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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) shares in Thousands, $ in Thousands | Common Stock | Additional Paid-In Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit | Total
--- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2013 | $ 5 | $ 193,207 | $ 13 | $ (117,807) | $ 75,418
Balance (in shares) at Dec. 31, 2013 | 4,889 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards |  | 2,236 |  |  | 2,236
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards (in shares) | 90 |  |  |  |
Stock-based compensation |  | 4,591 |  |  | 4,591
Change in unrealized gain (loss) on available-for-sale investments |  |  | (23) |  | (23)
Net loss |  |  |  | (32,682) | (32,682)
Balance at Dec. 31, 2014 | $ 5 | 200,034 | (10) | (150,489) | 49,540
Balance (in shares) at Dec. 31, 2014 | 4,979 |  |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards |  | 1,772 |  |  | 1,772
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards (in shares) | 133 |  |  |  |
Issuance of common stock, net of costs of $1,632 | $ 2 | 21,366 |  |  | 21,368
Number of shares of common stock issued in equity and public offering | 1,437 |  |  |  |
Stock-based compensation |  | 3,650 |  |  | 3,650
Change in unrealized gain (loss) on available-for-sale investments |  |  | (6) |  | (6)
Net loss |  |  |  | (31,483) | 31,500
Balance at Dec. 31, 2015 | $ 7 | 226,822 | (16) | (181,972) | $ 44,841
Balance (in shares) at Dec. 31, 2015 | 6,549 |  |  |  | 6,549
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards |  | 364 |  |  | $ 364
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards (in shares) | 81 |  |  |  |
Stock-based compensation |  | 2,155 |  |  | 2,155
Change in unrealized gain (loss) on available-for-sale investments |  |  | $ 16 |  | 16
Net loss |  |  |  | (32,048) | 32,000
Balance at Dec. 31, 2016 | $ 7 | $ 229,341 |  | $ (214,020) | $ 15,328
Balance (in shares) at Dec. 31, 2016 | 6,630 |  |  |  | 6,630
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Net loss |  |  |  |  | $ (10,142)
Balance at Sep. 30, 2017 |  |  |  |  | $ 7,727
Balance (in shares) at Sep. 30, 2017 |  |  |  |  | 8,068

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