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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Cash flows from operating activities: |  |  |
Net loss | $ 32,000,000 | $ 31,500,000 | $ (32,682,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 998,000 | 607,000 | 449,000
Stock-based compensation | 2,155,000 | 3,650,000 | 4,591,000
Amortization of intangible assets | 111,000 | 321,000 | 1,000,000
Impairment of goodwill | 9,858,000 |  |
Amortization of debt issuance costs | 37,000 |  |
Accrued interest | 650,000 |  |
Loss on disposal of assets | 4,000 |  |
Changes in assets and liabilities: |  |  |
Accounts receivable | 170,000 | (552,000) | (29,000)
Inventories | 146,000 | (716,000) | (314,000)
Prepaid expenses and other assets | 459,000 | 104,000 | 405,000
Accounts payable | (419,000) | 261,000 | (23,000)
Accrued expenses and other liabilities | (64,000) | 334,000 | 296,000
Net cash used in operating activities | (17,943,000) | (27,474,000) | (26,307,000)
Cash flows from investing activities: |  |  |
Purchases of property and equipment | (646,000) | (1,202,000) | (596,000)
Proceeds from sales and maturities of marketable securities | 50,486,000 | 44,953,000 | 39,270,000
Purchases of marketable securities | (36,874,000) | (36,873,000) | (15,859,000)
Net cash provided by investing activities | 12,966,000 | 6,878,000 | 22,815,000
Cash flows from financing activities: |  |  |
Proceeds from the sale of common stock, net of issuance costs |  | 21,368,000 |
Net proceeds from issuance of common stock | 364,000 | 1,772,000 | 2,238,000
Proceeds from the issuance of notes payable, net of issuance costs | 7,877,000 |  |
Payments on capital lease obligations | (138,000) | (14,000) |
Net cash provided by financing activities | 8,103,000 | 23,126,000 | 2,238,000
Net increase (decrease) in cash and cash equivalents | 3,126,000 | 2,530,000 | (1,254,000)
Cash and cash equivalents at beginning of period | 5,640,000 | 3,110,000 | 4,364,000
Cash and cash equivalents at end of period | 8,766,000 | 5,640,000 | 3,110,000
Supplemental disclosure: |  |  |
Issuance of convertible notes in settlement of accrued interest | 336,000 |  |
Cash paid for income taxes | $ 21,000 | $ 56,000 | $ 111,000

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