<SEC-DOCUMENT>0001192482-21-000586.txt : 20210702
<SEC-HEADER>0001192482-21-000586.hdr.sgml : 20210702
<ACCEPTANCE-DATETIME>20210702152919
ACCESSION NUMBER:		0001192482-21-000586
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20210630
FILED AS OF DATE:		20210702
DATE AS OF CHANGE:		20210702

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Chang William H
		CENTRAL INDEX KEY:			0001594408

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38306
		FILM NUMBER:		211069656

	MAIL ADDRESS:	
		STREET 1:		C/O SEMLER SCIENTIFIC, INC.
		STREET 2:		911 BERN COURT, SUITE 110
		CITY:			SAN JOSE
		STATE:			CA
		ZIP:			95112

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Ensysce Biosciences, Inc.
		CENTRAL INDEX KEY:			0001716947
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				822755287
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		7946 IVANHOE AVENUE
		STREET 2:		SUITE 201
		CITY:			LA JOLLA
		STATE:			CA
		ZIP:			92037
		BUSINESS PHONE:		(858) 263-4196

	MAIL ADDRESS:	
		STREET 1:		7946 IVANHOE AVENUE
		STREET 2:		SUITE 201
		CITY:			LA JOLLA
		STATE:			CA
		ZIP:			92037

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Leisure Acquisition Corp.
		DATE OF NAME CHANGE:	20170913
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2021-06-30</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001716947</issuerCik>
        <issuerName>Ensysce Biosciences, Inc.</issuerName>
        <issuerTradingSymbol>ENSC</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001594408</rptOwnerCik>
            <rptOwnerName>Chang William H</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ENSYSCE BIOSCIENCES, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>7946 IVANHOE AVENUE, SUITE 201</rptOwnerStreet2>
            <rptOwnerCity>LA JOLLA</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92037</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <remarks>No securities are beneficially owned.</remarks>

    <ownerSignature>
        <signatureName>/s/ William Chang</signatureName>
        <signatureDate>2021-07-02</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
