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General (Details Narrative) - USD ($)	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018	Dec. 31, 2018	Dec. 31, 2017
Accumulated deficit	$ 88,208,436		$ 87,186,783
Stockholder's deficit	(2,686,348)	$ (16,286,538)	$ (2,873,301)	$ (16,574,933)
Proceeds from issuance of common stock, net of issuance expenses	$ 750,116	924,398
Common stock par value	$ 0.001		$ 0.001
Common Stock [Member]
Stockholder's deficit	$ 146,447	$ 7,532	$ 141,638	$ 6,824
Number of common stock issued	3,499,693	435,556
Common stock par value	$ 0.001
Series D Units [Member] | Exercise Price Three [Member]
Warrant term	5 years
Warrants to purchase common stock	200,652
Warrant exercise price	$ 5.40
Series D Units [Member]
Proceeds from issuance of common stock, net of issuance expenses	$ 769,440
Number of common stock issued	200,652
Series D Units [Member] | Exercise Price One [Member]
Warrant term	5 years
Warrants to purchase common stock	200,652
Warrant exercise price	$ 1.80
Series D Units [Member] | Exercise Price Two [Member]
Warrant term	5 years
Warrants to purchase common stock	200,652
Warrant exercise price	$ 3.60

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