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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $)
In Thousands, unless otherwise specified
 6 Months Ended
Jun. 30, 2013
Jun. 30, 2012
Cash flows from operating activities:    
Net loss $ (11,393) $ (13,768)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 402 498
Stock-based compensation 1,849 2,063
Amortization of intangible assets 500 1,246
Gain on sale of assets (630) (1,856)
Other non-cash items 5  
Changes in assets and liabilities:    
Accounts receivable 206 643
Prepaid expenses and other assets (226) 308
Deferred revenue (240) (69)
Accounts payable 27 (190)
Accrued expenses and other liabilities (1,961) (87)
Net cash used in operating activities (11,461) (11,212)
Cash flows from investing activities:    
Purchases of property and equipment (84) (40)
Net proceeds from sale of assets 630 2,187
Proceeds from sales and maturities of marketable securities 31,018 19,396
Purchases of marketable securities (43,671) (46,417)
Net cash used in investing activities (12,107) (24,874)
Cash flows from financing activities:    
Proceeds from issuance of common stock 1,321 1,569
Proceeds from sale of common stock, net of issuance costs 27,890  
Repurchase of common stock (Note 4)   (1,444)
Payments on capital lease obligations   (94)
Net cash provided by financing activities 29,211 31
Net increase (decrease) in cash and cash equivalents 5,643 (36,055)
Cash and cash equivalents at beginning of period 2,529 40,025
Cash and cash equivalents at end of period $ 8,172 $ 3,970