XML 42 R31.htm IDEA: XBRL DOCUMENT
v3.10.0.1

Income taxes (Tables) | 12 Months Ended
--- | ---
Dec. 31, 2018
Income Tax Disclosure [Abstract] |
Schedule of Income (Loss) before Income Taxes | The components of loss before income taxes for the years ended December 31, 2018, 2017, and 2016, are presented below:
|  | 2018 |  | 2017 |  | 2016
Domestic |  | $ | (9,702,869 | ) |  | $ | (6,526,706 | ) |  | $ | (5,950,862 | )
Foreign |  | (679,190 | ) |  | (2,731,941 | ) |  | (2,519,799 | )
Loss before income taxes |  | $ | (10,382,059 | ) |  | $ | (9,258,647 | ) |  | $ | (8,470,661 | )
Schedule of Effective Income Tax Rate Reconciliation | Income taxes computed using the federal statutory income tax rate differs from the Company’s effective tax rate for the years ended December 31, 2018, 2017, and 2016, primarily due to the following:
|  | 2018 |  | 2017 |  | 2016
Income tax benefit |  | $ | (2,180,233 | ) |  | $ | (3,147,940 | ) |  | $ | (2,880,025 | )
State and provincial income tax, net of federal benefit |  | (534,789 | ) |  | (678,438 | ) |  | (604,354 | )
Permanent differences |  | 53,795 |  |  | (2,923 | ) |  | 234,247 |
US-Foreign rate differential |  | (13,955 | ) |  | 371,551 |  |  | 359,729 |
Other, net |  | 1,182,900 |  |  | (98,947 | ) |  | 73,220 |
Effect of tax reform |  | 0 |  |  | 3,687,844 |  |  | — |
|  | (1,492,282 | ) |  | 131,147 |  |  | (2,817,183 | )
Change in valuation allowance |  | 1,492,282 |  |  | (131,147 | ) |  | 2,817,183 |
Total income tax |  | $ | — |  |  | $ | — |  |  | $ | — |
Schedule of Deferred Tax Assets and Liabilities | Significant components of the Company’s deferred tax assets and liabilities are as follows:
|  | 2018 |  | 2017
Deferred tax assets: |  |  |  |
Net operating loss carryforwards |  | $ | 14,120,607 |  |  | $ | 12,411,425 |
Foreign research and development tax credit carryforwards |  | 2,628,190 |  |  | 2,832,340 |
Property and equipment |  | 463,343 |  |  | 482,161 |
Other |  | 19,695 |  |  | 13,627 |
Total deferred tax assets |  | $ | 17,231,835 |  |  | $ | 15,739,553 |
Valuation allowance |  | $ | (17,231,835 | ) |  | $ | (15,739,553 | )
Net deferred tax assets |  | $ | — |  |  | $ | — |

X
- References No definition available. + Details
Name: | us-gaap_IncomeTaxDisclosureAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319 + Details
Name: | us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | nonnum:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 + Details
Name: | us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | nonnum:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of income before income tax between domestic and foreign jurisdictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(h)(1)(i)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 + Details
Name: | us-gaap_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | nonnum:textBlockItemType
Balance Type: | na
Period Type: | duration