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Income Taxes - Current/Deferred (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Income tax provision, Current portion:      
State $ 3 $ 3 $ 3
Foreign 42 83 104
Income tax provision 45 86 $ 107
Deferred tax assets:      
Federal and state loss carryforwards 68,829 60,831  
Reserves, accruals and other 519 761  
Depreciation and amortization 1,718 1,304  
Deferred stock-based compensation 4,287 4,504  
Research and development credit carryforwards 13,867 12,886  
Foreign tax and other credits 536 1,131  
Total deferred tax assets 89,756 81,417  
Deferred tax liabilities:      
Acquired intangible assets and other 328 1,781  
Less: Valuation allowance (89,428) (79,636)  
Net deferred tax assets 0 0  
Increase in valuation allowance during the year 9,800 $ 12,900  
Federal      
Net operating loss carryforwards      
Net operating loss carryforwards, amount 184,100    
Net operating loss related to excess tax benefits from stock-based compensation that will be charged to additional paid-in capital when realized 5,700    
State      
Net operating loss carryforwards      
Net operating loss carryforwards, amount 116,500    
Net operating loss related to excess tax benefits from stock-based compensation that will be charged to additional paid-in capital when realized $ 4,800