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Consolidated Statements of Changes in Stockholders' Equity (Deficit) - USD ($)
Total
Common Stock
Additional paid-in capital
Accumulated other comprehensive loss
Accumulated deficit
Beginning balance (in shares) at Dec. 31, 2015   5,247,605      
Beginning balance at Dec. 31, 2015 $ (55,571) $ 5,248 $ 90,968,813 $ (226,432) $ (90,803,200)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (8,470,661)       (8,470,661)
Other comprehensive income (loss) (59,840)     (59,840)  
Conversion of debt and accrued interest to common stock (in shares)   1,212,908      
Conversion of debt and accrued interest to common stock 10,395,833 $ 1,213 10,394,620    
Exercise of options for common stock (in shares)   524      
Share based compensation (in shares)   2,899      
Share based compensation 218,294 $ 3 218,291    
Ending balance (in shares) at Dec. 31, 2016   6,463,936      
Ending balance at Dec. 31, 2016 2,028,055 $ 6,464 101,581,724 (286,272) (99,273,861)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (9,258,647)       (9,258,647)
Other comprehensive income (loss) 72,388     72,388  
Exercise of options for common stock (in shares)   8,334      
Exercise of options for common stock 27,502 $ 8 27,494    
Issuance of common stock, net of expenses (in shares)   2,421,073      
Issuance of common stock, net of expenses 24,989,257 $ 2,421 24,986,836    
Share based compensation (in shares)   1,751      
Share based compensation 122,134 $ 2 122,132    
Ending balance (in shares) at Dec. 31, 2017   8,895,094      
Ending balance at Dec. 31, 2017 17,980,689 $ 8,895 126,718,186 (213,884) (108,532,508)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss (10,382,059)       (10,382,059)
Other comprehensive income (loss) $ (360,302)     (360,302)  
Issuance of common stock, net of expenses (in shares) 2,500,285 3,692,307      
Issuance of common stock, net of expenses $ 10,616,046 $ 3,692 10,612,354    
Exercise of warrants for common stock, net of expenses including warrant inducement (in shares)   2,500,285      
Exercise of warrants for common stock, net of expenses including warrant inducement 5,116,533 $ 2,501 5,114,032    
Share based compensation (in shares)   11,151      
Share based compensation 263,396 $ 11 263,385    
Ending balance (in shares) at Dec. 31, 2018   15,098,837      
Ending balance at Dec. 31, 2018 $ 23,234,303 $ 15,099 $ 142,707,957 $ (574,186) $ (118,914,567)