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Stockholders' Equity - Common Stock - Additional Information (Detail) - USD ($)	1 Months Ended	3 Months Ended		9 Months Ended		20 Months Ended
	Jul. 31, 2016	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2018	Dec. 31, 2017	Mar. 17, 2018	Jul. 26, 2018	Mar. 31, 2018
Class Of Stock [Line Items]
Common stock reserved for future issuance		29,290,172		29,290,172
Issuance of common stock		117,769,919		117,769,919				111,032,957
Common stock, shares authorized		200,000,000		200,000,000				200,000,000
At-The-Market Facility [Member]
Class Of Stock [Line Items]
Issuance of common stock		5,560,514		5,560,514
Certificate of Amendment [Member]
Class Of Stock [Line Items]
Common stock, shares authorized							200,000,000
Equity Offering Sales Agreement [Member]
Class Of Stock [Line Items]
Equity sales agreement expiration date	Mar. 17, 2018
Issuance of common stock						7,304,286
Value of shares sold under equity distribution agreement			$ 3,100,000		$ 7,100,000	$ 19,900,000
Issuance of common stock from stock options exercises, net, Shares			2,255,541		3,793,758
Equity Offering Sales Agreement [Member] | Maximum [Member]
Class Of Stock [Line Items]
Common stock reserved for future issuance	26,600,000
2018 Sales Agreement [Member]
Class Of Stock [Line Items]
Equity sales agreement expiration date				Feb. 22, 2021
Issuance of common stock		5,560,514		5,560,514
Value of shares sold under equity distribution agreement				$ 6,900,000
2018 Sales Agreement [Member] | At-The-Market Facility [Member]
Class Of Stock [Line Items]
Value of shares sold under equity distribution agreement		$ 1,900,000		$ 6,900,000
Issuance of common stock from stock options exercises, net, Shares		1,798,384		5,560,514
Common stock value reserved for future issuance		$ 42,900,000		$ 42,900,000
2018 Sales Agreement [Member] | Maximum [Member]
Class Of Stock [Line Items]
Common stock value reserved for future issuance		$ 92,900,000		$ 92,900,000

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