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CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
Total
Common Stock
Additional Paid-In Capital
Accumulated Other Comprehensive Loss
Accumulated Deficit
Beginning Balance at Dec. 31, 2019 $ 4,836,000 $ 2,000 $ 243,281,000   $ (238,447,000)
Beginning Balance, shares at Dec. 31, 2019   2,179,000      
Issuance of common stock for release of awards (1,000)   (1,000)    
Issuance of common stock for release of awards, shares   20,000      
Exercise of pre-funded warrants 2,000   2,000    
Exercise of pre-funded warrants, shares   116,000      
Stock-based compensation 68,000   68,000    
Net loss (1,405,000)       (1,405,000)
Ending Balance at Mar. 31, 2020 3,500,000 $ 2,000 243,350,000   (239,852,000)
Ending Balance, shares at Mar. 31, 2020   2,315,000      
Beginning Balance at Dec. 31, 2019 4,836,000 $ 2,000 243,281,000   (238,447,000)
Beginning Balance, shares at Dec. 31, 2019   2,179,000      
Deemed dividend for warrant exercise price adjustment 392,000        
Net loss (2,751,000)        
Ending Balance at Sep. 30, 2020 3,901,000 $ 3,000 245,488,000   (241,590,000)
Ending Balance, shares at Sep. 30, 2020   3,553,000      
Beginning Balance at Mar. 31, 2020 3,500,000 $ 2,000 243,350,000   (239,852,000)
Beginning Balance, shares at Mar. 31, 2020   2,315,000      
Issuance of common stock for release of awards, shares   1,000      
Sale of common stock, net of placement costs 1,619,000 $ 1,000 1,618,000    
Sale of common stock, net of placement costs,shares   1,218,000      
Deemed dividend for warrant exercise price adjustment     392,000   (392,000)
Stock-based compensation 66,000   66,000    
Net loss (639,000)       (639,000)
Ending Balance at Jun. 30, 2020 4,546,000 $ 3,000 245,426,000   (240,883,000)
Ending Balance, shares at Jun. 30, 2020   3,534,000      
Issuance of common stock for release of awards (1,000)   (1,000)    
Issuance of common stock for release of awards, shares   19,000      
Stock-based compensation 63,000   63,000    
Net loss (707,000)       (707,000)
Ending Balance at Sep. 30, 2020 3,901,000 $ 3,000 245,488,000   (241,590,000)
Ending Balance, shares at Sep. 30, 2020   3,553,000      
Beginning Balance at Dec. 31, 2020 $ 2,932,000 $ 3,000 245,548,000   (242,619,000)
Beginning Balance, shares at Dec. 31, 2020 3,554,000 3,554,000      
Issuance of common stock under stock plan, net $ (2,000)   (2,000)    
Issuance of common stock under stock plan, net, shares   16,000      
Exercise of warrants 2,478,000 $ 1,000 2,477,000    
Exercise of warrants, shares   1,033,000      
Issuance of common stock for payment of accrued interest 140,000   140,000    
Issuance of common stock for payment of accrued interest,shares   43,000      
Sale of common stock, net of placement costs 6,817,000 $ 2,000 6,815,000    
Sale of common stock, net of placement costs,shares   1,488,000      
Stock-based compensation 68,000   68,000    
Unrealized loss on available-for-sale investments (1,000)     $ (1,000)  
Net loss (1,369,000)       (1,369,000)
Ending Balance at Mar. 31, 2021 11,063,000 $ 6,000 255,046,000 (1,000) (243,988,000)
Ending Balance, shares at Mar. 31, 2021   6,134,000      
Beginning Balance at Dec. 31, 2020 $ 2,932,000 $ 3,000 245,548,000   (242,619,000)
Beginning Balance, shares at Dec. 31, 2020 3,554,000 3,554,000      
Sale of common stock, net of placement costs $ 139,964        
Sale of common stock, net of placement costs,shares 42,672        
Unrealized loss on available-for-sale investments $ (6,000)        
Net loss (4,288,000)        
Ending Balance at Sep. 30, 2021 $ 22,063,000 $ 9,000 268,967,000 (6,000) (246,907,000)
Ending Balance, shares at Sep. 30, 2021 8,686,000 8,686,000      
Beginning Balance at Mar. 31, 2021 $ 11,063,000 $ 6,000 255,046,000 (1,000) (243,988,000)
Beginning Balance, shares at Mar. 31, 2021   6,134,000      
Issuance of common stock under stock plan, net, shares   2,000      
Exercise of warrants 1,696,000 $ 1,000 1,695,000    
Exercise of warrants, shares   706,000      
Sale of common stock, net of placement costs 11,969,000 $ 1,000 11,968,000    
Sale of common stock, net of placement costs,shares   1,818,000      
Stock-based compensation 97,000   97,000    
Unrealized loss on available-for-sale investments (3,000)     (3,000)  
Net loss (1,205,000)       (1,205,000)
Ending Balance at Jun. 30, 2021 23,617,000 $ 8,000 268,806,000 (4,000) (245,193,000)
Ending Balance, shares at Jun. 30, 2021   8,660,000      
Issuance of common stock under stock plan, net (3,000)   (3,000)    
Issuance of common stock under stock plan, net, shares   20,000      
Exercise of warrants 15,000 $ 1,000 14,000    
Exercise of warrants, shares   6,000      
Stock-based compensation 150,000   150,000    
Unrealized loss on available-for-sale investments (2,000)     (2,000)  
Net loss (1,714,000)       (1,714,000)
Ending Balance at Sep. 30, 2021 $ 22,063,000 $ 9,000 $ 268,967,000 $ (6,000) $ (246,907,000)
Ending Balance, shares at Sep. 30, 2021 8,686,000 8,686,000