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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2020
Income Taxes [Abstract] |
Components of Loss before Income Taxes | The components of loss before income taxes for the years ended December 31, 2020, 2019, and 2018, are presented below:
| 2020 |  | 2019 |  | 2018
Domestic | $ | (15,768,224) |  | $ | (12,950,725) |  | $ | (9,702,869)
Foreign |  | (631,761) |  |  | (276,917) |  |  | (679,190)
Loss before income taxes | $ | (16,399,985) |  | $ | (13,227,642) |  | $ | (10,382,059)
Schedule of Effective Income Tax Rate Reconciliation | Income taxes computed using the federal statutory income tax rate differs from the Company’s effective tax rate for the years ended December 31, 2020, 2019, and 2018, primarily due to the following:
| 2020 |  | 2019 |  | 2018
Income tax benefit | $ | (3,443,997) |  | $ | (2,777,805) |  | $ | (2,180,233)
State and provincial income tax, net of federal benefit |  | (732,994) |  |  | 397,081 |  |  | (534,789)
Permanent differences |  | 131,141 |  |  | 219,549 |  |  | 53,795
US-Foreign rate differential |  | (142,663) |  |  | 38,776 |  |  | (13,955)
Other, net |  | (145,973) |  |  | 866,250 |  |  | 1,182,900
| $ | (4,334,486) |  | $ | (1,256,149) |  | $ | (1,492,282)
Change in valuation allowance |  | 4,334,486 |  |  | 1,256,149 |  |  | 1,492,282
Total income tax | $ | — |  | $ | — |  | $ | —
Components of Deferred Tax Assets and Liabilities | Significant components of the Company’s deferred tax assets and liabilities are as follows:
|  | 2020 |  |  | 2019
Deferred tax assets: |  |  |  |  |
Net operating loss carryforwards | $ | 16,964,199 |  | $ | 12,251,892
Foreign research and development tax credit carryforwards |  | 2,679,180 |  |  | 2,564,679
Property and equipment |  | 56,697 |  |  | 429,764
Intangibles |  | 3,122,394 |  |  | 3,241,649
Total deferred tax assets | $ | 22,822,470 |  | $ | 18,487,984
Valuation allowance | $ | (22,822,470) |  | $ | (18,487,984)
Net deferred tax assets | $ | — |  | $ | —

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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319 + Details
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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 + Details
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