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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Cash flows from operating activities:      
Net loss $ (31,483) $ (32,682) $ (24,794)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 607 449 679
Amortization of intangible assets 321 1,000 999
Stock-based compensation 3,650 4,591 3,698
Gain on sale of assets     (630)
Other non-cash items     7
Changes in assets and liabilities:      
Accounts receivable (552) (29) 139
Inventories (716) (314) (315)
Prepaid expenses and other assets 104 405 1
Accounts payable 261 (23) (125)
Accrued expenses and other liabilities 334 296 (2,304)
Net cash used in operating activities (27,474) (26,307) (22,645)
Cash flows from investing activities:      
Purchases of property and equipment (1,202) (596) (154)
Net proceeds from sale of assets     630
Proceeds from sales and maturities of marketable securities 44,953 39,270 49,267
Purchases of marketable securities (36,873) (15,859) (57,202)
Net cash provided by (used in) investing activities 6,878 22,815 (7,459)
Cash flows from financing activities:      
Proceeds from the sale of common stock, net of issuance costs 21,368   27,746
Net proceeds from issuance of common stock 1,772 2,238 4,193
Payments on capital lease obligations (14)    
Net cash provided by financing activities 23,126 2,238 31,939
Net increase (decrease) in cash and cash equivalents 2,530 (1,254) 1,835
Cash and cash equivalents at beginning of period 3,110 4,364 2,529
Cash and cash equivalents at end of period 5,640 3,110 4,364
Supplemental disclosure:      
Cash paid for income taxes $ 56 $ 111 $ 92