<SUBMISSION>
<ACCESSION-NUMBER>0001002014-03-000515
<TYPE>8-K
<PUBLIC-DOCUMENT-COUNT>2
<PERIOD>20031031
<ITEMS>7
<ITEMS>9
<FILING-DATE>20031103
<FILER>
<COMPANY-DATA>
<CONFORMED-NAME>ORAGENICS INC
<CIK>0001174940
<ASSIGNED-SIC>2834
<IRS-NUMBER>593410522
<STATE-OF-INCORPORATION>FL
<FISCAL-YEAR-END>1231
</COMPANY-DATA>
<FILING-VALUES>
<FORM-TYPE>8-K
<ACT>34
<FILE-NUMBER>333-100568
<FILM-NUMBER>03971145
</FILING-VALUES>
<BUSINESS-ADDRESS>
<STREET1>12085 RESEARCH DRIVE
<CITY>ALACHUA
<STATE>FL
<ZIP>32615
<PHONE>3864184018
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>12085 RESEARCH DRIVE
<CITY>ALACHUA
<STATE>FL
<ZIP>32615
</MAIL-ADDRESS>
</FILER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>oi8k10312003.htm
<DESCRIPTION>FORM 8-K FOR ORAGENICS, INC.
<TEXT>
<HTML>
<HEAD>
<TITLE>Form 8-K For Oragenics, Inc.</TITLE>
</HEAD>
<BODY>

<P>===================================================================================</P>

<B><P ALIGN="CENTER">UNITED STATES<br>
SECURITIES AND EXCHANGE COMMISSION<br>
Washington, D.C. 20549</P></B>

<B><P ALIGN="CENTER">FORM 8-K</P></B>

<B><P ALIGN="CENTER">CURRENT REPORT<br>
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934</P></B>

<p align=left><CENTER><TABLE CELLSPACING=0 BORDER=0 CELLPADDING=0 WIDTH=680>
<TR><TD VALIGN="TOP">

<B><P ALIGN="CENTER">October 31, 2003</B></TD>
</TR>
<TR><TD VALIGN="TOP">

<P ALIGN="CENTER">Date of Report (Date of earliest event reported) </TD>
</TR>
</TABLE>
</CENTER>

<br>
<p align=left><CENTER><TABLE CELLSPACING=0 BORDER=0 CELLPADDING=0 WIDTH=680>
<TR><TD VALIGN="TOP">
<B><P ALIGN="CENTER">ORAGENICS, INC.</B></TD>
</TR>
<TR><TD VALIGN="TOP">
<P ALIGN="CENTER">(Exact name of registrant as specified in its charter)</TD>
</TR>
</TABLE>
</CENTER>

<br>
<p align=left><TABLE CELLSPACING=0 BORDER=0 CELLPADDING=0 WIDTH=680>
<TR><TD WIDTH="36%" VALIGN="TOP">

<B><P ALIGN="CENTER">Florida</B></TD>
<TD WIDTH="32%" VALIGN="TOP">

<B><P ALIGN="CENTER">333-100568</B></TD>
<TD WIDTH="32%" VALIGN="TOP">

<B><P ALIGN="CENTER">59-3410522</B></TD>
</TR>
<TR><TD WIDTH="36%" VALIGN="TOP">

<P ALIGN="CENTER">(State or other jurisdiction<br>
of incorporation)</TD>
<TD WIDTH="32%" VALIGN="TOP">

<P ALIGN="CENTER">(Commission<br>
File Number)</TD>
<TD WIDTH="32%" VALIGN="TOP">

<P ALIGN="CENTER">(IRS Employer<br>
Identification No.)</TD>
</TR>
</TABLE>
</CENTER>

<br>
<p align=left><CENTER><TABLE CELLSPACING=0 BORDER=0 CELLPADDING=0 WIDTH=680>
<TR><TD VALIGN="TOP">

<B><P ALIGN="CENTER">12085 Research Drive<br>
Alachua, Florida 32615</B></TD>
</TR>
<TR><TD VALIGN="TOP">

<P ALIGN="CENTER">(Address of principal executive offices including zip code)</TD>
</TR>
</TABLE>
</CENTER>

<br>
<p align=left><CENTER><TABLE CELLSPACING=0 BORDER=0 CELLPADDING=0 WIDTH=680>
<TR><TD VALIGN="TOP">

<B><P ALIGN="CENTER">(386) 418-4018</B></TD>
</TR>
<TR><TD VALIGN="TOP">

<P ALIGN="CENTER">Registrant's telephone number, including area code</TD>
</TR>
</TABLE>
</CENTER>

<br>
<p align=left><CENTER><TABLE BORDER=0 CELLSPACING=0 CELLPADDING=0 WIDTH=680>
<TR><TD VALIGN="TOP">

<B><P ALIGN="CENTER">None</B></TD>
</TR>
<TR><TD VALIGN="TOP">

<P ALIGN="CENTER">(Former name or former address, if changed since last report.)</TD>
</TR>
</TABLE>
</CENTER>

<p>&nbsp;</p>
<p>&nbsp;</p>

<P>==================================================================================</P>

<p>&nbsp;</p>
<page>
<hr>

<B><P>ITEM 7. &nbsp; &nbsp; &nbsp; FINANCIAL INFORMATION AND EXHIBITS</P></B>

<P ALIGN="LEFT"><CENTER><TABLE BORDER=0 CELLSPACING=0 CELLPADDING=0 WIDTH=420>
<TR><TD WIDTH="24%" VALIGN="TOP">

<B><P>Exhibit No.<hr></B></TD>
<TD WIDTH="76%" VALIGN="TOP">
<B><P>Description<hr></B></TD>
</TR>
<TR><TD WIDTH="24%" VALIGN="TOP">
<P>99.1</TD>
<TD WIDTH="76%" VALIGN="TOP">
<P>Press Release</TD>
</TR>
</TABLE>
</CENTER></P>


<br>
<B><P>ITEM 9. &nbsp; &nbsp; &nbsp; REGULATION FD DISCLOSURE</P></B>

<P>Oragenics, Inc. announces today that it has granted stock options to Paul Hassie and Brian Anderson.</P>

<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p align=center> - 2 - </p>
<page>
<hr>

<B><P ALIGN="CENTER">SIGNATURES</P></B>

<P>In accordance with the requirements of the Exchange Act, the registrant caused this report to be signed on its behalf by the undersigned, thereunto duly authorized on this 31<SUP>st</SUP> day of October, 2003.</P>

<DIR>
<DIR><TABLE BORDER=0 CELLSPACING=0 CELLPADDING=0 WIDTH=680>
<TR><TD WIDTH="38%" VALIGN="TOP">

<P>&nbsp;</TD>
<TD WIDTH="62%" VALIGN="TOP" COLSPAN=2>

<B><P>ORAGENICS, INC.<br>
(Registrant)</B></TD>
</TR>
<TR><TD WIDTH="38%" VALIGN="TOP">

<P>&nbsp;</TD>
<TD WIDTH="7%" VALIGN="TOP">

<P>BY:</TD>
<TD WIDTH="55%" VALIGN="TOP">

<P>/s/ Mento A. Soponis</TD>
</TR>
<TR><TD WIDTH="38%" VALIGN="TOP">

<P>&nbsp;</TD>
<TD WIDTH="7%" VALIGN="TOP">

<P>&nbsp;</TD>
<TD WIDTH="55%" VALIGN="TOP">

<P>Mento A. Soponis<br>
President, Principal Executive Officer and a member of the Board of Directors.</TD>
</TR>
</TABLE>


</DIR>
</DIR>

<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p align=center> - 3 - </p>
<page>
<hr>


</BODY>
</HTML>

</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>3
<FILENAME>exh991.htm
<DESCRIPTION>PRESS RELEASE
<TEXT>
<HTML>
<HEAD>
<TITLE>Exhibit 99.1</TITLE>
</HEAD>
<BODY>

<p>Exhibit 99.1</p>

<B><P ALIGN="CENTER">ORAGENICS, INC.</P></B>

<P ALIGN="CENTER">12085 Research Drive<br>
Alachua, Florida<br>
Tel: 386.418.4018    Fax: 386-462-0875<br>
<U>www.oragenics.com</P></U>

<B><P ALIGN="CENTER">NEWS RELEASE</P></B></FONT>

<p align-left><CENTER><TABLE CELLSPACING=0 BORDER=0 CELLPADDING=0 WIDTH=680>
<TR><TD WIDTH="43%" VALIGN="TOP">
<B><P>Trading Symbol - ORA.U (TSX-V) </B></FONT></TD>
<TD WIDTH="7%" VALIGN="TOP">
</TD>
<TD WIDTH="7%" VALIGN="TOP">
</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP">
</FONT></TD>
<TD WIDTH="7%" VALIGN="TOP">
</FONT></TD>
<TD WIDTH="28%" VALIGN="TOP">
<B><P>October 31, 2003</B></FONT></TD>
</TR>
</TABLE>
</CENTER>

<B><P ALIGN="CENTER">Grant of Stock Options</P>

<P>Alachua, Florida</B> - Oragenics, Inc. (the "Company") announces that it has granted stock options to Paul Hassie, Chief Financial Officer of the Company, and Brian Anderson, a director of the Company.  On July&nbsp;31, 2003, Mr. Hassie was granted options to purchase 20,000 shares at US$2.65 per share, exercisable until July&nbsp;31, 2008.  On September&nbsp;3, 2003, Mr. Anderson was granted options exercisable at a price of US$4.00 per share exercisable until September&nbsp;3, 2008.  The options will vest over a period of 3 years.  Any shares acquired on the exercise of the options will be subject to a hold period of four months from the date the options were granted and the options will terminate 90 days after the optionee ceases to serve the Company.  The grant of the options is subject to TSX Venture Exchange acceptance.</P>

<P>On Behalf of the Board of Directors of</P>

<B><P>ORAGENICS, INC.</P></B>

<P>/s/ Mento A. Sponis<br>
Mento A. Soponis, President</P>

<P>Contact: &nbsp; &nbsp; Mento A. ("Chuck") Soponis, Chief Executive Officer<br>
&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; Oragenics, Inc., Tel:  386-418-4018</P>

<P>&nbsp;</P>
<P>&nbsp;</P>
<P>&nbsp;</P>
<P>&nbsp;</P>
<P>&nbsp;</P>
<B><P>&nbsp;</P>
<P>The TSX Venture Exchange has not reviewed and does not accept responsibility for the adequacy or accuracy of the contents of this News Release.</P>
</B></FONT>

<page>
<hr>

</BODY>
</HTML>

</TEXT>
</DOCUMENT>
</SUBMISSION>
