<SEC-DOCUMENT>0001193125-23-146989-index.html : 20230517
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<ACCEPTANCE-DATETIME>20230517160747
ACCESSION NUMBER:		0001193125-23-146989
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		4
CONFORMED PERIOD OF REPORT:	20230517
FILED AS OF DATE:		20230517
DATE AS OF CHANGE:		20230517

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NuCana plc
		CENTRAL INDEX KEY:			0001709626
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38215
		FILM NUMBER:		23931736

	BUSINESS ADDRESS:	
		STREET 1:		3 LOCHSIDE WAY
		CITY:			EDINBURGH
		STATE:			X0
		ZIP:			EH12 9DT
		BUSINESS PHONE:		44-0-131-357-1111

	MAIL ADDRESS:	
		STREET 1:		3 LOCHSIDE WAY
		CITY:			EDINBURGH
		STATE:			X0
		ZIP:			EH12 9DT

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NuCana BioMed Ltd
		DATE OF NAME CHANGE:	20170619
</SEC-HEADER>
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<TYPE>6-K
<SEQUENCE>1
<FILENAME>d496920d6k.htm
<DESCRIPTION>6-K
<TEXT>
Document 1 - file: d496920d6k.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>d496920dex991.htm
<DESCRIPTION>EX-99.1
<TEXT>
Document 2 - file: d496920dex991.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.2
<SEQUENCE>3
<FILENAME>d496920dex992.htm
<DESCRIPTION>EX-99.2
<TEXT>
Document 3 - file: d496920dex992.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.3
<SEQUENCE>4
<FILENAME>d496920dex993.htm
<DESCRIPTION>EX-99.3
<TEXT>
Document 4 - file: d496920dex993.htm

</DOCUMENT>
</SEC-DOCUMENT>