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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) shares in Thousands | Total | Common Stock | Additional Paid-In Capital | Accumulated Deficit
--- | --- | --- | --- | ---
Beginning Balance at Dec. 31, 2018 | $ 7,157,000 | $ 2,000 | $ 243,022,000 | $ (235,867,000)
Beginning Balance, shares at Dec. 31, 2018 |  | 2,148 |  |
Issuance of common stock under stock plans, net | (4,000) |  | (4,000) |
Issuance of common stock under stock plans, net, shares |  | 31 |  |
Stock-based compensation | 263,000 |  | 263,000 |
Net loss | (2,580,000) |  |  | (2,580,000)
Ending Balance at Dec. 31, 2019 | $ 4,836,000 | $ 2,000 | 243,281,000 | (238,447,000)
Ending Balance, shares at Dec. 31, 2019 | 2,179 | 2,179 |  |
Issuance of common stock under stock plans, net | $ (2,000) |  | (2,000) |
Issuance of common stock under stock plans, net, shares |  | 41 |  |
Exercise of pre-funded warrants | 2,000 |  | 2,000 |
Exercise of pre-funded warrants, shares |  | 116 |  |
Sale of common stock, net of financing | 1,619,000 | $ 1,000 | 1,618,000 |
Sale of common stock, net of financing, shares |  | 1,218 |  |
Deemed dividend for warrant exercise price adjustment | 392,000 |  | 392,000 | (392,000)
Stock-based compensation | 257,000 |  | 257,000 |
Net loss | (3,780,000) |  |  | (3,780,000)
Ending Balance at Dec. 31, 2020 | $ 2,932,000 | $ 3,000 | $ 245,548,000 | $ (242,619,000)
Ending Balance, shares at Dec. 31, 2020 | 3,554 | 3,554 |  |

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