CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Net revenue
Product	$ 4,604	$ 2,400	$ 2,280
Royalty and other	1,420	1,990	3,100
Total net revenue	6,024	4,390	5,380
Cost of net revenue	3,075	2,474	2,318
Gross profit	2,949	1,916	3,062
Operating expenses
Research and development	18,086	27,108	29,261
Selling, general and administrative	5,693	6,299	6,519
Impairment of goodwill	9,858
Restructuring charges	676
Total operating expenses	34,313	33,407	35,780
Loss from operations	(31,364)	(31,491)	(32,718)
Interest expense	687
Other income, net	48	94	143
Loss before income taxes	(32,003)	(31,397)	(32,575)
Income tax provision	45	86	107
Net loss	(32,048)	(31,483)	(32,682)
Other comprehensive income (loss), net of tax:
Net unrealized gains (losses) on available-for-sale securities	16	(6)	(23)
Comprehensive loss	$ (32,032)	$ (31,489)	$ (32,705)
Net loss per share
Basic and diluted (in dollars per share)	$ (4.86)	$ (5.04)	$ (6.60)
Shares used in computing net loss per share
Basic and diluted (in shares)	6,601	6,249	4,952

Represents the amount of revenue earned during the period from the leasing or otherwise lending to a third party the entity's rights or title to certain property and revenues from the sale of other goods or rendering of other services, not elsewhere specified in the taxonomy; net of (reduced by) sales adjustments, returns, allowances, and discounts.

No definition available.