<SEC-DOCUMENT>0001192482-21-000613.txt : 20210702
<SEC-HEADER>0001192482-21-000613.hdr.sgml : 20210702
<ACCEPTANCE-DATETIME>20210702180804
ACCESSION NUMBER:		0001192482-21-000613
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20210630
FILED AS OF DATE:		20210702
DATE AS OF CHANGE:		20210702

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Schmidt William K
		CENTRAL INDEX KEY:			0001301122

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38306
		FILM NUMBER:		211071857

	MAIL ADDRESS:	
		STREET 1:		TWO CORPORATE DRIVE
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Ensysce Biosciences, Inc.
		CENTRAL INDEX KEY:			0001716947
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				822755287
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		7946 IVANHOE AVENUE
		STREET 2:		SUITE 201
		CITY:			LA JOLLA
		STATE:			CA
		ZIP:			92037
		BUSINESS PHONE:		(858) 263-4196

	MAIL ADDRESS:	
		STREET 1:		7946 IVANHOE AVENUE
		STREET 2:		SUITE 201
		CITY:			LA JOLLA
		STATE:			CA
		ZIP:			92037

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Leisure Acquisition Corp.
		DATE OF NAME CHANGE:	20170913
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2021-06-30</periodOfReport>

    <issuer>
        <issuerCik>0001716947</issuerCik>
        <issuerName>Ensysce Biosciences, Inc.</issuerName>
        <issuerTradingSymbol>ENSC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001301122</rptOwnerCik>
            <rptOwnerName>Schmidt William K</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ENSYSCE BIOSCIENCES, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>7946 IVANHOE AVENUE, SUITE 201</rptOwnerStreet2>
            <rptOwnerCity>LA JOLLA</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92037</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Medical Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>3.22</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2021-06-30</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>69142</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2026-02-04</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>69142</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>69142</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">On June 30, 2021, pursuant to that certain Agreement and Plan of Merger dated January 31, 2021 (the &quot;Merger Agreement&quot;) among Ensysce Biosciences, Inc. (f/k/a Leisure Acquisition Corp.) (the &quot;Issuer&quot;), EB Merger Sub, Inc., a Delaware corporation and wholly-owned, direct subsidiary of the Issuer (&quot;Merger Sub&quot;), and Ensysce Biosciences, Inc., a Delaware corporation (&quot;Ensysce&quot;), Merger Sub merged with and into Ensysce (the &quot;Merger&quot;), with Ensysce surviving as a wholly owned subsidiary of the Issuer. Pursuant to the Merger Agreement, each option and warrant of Ensysce that was outstanding and unexercised immediately prior to the Effective Time was assumed by the Issuer (each, a &quot;Derivative Security&quot;) and represents the right to acquire an adjusted number of shares of Common Stock at an adjusted exercise price, in each case, pursuant to the terms of the Merger Agreement.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ William Schmidt</signatureName>
        <signatureDate>2021-07-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
