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Income taxes - Components of Deferred Tax Assets and Liabilities (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017
Income Tax Disclosure [Abstract] |  |
Net operating loss carryforwards | $ 14,120,607 | $ 12,411,425
Foreign research and development tax credit carryforwards | 2,628,190 | 2,832,340
Property and equipment | 463,343 | 482,161
Other | 19,695 | 13,627
Total deferred tax assets | 17,231,835 | 15,739,553
Valuation allowance | (17,231,835) | (15,739,553)
Net deferred tax assets | 0 | 0
Increases in valuation allowance | $ 1,500,000 | $ 131,147

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