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JOINT VENTURE FOR DEVELOPMENT OF APO E MIMETIC PEPTIDE MOLECULE AEM-28 AND ANALOGS (Details Textual) - USD ($) |  |  |  | 1 Months Ended | 12 Months Ended | 77 Months Ended |
--- | --- | --- | --- | --- | --- | --- | ---
Aug. 11, 2017 | Jul. 14, 2017 | Aug. 03, 2012 | Jan. 01, 2019 | Apr. 30, 2018 | Oct. 27, 2017 | Aug. 31, 2017 | Aug. 25, 2016 | Jun. 01, 2016 | Mar. 31, 2016 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2018 | Jan. 30, 2018
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Investments in and Advance to Affiliates, Subsidiaries, Associates, and Joint Ventures |  |  | $ 6,000,000 |  |  |  |  |  |  |  | $ 6,000,000 |  |  | $ 6,000,000 |
Joint Venture Investments In Voting Common Ownership Units (in shares) |  |  | 600,000 |  |  |  |  |  |  |  |  |  |  |  |
Joint Venture Investments In Non Voting Preferred Ownership Units |  |  | 5,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Development Activities Monthly Fee |  |  | $ 63,000 |  |  |  |  |  |  |  |  |  |  |  |
Joint Venture, Operating Expenses, Inter Company Transactions |  |  |  |  |  |  |  |  |  |  | 53,000 |  |  | 9,598,000 |
Joint Venture, Operating Expenses Allocated To Company |  |  |  |  |  |  |  |  |  |  |  |  |  | 7,985,000 |
Percentage Of Non Royalty Income |  |  | 5.00% |  |  |  |  |  |  |  |  |  |  |  |
Long-term Line of Credit |  |  |  |  |  |  |  |  |  |  | 1,720,000 |  |  | $ 1,720,000 |
Conversion of Stock, Shares Converted | 3,500,000 |  |  |  |  |  |  |  |  | 1,500,000 |  |  |  |  |
Conversion of Stock, Shares Issued |  |  |  |  |  |  |  |  |  | 120,000 |  |  |  |  |
Joint Venture Method Investment Ownership Percentage |  |  | 60.00% |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Preferred Stock and Preference Stock |  |  |  |  |  |  |  |  |  |  | $ 0 | $ (15,000) | $ 946,000 |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  |  |  |  |  |  |  | 33,088 |  |  | 6,321,930 |  |  | 6,321,930 |
Class of Warrant or Right, Exercise Price of Warrants or Rights |  |  |  |  |  |  |  | $ 10.70 |  |  |  |  |  |  | $ 0.075
Management Fees |  |  |  |  | $ 50,000 |  |  |  | $ 80,000 |  |  |  |  |  |
Professional Fees |  |  |  |  |  |  |  |  | $ 10,000 |  |  |  |  |  |
Operating Expenses Net Of Elimination Of Intercompany Transactions |  |  |  |  |  |  |  |  |  |  | $ 53,000 |  |  |  |
Conversion of Stock, Amount Converted | $ 3,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Amount Issued | $ 1,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Interest Payable |  |  |  |  |  |  |  |  |  |  | 213,000 | 68,000 |  | $ 213,000 |
Other Assets, Current |  |  |  |  |  |  |  |  |  |  | $ 97,000 | $ 98,000 |  | $ 97,000 |
Accrued Professional Fees |  |  |  |  |  |  | $ 20,000 |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant |  |  |  |  |  |  |  |  |  |  | 83,480 |  |  | 83,480 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  |  |  | 14,126 |  |  |  |  | 0 | 0 |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price |  |  |  |  |  | $ 10.70 |  |  |  |  |  | $ 0.37 |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage |  |  |  |  |  |  |  |  |  |  | 50.00% |  |  |  |
Payment for Management Fee |  |  |  | $ 50,000 |  |  |  |  |  |  |  |  |  |  |
Mr Holliman [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period |  |  |  |  |  |  |  |  |  |  | 5 years |  |  |  |
Ownership As Converted [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Joint Venture Method Investment Ownership Percentage |  |  |  |  |  |  |  |  |  |  | 65.11% |  |  |  |
Ownership As Converted Including Options And Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Joint Venture Method Investment Ownership Percentage |  |  |  |  |  | 64.31% |  |  |  |  |  |  |  |  |
Series B1 Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds From Issuance Of Preferred Stock Before Adjusted Stock Issuance Costs |  |  |  |  |  |  |  | $ 1,012,000 |  |  |  |  |  |  |
Proceeds from Issuance of Preferred Stock and Preference Stock |  |  |  |  |  |  |  | 946,000 |  |  |  |  |  |  |
Payments of Stock Issuance Costs |  |  |  |  |  |  |  | $ 66,000 |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues |  |  |  |  |  |  |  | 94,537 |  |  |  |  |  |  |
Management Fees |  |  |  |  |  |  | $ 300,000 |  |  |  |  |  | 300,000 |  |
Professional Fees |  |  |  |  |  |  |  |  |  |  |  |  | 60,000 |  |
Management Fee Expense |  |  |  |  |  |  |  |  |  |  | $ 150,000 | $ 150,000 | 250,000 |  |
Other Assets, Current |  |  |  |  |  |  |  |  |  |  |  |  | $ 50,000 |  |
Accrued Professional Fees |  |  |  |  |  |  |  |  |  |  | $ 340,000 |  |  | $ 340,000 |
Series B2 Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs |  | $ 287,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Acquisitions | 93,458 |  |  |  |  |  | 93,458 | 93,458 |  |  |  |  |  |  |
Stock Issued During Period, Value, Acquisitions | $ 1,000,000 |  |  |  |  |  | $ 1,000,000 | $ 1,000,000 |  |  |  |  |  |  |
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs | $ 15,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Series B Preferred Stock [Member] | Preferred Stock And Warrant Purchase Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Dividend Rate, Percentage |  |  |  |  |  |  |  | 5.00% |  |  |  |  |  |  |
Series B1 And B2 Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Joint Venture Method Investment Ownership Percentage |  |  | 62.20% |  |  |  |  |  |  |  |  |  |  |  |
Series A Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Joint Venture Method Investment Ownership Percentage |  |  | 69.75% |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock [Member] | Ownership As Converted [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Noncontrolling Interest, Ownership Percentage by Parent |  |  |  |  |  |  |  |  |  |  | 100.00% |  |  | 100.00% |
Noncontrolling Interest [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Noncash or Part Noncash Acquisition, Other Liabilities Assumed |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 667,000 |
Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Joint Venture Method Investment Ownership Percentage |  |  |  |  |  |  |  |  |  | 64.00% |  |  |  |  |
Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Joint Venture Method Investment Ownership Percentage |  |  |  |  |  |  |  |  |  | 60.00% |  |  |  |  |
Exclusive License Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage Of Royalty Payment |  |  |  |  |  |  |  | 3.00% |  |  |  |  |  |  |
Annual Maintenance Payments |  |  |  |  |  |  |  | $ 25,000 |  |  |  |  |  |  |
Exclusive License Agreement [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payments |  |  |  |  |  |  |  | 500,000 |  |  |  |  |  |  |
Royalty Expense |  |  | $ 1,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Exclusive License Agreement [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payments |  |  |  |  |  |  |  | $ 50,000 |  |  |  |  |  |  |
Royalty Expense |  |  | $ 500,000 |  |  |  |  |  |  |  |  |  |  |  |
Lipimetix [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Joint Venture Investments Common Ownership Units, Co-venture (in shares) |  |  | 400,000 |  |  |  |  |  |  |  |  |  |  |  |
Ownership Percentage Co-venture |  |  | 40.00% |  |  |  |  |  |  |  |  |  |  |  |
Noncash or Part Noncash Acquisition, Other Liabilities Assumed |  |  |  |  |  |  |  |  |  |  | $ 667,000 |  |  |  |
Noncash or Part Noncash Acquisition, Net Nonmonetary Assets Acquired (Liabilities Assumed) |  |  | $ 378,000 |  |  |  |  |  |  |  | $ 378,000 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  |  |  |  |  |  |  |  | 81,479 |  |  |  |
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price |  |  |  |  |  |  |  |  |  |  | $ 1.07 |  |  |  |
Voting Common Ownership Units [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Investments in and Advance to Affiliates, Subsidiaries, Associates, and Joint Ventures |  |  | 1,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Non Voting Preferred Ownership Units [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Investments in and Advance to Affiliates, Subsidiaries, Associates, and Joint Ventures |  |  | $ 5,000,000 |  |  |  |  |  |  |  |  |  |  |  |

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