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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Cash flows from operating activities:    
Net loss $ (6,865) $ (7,965)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 291 145
Stock-based compensation 605 1,227
Amortization of intangible assets 28 237
Accrued interest 33  
Changes in assets and liabilities:    
Accounts receivable (69) 95
Inventories 129 (296)
Prepaid expenses and other assets (238) (102)
Accounts payable (721) (184)
Accrued expenses and other liabilities (411) (166)
Net cash used in operating activities (7,218) (7,009)
Cash flows from investing activities:    
Purchases of property and equipment (200) (121)
Proceeds from sales and maturities of marketable securities 12,429 11,579
Purchases of marketable securities (8,197) (22,552)
Net cash provided by (used in) investing activities 4,032 (11,094)
Cash flows from financing activities:    
Proceeds from the sale of common stock, net of issuance costs   21,479
Proceeds from issuance of common stock 197 534
Proceeds from the issuance of notes payable, net of issuance costs 7,879  
Payments on capital lease obligations (27)  
Net cash provided by financing activities 8,049 22,013
Net increase in cash and cash equivalents 4,863 3,910
Cash and cash equivalents at beginning of period 5,640 3,110
Cash and cash equivalents at end of period $ 10,503 $ 7,020