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v3.23.1

Research, Consulting and Supply Agreements (Details Narrative) |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | ---
Jun. 13, 2022 USD ($) | Dec. 03, 2021 USD ($) | Apr. 30, 2022 USD ($) | Mar. 31, 2023 USD ($) | Mar. 31, 2022 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2017 Integer
Research and development expense |  |  |  | $ 2,052,000 | $ 1,036,000 |  |  |
Amarex Clinical Research LLC [Member] |  |  |  |  |  |  |  |
Research and development expense | $ 4,400,000 |  | $ 1,000,000.0 | 520,800 |  |  |  |
Research and development expense |  |  | $ 8,200,000 |  |  |  |  |
Estimated lives |  |  | 4 years 7 months 6 days |  |  |  |  |
Development cost | 125,470 |  |  |  |  |  |  |
Invigilators cost | $ 2,400,000 |  |  |  |  |  |  |
Amarex Clinical Research LLC [Member] | Pancreatic Cancer [Member] |  |  |  |  |  |  |  |
Research and development expense |  |  |  | 309,400 |  |  |  |
Amarex Clinical Research LLC [Member] | Post C O V I D [Member] |  |  |  |  |  |  |  |
Research and development expense |  |  |  | 211,400 |  |  |  |
H V I V O Services Limited [Member] | Reservation And Start Up Agreement [Member] |  |  |  |  |  |  |  |
Research and development expense |  | $ 2,340,000 |  |  |  |  |  |
Cancellation fees |  |  |  |  | $ 60,000 |  |  |
Impatients N V [Member] | Research Consulting And Supply Agreements [Member] |  |  |  |  |  |  |  |
Research and development expense |  |  |  | 8,000 |  |  |  |
Jubilant Hollister Stier [Member] |  |  |  |  |  |  |  |
Research and development expense | Integer |  |  |  |  |  |  |  | 16,000
Research and development expense |  |  |  | 1,432,257 |  |  |  |
Jubilant Hollister Stier [Member] | Research Consulting And Supply Agreements [Member] |  |  |  |  |  |  |  |
Research and development expense |  |  |  | 0 |  |  |  |
Pharmaceutics International, Inc [Member] |  |  |  |  |  |  |  |
Research and development expense |  |  |  |  |  | $ 278,000 |  |
Pharmaceutics International, Inc [Member] | Research Consulting And Supply Agreements [Member] |  |  |  |  |  |  |  |
Research and development expense |  |  |  | 9,300 |  |  |  |
Polysciences Inc [Member] |  |  |  |  |  |  |  |
Research and consulting |  |  |  | 103,000 |  |  | $ 250,000 |
Polysciences Inc [Member] | Research Consulting And Supply Agreements [Member] |  |  |  |  |  |  |  |
Research and development expense |  |  |  | 0 |  |  |  |
Yamasa Corporation [Member] |  |  |  |  |  |  |  |
Research and development expense |  |  |  | 327,730 |  |  |  |
Pharma Solutions [Member] | Master Service Agreement and Quality Agreement [Member] |  |  |  |  |  |  |  |
Research and development expense |  |  |  | $ 0 |  |  |  |

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