-align: justify; text-indent: 54pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: justify; text-indent: 27pt; line-height: 1.25;">
              <div style="text-indent: 27pt; line-height: 1.25;">The SEC maintains an Internet site that contains reports, proxy and information statements, and other information regarding issuers, such as us, that file electronically with the SEC (<font style="font-style: italic;">http://www.sec.gov</font>). These SEC filings are also available to the public from commercial document retrieval services.</div>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">As a foreign private issuer, we are exempt from the rules under the Exchange Act prescribing the furnishing and content of proxy statements to shareholders and our
                officers, directors and principal shareholders are exempt from the &#8220;short-swing profits&#8221; reporting and liability provisions contained in Section 16 of the Exchange Act and related Exchange Act rules.</div>
            </div>
            <div style="text-indent: 54pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="INCORPORA1TIONOFCERTAINDOC"></a>INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">We file annual and special reports and other information with the SEC. These filings contain important information which does not appear in this prospectus. The SEC
                allows us to &#8220;incorporate by reference&#8221; information into this prospectus, which means that we can disclose important information to you by referring you to other documents which we have filed or will file with the SEC. We are incorporating
                by reference in this prospectus the documents listed below and all amendments or supplements we may file to such documents, as well as any future filings we may make with the SEC on Form 20-F under the Exchange Act before the time that all
                of the securities offered by this prospectus have been sold or de-registered:</div>
            </div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;&#160;</div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">
                      <div style="text-align: left; line-height: 1.25; font-family: 'Times New Roman', Times, serif;">the description of our Ordinary Shares contained in our Registration Statement on Form 20-F filed with the SEC on December 26, 2012;</div>
                    </div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">our Annual Report on Form 20-F for the fiscal year ended December 31, 2020, filed with the SEC on March 18, 2021; and</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">
                      <div style="line-height: 1.25; font-family: 'Times New Roman', Times, serif;">reports on Form 6-K filed on March 22, 2021,&#160;March 25, 2021, April 9, 2021, May 20, 2021, May 21, 2021, May 24, 2021, May 26, 2021 (two filings), May 27,
                        2021, June 7, 2021, June 9, 2021, June 10, 2021, June 17, 2021, June 21, 2021,&#160;June 28, 2021, July 13, 2021, July 19, 2021, July 20, 2021, July 22, 2021, and July 26, 2021 (in each case only to the extent provided in such Form 6-K).</div>
                    </div>
                  </td>
                </tr>

            </table>
            <div style="text-align: justify; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">In addition, all subsequent annual reports on Form 20-F filed prior to the termination of this offering, and any reports on Form 6-K subsequently submitted to the SEC
                or portions thereof that we specifically identify in such forms as being incorporated by reference into the registration statement of which this prospectus forms a part, shall be considered to be incorporated into this prospectus by
                reference and shall be considered a part of this prospectus from the date of filing or submission of such documents.</div>
            </div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;</div>
            <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
              <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">18</font></div>
              <div class="BRPFPageBreak" style="page-break-after: always;">
                <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="text-indent: 28.35pt; line-height: 1.25;">Certain statements in and portions of this prospectus update and replace information in the above-listed documents incorporated by reference. Likewise, statements in or portions of a
                    future document incorporated by reference in this prospectus may update and replace statements in and portions of this prospectus or the above-listed documents.</div>
                </div>
              </div>
            </div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">We will provide you without charge, upon your written or oral request, a copy of any of the documents incorporated by reference in this prospectus, other than exhibits
                to such documents which are not specifically incorporated by reference into such documents. Please direct your written or telephone requests to RedHill Biopharma Ltd., 21 Ha'arba'a Street, Tel Aviv 6473921, Israel, Attn: Dror Ben-Asher,
                telephone number: +972 (3) 541-3131. You may also obtain information about us by visiting our website at&#160;<font style="font-style: italic;">www.redhillbio.com</font>. Information contained in our website is included as an inactive textual
                reference only and is not part of this prospectus. The SEC maintains an Internet site, http://www.sec.gov, that contains reports, proxy and information statements, and other information regarding issuers that file electronically with the
                SEC.</div>
            </div>
            <div style="text-indent: 36pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="ENFORCEABILITYOFCIVILLIAB"></a>ENFORCEABILITY OF CIVIL LIABILITIES</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">We are incorporated under the laws of the State of Israel. Service of process upon us and upon our directors and officers and the Israeli experts named in this
                prospectus, substantially all of whom reside outside the United States, may be difficult to obtain within the United States. Furthermore, because substantially all of our assets and substantially all of our directors and officers are
                located outside the United States, any judgment obtained in the United States against us or any of our directors and officers may not be collectible within the United States.</div>
            </div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">
                <div style="line-height: 1.25;">
                  <div style="text-indent: 28.35pt; line-height: 1.25;">It may be difficult to assert U.S.&#160;securities law claims in original actions instituted in Israel. Israeli courts may refuse to hear a claim based on a violation of U.S.&#160;securities
                    laws because Israel is not the most appropriate forum to bring such a claim. In addition, even if an Israeli court agrees to hear a claim, it may determine that Israeli law and not U.S.&#160;law is applicable to the claim. If U.S.&#160;law is
                    found to be applicable, the content of applicable U.S.&#160;law must be proved as a fact which can be a time-consuming and costly process. Certain matters of the procedure will also be governed by Israeli law.</div>
                </div>
              </div>
            </div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">Subject to specified time limitations and legal procedures, Israeli courts may enforce a United States judgment in a civil matter which, subject to certain exceptions,
                is non-appealable, including judgments based upon the civil liability provisions of the Securities Act and the Exchange Act and including a monetary or compensatory judgment in a non-civil matter, provided that:</div>
            </div>
            <div style="line-height: 1.25;"><br style="line-height: 1.25;">
            </div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the judgments are obtained after due process before a court of competent jurisdiction, according to the laws of the state in which the judgment is given and the rules of private
                      international law currently prevailing in Israel;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the prevailing law of the foreign state in which the judgments were rendered allows the enforcement of judgments of Israeli courts (however, the Israeli courts may waive this
                      requirement following a request by the attorney general);</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">adequate service of process has been effected and the defendant has had a reasonable opportunity to be heard and to present his or her evidence;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the judgments are not contrary to public policy, and the enforcement of the civil liabilities set forth in the judgment does not impair the security or sovereignty of the State of
                      Israel;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the judgments were not obtained by fraud and do not conflict with any other valid judgment in the same matter between the same parties;</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">an action between the same parties in the same matter is not pending in any Israeli court at the time the lawsuit is instituted in the foreign court;&#160;and</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 4%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">&#160;</td>
                  <td style="width: 3.28%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">&#8226;</div>
                  </td>
                  <td style="width: 93.44%; vertical-align: top; font-family: 'Times New Roman',Times,serif;">
                    <div style="text-align: justify; line-height: 1.25;">the obligations under the judgment are enforceable according to the laws of the State of Israel and according to the law of the foreign state in which the relief was granted.</div>
                  </td>
                </tr>

            </table>
            <div style="text-align: justify; line-height: 1.25;">&#160;</div>
            <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
              <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">19</font></div>
              <div class="BRPFPageBreak" style="page-break-after: always;">
                <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
            </div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">We have irrevocably appointed RedHill Biopharma Inc. as our agent to receive service of process in any action against us in any United States federal or state court
                arising out of this offering or any purchase or sale of securities in connection with this offering.</div>
            </div>
            <div style="text-align: justify; text-indent: 35.3pt; line-height: 1.25;">&#160;</div>
            <div style="line-height: 1.25;">
              <div style="text-align: justify; text-indent: 28.35pt; line-height: 1.25;">If a foreign judgment is enforced by an Israeli court, it generally will be payable in Israeli currency, which can then be converted into non-Israeli currency and
                transferred out of Israel. The usual practice in an action before an Israeli court to recover an amount in a non-Israeli currency is for the Israeli court to issue a judgment for the equivalent amount in Israeli currency at the rate of
                exchange in force on the date of the judgment, but the judgment debtor may make payment in foreign currency. Pending collection, the amount of the judgment of an Israeli court stated in Israeli currency ordinarily will be linked to the
                Israeli consumer price index plus interest at the annual statutory rate set by Israeli regulations prevailing at the time. Judgment creditors must bear the risk of unfavorable exchange rates.</div>
            </div>
            <div style="text-align: justify; text-indent: 36pt; line-height: 1.25;">&#160;</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;"><a name="OFFERINGEXPENSES"></a>OFFERING EXPENSES</div>
            <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;</div>
            <div style="text-indent: 27pt; line-height: 1.25;">
              <div style="text-align: justify; text-indent: 27pt; line-height: 1.25;">The following table sets forth the expenses (other than underwriting discounts and commissions or agency fees and other items constituting underwriters&#8217; or agents&#8217;
                compensation, if any) expected to be incurred by us in connection with a possible offering of securities registered under this registration statement.</div>
            </div>
            <div style="text-indent: 35.3pt; line-height: 1.25;">&#160;</div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000; width: 100%;">

                <tr>
                  <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 88%;">
                    <div style="line-height: 1.25;">SEC registration fees</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
                  <td valign="bottom" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; width: 1%;">
                    <div style="line-height: 1.25;">$</div>
                  </td>
                  <td valign="bottom" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; text-align: right; width: 9%;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">13,066</div>
                    </div>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; width: 1%;">&#160;</td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; width: 88%;">
                    <div style="line-height: 1.25;">FINRA fees</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">
                    <div style="line-height: 1.25;">$</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;">-<br>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 88%;">
                    <div style="line-height: 1.25;">Legal fees and expenses</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
                  <td valign="bottom" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; width: 1%;">
                    <div style="line-height: 1.25;">$</div>
                  </td>
                  <td valign="bottom" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; text-align: right; width: 9%;">
                    <div style="line-height: 1.25;">*</div>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; width: 1%;">&#160;</td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; width: 88%;">
                    <div style="line-height: 1.25;">Accountants&#8217; fees and expenses</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">
                    <div style="line-height: 1.25;">$</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;">
                    <div style="line-height: 1.25;">*</div>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 88%;">
                    <div style="line-height: 1.25;">Miscellaneous</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
                  <td valign="bottom" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; width: 1%;">
                    <div style="line-height: 1.25;">$</div>
                  </td>
                  <td valign="bottom" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; text-align: right; width: 9%;">
                    <div style="line-height: 1.25;">*</div>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; width: 1%;">&#160;</td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; width: 88%;">
                    <div style="line-height: 1.25;">&#160;</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; text-align: right; width: 9%;">&#160;</td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="vertical-align: bottom; width: 1%;">&#160;</td>
                </tr>
                <tr>
                  <td valign="bottom" style="vertical-align: bottom; background-color: rgb(204, 238, 255); width: 88%;">
                    <div style="line-height: 1.25;">Total</div>
                  </td>
                  <td valign="bottom" colspan="1" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);">&#160;</td>
                  <td valign="bottom" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; width: 1%;">
                    <div style="line-height: 1.25;">$</div>
                  </td>
                  <td valign="bottom" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; text-align: right; width: 9%;">
                    <div style="line-height: 1.25;">*</div>
                  </td>
                  <td valign="bottom" nowrap="nowrap" colspan="1" style="background-color: rgb(204, 238, 255); vertical-align: bottom; width: 1%;">&#160;</td>
                </tr>

            </table>
            <div> <br>
            </div>
            <div style="line-height: 1.25;">___________________</div>
            <div style="text-align: justify; line-height: 1.25;">
              <div style="text-align: left; line-height: 1.25;">* These fees are calculated based on the securities offered and the number of issuances and accordingly cannot be estimated at this time.</div>
            </div>
            <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
              <div class="BRPFPageNumberArea" style="text-align: center;"><font class="BRPFPageNumber" style="color: #000000; font-weight: normal; font-style: normal;">20</font></div>
              <div class="BRPFPageBreak" style="page-break-after: always;">
                <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
            </div>
          </div>
          <br>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">21,775,000 Units Each Consisting of</div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">One American Depositary Share and One Warrant to Purchase One American Depositary Share</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">10,225,000 Pre-Funded Units Each Consisting of</div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">One Pre-Funded Warrant to Purchase One American Depositary Share and One Warrant to Purchase One American Depositary Share</div>
          <div style="text-align: center; line-height: 1.25;"><img width="362" height="214" src="image0.jpg"></div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">RedHill Biopharma Ltd.</div>
          <div style="text-align: center; line-height: 1.25;">___________________________________</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">PROSPECTUS SUPPLEMENT</div>
          <div style="text-align: center; line-height: 1.25;">___________________________________</div>
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          </div>
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">Aegis Capital Corp.</div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="text-align: center; line-height: 1.25;">December 2, 2022</div>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
