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Income Taxes (Details 2) (USD $)
12 Months Ended 3 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2012
Federal
Mar. 31, 2013
Federal
Subsequent event
Dec. 31, 2012
Research and development
Federal
Dec. 31, 2012
Research and development
California
Tax credit carryforwards              
Tax credit carryforwards with expiration           $ 4,600,000  
Tax credit carryforwards without expiration             4,400,000
Foreign tax credit carryforward that begin to expire in 2014       1,100,000      
Increase in tax credit carryforward         1,000,000    
Reconciliation of income taxes provided at the federal statutory rate (35%) to actual income tax provision (benefit)              
Federal statutory rate 35.00%            
Income tax benefit computed at U.S. statutory rate (9,626,000) 4,040,000 (8,054,000)        
Federal alternative minimum tax   247,000          
State income tax (net of federal benefit) 2,000 2,000 2,000        
Foreign income tax at rate different from U.S. statutory rate (13,000) (9,000) (90,000)        
Research and development credits (691,000) (1,254,000) (1,239,000)        
Foreign tax credit   (17,000) (21,000)        
Stock-based compensation 252,000 292,000 607,000        
Amortization of intangible assets (100,000) (657,000)          
Valuation allowance changes affecting tax provision 10,526,000 (2,363,000) 8,979,000        
Other (240,000) 7,000 (133,000)        
Total 110,000 288,000 51,000        
Domestic and foreign components of income (loss) before income tax provision (benefit)              
U.S. (27,737,000) 11,363,000 (23,499,000)        
Non-U.S. 233,000 181,000 488,000        
Income (loss) before income taxes $ (27,504,000) $ 11,544,000 $ (23,011,000)