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Income Taxes (Details) (USD $)
 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Income tax provision, Current portion:      
Federal   $ (5,000) $ 247,000
State 2,000 3,000 3,000
Foreign 69,000 112,000 38,000
Total 71,000 110,000 288,000
Deferred tax assets:      
Federal and state loss carryforwards 39,455,000 30,977,000  
Reserves, accruals and other 372,000 341,000  
Depreciation and amortization 1,797,000 1,991,000  
Deferred stock-based compensation 3,793,000 3,319,000  
Research and development credit carryforwards 9,512,000 7,476,000  
Foreign tax and other credits 1,326,000 1,326,000  
Total deferred tax assets 56,255,000 45,430,000  
Deferred tax liabilities:      
Acquired intangible assets and other 1,618,000 1,652,000  
Less: Valuation allowance (54,637,000) (43,778,000)  
Increase in valuation allowance during the year 10,900,000 11,400,000  
Valuation allowance related to stock option deductions incurred prior to January 1, 2006, the benefit of which will be credited to additional paid-in capital if they become realized 1,800,000    
Federal
      
Net operating loss carryforwards      
Net operating loss carryforwards, amount 103,600,000    
Net operating loss related to excess tax benefits from stock-based compensation that will be charged to additional paid-in capital when realized 5,600,000    
State
      
Net operating loss carryforwards      
Net operating loss carryforwards, amount 94,300,000    
Net operating loss related to excess tax benefits from stock-based compensation that will be charged to additional paid-in capital when realized $ 4,800,000