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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Cash flows from operating activities:      
Net loss $ (32,048) $ (31,483) $ (32,682)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 998 607 449
Stock-based compensation 2,155 3,650 4,591
Amortization of intangible assets 111 321 1,000
Impairment of goodwill 9,858    
Amortization of debt issuance costs 37    
Accrued interest 650    
Loss on disposal of assets 4    
Changes in assets and liabilities:      
Accounts receivable 170 (552) (29)
Inventories 146 (716) (314)
Prepaid expenses and other assets 459 104 405
Accounts payable (419) 261 (23)
Accrued expenses and other liabilities (64) 334 296
Net cash used in operating activities (17,943) (27,474) (26,307)
Cash flows from investing activities:      
Purchases of property and equipment (646) (1,202) (596)
Proceeds from sales and maturities of marketable securities 50,486 44,953 39,270
Purchases of marketable securities (36,874) (36,873) (15,859)
Net cash provided by investing activities 12,966 6,878 22,815
Cash flows from financing activities:      
Proceeds from the sale of common stock, net of issuance costs   21,368  
Net proceeds from issuance of common stock 364 1,772 2,238
Proceeds from the issuance of notes payable, net of issuance costs 7,877    
Payments on capital lease obligations (138) (14)  
Net cash provided by financing activities 8,103 23,126 2,238
Net increase (decrease) in cash and cash equivalents 3,126 2,530 (1,254)
Cash and cash equivalents at beginning of period 5,640 3,110 4,364
Cash and cash equivalents at end of period 8,766 5,640 3,110
Supplemental disclosure:      
Issuance of convertible notes in settlement of accrued interest 336    
Cash paid for income taxes $ 21 $ 56 $ 111