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Note 5 - Equity - Stock Option Activity (Details) - $ / shares	9 Months Ended	12 Months Ended
	Sep. 30, 2019	Dec. 31, 2018
Outstanding, number of shares (in shares)	4,535,681	2,628,749
Outstanding, weighted average exercise price (in dollars per share)	$ 3.31	$ 1.31
Options granted, number of shares (in shares)	1,461,715	2,034,525
Options granted, weighted average exercise price (in dollars per share)	$ 1.60	$ 6.21
Options exercised, number of shares (in shares)
Options exercised, weighted average exercise price (in dollars per share)
Options expired, number of shares (in shares)	(91,813)	(127,593)
Options expired, weighted average exercise price (in dollars per share)
Outstanding, number of shares (in shares)	5,905,583	4,535,681
Outstanding, weighted average exercise price (in dollars per share)	$ 2.94	$ 3.31

X

- Definition

Number of options or other stock instruments for which the right to exercise has lapsed under the terms of the plan agreements.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(iv)(4)
-URI http://asc.fasb.org/extlink&oid=116856206&loc=d3e5070-113901

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- Definition

Weighted average price of options that were either forfeited or expired.

+ References

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-Publisher FASB
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-Topic 718
-SubTopic 10
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Gross number of share options (or share units) granted during the period.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Weighted average price at which option holders acquired shares when converting their stock options into shares.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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