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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Net revenue |  |  |
Product | $ 4,604 | $ 2,400 | $ 2,280
Royalty and other | 1,420 | 1,990 | 3,100
Total net revenue | 6,024 | 4,390 | 5,380
Cost of net revenue | 3,075 | 2,474 | 2,318
Gross profit | 2,949 | 1,916 | 3,062
Operating expenses |  |  |
Research and development | 18,086 | 27,108 | 29,261
Selling, general and administrative | 5,693 | 6,299 | 6,519
Impairment of goodwill | 9,858 |  |
Restructuring charges | 676 |  |
Total operating expenses | 34,313 | 33,407 | 35,780
Loss from operations | (31,364) | (31,491) | (32,718)
Interest expense | 687 |  |
Other income, net | 48 | 94 | 143
Loss before income taxes | (32,003) | (31,397) | (32,575)
Income tax provision | 45 | 86 | 107
Net loss | (32,048) | (31,483) | (32,682)
Other comprehensive income (loss), net of tax: |  |  |
Net unrealized gains (losses) on available-for-sale securities | 16 | (6) | (23)
Comprehensive loss | $ (32,032) | $ (31,489) | $ (32,705)
Net loss per share |  |  |
Basic and diluted (in dollars per share) | $ (4.86) | $ (5.04) | $ (6.60)
Shares used in computing net loss per share |  |  |
Basic and diluted (in shares) | 6,601 | 6,249 | 4,952

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