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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
shares in Thousands, $ in Thousands
Common Stock
Additional Paid-In Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Total
Balance at Dec. 31, 2012 $ 401 $ 157,143 $ 11 $ (93,013) $ 64,542
Balance (in shares) at Dec. 31, 2012 40,054        
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards $ 13 4,211     4,224
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards (in shares) 1,365        
Issuance of common stock, net of costs of $2,154 and $1,632 at December 31, 2013 and 2015, respectively. $ 75 27,671     27,746
Issuance of common stock, net of costs (in shares) 7,475        
Stock-based compensation   3,698     3,698
Change in unrealized gain (loss) on available-for-sale investments     2   2
Net loss       (24,794) (24,794)
Balance at Dec. 31, 2013 $ 489 192,723 13 (117,807) 75,418
Balance (in shares) at Dec. 31, 2013 48,894        
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards $ 9 2,227     2,236
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards (in shares) 899        
Stock-based compensation   4,591     4,591
Change in unrealized gain (loss) on available-for-sale investments     (23)   (23)
Net loss       (32,682) (32,682)
Balance at Dec. 31, 2014 $ 498 199,541 (10) (150,489) $ 49,540
Balance (in shares) at Dec. 31, 2014 49,793       49,793
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards $ 13 1,759     $ 1,772
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards (in shares) 1,328        
Issuance of common stock, net of costs of $2,154 and $1,632 at December 31, 2013 and 2015, respectively. $ 144 21,224     21,368
Issuance of common stock, net of costs (in shares) 14,375        
Stock-based compensation   3,650     3,650
Change in unrealized gain (loss) on available-for-sale investments     (6)   (6)
Net loss       (31,483) (31,483)
Balance at Dec. 31, 2015 $ 655 $ 226,174 $ (16) $ (181,972) $ 44,841
Balance (in shares) at Dec. 31, 2015 65,496       65,496