<SEC-DOCUMENT>0001193125-17-298083-index.html : 20170929
<SEC-HEADER>0001193125-17-298083.hdr.sgml : 20170929
<ACCEPTANCE-DATETIME>20170928184356
ACCESSION NUMBER:		0001193125-17-298083
CONFORMED SUBMISSION TYPE:	424B4
PUBLIC DOCUMENT COUNT:		19
FILED AS OF DATE:		20170929
DATE AS OF CHANGE:		20170928

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NuCana plc
		CENTRAL INDEX KEY:			0001709626
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B4
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-220321
		FILM NUMBER:		171108666

	BUSINESS ADDRESS:	
		STREET 1:		3 LOCHSIDE WAY
		CITY:			EDINBURGH
		STATE:			X0
		ZIP:			EH12 9DT
		BUSINESS PHONE:		44-0-131-248-3660

	MAIL ADDRESS:	
		STREET 1:		3 LOCHSIDE WAY
		CITY:			EDINBURGH
		STATE:			X0
		ZIP:			EH12 9DT

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NuCana BioMed Ltd
		DATE OF NAME CHANGE:	20170619
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B4
<SEQUENCE>1
<FILENAME>d393013d424b4.htm
<DESCRIPTION>424B4
<TEXT>
Document 1 - file: d393013d424b4.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>g393013g18b14.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: g393013g18b14.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>g393013g22k80.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: g393013g22k80.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>g393013g22t34.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: g393013g22t34.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>g393013g29a71.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: g393013g29a71.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>g393013g30u61.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 6 - file: g393013g30u61.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>g393013g32d01.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 7 - file: g393013g32d01.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>8
<FILENAME>g393013g36d58.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 8 - file: g393013g36d58.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>9
<FILENAME>g393013g36w38.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 9 - file: g393013g36w38.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>10
<FILENAME>g393013g38x85.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 10 - file: g393013g38x85.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>11
<FILENAME>g393013g40y33.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 11 - file: g393013g40y33.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>12
<FILENAME>g393013g49h81.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 12 - file: g393013g49h81.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>13
<FILENAME>g393013g61t74.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 13 - file: g393013g61t74.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>14
<FILENAME>g393013g62y23.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 14 - file: g393013g62y23.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>15
<FILENAME>g393013g63b14.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 15 - file: g393013g63b14.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>16
<FILENAME>g393013g68e09.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 16 - file: g393013g68e09.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>17
<FILENAME>g393013g77v72.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 17 - file: g393013g77v72.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>18
<FILENAME>g393013g80f34.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 18 - file: g393013g80f34.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>19
<FILENAME>g393013g86p18.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 19 - file: g393013g86p18.jpg

</DOCUMENT>
</SEC-DOCUMENT>