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Patents (Details) - USD ($) | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | ---
Patents, gross | $ 0 | $ 618,810
Less: accumulated amortization | 0 | (62,690)
Less impairment loss | 0 | (556,120)
Total | 0 | 0
Adva-27a US Patent |  |
Patents, gross | 0 | 155,940
Adva-27a Worldwide Patents |  |
Patents, gross | $ 0 | $ 462,870

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