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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) shares in Thousands, $ in Thousands | Total | Common Stock | Additional Paid-In Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2015 | $ 44,841 | $ 7 | $ 226,822 | $ (16) | $ (181,972)
Balance (in shares) at Dec. 31, 2015 |  | 6,549 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards | 364 |  | 364 |  |
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards (in shares) |  | 81 |  |  |
Stock-based compensation | 2,155 |  | 2,155 |  |
Change in unrealized loss on available- for-sale investments | 16 |  |  | $ 16 |
Net loss | (32,048) |  |  |  | (32,048)
Balance at Dec. 31, 2016 | 15,328 | $ 7 | 229,341 |  | (214,020)
Balance (in shares) at Dec. 31, 2016 |  | 6,630 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards | (20) |  | (20) |  |
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards (in shares) |  | 113 |  |  |
Issuance of common stock, net of issuance costs | 1,987 | $ 1 | 1,986 |  |
Issuance of common stock, net of issuance costs (in shares) |  | 1,325 |  |  |
Stock-based compensation | 719 |  | 719 |  |
Net loss | (10,668) |  |  |  | (10,668)
Balance at Dec. 31, 2017 | $ 7,346 | $ 8 | 232,026 |  | (224,688)
Balance (in shares) at Dec. 31, 2017 | 8,068 | 8,068 |  |  |
Increase (Decrease) in Stockholders' Equity |  |  |  |  |
Cumulative effect of accounting change | $ 230 |  |  |  | 230
Issuance of common stock and warrants, net of issuance costs | 10,362 | $ 35 | 10,327 |  |
Issuance of common stock and warrants, net of issuance costs (in shares) |  | 34,600 |  |  |
Issuance of common stock for exercise of options and release of awards | (46) |  | (46) |  |
Issuance of common stock for exercise of options release of awards (in shares) |  | 299 |  |  |
Stock-based compensation | 674 |  | 674 |  |
Net loss | (11,409) |  |  |  | (11,409)
Balance at Dec. 31, 2018 | $ 7,157 | $ 43 | $ 242,981 |  | $ (235,867)
Balance (in shares) at Dec. 31, 2018 | 42,967 | 42,967 |  |  |

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