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Note 4 - Equity (Details Textual) - USD ($)
 3 Months Ended 9 Months Ended 12 Months Ended
Jan. 01, 2022
Feb. 10, 2021
Jan. 01, 2021
Sep. 30, 2022
Jun. 30, 2022
Mar. 31, 2022
Sep. 30, 2021
Jun. 30, 2021
Mar. 31, 2021
Sep. 30, 2022
Sep. 30, 2021
Dec. 31, 2021
Dec. 31, 2020
Apr. 03, 2018
Mar. 31, 2018
Jan. 29, 2018
Shares Issued, Price Per Share (in dollars per share)       $ 0.02           $ 0.02            
Proceeds from Issuance of Common Stock                   $ 1,754 $ 25,677,911          
Stock Issued During Period, Shares, Issued for Services (in shares)                   15,000   86,138        
Stock Issued During Period, Value, Issued for Services       $ 6,900 $ 17,972 $ 17,500 $ 16,800 $ 21,100 $ 20,650     $ 156,045        
Stock Issued During Period, Shares, Exercise of Cashless Warrants (in shares)                   13,643            
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period (in shares)                   116,973   670,889        
Stock Issued During Period, Value, Stock Options Exercised                       $ 677,912        
Preferred Stock, Shares Authorized (in shares)       10,000,000           10,000,000   10,000,000   10,000,000 10,000,000  
Preferred Stock, Par or Stated Value Per Share (in dollars per share)       $ 0.001           $ 0.001   $ 0.001   $ 0.001 $ 0.001  
Preferred Stock, Shares Outstanding, Ending Balance (in shares)       0           0   0        
Common Stock, Shares Authorized (in shares)       200,000,000           200,000,000   200,000,000   200,000,000 200,000,000  
Common Stock, Par or Stated Value Per Share (in dollars per share)       $ 0.001           $ 0.001   $ 0.001   $ 0.001 $ 0.001  
Common Stock, Shares, Outstanding, Ending Balance (in shares)       48,020,324           48,020,324   47,874,708        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)       $ 4.28           $ 4.28   $ 4.39 $ 4.37      
Class of Warrant or Right, Issued in Period (in shares)                   100,000   50,000        
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number, Ending Balance (in shares)       11,291,827           11,291,827   8,574,301 6,844,069      
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period (Year)                   10 years            
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance (in dollars per share)       $ 3.09           $ 3.09   $ 3.35 $ 2.81      
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross (in shares)                   2,901,166   2,519,628        
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price (in dollars per share)                   $ 2.18   $ 4.26        
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Total (in shares)                   66,667   118,507        
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price (in dollars per share)                   $ 2.55   $ 3.00        
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term (Year)                   7 years 3 months 21 days   7 years 2 months 26 days        
Class of Warrant or Right, Outstanding (in shares)       2,178,111           2,178,111   2,204,747 2,154,747      
Share-Based Payment Arrangement, Option [Member]                                
Share-Based Payment Arrangement, Expense                   $ 3.2            
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total       $ 9.6           $ 9.6            
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition (Year)                   1 year 11 months 19 days            
Performance Shares [Member]                                
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number, Ending Balance (in shares)       0           0            
Minimum [Member]                                
Shares Issued, Price Per Share (in dollars per share)                       $ 0.015        
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Month)                   12 months            
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance (in dollars per share)       $ 0.30           $ 0.30            
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Grant Date Fair Value (in dollars per share)                   0.24            
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price (in dollars per share)                   1.36   2.72        
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price (in dollars per share)                   $ 2.00   1.45        
Maximum [Member]                                
Shares Issued, Price Per Share (in dollars per share)                       2.15        
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Month)                   48 months            
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance (in dollars per share)       $ 9.80           $ 9.80            
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Grant Date Fair Value (in dollars per share)                   7.93            
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price (in dollars per share)                   3.50   7.22        
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price (in dollars per share)                   $ 3.66   $ 7.22        
The 2018 Equity Incentive Plan [Member]                                
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in shares)       564,272           564,272       4,160,000    
Share Based Compensation Arrangement By Share Based Payment Award, Percentage Applied on Outstanding Shares of Common Stock For Automatically Increase on Each Year                           5.00%    
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized (in shares) 2,393,735   2,155,884                          
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized (in shares)                           208,050    
The 2009 Plan [Member]                                
Common Stock, Capital Shares Reserved for Future Issuance (in shares)                           2,628,749    
The 2018 Employee Stock Purchase Plan [Member]                                
Share Based Compensation Arrangement By Share Based Payment Award, Percentage Applied on Outstanding Shares of Common Stock For Automatically Increase on Each Year                           2.00%    
Warrant For Service Provider [Member]                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)       50,000           50,000            
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)       $ 1.38           $ 1.38            
Warrant For Service Provider 2 [Member]                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)       50,000           50,000            
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)       $ 1.49           $ 1.49            
Vesting of Warrants For Service Provider [Member]                                
Share-Based Payment Arrangement, Expense                   $ 47,882            
Bear Creek Capital Warrant One [Member]                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                       25,000        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)                       $ 7.22        
Bear Creek Capital Warrant Two [Member]                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                       25,000        
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)                       $ 3.36        
Bear Creek Capital Warrants [Member]                                
Share-Based Payment Arrangement, Expense                       $ 200,282        
Performance-based Warrant [Member]                                
Class of Warrant or Right, Outstanding (in shares)       1           1            
Warrant, Nonvested Award, Cost Not yet Recognized, Amount       $ 300,000           $ 300,000            
Scientific Advisory Board Chairman [Member]                                
Stock Issued During Period, Value, Issued for Services                   $ 35,550            
FundAthena, Inc [Member] | Warrants Issued for Services [Member]                                
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)                               6,000
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)                               $ 5.00
Accounts Payable, Total                               $ 30,000
Class of Warrant or Right, Issued in Period (in shares)                   0            
Registered Direct Offering [Member] | Investors [Member]                                
Stock Issued During Period, Shares, New Issues (in shares)   4,000,000                            
Shares Issued, Price Per Share (in dollars per share)   $ 6.25                            
Proceeds from Issuance of Common Stock   $ 23,200,000