v3.22.1

Stockholders' Equity and Warrants (Details) - USD ($) $ / shares in Units, $ in Thousands									1 Months Ended	3 Months Ended	12 Months Ended
	Jan. 01, 2021	Dec. 21, 2020	Dec. 17, 2020	Aug. 28, 2020	Aug. 25, 2020	Jun. 19, 2020	Jun. 04, 2020	Apr. 06, 2020	Mar. 31, 2020	Jun. 30, 2020	Dec. 31, 2021	Dec. 31, 2020	Jun. 17, 2020	Mar. 19, 2020	Mar. 06, 2020	May 31, 2018
Warrants [Line Items]
Number of shares per warrant							1.5		1.5
Gross proceeds									$ 4,258
Warrants to purchase shares of common stock							1,374,750			1,942,131
Warrant exercise price												$ 1.70
Warrants converted into shares of common stock										2,913,197
Warrant Exchange for Common Stock (in shares)	510,460						2,062,126					1,221,945
Number of shares issued									6,511,280
Equity offering costs									$ 626
Conversion price														$ 0.525	$ 1.68
Deemed dividend												$ 140
Offerings
Warrants [Line Items]
Gross proceeds						$ 40,000
Warrants to purchase shares of common stock													7,614,700
Warrant exercise price													$ 5.25
Equity offering costs						$ 4,414
Warrants term													21 months
Series E Convertible Preferred Stock
Warrants [Line Items]
Number of shares issued												10,123
Series F Convertible Preferred Stock
Warrants [Line Items]
Number of shares issued												8,996
Preferred stock, par value																$ 0.01
Preferred stock, stated value																100
Conversion price															6.00	$ 6.00
March Exchange Agreement [Member]
Warrants [Line Items]
Aggregate fair value										$ 6,434
June Exchange Agreement [Member]
Warrants [Line Items]
Aggregate fair value							$ 11,755
Purchase agreement
Warrants [Line Items]
Number of shares per warrant			1									754,902
Gross proceeds				$ 35,333				$ 2,806
Warrants to purchase shares of common stock			24,509,806		11,216,932			481,818					7,614,700
Cash fees paid				$ 3,914
Warrant exercise price			$ 1.70		$ 3.02
Number of shares issued			24,509,806		10,407,408			4,139,393
Equity offering costs		$ 5,118						$ 244
Share price			$ 0.01		$ 3.15			$ 0.66					$ 5.253
Offering price per pre-funded warrant								$ 0.63
Proceeds from issuance of warrants		$ 41,667
Warrants term			24 months
Placement Agent Agreement
Warrants [Line Items]
Cash fees paid											$ 2,162
Warrants
Warrants [Line Items]
Exercised									1,900,625
Calm Warrants
Warrants [Line Items]
Warrant exercise price														$ 0.0525	$ 1.68
Pre-funded warrant | Purchase agreement
Warrants [Line Items]
Number of shares per warrant					1
Warrants to purchase shares of common stock					809,524
Warrant exercise price					$ 0.001
Palladium Warrants
Warrants [Line Items]
Warrants to purchase shares of common stock											325,500
Warrant exercise price											$ 1.70
Palladium Warrants | Purchase agreement
Warrants [Line Items]
Number of shares per warrant													133,258
Warrants to purchase shares of common stock					222,222
Warrant exercise price					$ 3.02								$ 5.25
Palladium Warrants | Placement Agent Agreement
Warrants [Line Items]
Warrants to purchase shares of common stock											325,500
Warrant exercise price											$ 1.70
H.C.W. Warrants
Warrants [Line Items]
Warrants to purchase shares of common stock											846,588
Cash fees paid											$ 2,162
Warrant exercise price											$ 2.125
H.C.W. Warrants | Purchase agreement
Warrants [Line Items]
Number of shares per warrant												1,960,784	609,176
Warrants to purchase shares of common stock					897,355
Warrant exercise price					$ 3.9375							$ 2.13	$ 6.5663
H.C.W. Warrants | Placement Agent Agreement
Warrants [Line Items]
Warrants to purchase shares of common stock											846,588
Warrant exercise price											$ 2.125
December 2020 Warrants
Warrants [Line Items]
Total of warrants exercised											11,273,529
Gross proceeds											$ 19,245

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