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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
shares in Thousands, $ in Thousands
Total
Common Stock
Additional Paid-In Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Balance at Dec. 31, 2015 $ 44,841 $ 7 $ 226,822 $ (16) $ (181,972)
Balance (in shares) at Dec. 31, 2015   6,549      
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards 364   364    
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards (in shares)   81      
Stock-based compensation 2,155   2,155    
Change in unrealized loss on available- for-sale investments 16     $ 16  
Net loss (32,048)       (32,048)
Balance at Dec. 31, 2016 15,328 $ 7 229,341   (214,020)
Balance (in shares) at Dec. 31, 2016   6,630      
Increase (Decrease) in Stockholders' Equity          
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards (20)   (20)    
Issuance of common stock for exercise of options, employee stock purchase plan and release of awards (in shares)   113      
Issuance of common stock, net of issuance costs 1,987 $ 1 1,986    
Issuance of common stock, net of issuance costs (in shares)   1,325      
Stock-based compensation 719   719    
Net loss (10,668)       (10,668)
Balance at Dec. 31, 2017 $ 7,346 $ 8 232,026   (224,688)
Balance (in shares) at Dec. 31, 2017 8,068 8,068      
Increase (Decrease) in Stockholders' Equity          
Cumulative effect of accounting change $ 230       230
Issuance of common stock and warrants, net of issuance costs 10,362 $ 35 10,327    
Issuance of common stock and warrants, net of issuance costs (in shares)   34,600      
Issuance of common stock for exercise of options and release of awards (46)   (46)    
Issuance of common stock for exercise of options release of awards (in shares)   299      
Stock-based compensation 674   674    
Net loss (11,409)       (11,409)
Balance at Dec. 31, 2018 $ 7,157 $ 43 $ 242,981   $ (235,867)
Balance (in shares) at Dec. 31, 2018 42,967 42,967