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Significant Accounting Policies - Additional Information (Detail) £ in Thousands | 12 Months Ended |  |  |
--- | --- | --- | --- | ---
Dec. 31, 2020 GBP (£) Segment | Dec. 31, 2019 GBP (£) | Dec. 31, 2018 GBP (£) | Dec. 31, 2017 GBP (£)
Disclosure Of Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Cash and cash equivalents | £ 87,356 | £ 51,962 | £ 76,972 | £ 86,703
Accrued clinical trial expenses | 3,500 | 1,700 |  |
Prepayments for clinical trial expenses | 2,200 | 2,600 |  |
Accrued contracted manufacturing expense | £ 100 | £ 200 |  |
Number of operating segment | Segment | 1 |  |  |
Cash at banks maturity period | Less than three months |  |  |
Right of Use Assets [member] |  |  |  |
Disclosure Of Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Depreciation method | Straight-line |  |  |
Maximum [member] |  |  |  |
Disclosure Of Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Income tax credit, cash rebate percentage | 33.35% |  |  |
Maximum [member] | Right of Use Assets [member] |  |  |  |
Disclosure Of Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Depreciation rate | 5 years |  |  |
Bottom Of Range [Member] | Right of Use Assets [member] |  |  |  |
Disclosure Of Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Depreciation rate | 2 years |  |  |
Patents [member] |  |  |  |
Disclosure Of Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Amortization rate | 20 years |  |  |

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- Definition The amount of cash on hand and demand deposits, along with short-term, highly liquid investments that are readily convertible to known amounts of cash and that are subject to an insignificant risk of changes in value. [Refer: Cash; Cash equivalents] + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Name IAS -Number 7 -IssueDate 2020-01-01 -Paragraph 45 -URI http://eifrs.ifrs.org/eifrs/xifrs-link?type=IAS&num=7&code=ifrs-tx-2020-en-r&anchor=para_45&doctype=Standard -URIDate 2020-01-01 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Name IFRS -Number 12 -IssueDate 2020-01-01 -Paragraph B13 -Subparagraph a -URI http://eifrs.ifrs.org/eifrs/xifrs-link?type=IFRS&num=12&code=ifrs-tx-2020-en-r&anchor=para_B13_a&doctype=Appendix&subtype=B -URIDate 2020-01-01 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Name IAS -Number 1 -IssueDate 2020-01-01 -Paragraph 54 -Subparagraph i -URI http://eifrs.ifrs.org/eifrs/xifrs-link?type=IAS&num=1&code=ifrs-tx-2020-en-r&anchor=para_54_i&doctype=Standard -URIDate 2020-01-01 + Details
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