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Note 4 - Equity - Stock Option Activity (Details) - $ / shares
 9 Months Ended 12 Months Ended
Sep. 30, 2022
Dec. 31, 2021
Outstanding, number of shares (in shares) 8,574,301 6,844,069
Outstanding, weighted average exercise price (in dollars per share) $ 3.35 $ 2.81
Options granted, number of shares (in shares) 2,901,166 2,519,628
Options granted, weighted average exercise price (in dollars per share) $ 2.18 $ 4.26
Options exercised, number of shares (in shares) (116,973) (670,889)
Options exercised, weighted average exercise price (in dollars per share) $ 0.02 $ 1.01
Options expired or cancelled, number of shares (in shares) (66,667) (118,507)
Options expired, weighted average exercise price (in dollars per share) $ 2.55 $ 3.00
Outstanding, number of shares (in shares) 11,291,827 8,574,301
Outstanding, weighted average exercise price (in dollars per share) $ 3.09 $ 3.35
Vested or expected to vest, number of shares (in shares) 578,807  
Vested or expected to vest, weighted average exercise price (in dollars per share) $ 2.94  
Exercisable, number of shares (in shares) 6,579,287  
Exercisable, weighted average exercise price (in dollars per share) $ 3.23