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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) shares in Thousands, $ in Thousands | Common Stock | Additional Paid-In Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit | Total
--- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2012 | $ 401 | $ 157,143 | $ 11 | $ (93,013) | $ 64,542
Balance (in shares) at Dec. 31, 2012 | 40,054 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards | $ 13 | 4,211 |  |  | 4,224
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards (in shares) | 1,365 |  |  |  |
Issuance of common stock, net of costs of $2,154 and $1,632 at December 31, 2013 and 2015, respectively. | $ 75 | 27,671 |  |  | 27,746
Issuance of common stock, net of costs (in shares) | 7,475 |  |  |  |
Stock-based compensation |  | 3,698 |  |  | 3,698
Change in unrealized gain (loss) on available-for-sale investments |  |  | 2 |  | 2
Net loss |  |  |  | (24,794) | (24,794)
Balance at Dec. 31, 2013 | $ 489 | 192,723 | 13 | (117,807) | 75,418
Balance (in shares) at Dec. 31, 2013 | 48,894 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards | $ 9 | 2,227 |  |  | 2,236
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards (in shares) | 899 |  |  |  |
Stock-based compensation |  | 4,591 |  |  | 4,591
Change in unrealized gain (loss) on available-for-sale investments |  |  | (23) |  | (23)
Net loss |  |  |  | (32,682) | (32,682)
Balance at Dec. 31, 2014 | $ 498 | 199,541 | (10) | (150,489) | $ 49,540
Balance (in shares) at Dec. 31, 2014 | 49,793 |  |  |  | 49,793
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards | $ 13 | 1,759 |  |  | $ 1,772
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards (in shares) | 1,328 |  |  |  |
Issuance of common stock, net of costs of $2,154 and $1,632 at December 31, 2013 and 2015, respectively. | $ 144 | 21,224 |  |  | 21,368
Issuance of common stock, net of costs (in shares) | 14,375 |  |  |  |
Stock-based compensation |  | 3,650 |  |  | 3,650
Change in unrealized gain (loss) on available-for-sale investments |  |  | (6) |  | (6)
Net loss |  |  |  | (31,483) | (31,483)
Balance at Dec. 31, 2015 | $ 655 | $ 226,174 | $ (16) | $ (181,972) | $ 44,841
Balance (in shares) at Dec. 31, 2015 | 65,496 |  |  |  | 65,496

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