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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Cash flows from operating activities:    
Net loss $ (17,570) $ (24,976)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 780 466
Stock-based compensation 1,794 2,864
Amortization of intangible assets 83 293
Amortization of debt issuance costs 23  
Accrued interest 440  
Loss on disposal of assets 5  
Changes in assets and liabilities:    
Accounts receivable 103 (249)
Inventories 173 (383)
Prepaid expenses and other assets 343 (624)
Accounts payable (759) (238)
Accrued expenses and other liabilities (383) (275)
Net cash used in operating activities (14,968) (23,122)
Cash flows from investing activities:    
Purchases of property and equipment (646) (369)
Proceeds from sales and maturities of marketable securities 40,612 34,172
Purchases of marketable securities (28,749) (35,347)
Net cash provided by (used in) investing activities 11,217 (1,544)
Cash flows from financing activities:    
Proceeds from the sale of common stock, net of issuance costs   21,368
Net proceeds from issuance of common stock 363 1,773
Proceeds from the issuance of notes payable, net of issuance costs 7,879  
Payments on capital lease obligations (123)  
Net cash provided by financing activities 8,119 23,141
Net increase (decrease) in cash and cash equivalents 4,368 (1,525)
Cash and cash equivalents at beginning of period 5,640 3,110
Cash and cash equivalents at end of period 10,008 $ 1,585
Supplemental disclosure:    
Issuance of convertible notes in settlement of accrued interest $ 336