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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $)
In Thousands, unless otherwise specified
 9 Months Ended
Sep. 30, 2013
Sep. 30, 2012
Cash flows from operating activities:    
Net loss $ (18,338) $ (19,841)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 565 730
Stock-based compensation 2,800 2,991
Amortization of intangible assets 750 1,496
Gain on sale of assets (630) (3,291)
Other non-cash items 13 (27)
Changes in assets and liabilities:    
Accounts receivable 233 968
Prepaid expenses and other assets (368) 161
Deferred revenue (276) (257)
Accounts payable (198) (211)
Accrued expenses and other liabilities (2,268) (203)
Net cash used in operating activities (17,717) (17,484)
Cash flows from investing activities:    
Purchases of property and equipment (120) (257)
Net proceeds from sale of assets 630 3,437
Proceeds from sales and maturities of marketable securities 40,967 29,175
Purchases of marketable securities (53,885) (50,497)
Net cash used in investing activities (12,408) (18,142)
Cash flows from financing activities:    
Proceeds from issuance of common stock 2,024 3,146
Proceeds from sale of common stock, net of issuance costs 27,746  
Repurchase of common stock (Note 4)   (1,444)
Payments on capital lease obligations   (134)
Net cash provided by financing activities 29,770 1,568
Net decrease in cash and cash equivalents (355) (34,058)
Cash and cash equivalents at beginning of period 2,529 40,025
Cash and cash equivalents at end of period $ 2,174 $ 5,967