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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Net revenue
Product	$ 2,400	$ 2,280	$ 394
Royalty and other	1,990	3,100	4,004
Total net revenue	4,390	5,380	4,398
Cost of net revenue	2,474	2,318	474
Gross profit	1,916	3,062	3,924
Operating expenses
Research and development	27,108	29,261	23,325
Selling, general and administrative	6,299	6,519	6,161
Gain on sale of assets			(630)
Total operating expenses	33,407	35,780	28,856
Loss from operations	(31,491)	(32,718)	(24,932)
Other income, net	94	143	209
Loss before income taxes	(31,397)	(32,575)	(24,723)
Income tax provision	86	107	71
Net loss	(31,483)	(32,682)	(24,794)
Other comprehensive loss, net of tax:
Net unrealized gains (losses) on available-for-sale securities	(6)	(23)	2
Comprehensive loss	$ (31,489)	$ (32,705)	$ (24,792)
Net loss per share
Basic and diluted (in dollars per share)	$ (0.50)	$ (0.66)	$ (0.55)
Shares used in computing net loss per share
Basic and diluted (in shares)	62,497	49,528	45,246

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