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Consolidated Statements of Changes in Stockholders' Equity (Deficit) - USD ($) | Total | Common Stock | Additional paid-in capital | Accumulated other comprehensive loss | Accumulated deficit
--- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2015 |  | 5,247,605 |  |  |
Beginning balance at Dec. 31, 2015 | $ (55,571) | $ 5,248 | $ 90,968,813 | $ (226,432) | $ (90,803,200)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |
Net loss | (8,470,661) |  |  |  | (8,470,661)
Other comprehensive income (loss) | (59,840) |  |  | (59,840) |
Conversion of debt and accrued interest to common stock (in shares) |  | 1,212,908 |  |  |
Conversion of debt and accrued interest to common stock | 10,395,833 | $ 1,213 | 10,394,620 |  |
Exercise of options for common stock (in shares) |  | 524 |  |  |
Share based compensation (in shares) |  | 2,899 |  |  |
Share based compensation | 218,294 | $ 3 | 218,291 |  |
Ending balance (in shares) at Dec. 31, 2016 |  | 6,463,936 |  |  |
Ending balance at Dec. 31, 2016 | 2,028,055 | $ 6,464 | 101,581,724 | (286,272) | (99,273,861)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |
Net loss | (9,258,647) |  |  |  | (9,258,647)
Other comprehensive income (loss) | 72,388 |  |  | 72,388 |
Exercise of options for common stock (in shares) |  | 8,334 |  |  |
Exercise of options for common stock | 27,502 | $ 8 | 27,494 |  |
Issuance of common stock, net of expenses (in shares) |  | 2,421,073 |  |  |
Issuance of common stock, net of expenses | 24,989,257 | $ 2,421 | 24,986,836 |  |
Share based compensation (in shares) |  | 1,751 |  |  |
Share based compensation | 122,134 | $ 2 | 122,132 |  |
Ending balance (in shares) at Dec. 31, 2017 |  | 8,895,094 |  |  |
Ending balance at Dec. 31, 2017 | 17,980,689 | $ 8,895 | 126,718,186 | (213,884) | (108,532,508)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |
Net loss | (10,382,059) |  |  |  | (10,382,059)
Other comprehensive income (loss) | $ (360,302) |  |  | (360,302) |
Issuance of common stock, net of expenses (in shares) | 2,500,285 | 3,692,307 |  |  |
Issuance of common stock, net of expenses | $ 10,616,046 | $ 3,692 | 10,612,354 |  |
Exercise of warrants for common stock, net of expenses including warrant inducement (in shares) |  | 2,500,285 |  |  |
Exercise of warrants for common stock, net of expenses including warrant inducement | 5,116,533 | $ 2,501 | 5,114,032 |  |
Share based compensation (in shares) |  | 11,151 |  |  |
Share based compensation | 263,396 | $ 11 | 263,385 |  |
Ending balance (in shares) at Dec. 31, 2018 |  | 15,098,837 |  |  |
Ending balance at Dec. 31, 2018 | $ 23,234,303 | $ 15,099 | $ 142,707,957 | $ (574,186) | $ (118,914,567)

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